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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Mandala Pharmacon Indonesia AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Jurnal Vokasi Sains dan Teknologi Jurnal Seni dan Desain International Journal of Renewable Energy Development JUKEMAS : Jurnal Pengabdian Kepada Masyarakat
Hariana, Hariana
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Identification of Bioactive Constituents in Forest Honey Using GC-MS and Anti-Inflammatory Activity Through Protein Denaturation Hariana, Hariana; Fristiohady, Adryan; Purnama, La Ode Muhammad Julian; Yodha, Agung Wibawa Mahatva; Irnawati, Irnawati; Wahyuni, Wahyuni; Jumriani, Jumriani
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.62972

Abstract

Honey is a natural product rich in bioactive compounds with various pharmacological and anti-inflammatory effects. Bee species and nectar sources influence the composition of bioactive compounds in honey. This study aimed to identify bioactive compounds and evaluate the anti-inflammatory activity of honey from Apis mellifera and Apis dorsata. Compound identification from both honey types was performed using Gas Chromatography-Mass Spectrometry (GC-MS). At the same time, anti-inflammatory activity was assessed through the human red blood cell (HRBC) membrane stabilization method and protein denaturation inhibition assay, with sodium diclofenac as a positive control. GC-MS analysis revealed various bioactive compounds, notably 2-Propenoic acid, 3-(4-methoxyphenyl)-2-ethylhexyl ester, consistently present in both honey types. In the HRBC assay, Apis mellifera honey showed the highest stabilization value of 94.14% at a concentration of 6.25 mg/L honey solution, surpassing sodium diclofenac (87.96%), while Apis dorsata honey reached 85.21%. All samples achieved over 95% stabilization at 100 mg/L. In the protein denaturation assay, Apis dorsata honey exhibited stronger anti-inflammatory potential with an IC₅₀ of 12.85 ± 1.477 mg/L compared to Apis mellifera (25.35 ± 0.024 mg/L). In conclusion, both types of honey possess promising natural anti-inflammatory potential through membrane stabilization and protein protection mechanisms.
Co-Authors Agung Wibawa Mahatva Yodha Arrazaq, Naufal Raffi Choirully, Rodifa Desy Sulistyowati, Desy Dondick Wicaksono Wiroto, Dondick Wicaksono Felani, Muhamad Iqbal Fenti Prihatini Dance Tui Fitrawan, La Ode Muhammad Fristiohady, Adryan Harun, Dita Nurfajrin hasdiana, hasdiana Hasmah Hasmah Hasmah, Hasmah I Wayan Candra I Wayan Sudana Irnawati Irnawati Isnawati Mohamad Jumriani, Jumriani Kadir, Popin Y Maulinda, Maulinda Munasari, Dian Mursidah Waty Nur Cahyo Paryanto Prismantoko, Adi Purnama, La Ode Muhammad Julian Rahmanta, Mujammil Asdhiyoga Rahmatiah Rahmatiah Ridwan Ibrahim Soleh, Mochamad Ulin Naini wahyuni wahyuni Yusuf, Risnawati