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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Tropical and Infectious Disease MEDISAINS JURNAL FARMASIMED (JFM) Indonesian Journal of Global Health research MEDIC MEdical Dedication Electronic Journal Scientific of Environmental Health And Diseases Riset Informasi Kesehatan
Humaryanto, Humaryanto
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Earth & Planetary Sciences Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health

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Journal : JURNAL FARMASIMED (JFM)

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Test of 25% Ethanol Extract of Betel Nut as a Burn Wound Healing Agent in Male White Mice Farhan, Muhammad; Kasmadi, Fathnur Sani; Humaryanto, Humaryanto; Kusdiyah, Erni; Harahap, Huntari
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/adcwgh75

Abstract

Burns are a serious injury that requires effective therapy to accelerate the healing process. This study aims to evaluate the effectiveness of 25% ethanol extract of areca nut (Areca catechu L.) on healing second-degree burns in male white rats (Rattus norvegicus). The extract was obtained through a maceration method and characterized for its secondary metabolite content. A total of 25 rats were divided into five groups: a negative control (Vaseline flavum), a positive control (Bioplacenton®), and three treatment groups with extract concentrations of 2%, 4%, and 6%. The topical preparation was applied daily for 21 days, then clinical observations were carried out in the form of wound diameter measurements and histopathological analysis (re-epithelialization, collagenization, angiogenesis, and the number of fibroblasts). Phytochemical results showed that the extract contained flavonoids, alkaloids, tannins, phenols, and steroids. Clinically, the treatment group with a concentration of 6% showed the greatest reduction in wound diameter (56.6%) compared to the low concentration extract group and the negative control, although not exceeding the positive control. Histological analysis showed more even re-epithelialization, increased fibroblasts, and a more organized collagen fiber arrangement in the 6% group. These findings indicate that a 25% ethanol extract of areca nut has the potential to accelerate burn wound healing through antioxidant, antimicrobial, astringent, and anti-inflammatory mechanisms, although its effectiveness is still below standard therapy. Further research is needed to optimize the dosage and formulation for its development as an affordable, natural-based alternative phytotherapy.
Co-Authors Ahmad Syauqy Anati Purwakanthi, Anati Ave Olivia Rahman dewi, hasna Fairuz, Fairuz Fitriyanti Fitriyanti Hanina, Hanina Huntari Harahap Husnul, Husnul Iskandar, Mirna Marhami Justisia, Budi Justitia, Budi Kusdiyah, Erni Lipinwati ., Lipinwati Maria, Ima Miftahurrahma, Miftahurrahma Muhammad Farhan Mulyadi, Deri Nuriyah, Nuriyah Rita Halim Sani K, Fathnur Simanjuntak, Charles Apul Simanjuntak, Patrick William Gading Siregar, Mara Imam Taufiq Suzan, Raihanah Tobing, Maudy Rominar Br Utami, Erisca Wahyu Indah Dewi Aurora