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All Journal International Journal of Public Health Science (IJPHS) Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung The Indonesian Biomedical Journal Universa Medicina Paediatrica Indonesiana Indonesian Journal of Medicine Health and Medical Journal Jurnal Ilmu Faal Olahraga Indonesia Jurnal Kedokteran Meditek The International Journal of Medical Science and Health Research
Neng Tine Kartinah Almuktabar
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Role of Physical Exercise in Food Intake Suppression Sari, Widia; Kartinah, Neng Tine
Health and Medical Journal Vol 6, No 1 (2024): HEME January 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i1.1416

Abstract

Obesity is a global health issue since it is related to diseases that are the leading causes of mortality, such as diabetes, stroke, and cardiovascular disease. A long-term imbalance between energy intake and energy expenditure is one of the factors contributing to obesity. In addition to increasing energy expenditure, physical exercise can also aid in weight loss by decreasing food intake. An increase in appetite-regulating hormones (ghrelin, GLP-1, leptin, and adiponectin), myokines (IL-6 and irisin), and lactate mediates the suppression of food intake during physical exercise. These substances function as signals that regulate food intake at the peripheral and/or central nervous system levels. Peripherally, lactate inhibits ghrelin secretion, while IL-6 increases GLP-1 secretion. In the center for regulating food intake, lactate, IL-6, leptin, and adiponectin act by inhibiting the release of orexigenic neuropeptides (NPY/AgRP) and increasing the release of anorexigenic neuropeptides (POMC). This review highlighted the role of physical exercise in overcoming obesity through suppression of food intake mediated by hormones and myokine changes that play a role in regulating food intake either in the periphery or directly in the central nervous system.
Co-Authors Ahmad Aulia Ali Sungkar Anggraini, Suci Ardesy Melizah Kurniati Diah Ayu Aguspa Dita Diana Sunardi Goenarjo, Roman Ardian Hanna Cakrawati Imelda Rosalyn Sianipar Irena Ujianti Minarma Siagian Minarma Siagian Murti, Krishna Aditya Nisa Kartika Komara Nuraini Diah Noviati Nurhadi Ibrahim Nuridzin, Dion Zein Nurul Paramita Patwa Amani, Patwa Ria Kodariah Rickie Rossa Amelia, Rossa Ryza Jazid Baharuddin Nur Santoso, Dewi Irawati Soeria Saptawati Bardosono Sari, Widia Sayekti Yuliyanti Sophie Yolanda Suci Anggraini