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All Journal International Journal of Public Health Science (IJPHS) Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung The Indonesian Biomedical Journal Universa Medicina Paediatrica Indonesiana Indonesian Journal of Medicine Health and Medical Journal Jurnal Ilmu Faal Olahraga Indonesia Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Jurnal Kedokteran Meditek The International Journal of Medical Science and Health Research
Neng Tine Kartinah Almuktabar
Universitas Indonesia
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The Role of Physical Exercise in Food Intake Suppression Sari, Widia; Kartinah, Neng Tine
Health and Medical Journal Vol 6, No 1 (2024): HEME January 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i1.1416

Abstract

Obesity is a global health issue since it is related to diseases that are the leading causes of mortality, such as diabetes, stroke, and cardiovascular disease. A long-term imbalance between energy intake and energy expenditure is one of the factors contributing to obesity. In addition to increasing energy expenditure, physical exercise can also aid in weight loss by decreasing food intake. An increase in appetite-regulating hormones (ghrelin, GLP-1, leptin, and adiponectin), myokines (IL-6 and irisin), and lactate mediates the suppression of food intake during physical exercise. These substances function as signals that regulate food intake at the peripheral and/or central nervous system levels. Peripherally, lactate inhibits ghrelin secretion, while IL-6 increases GLP-1 secretion. In the center for regulating food intake, lactate, IL-6, leptin, and adiponectin act by inhibiting the release of orexigenic neuropeptides (NPY/AgRP) and increasing the release of anorexigenic neuropeptides (POMC). This review highlighted the role of physical exercise in overcoming obesity through suppression of food intake mediated by hormones and myokine changes that play a role in regulating food intake either in the periphery or directly in the central nervous system.
THE EFFECT OF HIBISCUS SABDARIFFA LINN ON TRABECULAR BONE MICROARCHITECTURE IN AN AGING MODEL DUE TO D-GALACTOSE INDUCTION: A HISTOMORPHOMETRIC STUDY Fransiscus Asisi Alfareza; Neng Tine Kartinah; Trinovita Andraini; Imelda Rosalyn Sianipar
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 5 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.22022656

Abstract

The aging process can cause an imbalance in bone remodeling and changes in trabecular bone microarchitecture. D-galactose induction is used as an experimental aging model because it can increase oxidative stress, while Hibiscus sabdariffa Linn. contains antioxidant compounds that have the potential to provide a protective effect on bone tissue. This study aims to analyze changes in trabecular bone microarchitecture in aging models due to D-galactose induction and the effect of Hibiscus sabdariffa Linn. This experimental study involved 22 samples divided into young normal (NM; n = 6), old normal (NA; n = 4), aging due to D-galactose induction (AA; n = 6), and aging due to D-galactose induction given by Hibiscus sabdariffa Linn. (AH; n = 6). Femur bone tissue was fixed, decalcified using formic acid, processed into paraffin blocks, and stained with hematoxylin-eosin. Trabecular bone images were taken in five fields of view using a 20× objective lens. Histomorphometric examination was performed to assess trabecular thickness (Tb.Th) and bone volume per tissue volume (BV/TV). Data met the assumptions of normality and homogeneity so they were analyzed using one-way analysis of variance followed by Tukey's post hoc test if there were significant differences. The significance level was set at p < 0.05. The mean Tb.Th in the NM, NA, AA, and AH groups were 71.61 ± 15.90 µm; 130.98 ± 11.31 µm; 120.61 ± 37.79 µm; and 100.48 ± 20.92 µm, respectively. There was a significant difference in Tb.Th values between groups with F (3,18) = 5.975 and p = 0.005. Post hoc test showed a significant difference between the NM and NA groups (p = 0.008) and between the NM and AA groups (p = 0.014). There was no significant difference between the AA and AH groups (p = 0.509). The mean BV/TV in the NM, NA, AA, and AH groups were 55.06 ± 11.06%, respectively.
Co-Authors Ahmad Aulia Ali Sungkar Anggraini, Suci Ardesy Melizah Kurniati Diah Ayu Aguspa Dita Diana Sunardi Fransiscus Asisi Alfareza Goenarjo, Roman Ardian Hanna Cakrawati Imelda Rosalyn Sianipar Irena Ujianti Minarma Siagian Minarma Siagian Murti, Krishna Aditya Nisa Kartika Komara Nuraini Diah Noviati Nurhadi Ibrahim Nuridzin, Dion Zein Nurul Paramita Patwa Amani, Patwa Ria Kodariah Rickie Rico Kurniawan Rossa Amelia, Rossa Ryza Jazid Baharuddin Nur Santoso, Dewi Irawati Soeria Saptawati Bardosono Sari, Widia Sayekti Yuliyanti Sophie Yolanda Suci Anggraini Trinovita Andraini