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All Journal ODONTO Dental Journal Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students Jurnal Material Kedokteran Gigi Denta: Jurnal Kedokteran Gigi Odonto dental journal JPMP
Twi Agnita Cevanti
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Humanities Biochemistry, Genetics & Molecular Biology Dentistry Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Perbandingan daya antibakteri serat selulosa sabut kelapa (Cocos nucifera L.) pada konsentrasi berbeda terhadap Streptococcus mutansComparison of the antibacterial power of coconut cellulose fiber (Cocos nucifera L.) at different concentrations against Streptococcus mutans Sinta Puspita; Diana Soesilo; Linda Rochyani; Twi Agnita Cevanti
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 34, No 1 (2022): April 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v34i1.35076

Abstract

Pendahuluan: Kelemahan dari komposit konvensional adalah terjadinya shrinkage dan stress polimerisasi. Penggunaan serat sebagai bahan pengisi pada resin komposit dapat menurunkan kontraksi polimerisasi. Berdasarkan penelitian sebelumnya serat sabut kelapa memiliki daya antibakteri yang cukup baik karena mengandung golongan senyawa metabolit sekunder yaitu tanin, flavonoid, dan polifenol. Selain itu juga memiliki beberapa senyawa, antara lain asam elagat, asam galat, epikatekin, dan katekin yang juga diperkirakan memiliki aktivitas sebagai anti bakteri. Serat sabut kelapa tidak dapat digunakan secara langsung dalam bentuk aslinya sehingga dibutuhkan modifikasi untuk membersihkan serat. Tujuan penelitian menganalisis perbandingan daya antibakteri serat selulosa sabut kelapa (Cocos nucifera L.) pada konsentrasi berbeda terhadap S. mutans. Metode: Jenis penelitian true experimental dengan desain penelitian posttest only control design. Ekstraksi serat selulosa dari sabut kelapa melalui proses bleaching kemudian sintesis selulosa menggunakan NaOH dan urea selanjutnya di nukleasi dengan etanol sebagai anti solvent organik dan dikeringkan dengan proses sublimasi. Pengujian aktivitas antibakteri menggunakan metode sumur difusi dengan dua konsentrasi uji yaitu kelompok 1 menggunakan anti solvent etanol 70% dan, pada kelompok 2 menggunakan etanol 96%. Kontrol negatif menggunakan aquadest steril. Selanjutnya diamati dan diukur diameter zona hambat dengan jangka sorong. Data yang diperoleh diuji statistik menggunakan independent t-test. Hasil: Daya antibakteri kelompok sampel yang diberi perlakuan etanol 96% lebih tinggi dibandingkan dengan kelompok sampel etanol 70%.  Hasil uji independent t-test menunjukkan bahwa nilai p yang signifikan p=0,000<0,05, Simpulan: Serat sabut kelapa yang diberi etanol dengan konsentrasi 96% terbukti memiliki daya antibakteri yang lebih tinggi daripada yang diberi etanol dengan konsentrasi 70%.Kata kunci: daya antibakteri; serat sabut kelapa; Streptococcus mutans ABSTRACTIntroduction: The weakness of conventional composites is the occurrence of shrinkage and polymerisation stress. The use of fiber as a filler in composite resins can reduce polymerisation contraction. Based on previous research, coconut fiber has good antibacterial properties because it contains a class of secondary metabolites, namely tannins, flavonoids, and polyphenols. In addition, it also has several compounds, including ellagic acid, gallic acid, epicatechins and catechins which are also thought to have antibacterial activity. However, coconut fiber cannot be used directly in its original form so modifications are needed to clean the fiber. This study aimed to compare the antibacterial power of coconut cellulose (Cocos nucifera L.) fibers at different concentrations against S. mutans. Methods: This type of research is true experimental with posttest only control design. Extraction of cellulose fiber from coconut fiber through a bleaching process and then synthesis of cellulose using NaOH and urea then nucleated with ethanol as an organic anti-solvent and dried by sublimation process. The antibacterial activity was tested using the diffusion well method with two test concentrations, namely group 1 using 70% ethanol anti-solvent and, in group 2 using 96% ethanol. Negative control using sterile distilled water. Then observed and measured the diameter of the inhibition zone with a caliper. The data obtained were statistically tested using independent t-test. Results: The antibacterial power of the sample group that was treated with ethanol was 96% higher than that of the 70% ethanol sample group. The results of the independent t-test obtained the p-value of p=0.000; p<0.05. Conclusion: Coconut fiber which was given ethanol with a concentration of 96%, proved to have higher antibacterial power than that given ethanol with a concentration of 70%.Keywords: antibacterial activity; coconut fiber; Streptococcus mutans
Perbedaan kekuatan impak mahkota pasak prefabricated logam dengan mahkota pasak prefabricated non logamImpact strength difference between prefabricated metal post crown and prefabricated non-metal post crown Annisa Tri Ariyanti; Twi Agnita Cevanti; Arifzan Razak
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 30, No 1 (2018): April
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.38 KB) | DOI: 10.24198/jkg.v30i1.18183

Abstract

Pendahuluan:  Gigi yang masih vital memiliki ketahanan yang paling tinggi, diikuti pasak prefabricated resin fiber, dan pasak prefabricated stainless steel. Bahan pasak logam memiliki sifat mekanik seperti modulus elastisitas yang tinggi daripada bahan pasak non logam yang mempengaruhi kekuatan impak bahan pasak. Kekuatan impak adalah energi yang diperlukan untuk mematahkan suatu bahan dengan gaya benturan. Penelitian ini bertujuan untuk mengetahui perbedaan kekuatan impak antara mahkota pasak prefabricated  logam berbahan titanium dengan mahkota pasak prefabricated non logam bahan resin fiber. Metode: Sebanyak 6 sampel gigi premolar dengan mahkota pasak prefabricated berbahan resin fiber. dengan rahang atas yang telah diobturasi dan dibagi kedalam 2 kelompok: kelompok I adalah kelompok yang akan diberikan pasak prefabricated bahan resin fiber (n=3), kelompok II dengan pasak prefabricated bahan titanium (n=3), kemudian ditumpat dengan bahan core build-up dari komposit. Semua kelompok ditanam di balok besi yang berbentuk persegi panjang. Selanjutnya dilakukan uji impak menggunakan mini impact tester tipe KRY sampai sampel patah. Hasil: Rerata kelompok pasak prefabricated bahan resin fiber adalah 1,9267 ± 0,99203 J/mm2 sedangkan kelompok pasak prefabricated bahan titanium adalah 5,7567 ± 0,41477 J/mm2. Independent sample t-test menunjukkan terdapat perbedaan pada semua kelompok. Simpulan: Kekuatan impak mahkota pasak prefabricated logam berbahan titanium lebih tinggi daripada kekuatan impak mahkota pasak prefabricated non logam berbahan resin fiber.Kata kunci: Kekuatan impak, pasak prefabricated logam, titanium, pasak prefabricated non logam, resin fiber. ABSTRACTIntroduction: Vital teeth are having the highest strength followed by prefabricated fibre resin post, and prefabricated stainless steel post. The metal post has higher mechanical properties such as its high elastic modulus rather than a non-metallic post which affects the material impact strength. Impact strength defined as the energy required to break material with impact force. This study was aimed to determine the difference between the impact strength of prefabricated metal post crown made of titanium and prefabricated non-metal post crown made of fibre resin. Methods:  Six obturated mandibular premolars with prefabricated fibre resin post were divided into two groups: Group I was given a prefabricated fibre resin post (n = 3); group II was given a prefabricated titanium post (n = 3). They were all then filled with build-up core composite material. All groups were planted in a rectangular iron block. Furthermore, the impact test was performed using a mini-impact tester (KRY type) until all samples were broken. Result: The average impact strength of the post crown with prefabricated fibre resin material was 1.9267 ± 0.99203 J/mm2, while prefabricated titanium was 5.7567 ± 0.41477 J/mm2. Independent sample t-test showed that there were differences in all groups. Conclusion: The impact strength of the prefabricated metal post crown made of titanium was higher than the impact strength of the prefabricated non-metal post crown made of fibre resin.Keywords: Impact strength, prefabricated metal post crown, titanium, prefabricated non-metal post crown, fibre resin.
The Secondary Metabolites Screening and the Effectiveness (Ananas comosus (L.) Merr of the Queen Pineapple Stems in Decreasing the Number of Enterococcus faecalis’s Colonies Shinta Nurmaraya Febrianti; Twi Agnita Cevanti; Henu Sumekar
Denta Journal Kedokteran Gigi Vol 10 No 1 (2016): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: A cause of endodontic treatment failure was sterilization process error so that bacterias still left in the root canal. Enterococcus faecalis were resistant to sterilization medicines, it was necessary to develop natural sterilization medicines such as the Queenpineapple stems that had the antibacterial content. Purpose: The aim of this research was to determine the effectivity of the Queen pineapple (Ananas comosus (L.) Merr) stems extract in decreasing the Enterococcus faecalis’s colonies Materials and Methods: This research was true experimental with the post test only control group design. The Queen pineapple stems extract tested its secondary metabolites contents. Enterococcus faecalis ATCC 29212 cultured in Brain Heart Infusion Broth synchronized with Mc Farland 0,5 solution and divided into seven groups (n=7). It used dilution series method, each BHIB tube given by the 100% extract (P1); 50% (P2); 25% (P3); 12,5% (P4) ; 6,25% (P5) ; 3,125% (P6) and without the extract (K(-)), incubated for 24 hours and streaked on Mueller Hinton Agar and incubated for 24 hours, then calculate the colonies’ amount of each group. Datas analyzed by Mann-Whitney U-Test because only 50% and 25% concentration can be calculated. Result: The resultshowed that the Queen pineapple stems contained flavonoids, tannins, alkaloids, saponins, also there were significant differences among the 50% and 25% concentration groups p<0.05. Conclusion: The Queen pineapple stems extract’s 50% concentration was effective to decrease the number of Enterococcus faecalis’s colonies.
The effect of low viscous coir fiber resin composite immersion time on composition dissolution Yongki Hadinata Wijaya; Twi Agnita Cevanti; Diana Soesilo; Linda Rochyani
Odonto : Dental Journal Vol 10, No 1 (2023): July 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.1.82-89

Abstract

Background: E glass fiber dental is a fiber that is often used in dentistry. The availability of E glass fiber in Indonesia is still very limited. Various types of non-dental glass fiber materials are found in the market as engineering materials with relatively cheap prices so that they are expected to be used as an alternative to E glass fiber dental, which one of is coconut fiber. The composition of non-dental glass fiber is almost the same as that of dental E glass fiber. The composition affects the mechanical properties and chemical properties of the fiber. Glass fiber compositions such as Na2O and K2O will increase water resistance. Method: This study was conducted using a post test only control group design. The material used in this study was a composite of coconut coir fiber. The subjects of the coco fiber composite were divided into 4 groups for solubility test based on ISO 4049. The results obtained were analyzed using one-way ANOVA (p = 0.000). The results showed the lowest mean component solubility (%) was in the coconut fiber composite group A (0.476±0.03) and the highest yield was in the coco coir fiber composite D (0.6±0.01). Results: The results of the one-way ANOVA test showed a significant difference in the coco fiber composite in the solubility of the components (p
Sitotoksisitas komposit serat selulosa sabut kelapa sebagai kandidat novelty basis pada material kedokteran gigi: studi eksperimental cevanti, Twi agnita; Soesilo, Diana; Pangabdian, Fani; Wijaya, Yongki Hadinata; Puspita, Sinta; Hollanda, Ghita Hadi
Padjadjaran Journal of Dental Researchers and Students Vol 7, No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v7i2.46092

Abstract

ABSTRAKPendahuluan: Teknologi Fiber-reinforced composite (FRC) sedang dikembangkan sebagai bahan inovatif dalam kedokteran gigi. Menipisnya sumber daya fosil merupakan masalah kritis untuk resin komposit serat saat ini. Sabut kelapa Cocos nucifera L.(coir) memiliki potensi tinggi untuk menggantikan bahan penguat serat sintetis sebagai bahan baru yang akan dikembangkan. Tujuan penelitian mengetahui toksisitas komposit serat selulosa coir sebagai material basis. Metode: Jenis penelitian eksperimental post-test only control group. Selulosa dari coir disintesis menggunakan organosolvent, di bleaching dengan peroxide dalam larutan alkali, serta di nukleasi dengan etanol absolut. Dilakukan uji viabilitas sel fibroblas GT1 untuk serat selulosa kemudian pembuatan komposit selulosa coir dengan fraksi berat 70% filler serat selulosa, dan 30% matriks BisGMA, TEGDMA dan DGEBA. Selanjutnya komposit selulosa coir dilakukan uji toksisitas dari hasil rendaman komposit pada saliva buatan selama 7,14, dan 21 hari menggunakan sel fibroblas BHK-21. Hasil: Hasil uji Post Hoc LSD memberikan kesimpulan bahwa kelompok P-21 didapatkan perbedaan yang signifikan antara kelompok perlakuan K.Sel, P-7, P-14 dengan nilai p<0,05. Dosis paling aman serat selulosa coir sebesar 12,5mg/ml; hasil uji Kruskal-wallis dari lama perendaman komposit terdapat perbedaan yang bermakna antar kelompok dengan nilai signifikansi p<0,05 (p=0,001). Simpulan: Serat selulosa coir tidak toksik sehingga dapat menjadi filler komposit sebagai salah satu prasyarat untuk menjadi kandidat novelty basis pada material komposit kedokteran gigi.KATA KUNCI: coir, komposit, toksistas, basis kedokteran gigiCytotoxicity of cellulose fiber from coconut coir as a novelty base candidate on dental materials: experimental studyABSTRACTIntroduction: Fiber-reinforced composite (FRC) technology is being developed as an innovative material in dentistry. The depletion of fossil resources is a critical issue for current fiber composite resins. Cocos nucifera L. coconut fiber (coir) has high potential to replace synthetic fiber reinforcement as a new material to be developed. The aim of the study was to determine the toxicity of coir cellulose fiber composites as a base material. Methods: This was a post-test only control group experimental study. Cellulose from coir was synthesized using organosolvent, bleached with peroxide in alkaline solution, and nucleated with absolute ethanol. GT1 fibroblast cell viability test was conducted for cellulose fibers and then coir cellulose composites were made with a weight fraction of 70% cellulose fiber filler, and 30% BisGMA, TEGDMA and DGEBA matrix. Furthermore, cellulose coir composites were tested for toxicity from the results of composite immersion in artificial saliva for 7, 14, and 21 days using BHK-21 fibroblast cells. Results: The results of the Post Hoc LSD test concluded that the P-21 group had a significant difference between the K.Sel, P-7, P-14 treatment groups with a value of p<0.05.The safest dose of coir cellulose fiber is 12.5mg/ml; the results of the Kruskal-wallis test of the composite soaking time have significant differences between groups with a significance value of p<0.05 (p=0.001). Conclusion: Coir cellulose fiber is non-toxic so it can be a composite filler as one of the prerequisites to be a novelty base candidate in dental composite materials.KEY WORDS: coir, composite, toxicity, dental base
Pengaruh Metode Pencampuran Coupling Agent Terhadap Sitotoksisitas Komposit Serat Selulosa Sabut Kelapa / Coir Cevanti, Twi Agnita; Prananingrum, Widyasri; Soesilo, Diana
Jurnal Material Kedokteran Gigi Vol 11 No 1 (2022): JMKG Vol 11 No 1 Maret 2022
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jmkg.v11i1.1032

Abstract

Research about cellulose fiber from coconut fibers (Cocos nucifera L/coir) was currently done as an organic fillers for dental composite materials. DGEBA was chosen as a coupling agent to obtain covalent chemical bonds between BisGMA, TEDGMA matrices and coir cellulose fibers. The mixing method of DGEBA played an important role in the biocompatibility of the material. The ideal requirement for dental materials must be non-toxic through cytotoxicity tests. Objective to modify the synthesis method of coir-based cellulose as a natural fiber to optimize chemical bonding through polymerization reaction between fiber, coupling agent and matrix. Methods: There were 2 kinds of cellulose synthesis methods, which were (1) synthesis of cellulose solution using DGEBA and ethanol, (2) synthesis of cellulose solution using ethanol without DGEBA. Cytotoxicity test on pulp fibroblast cells with MTT Assay method on coir cellulose fiber composite samples from the two methods. Method 1 cell viability rate for 7 days immersion was 93.30855%, 14 days was 99.07063%, 21 days was 74.53532%. Method 2 obtained 64.68401% for 7 days immersion, 73.79182% for 14 days and 53.15985% for 21 days. Conclusion, the cellulose solution synthesis method using DGEBA and ethanol produces composites with better chemical bonds seen from the results of the cytotoxicity test
Cocos nucifera l. (coir) fiber application as a filler and its effect on the volumetric shrinkage of flowable composite resin: an in vitro study cevanti, Twi agnita; Tameno, Yolanda Agustina; Mawarani, Lizda Johar; Akwan, Yulie Emilda; Prananingrum, Widyasri; Son, Meekyoung
Padjadjaran Journal of Dentistry Vol 37, No 1 (2025): March 2025
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no1.58864

Abstract

Introduction: The use of composite resin as a restorative material has the disadvantage of experiencing volumetric shrinkage during polymerization, which can lead to restoration failure. Fiber-reinforced composites can reduce volumetric shrinkage in restorative materials. Coir fiber has the potential to replace synthetic fillers because its hollow fiber structure resembles foam, supporting a compact yet lightweight structure. This characteristic is expected to reduce the volumetric shrinkage of composite resin. This study aims to analyze the effect of coir fiber application as a filler on flowable composite resin on shrinkage, comparing it with flowable composite resin containing synthetic filler. Methods: The cellulose fiber used as a filler was synthesized from coir, while the matrix consisted of BisGMA and TEGDMA resins in a ratio 5:1. The composite was prepared with a coir fiber-to-matrix resin composition of 70:30, and polymerization was carried out by irradiation for 40 seconds. Volumetric shrinkage was tested 90 minutes after irradiation. The dimensions of the composite sample were measured from images captured using a digital microscope and analyzed with ImageJ software. The volume shrinkage was then calculated based on these dimensions. Shrinkage was further confirmed through SEM analysis of marginal adaptation tests. Results: The application of coir fiber as a filler effectively reduced the volumetric shrinkage of the composite compared to the composites with synthetic filler. Statistical analyses using the Mann-Whitney test results indicated that the type of filler in flowable composite resin had a significant effect, with a p-value of 0.047 (p<0.05). Conclusion: Application of coconut fiber as filler in flowable composite resin significantly reduce volumetric shrinkage, making it three times smaller than that of flowable composite resin with a synthetic filler.
EFEKTIVITAS EDUKASI KESEHATAN GIGI DENGAN METODE TRAIN THE TRAINERS DALAM MENINGKATKAN PENGETAHUAN GURU DAN WALI MURID SD YAPITA SURABAYA Andriani, Dwi; Twi Agnita Cevanti; Nora Lelyana; Aprilia; Dianty Saptaswari; Bambang Sucahyo; Dwi Setianingtyas; Nafiah; Henu Sumekar; Arya Brahmanta; Shintya Rizki Ayu Agitha; Sularsih; Yufita Fitriani; Vivin Ariestania; Arifzan Razak
Jurnal Pengabdian Masyarakat Pesisir VOLUME 4 NOMOR 1
Publisher : Universitas Hang Tuah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/jpmp.v4i1.137

Abstract

Dental and oral problems in Indonesian children are caused by low knowledge, comprehension, and behavior that ignores dental and oral health maintenance, resulting in tooth and mouth damage. This activity is in partnership with SD Yapita which is a school supported by the Faculty of Dentistry, Hang Tuah University. The aim is to prepare parents and teachers of Yapita Elementary School students to become ambassadors for oral and dental hygiene so that they can become mentors for their children or students. This method is carried out online and offline from classes 1 to 6 using a simple random sampling technique. The results were statistically analyzed using the Paired T-test. The average pre-test score from the teacher was 60 and the parents were 56, while the post-test result from the teacher was 84 and the parents was 85. The results of the data analysis were normally distributed (p>0.05) followed by the Paired correlation test T-test. The results show a relationship between the pre and post-test of teachers and parents. This shows that this educational activity can increase the knowledge of teachers and parents so that they can become ambassadors of oral and dental hygiene to their children or students.
Antifungal effect of calsium hydroxide and cresotin against candida albicans as root canal treatment materials Aprilia, Aprilia; Cevanti, Twi Agnita; Soesilo, Diana; Damaiyanti, Dian Widya; Velisia, Jessica
Padjadjaran Journal of Dentistry Vol 33, No 2 (2021): July 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no2.28252

Abstract

Introduction: Candida albicans can cause quiet high prevalance of root canal treatment failure (35%). Candida albicans are difficult to eliminate and resistant to Calsium hydroxide. Therefore the research was conduct to determinate sterilization material which is effective as antifungal material to eliminate Candida albicans so can minimize the possibility of falure in root canal treatment. Purpose Obtain the optimum concentration of paste that consist of Calsium hydroxide powder combine with Cresatin liquid against the Candida albicans and must be safe to used in root canal tratement medication. Method: The initial examination of antifungal activities was carried out using the disc diffusion with spread plate technique. Medium that used in this method is Medium SGA (Saburoud’s Glucose Agar). Result: The result of the One-way ANOVA test showed a significant value of p= 0,000 (p<0,05). The result of Least Significant Difference test showed that each group had a significant difference because the value of p=0 (p<0,05).  There is significant difference between each group. Conclusion: The most effective as antifungal against Candida albicans is in mixing 1:2 of calsium hydroxide powder and Cresotin liquid which mean 1 full measuring spoon and 2 drops of Cresotin liquid. Mixture of Ca(OH)2 with metacresylacetate produce a chemical reaction namely calsium cresilate and Acetic acid. Calsium cresilate is strong disinfectant. Acetic Acid dissociates and releases hydroxyl ions (H+). Changes in pH cause the transformation of Candida albicans from Y form into M form so it inhibitis cell division. 
Effectiveness of Sargassum sp. ethanolic extract on traumatic ulcers healing in the labial mucosa of Wistar strain (Rattus norvegicus) Arwidasari, Annisya Ristie; Cevanti, Twi Agnita; Soewondo, Isidora Karsini
Padjadjaran Journal of Dentistry Vol 31, No 1 (2019): March 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.301 KB) | DOI: 10.24198/pjd.vol31no1.16513

Abstract

Introduction: Oral ulcer lesions are one of the most common lesions in the oral cavity. The prevalence of traumatic ulcers is quite high compared to other oral lesions. Brown algae, Sargassum sp. is one of the algae contains flavonoids, vitamin A, vitamin C, iron, and calcium, which play a role in wound healing and has economic value. This study was aimed to determine the effectiveness of Sargassum sp. ethanolic extract on traumatic ulcers healing in the labial mucosa of Wistar strain (Rattus norvegicus). Methods: 28 Wistar strain (Rattus norvegicus) weighed 150-200 grams. The samples were divided into 4 groups (K1, K2, P1, P2); each group consisted of 7 mice. K1 group was administered with Hydroxy Propyl Methyl Cellulose (HPMC), K2 was administered with 0.2% hyaluronic acid gel, P1 was administered with 50% Sargassum sp. extract gel, and P2 was administered with 75% Sargassum sp. extract gel. In each group, the ulcer was made on the mice labial mucosa; then the ulcer diameter was measured and observed on day 1 and day 7. Results: The mean diameter ± standard deviation of traumatic ulcer calculations were K1 (1.09 ± 0.40), K2 (1.81 ± 0.67), P1 (1.39 ± 0.43) and P2 (2.16 ± 0.49) respectively. One way ANOVA test results showed significant differences in K1, K2, P1, and P2 groups. Conclusion: Ethanol extract of Sargassum sp. is effective in accelerating the traumatic ulcers healing at the concentration of 75%.Keywords: Traumatic ulcer, Sargassum sp., wound healing.
Co-Authors Akwan, Yulie Emilda Annisa Tri Ariyanti Aprilia Aprilia Aprilia, Aprilia Arifzan Razak Arifzan Razak Arwidasari, Annisya Ristie Arya Brahmanta Bambang Sucahyo Damaiyanti, Dian Widya Diana Soesilo Diana Soesilo, Diana Dwi Andriani, Dwi Dwi Setianingtyas Fani Pangabdian, Fani Febrianti, Shinta Nurmaraya Fitria Rahmitasari Henu Sumekar Henu Sumekar Henu Sumekar, Henu Hollanda, Ghita Hadi Isidora Karsini Soewondo, Isidora Karsini Linda Rochyani Linda Rochyani Lizda Johar Mawarani Nafiah Nora Lelyana Puguh Bayu Prabowo, Puguh Bayu Puspita, Sinta Putri, Ratna Ratna Putri Saptaswari, Dianty Shinta Nurmaraya Febrianti Shintya Rizki Ayu Agitha Sinta Puspita Son, Meekyoung Sularsih Sularsih, S Sumekar, Henu Tameno, Yolanda Agustina Velisia, Jessica Vivin Ariestania Widyasri Prananingrum Yongki Hadinata Wijaya Yufita Fitriani