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All Journal Padjadjaran Journal of Dental Researchers and Students Denta: Jurnal Kedokteran Gigi Indonesian Journal of Community Empowerment
Wedarti, Yoifah Rizka
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health

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SCHOOL DENTAL HEALTH PROGRAM: TRAINING OF TRAINER KESEHATAN GIGI DAN MULUT PADA GURU DAN ORANG TUA SEBAGAI UPAYA MENUJU PROGRAM “ INDONESIA BEBAS KARIES 2030” Rahman, Kurnia Hayati; paramita, Ayulistya; Sucahyo, Bambang; Revianti, Syamsulina; Pinasti, Restika Anindya; Paramita, Anisa Listya; Prameswari, Noengki; Lelyna, Nora; Handayani, Budi; Widaningsih, Widaningsih; Wedarti, Yoifah Rizka; Nilawati, Nina; Harnowo, Setyo; Prabowo, Puguh Bayu; Damaiyanti, Dian Widya
MAJU : Indonesian Journal of Community Empowerment Vol. 1 No. 6 (2024): MAJU : Indonesian Journal of Community Empowerment, November 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/aj2jgc13

Abstract

Oral and dental health among school-age children is often neglected, despite its importance in supporting their quality of life. A Training of Trainer (ToT) program on oral and dental health was conducted for teachers and parents at MI KH Ramly Surabaya to support the vision of Indonesia Free from Dental Caries 2030. This training included educational sessions and guidance on proper tooth-brushing habits using fluoride toothpaste. The results showed an improvement in participants' knowledge, with higher average post-test scores compared to pre-test scores. Additionally, there was a positive behavioral change among children in maintaining oral hygiene. Although statistical tests indicated insignificant results, the intervention had a practical impact on establishing healthy habits. Support from teachers, parents, and healthcare professionals is essential to reducing the prevalence of dental caries in the future. .
Antibacterial Activity and Cytotoxicity Evaluation of Eucheuma spinosum Extract Against Porphyromonas gingivalis and BHK-21 Cells Kurniawan, Hansen; Saptaswari, Dianty; Yoyada, Novendy; Hendro, Onge Victoria; Widyastuti, Widyastuti; Nilawati, Nina; Wedarti, Yoifah Rizka; Elidasari, Monika; Soesilo, Diana; Az-Zahra, Hilaliya Rosyadah; Najwa, Naura Salsabilah; Rizal, Moh. Basroni
Denta Journal Kedokteran Gigi Vol 20 No 2 (2026): August
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v20i2.2

Abstract

Background: Porphyromonas gingivalis (P. gingivalis) is a major pathogenic bacterium that causes periodontitis, with diverse virulence factors and resistance to conventional therapies. Therefore, the search for natural antibacterial agents is important. One potential candidate is Eucheuma spinosum (E. spinosum), which contains bioactive compounds such as flavonoids, alkaloids, and terpenoids. Objectives: This study aimed to evaluate the antibacterial activity and cytotoxic effects of E. spinosum extract against P. gingivalis and BHK-21 fibroblast cells. Materials and Methods: A true experimental laboratory study was conducted using ethanol extract of E. spinosum at concentrations of 12.5%, 25%, and 50%. Antibacterial activity was assessed by disc diffusion on Mueller-Hinton agar, while cytotoxicity was evaluated by the MTT assay in BHK-21 cells. Statistical analysis was performed using Kruskal–Wallis and Mann–Whitney tests. Discussion: The results showed that E. spinosum extract exhibited significant antibacterial activity against P. gingivalis, with inhibition zones increasing in a concentration-dependent manner (10.31, 13.57, and 15.41 mm, respectively), categorized as strong inhibition. However, cytotoxicity testing revealed reduced cell viability across all concentrations (40.49%, 36.58%, and 36.53%), indicating toxic effects in accordance with ISO 10993-5. Statistical analysis confirmed significant differences between groups (p < 0.05). Conclusion: E. spinosum extract demonstrates promising antibacterial properties against P. gingivalis, but its cytotoxic effects on fibroblast cells limit its direct clinical application. Further research is required to optimize safe concentrations and improve biocompatibility for periodontal therapy.
Potensi kitosan kepiting rajungan (Portunus pelagicus) dalam penghambatan pembentukan biofilm Porphyromonas gingivalis dan pertumbuhan Candida albicansPotential of flower crab (Portunus pelagicus) chitosan in the inhibition of Porphyromonas gingivalis and Candida albicans biofilm Wedarti, Yoifah Rizka; Loekito, Laurencia Isabella; Pangabdian, Fani; Andriani, Dwi
Padjadjaran Journal of Dental Researchers and Students Vol 4, No 2 (2020): Oktober 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v4i2.26636

Abstract

Pendahuluan: Pembentukan biofilm sangat penting dalam patogenesis periodontitis. Porphyromonas gingivalis merupakan bakteri yang banyak ditemukan pada plak gigi dan memiliki kemampuan membentuk biofilm demikian juga Candida albicans memiliki faktor virulensi yang dapat membantu kolonisasi dan proliferasi bakteri di dalam poket periodontal. Ekstrak kitosan kepiting rajungan (Portunus pelagicus) mempunyai potensi antimikrobial yang dapat digunakan sebagai alternatif terapi. Tujuan penelitian ini adalah untuk menganalisis potensi kitosan kepiting rajungan (Portunus pelagicus) dalam penghambatan biofilm Porphyromonas gingivalis dan Candida albicans. Metode: Jenis penelitian adalah eksperimental murni. Penelitian ini menggunakan ekstrak kitosan kepiting rajungan (Portunus pelagicus) terhadap biofilm Porphyromonas gingivalis dan biofilm Candida albicans.  Dibagi menjadi 4 kelompok, di mana tiap kelompok terdiri dari 4 sampel. Kelompok K+ (kelompok kontrol positif), P1(kitosan 0,25%), P2 (kitosan 0,5%), P3 (kitosan 1%). Penghambatan biofilm ditentukan dengan menggunakan metode microtiter plate yang menghasilkan nilai optical density kemudian dihitung dengan menggunakan rumus persen penghambatan. Analisis data menggunakan one-way ANOVA diikuti dengan uji LSD. Hasil: Terdapat perbedaan yang signifikan penghambatan biofilm dari kitosan Portunus pelagicus terhadap Porphyromonas gingivalis (p<0,05) antara kelompok, kecuali K + dengan P3. Sedangkan untuk penghambatan Candida albicans menunjukkan bahwa ada perbedaan yang signifikan dalam persentase penghambatan biofilm (p<0,05), antara kelompok K+ dengan P2 dan P3; kelompok P1 dengan P2 dan P3; kelompok P2 dengan P3. Simpulan: Kitosan Portunus pelagicus memiliki potensi dalam menghambat pembentukan biofilm Porphyromonas gingivalis dan pertumbuhan Candida albicans. Kitosan Portunus pelagicus 1% memiliki efek antimikrobial terbesar pada biofilm.Kata kunci: Biofilm, Porphyromonas gingivalis, Candida albicans, kitosan portunus pelagicus, periodontitis. ABSTRACTIntroduction: Biofilm formation is important in periodontitis pathogenesis. Porphyromonas gingivalis and Candida albicans, which are found in dental plaque and can form a biofilm, have virulence factor that facilitates the bacterial colonisation and proliferation in periodontal pockets. Chitosan extract of flower crab (Portunus pelagicus) has antimicrobial potential which can be used as an alternative therapy. The objective of this research was to analyse the potential of flower crab (Portunus pelagicus) chitosan in the inhibition of Porphyromonas gingivalis and Candida albicans biofilms. Methods: This research was a pure experimental laboratory. This study used flower crab (Portunus pelagicus) chitosan to inhibit the biofilm formation of Porphyromonas gingivalis and Candida albicans. The subjects were divided into four groups, where each group consisted of 4 samples. The K+ (positive control group), P1 (0.25% chitosan), P2 (0.5% chitosan), and P3 (1% chitosan). The biofilm inhibition was determined using the microtiter plate methods, which results in the value of optical density, then calculated using the inhibition formula percentage. Data analysis was conducted using the one-way ANOVA followed by the LSD test. Results: There were significant differences in the Porphyromonas gingivalis biofilm inhibition between groups (p < 0.05), except in group K+ with P3. Whereas for Candida albicans biofilm inhibition showed no significant difference (p < 0.05) between group K+ with P2 and P3; group P1 with P2 and P3; and group P2 with P3. Conclusion: The chitosan of flower crab (Portunus pelagicus) has the potential in inhibiting the biofilm formation of  Porphyromonas gingivalis and Candida albicans. The highest antibacterial effect on the biofilm formation is shown in the concentration of 1%.Keywords: Biofilm, Porphyromonas gingivalis, Candida albicans, chitosan, Portunus pelagicus, periodontitis.
Co-Authors Agustina, Felisitas Maria Az-Zahra, Hilaliya Rosyadah Damaiyanti, Dian Widya Dian Mulawarmanti, Dian Diana Soesilo, Diana Dwi Andriani, Dwi Elidasari, Monika Fani Pangabdian, Fani Handayani, Budi Harnowo, Setyo Hendro, Onge Victoria Kurnia Hayati Rahman Kurniawan, Hansen Lelyna, Nora Loekito, Laurencia Isabella Najwa, Naura Salsabilah Nina Nilawati Noengki Prameswari Paramita, Anisa Listya Pinasti, Restika Anindya Puguh Bayu Prabowo, Puguh Bayu Rizal, Moh. Basroni Saptaswari, Dianty Sucahyo, Bambang Sutarto, Ayulistya Paramita Syamsulina Revianti Widaningsih Widaningsih, Widaningsih Widyastuti Widyastuti Yoyada, Novendy