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All Journal Indonesian Journal of Tropical and Infectious Disease Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya J-Dinamika: Jurnal Pengabdian Kepada Masyarakat JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Folia Medica Indonesiana
Wahyunitisari, Manik Retno
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Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Comparison of Clinical Characteristics of Pulmonary Tuberculosis Patients with and without Diabetes Mellitus at Dr. Soetomo Hospital Idwar, Fadiah Dini Putri; Wahyunitisari, Manik Retno; Wironegoro, Rio; Rosyid, Alfian Nur
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.78117

Abstract

Tuberculosis (TB) is a transmissible infectious condition attributable to Mycobacterium tuberculosis. Common symptoms of tuberculosis include a persistent cough lasting more than two weeks, fever, fatigue, malaise, and unintended weight loss. These symptoms may become more severe in individuals with co-infected Diabetes Mellitus (DM) due to impaired immunity. In 2021, approximately 400,000 people were reported to have TB-DM. Active TB can disrupt glucose tolerance, contributing to TB-DM2. Studies indicate this combination affects disease progression and treatment outcomes from both patients. This study employed an observational design with descriptive and analytical approaches. The study utilized medical record data from individuals diagnosed with TB who were managed at Dr. Soetomo General Academic Hospital in 2023.  There were 245 total patients, comprising 151 TB without DM and 94 TB with DM cases. The analysis demonstrated a statistically significant difference in mean age between the two groups (p = 0.000). In both groups, the majority were male (69.5%; 63.8%). Cough was more frequent in TB with DM patients (p = 0.038). The most common systemic symptom in both groups was weight loss (70.9%; 63.8%). AFB and GeneXpert MTB/RIF assays results showed no significant differences in between. However, significant differences were found in leukocyte, ALT, AST, and BUN levels (p = 0.001; 0.004; 0.019; 0.007). Radiological examinations showed no significant differences. TB patients with and without DM differ significantly in age, symptoms, and several laboratory parameters, suggesting that comorbidity may influence TB characteristics and clinical presentation.
Co-Authors Adhima, Fauziah Agung Dwi Wahyu Widodo Aziz, Nahdah Aulia Dewi, Firnanda Iptita Eko Budi Koendhori, Eko Budi Erwin Astha Triyono Fikri Sasongko Widyatama Firmanda, Hafidz Hariani, Lynda Idwar, Fadiah Dini Putri Imam Susilo Juniastuti Juniastuti Linda Dewanti Lindarto, Wira Widjaya Muna, Nafdzu Makhmudatul Mustikasari, Melisa Indah Nunuk Mardiana, Nunuk Nurul Wiqoyah, Nurul Pepy Dwi Endraswari, Pepy Dwi Priyo Budi Purwono Ramadhan, Erlangga Lazuardi Rebekah Setiabudi, Rebekah Rehana, Anindita Resti Yudhawati Risky Vitria Prasetyo Rosyid, Alfian Nur Sardjono, Lindawati Alim Setiabudi, Rebekah J. Setiawan, Firman Sulistiawati Sulistiawati Tan, Feriawan Theresia Trishavena Yuanita Pramesty Utami, Mahrumi Dewi Tri Vermasari, Naritha Wironegoro, Rio Wiwin Retnowati