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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Tropical and Infectious Disease MEDISAINS JURNAL FARMASIMED (JFM) Canrea Journal: Food Technology, Nutritions, and Culinary Journal Indonesian Journal of Global Health research MEDIC MEdical Dedication Electronic Journal Scientific of Environmental Health And Diseases Riset Informasi Kesehatan
Humaryanto, Humaryanto
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health

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Journal : MEDISAINS

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Effect of essential oil on hypertrophic scars Rahman, Ave Olivia; Humaryanto, Humaryanto; Purwakanthi, Anati; Simanjuntak, Charles Apul
MEDISAINS Vol 19, No 1 (2021)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v19i1.10192

Abstract

Background: Hypertrophic scars are abnormal scars resulted from a disrupted wound healing process. Hypertrophic scars can affect the body aesthetic of the sufferers, but, on the other hand, conventional therapy has not been optimally effective. The application of essential oil combinations as an alternative therapy for hypertrophic scars has not been scientifically proven.Purposes: This study was to determine the effectiveness of the essential oil as a hypertrophic scar therapy.Methods: This study used a pre and post-test design. As many as 24 subjects aged 17-25 years with hypertrophic scars were given essential oil combinations every morning and evening for six months. Assessment of hypertrophic scars was done using the POSAS  (Patient and Observer Scar Assessment Scale).Results: The results showed that the POSAS score decreased after the essential oil combination administration for six months, 14.40±6.08 vs. 22.67±8.31 (p<0.001).Conclusion: the combination of essential oil oils used in this study reduces hypertrophic scars based on the POSAS assessment.
Antidiabetic effect of Psychotria malayana Jack in induced type 1 diabetic rat Fairuz, Fairuz; Dewi, Hasna; Humaryanto, Humaryanto
MEDISAINS Vol 18, No 1 (2020)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v18i1.6909

Abstract

Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results:  A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.
Co-Authors Addion Nizori Ahmad Syauqy Ahmad Syauqy Amalya Nasution, Riska Anati Purwakanthi, Anati Attiya Istarini Ave Olivia Rahman Budi Aswin Budiyanto Budiyanto dewi, hasna Dwi Puspita, Puspa Eka Putra, Nofrans Fairuz, Fairuz Fauzan Azima Fitriyanti Fitriyanti Fitriyanti Hanina, Hanina Hasna Dewi Huntari Harahap Husnul, Husnul Indra Lasmana Tarigan Iskandar, Mirna Marhami Juanda, Syahreza Hadi Justisia, Budi Justitia, Budi Kusdiyah, Erni Lipinwati ., Lipinwati Madyawati Latief Maharini, Indri Maria, Ima Miftahurrahma, Miftahurrahma Muhammad Farhan Mulyadi, Deri Mursyid Djawas Nuriyah, Nuriyah Rion Nofrianda Rita Halim Rizki Ananda Sani K, Fathnur Sanik, Fathnur Seow, Eng Keng Simanjuntak, Charles Apul Simanjuntak, Patrick William Gading Siregar, Mara Imam Taufiq Suzan, Raihanah Tengku Arief Buana Perkasa Tobing, Maudy Rominar Br Ummi Kalsum Utami, Erisca Wahyu Indah Dewi Aurora Wazzan, Huda Yana Cahyana Zikri, Rahmat