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All Journal E-Jurnal Medika Udayana Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Cardiology Jurnal Ilmu Kedokteran dan Kesehatan Heart Science Journal
Pintaningrum, Yusra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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HUBUNGAN ANTARA MPV (MEAN PLATELET VOLUME) DENGAN LUAS INFARK MIOKARD PADA PASIEN STEMI (ST-SEGMENT ELEVATED MYOCARDIAL INFARCTION) YANG DIUKUR BERDASARKAN SKOR QRS SELVESTER Bagus Kantwa Abhimantra, Gede; Rahmat, Basuki; Pintaningrum, Yusra
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P13

Abstract

Background: Globally heart disease occupy the first order of mortality population in the world. Acute myocardial infarction is one of them, in its classification AMI can be divided into STEMI and NSTEMI. Pathological changes in AMI will involve many things, one of them is platelets. The aim of the study is to know the correlation between Mean Platelet Volume (MPV) and the myocardial infarction size in STEMI patient based on QRS Selvester score. Methods: This study was an observational analytic study with a cross sectional approach. This research was conducted in July 2020-March 2021 at the Rumah Sakit Umum Kota Mataram, involving 63 subjects. Data obtained from patient medical records using non-probability sampling technique which is consecutive sampling. Results: From 63 data, there are 50 male patients and 13 female patients, the average of the patients age is 57.97 years old. MPV mean is 8.77 fL and the mean of myocardial infarction size is 25.33%. The data scale of the two variables is numerical for MPV and numerical for the myocardial infarction size. The normality test was performed using the Kolmogorov-Smirnov test and the MPV significance value was 0.200 and the myocardial infarction size was 0.200 (normal distribution). Pearson correlation test results obtained p=0.885 (p> 0.05). Conclusion: There is no significant correlation between the MPV and the myocardial infarction size.
The Predictors of Spontaneous Coronary Reperfusion in Patients with ST-segment Elevation Myocardial Infarction Ermawan, Romi; Pintaningrum, Yusra; Sari, Dian Puspita; Indrayana, Yanna; Aprilia, Kartika
Heart Science Journal Vol. 5 No. 3 (2024): The Science and Art of Revascularization in Acute Coronary Syndrome
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.03.6

Abstract

BACKGROUND: In ST-segment elevation myocardial infarction (STEMI) management, some patients undergo spontaneous coronary reperfusion (SCR) with a better prognosis than those without SCR, but predictors for SCR remain unclear.OBJECTIVE: To investigate several potential predictors of SCR, including smoking status, BMI, DAPT loading time, hemoglobin levels, platelet count, random blood sugar levels, uric acid levels, creatinine clearance, and the Syntax score.METHODS: This case-control study was conducted at the West Nusa Tenggara General Hospital in Indonesia from December 2022 to September 2023. Data collection encompassed various patient demographics and clinical parameters, including name, medical record number, age, gender, smoking status, BMI, DAPT loading time, hemoglobin levels, platelet count, random blood sugar, uric acid, creatinine clearance, the Syntax score, and the occurrence of SCR. Statistical analysis for this study involved multivariate logistic regression analysis.RESULTS: A total of thirty-two patients was included, evenly divided into 16 subjects allocated to the SCR group and 16 to the non-SCR group. The analysis indicated that only BMI demonstrated a statistically significant association with SCR occurrence. However, the study did not yield conclusive evidence regarding the influence of smoking status, DAPT loading time, hemoglobin levels, platelet count, random blood sugar levels, uric acid levels, creatinine clearance, and the Syntax score on the likelihood of SCR.CONCLUSION: A normal BMI is identified as a robust predictor for the incidence of SCR in patients diagnosed with STEMI.
Predictors of right subclavian artery tortuosity in trans-radial coronary angiography access Ermawan, Romi; Pintaningrum, Yusra; Rahmat, Basuki; Putra, AASM Meiswaryasti; Indrayana, Yanna
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.13

Abstract

BACKGROUND: Trans-radial access has become the new standard and is increasingly in demand in coronary angiography. However, this method can fail due to tortuosity of the right subclavian artery. OBJECTIVES: This study aims to identify the predictors of right subclavian artery tortuosity. METHODS: This retrospective case-control study was conducted at two of the largest hospitals in West Nusa Tenggara, Indonesia. All research data were obtained from secondary sources, including video recordings of coronary angiographies, angiography reports, and patient medical records. Predictors included age, gender, smoking, height, body mass index, hypertension, diabetes mellitus, systolic and diastolic blood pressure, and random blood sugar. RESULTS: The study involved 80 subjects, divided into right subclavian artery tortuosity and normal group, with 40 subjects each. The prevalence of tortuosity was 8.1%, while the success rate of trans-radial access was 70.0%. Four significant predictors were identified: smoking (adjusted OR 0.26; p = 0.019), hypertension (adjusted OR 4.83; p = 0.020), diastolic blood pressure (adjusted OR 1.05; p = 0.044), and body mass index (adjusted OR 1.16; p = 0.035). The optimal cutoff points were determined to be a body mass index of ≥ 24.4 (sensitivity 60.0%; specificity 60.0%; p = 0.006; AUC = 0.665) and diastolic blood pressure of ≥ 78.5 mmHg (sensitivity 67.5%; specificity 67.5%; p = 0.002; AUC = 0.685). CONCLUSION: This study has identified smoking, hypertension, diastolic blood pressure, and body mass index as significant predictors of right subclavian artery tortuosity in trans-radial coronary angiography access. 
Dyslipidemia management among patients with high and very high cardiovascular risk in Indonesia: a multi-center registry Ng, Sunanto; Santoso, Anwar; Sukmawan, Renan; Erwinanto, Erwinanto; Adam, Erika; Desandri, Dwita Rian; Zahra, Rita; Wicaksono, Sony Hilal; Putra, Magma Purnawan; Heriansyah, Teuku; Tiksnadi, Badai Bhatara; Pintaningrum, Yusra
Jurnal Kardiologi Indonesia Vol 46 No 2 (2025): April - June, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1880

Abstract

Background Indonesia, the world's largest archipelago, faces significant challenges in equitable healthcare delivery due to its geographical and infrastructural disparities. Atherosclerotic Cardiovascular Disease (ASCVD) remains the leading cause of mortality, with over 659,000 deaths recorded in 2019. Effective dyslipidemia management is crucial for preventing adverse ASCVD events. Unfortunately, the lack of implementation of an updated national lipid management registry might hinder optimal strategy for the adverse events. This study evaluated dyslipidemia cholesterol management practices among high- and very high-risk patients across the country. Methods The study recruited 322 patients from eight centers across six provinces in Indonesia between May 2022 and March 2023. Patients were stratified based on the ASCVD risk and followed over three visits. Baseline clinical characteristics, lipid profiles, and treatment regimens were analyzed. Descriptive statistics summarized continuous and categorical variables, and low-density lipoprotein cholesterol (LDL-C) achievement was assessed. Results Of the 322 patients, 98.8% were very high-risk, with only 4.9% achieving <55 mg/dL and 21.2% achieving <70 mg/dL. Moderate-intensity statins were the most prescribed (51.2%), followed by high-intensity (36.6%). LDL-C reduction was most pronounced in private insurance patients, achieving a mean LDL-C of 69.8 mg/dL at the third visit compared to 98.9 mg/dL in National Health Insurance (Jaminan Kesehatan Nasional/JKN) participants. Missed visit rates increased over time, with 57.5% of patients missing the third visit, predominantly among JKN participants and low-income groups. Conclusion Majority of the population failed to achieve the recommended target of LDL-C levels. Dyslipidemia management in Indonesia remains suboptimal, with disparities driven by socioeconomic factors. Improved policies addressing medication availability, national lipid registry establishment, and equitable healthcare access are essential to enhance lipid management and reduce the burden of ASCVD in Indonesia.
STUDI LITERATUR : PATOFISIOLOGI, DIAGNOSIS DAN PENATALAKSANAAN KOLITIS ULSERATIF Abiyyu, Muhammad Farras; Irawan, Muhammad R; Safitri, Nasywa A; Meta S B Duarsa, Ni Made; ’rifatullah, Nurma; Pintaningrum, Yusra
Jurnal Ilmu Kedokteran dan Kesehatan Vol 10, No 12 (2023): Volume 10 Nomor 12
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v10i12.12543

Abstract

Abstrak: Studi Literatur: Patofisiologi, Diagnosis Dan Penatalaksanaan Kolitis Ulseratif. Kolitis ulseratif merupakan penyakit kronis dengan insidensi hampir sebagian besar dari populasi dunia. Penyakit ini mempengaruhi usus besar dengan menimbulkan relaps dan peradangan pada mukosa yang dapat meluas dari rektum hingga bagian proksimal usus besar. Kolitis ulseratif dapat terjadi baik pada pria dan wanita dengan insidensi terbanyak pada rentang usia 30-40 tahun. Kolitis ulseratif disebabkan karena adanya defek dari lapisan epitel, respon imun dan keterlibatan dari mikroflora di kolon. Manifestasi klinis yang dapat ditemukan dari kolitis ulseratif adalah diare, nyeri perut, tenesmus, hematochezia dan ditemukan darah serta lendir pada feses. Diagnosis dari kolitis ulseratif biasanya dibandingkan dengan penyakit crohn karena keduanya termasuk dalam penyakit yang menyebabkan peradangan pada usus atau dikenal dengan Inflammatory Bowel Disease (IBS). Prognosis dari kolitis ulseratif sekitar 10% serangan awal dapat berkembang dan mengakibatkan komplikasi serius, 10% lainnya dapat sembuh sepenuhnya setelah satu kali serangan dan sisanya lagi bisa mendapatkan rekurensi dari penyakit ini. Dalam penatalaksanaan kolitis ulseratif, dapat bergantung dari tingkat keparahan penyakit.
Sindrom Koroner Kronik: Diagnosis yang Tepat Berdasarkan Pedoman Terbaru Pintaningrum, Yusra; Harliza, Baiq Fanindya; Gifari, Lalu Maulana Azmi; Arsy, Lazuardi; Rahman, Moch. Aulia; Saraswati, Ni Wayan Citra Ayu; Dwi putri, Adelya Rahma; Girsang, Andrew Deardo Purba; Exhasna, Artiani Tresna Imut; Syafitri, Bq. Annisa Salmaadani; Abdurrrosyid, Muhammad
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 6 (2024): Volume 11 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i6.14515

Abstract

Penyakit Jantung Koroner (PJK) merupakan salah satu penyakit kardiovaskuler yang sering menyebabkan kematian di seluruh dunia. PJK memiliki patofisiologi dinamis, yang membaginya menjadi dua kategori manifestasi klinis yaitu Sindrom Koroner Akut (SKA) dan Sindrom Koroner Kronik (SKK). Metode: Artikel ini merupakan sebuah tinjauan Pustaka dari berbagai sumber kepustakaan elektronik yang dirangkum menjadi sebuah artikel ilmiah tinjauan Pustaka. Hasil dan Pembahasan: European Society of Cardiology (ESC) mendefinisikan SKK sebagai tahapan-tahapan evolusioner yang berbeda dari berkembangnya PJK, namun tidak termasuk manifestasi klinis dari SKA. Penyakit ini memiliki gejala angina pektoris atau nyeri dada yang dapat diprediksi akibat dari iskemia miokardium, stress emosional, dan stres fisik. Diagnosis dan penggolongan dari risiko penyakit pada pasien SKK penting untuk dilakukan agar dapat membantu dalam pencegahan SKA.
Hasil Tomografi Koherensi Optik Dibandingkan dengan Ultrasonografi Intravaskular untuk Memandu Intervensi Koroner Perkutan: Tinjauan Sistematis dan Analisis Meta dari Uji Coba Kontrol Acak Pramana, Ketut Angga Aditya Putra; Cahyani, Ni Gusti Ayu Made Sintya Dwi; Pintaningrum, Yusra
Jurnal Penelitian Pendidikan IPA Vol 9 No 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.4870

Abstract

In the recent years, the alternative intravascular imaging modalities that are most frequently employed to direct and optimize PCI have been intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The comparative effectiveness of OCT-guided vs IVUS-guided PCI is still up for debate. The purpose of this study was to conduct a systematic review and meta-analysis of all available studies comparing OCT-guided versus intravascular ultrasound (IVUS)-guided PCI. Electronic journals searching were performed in PubMed, ScienceDirect, and Cochrane from January 2015 to March 2023 to identify randomized control trial (RCT) studies that compare OCT‐guided PCI to IVUS‐guided PCI. Meta-analyses were performed on included studies and Odds ratio (OR) and 95% Confidence Interval (CI) were estimated using Review Manager v5.4. A total of four RCT enrolling 1316 participants were included in our analysis. There is no statistical significance was observed in the OCT versus IVUS comparison on all cause mortality [OR = 1.75, 95% CI (0.52, 5.88), p = 0.37], cardiovascular mortality [OR = 1.40, 95% CI (0.27, 7.11), p = 0.69], MACE [OR = 1.04, 95% CI (0.63, 1.71), p = 0.88], ST [OR = 0.94, 95% CI (0.16, 5.52), p = 0.95], TLR [OR = 0.77, 95% CI (0.39, 1.50), p = 0.44], and TVR [OR = 1.19, 95% CI (0.68, 2.07), p = 0.54].
Efikasi Terapi Empagliflozin pada Pasien Gagal Jantung Akut: Meta-analisis Pintaningrum, Yusra; Pranayoga, Komang
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.5000

Abstract

Heart failure is still a common disorder with a high morbidity and mortality rate around the world. New drugs sodium-glucose cotransporter 2 inhibitors (SGLT2i) such as empagliflozin are currently showing promising results across the HF spectrum. Based on this, the authors are interested in researching the efficacy of Empaglifozin Therapy in Patient with Acute Heart Failure. This study used a systematic search using PRISMA principle in several online databases (Pubmed, Cochrane library and Google scholar). The selected study was an RCT or clinical trial with a population of Acute HF patients. The intervention group is Empagliflozin in any dose compared to placebo. The primary outcome for this meta-analysis is the levels of BNP or NT-proBNP and mortality after intervention. Selected study will be assessed and analyzed using Review Manager software version 5.3 with 95% CI. The two studies selected in this meta-analysis had a total sample size of 290 in the intervention group and 285 in the placebo group. Heterogenecity test obtained [p=0.44; I2 0%], indicating the homogenous data and the study is recommended to use the fixed effect method. The pooled effect size of RR is 0.472 [CI95% 0.24-0.75, P=0.003], meaning that there is a significant favorable outcome in empagliflozin group than in the placebo group. The results showed that empagliflozin had shown a favorable effect in reduction of the risk of death and reducing level of NT-proBNP in patient with acute heart failure.
Trends in Distribution and Case Fatality Rates of Cardiovascular Disease in West Nusa Tenggara General Hospital for 2014-2022 Pintaningrum, Yusra; Ermawan, Romi; Indrayana, Yanna; Putra, AASG Mas Meiswaryasti; Luthfi, M. Syahrial; Pramana, Ketut Angga Aditya Putra; Cahyani, Ni Gusti Ayu Made Sintya Dwi
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.9949

Abstract

Background: Cardiovascular disease (CVD) is the leading cause of death, which affects 17.9 million people every year. This study aimed to determine trends in CVD distribution and case fatality rate (CFR) at the West Nusa Tenggara Province General Hospital, the major referral hospital in West Nusa Tenggara Province of Indonesia Methods: This study was descriptive with a retrospective approach using medical records of patients with CVD at the West Nusa Tenggara General Hospital from January 2014 to December 2022. Consecutive sampling was performed. Data based on diagnosis, patient age, gender, and case fatality rates were analyzed descriptively and expressed in frequency and percentage distribution. Results: Of the 11,742 patients included, more than half of the patients (58.92%) were male. In this study, the most common CVD was ischemic heart disease (IHD) (44.23%, n=5,194), followed by patients with hypertension (24.55%, n=2,883), and heart failure (19.30%, n=2,265) which were dominated by males, 68.34%, 57.25%, and 50.53%, respectively. Females were lower in those CVD due to estrogen hormone which has role as cardio protector that maintains the elasticity of blood vessels and prevents atherosclerosis. Meanwhile, mitral valve disease is the fourth most common CVD, approximately 6.69%, followed by atrial fibrillation or atrial flutter at 5.97%, which were dominated by females, 57.78% and 54.17%, respectively. Our data showed that the highest CFR was in patients with atrial fibrillation or atrial flutter, which was 17.5% in 2022. Conclusion. IHD is the most commonly found in the majority of patients with CVD. The highest case fatality rate is in atrial fibrillation or atrial flutter. CVD prevalence, or CFR, is essential to focus on treatment and prevention strategies.
The Efficacy of Statin on Coronary Artery Calcification based on Agatston Score: An Updated Meta-analysis of Randomized Control Trials Wicaksono, Sony Hilal; Pintaningrum, Yusra; Pramana, Ketut Angga Aditya Putra
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.10221

Abstract

The purpose of this study is to assess the efficacy of statin treatment on coronary artery calcifcation (CAC) in patients with asymptomatic coronary artery disease (CAD). For randomized controlled trials (RCTs) that assess the efficacy of statin treatment on CAC in patients with asymptomatic CAD, we searched in PubMed, ScienceDirect, and Cochrane. The included publications were subjected to meta-analyses using Review Manager v5.4. In comparison to control, patients with statistically significant had a lower Agatston score (MD -46.25; 95% CI -56.37 - -36.12; p < 0.00001) and had lower CAC volume (MD -24.36; 95% CI -38.21 - -10.51; p = 0.0006). Statin treatment was also linked to a decreased risk of atherosclerotic cardiovascular disease (ASCVD) events (OR 0.60, 95% CI 0.43-0.83; p = 0.002). According to our meta-analysis, the statin treatment was significant to lowering the Agatston score and CAC volume in patients with aysmptomatic CAD. Statin was also linked to a decreased risk of ASCVD events compared to control
Co-Authors Abdurrrosyid, Muhammad Abiyyu, Muhammad Farras Adam, Erika Anwar Santoso Aprilia, Kartika Badai Bhatara Tiksnadi Bagus Kantwa Abhimantra, Gede Basuki Rahmat Masdi Siduppa Cahyani, Ni Gusti Ayu Made Sintya Dwi Desandri, Dwita Rian Dian Puspita Sari Dwi putri, Adelya Rahma Erwinanto, Erwinanto Exhasna, Artiani Tresna Imut Gifari, Lalu Maulana Azmi Girsang, Andrew Deardo Purba Harliza, Baiq Fanindya Indrayana, Yanna Irawan, Muhammad R Lazuardi Arsy, Lazuardi Luthfi, M. Syahrial Meta S B Duarsa, Ni Made Pramana, Ketut Angga Aditya Putra Pranayoga, Komang Putra, AASG Mas Meiswaryasti Putra, AASM Meiswaryasti Putra, Magma Purnawan Rahman, Moch. Aulia Renan Sukmawan Romi Ermawan, Romi Safitri, Nasywa A Saraswati, Ni Wayan Citra Ayu Sunanto Ng Syafitri, Bq. Annisa Salmaadani Teuku Heriansyah, Teuku Wicaksono, Sony Hilal ZAHRA, RITA ’rifatullah, Nurma