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All Journal BERKALA SAINSTEK Jurnal Inovasi Pendidikan Kimia Jurnal Bahan Alam Terbarukan JURNAL FISIKA Indonesian Journal of Cancer Chemoprevention Journal of Natural Sciences and Mathematics Research Indonesian Journal of Chemical Science PAEDAGOGIA Spektra: Jurnal Fisika dan Aplikasinya Walisongo Journal of Chemistry Sarwahita : Jurnal Pengabdian Kepada Masyarakat Jurnal Komunikasi Pendidikan JURNAL PENDIDIKAN MIPA Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Pengabdian Nasional (JPN) Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) INDRA: Jurnal Pengabdian kepada Masyarakat Journal of Science and Technology Research for Pharmacy Jurnal Pengabdian Nasional (JPN) Indonesia Biosaintifika: Journal of Biology & Biology Education Jurnal Abdimas Science and Community Pharmacy Journal
Alighiri, Dante
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Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Social Sciences Other

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Isolation and Antifungal Activity of Caryophyllene from Clove Leaf Oil (Syzygium aromaticum L.) on Mahogany Leaf Composites Alighiri, Dante
Science and Community Pharmacy Journal Vol. 1 No. 1 (2022): Science and Community Pharmacy
Publisher : STIKES Telogorejo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63520/scpj.v1i1.248

Abstract

Mahogany leaf composites mostly consist of cellulose which is easily weathered due to rotting fungi. One way to overcome this is to use anti-weathering chemicals. Chemical potential as a natural anti-weathering and abundant in Indonesia is caryophyllene compounds as a by-product in the eugenol industry which processes it from clove leaf oil. In this work, isolation and antifungal activity of caryophyllene from clove leaf oil on mahogany leaf composites was evaluated. Based on GC-MS analysis of clove leaf oil is known that eugenol and caryophyllene has yielded 42.83% and 23.87%, respectively. Selective extraction by using sodium hydroxide solution (2,5% NaOH, the ratio of oil to solution is 1:5) and fractional distillation under reduced pressure (Distillate fraction, DF P= -76 cmHg, R=5:1) and continued redistilled are needed to isolate of caryophyllene. Redistilled can improve the purity, then distillate collected while the temperature changed with a purity of 99.10%. Meanwhile, mahogany leaf composite has been successfully synthesized from mahogany leaves by using a polyurethane binder and glass fiber as reinforcement. Minimum inhibitory concentration (MIC) of caryophyllene was determined. The composite was coated with caryophyllene and evaluated for its antifungal activity against Aspergillus fumigatus. Observation using a CCD camera (Charge Couple Device) microscope with a magnification of 50x shows the growth of fungal spores on the composite surface. As a result, A. fumigatus can be inhibited by caryophyllene oil in a 1.2% concentration on mahogany leaf composite
Antibacterial Activity from Fraction of Liquid-Liquid Extraction in Temulawak Rhizome (Curcuma xanthorrhiza Roxb.) Alighiri, Dante; Firnanda, Indah Putri; Abdullah, Ravely Adhitya; Widodo, Naufaldi Bani; Drastisianti, Apriliana
Walisongo Journal of Chemistry Vol. 7 No. 2 (2024): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v7i2.23333

Abstract

The rhizome of Temulawak (Curcuma xanthorrhiza Roxb) has been traditionally used to treat various ailments due to its rich content of curcumin, demethoxycurcumin, and bisdemethoxycurcumin. These compounds exhibit notable antioxidant and antibacterial properties. This study aimed to evaluate the antibacterial efficacy of Temulawak rhizome extracts in n-hexane, ethyl acetate, and methanol, focusing on Escherichia coli and Staphylococcus aureus. The extraction process involved successive maceration with each solvent. The antibacterial activity was tested using well diffusion and microdilution methods, determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Phytochemical screening revealed the presence of flavonoids, alkaloids, phenolics, steroids, and triterpenoids in the extracts. The results indicated that the n-hexane and ethyl acetate fractions exhibited intense antibacterial activity against Staphylococcus aureus, while all fractions showed potent activity against Escherichia coli. The MIC values ranged from 39.0625 to 625 ppm for Staphylococcus aureus and 39.0625 to 78.125 ppm for Escherichia coli, with MBC values generally higher than MIC values. These findings highlight the potential of Temulawak rhizome extracts as effective antibacterial agents.
Edukasi deteksi dini kanker payudara sebagai upaya pencegahan penyakit kronis mematikan di Kelurahan Kalisegoro Semarang Eden, Willy Tirza; Savitri, Annisa Aulia; Ni`ma, Neli Syahida; Rahmaniar, Ranita; Alighiri, Dante
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/indra.v6i1.360

Abstract

A major health concern for women is breast cancer, which is the most common cause of death in this population and delayed diagnosis is a major contributor to this. This delay often arises from a lack of public understanding about breast cancer and its potential for harm. However, performing regular breast self-exams (BSE) offers a method for early identification. Therefore, this community service aims to socialize the BSE method to The Family Welfare Program (PKK) mothers in Kalisegoro Urban Village. The method used in this socialization process uses direct counseling. This education seeks to increase knowledge and promote the regular use of the BSE method. This community service is descriptive community service and gathering the data through an evaluation questionnaire administered after the activity's completion. A number of respondents in this community service were residents of Kalisegoro Urban Village. These results show that the service team effectively communicated information about the early detection of breast cancer, and the participants responded positively to it.
Formulation and Evaluation of Lozenges from Durian Peel Extract (Durio zibethinus Murr) as an Antioxidant Humairoh, Lia Intan; Alighiri, Dante
Journal of Science and Technology Research for Pharmacy Vol 3 No 1 (2023)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v3i1.75516

Abstract

The durian peel is known to possess antioxidant activity due to the presence of flavonoid compounds in it. However, the potential of durian peel as an antioxidant is yet to be fully utilized, necessitating innovative approaches. This research aimed to formulate durian peel extract into antioxidant lozenge tablets. The durian peel was extracted using the reflux method with 96% ethanol as the solvent. The lozenge tablets were prepared in three formulations with varying fillers, Formula 1 with mannitol, Formula 2 with combination of mannitol-lactose, and Formula 3 with lactose. Evaluation of granule quality and physical properties of the lozenge tablets showed that Formula 2, with 50% mannitol and 50% lactose concentration, had exhibited better granule quality and physical properties compared to the other formulations. It had a flow rate of 0,88 seconds, an angle of repose of 19,85°, a compressibility index of 10%, tablet friability of 0,33%, tablet hardness of 11,67 kg, and a disintegration time of 16 minutes. The antioxidant activity of the durian peel extract lozenge tablets was identified using the DPPH method, with vitamin C tablets and imboost lozenge tablets as positive controls. The sample of durian peel extract lozenge tablet demonstrated higher antioxidant activity (IC50 value = 197,25 µg/mL) compared to the imboost lozenge tablet (IC50 value = 268,09 µg/mL). However, the antioxidant activity was still inferior to that of the vitamin C tablet, which had an IC50 value of 86.81 µg/mL.
Formulation of Effervescent Tablet From Extract of Durian (Durio zibethinus Murr.) Peels and Its Antioxidant Activity Pramesti, Citra; Alighiri, Dante
Journal of Science and Technology Research for Pharmacy Vol 3 No 1 (2023)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v3i1.75595

Abstract

Durian (Durio zibethinus Murr.) is one of the seasonal fruits whose existence is abundant in Indonesia that leaves the waste of durian peels that are usually discarded after the durian fruit is consumed. While durian peel contains flavonoid, phenolic, alkaloid, steroid, saponin and a few terpenoid compounds based on durian fruit skin have a variety of pharmacological activities, one of which is as a natural source of antioxidants.The study aims to formulate durian fruit peels extract in an effervescent tablet preparation that is expected to be able to be one of the variations of natural antioxidants that can be easily consumed by society. The formula of effervescent tablets of durian fruit peels extract is made with variations in the concentration of Formula 1 dry extract of 0%, Formula 2 of 16%, Formula 3 of 20%, Formula 4 of 30%. The extraction method used in this study was the reflux method with 96% ethanol solvent. Effervescent tablets of durian skin extract were then tested for its antioxidant activity using the DPPH method and measured the value. In this study, durian peels extract was formulated into the form of an effervescent 1000 mg tablet preparation with variations in the concentration of dry extract 0%, 16%, 20% and 30%. All formulas showed the results of the evaluation of the physical properties of the granules and tablets were good and met the required standards. Formula 4 showed higher antioxidant activity compared to the other three formulas. This can be seen from the concentration of the added dry extract reaching 30%. Furthermore, formula 4 showed the smallest value of 117,7329 μg/mL, where the smaller the value of , the stronger its antioxidant activity. Based on these values, the formula 4 effervescent tablets are included in the moderate antioxidant activity.
Cytotoxic Effects of Cinnamon Powder and Lemongrass Oil-Enriched Roselle Tea on T47D Breast Cancer Cells Aisyah, Sabila; Cahyono, Edy; WH, Nugrahaningsih; Alighiri, Dante; Alauhdin, Mohammad; Zaky, Adrian Maulana; Handayani, Tri; Permatasari, Bella
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp186-197

Abstract

Breast cancer is the most prevalent cancer among women and is the leading cause of cancer-related mortality worldwide. This underlines the importance of preventive strategies to reduce the risk. Harnessing natural products like tea could be an alternative preventive strategy. In this study, the chemopreventive potential of roselle flower tea (Hibiscus sabdariffa L.) enriched with cinnamon oil (Cinnamomum burmannii) and lemongrass (Cymbopogon citratus) was evaluated. The tea was formulated using a stirred boiler tank and tested for its cytotoxicity against T47D cells using the MTT method. The cytotoxicity test showed that with the addition of cinnamon oil and lemongrass, roselle tea had more significant cytotoxic activity against T47D cancer cells than pristine roselle tea. Adding 5 g of cinnamon and lemongrass oil vapor for 15 seconds into the tea showed the highest cytotoxicity, with an IC50 of 730 μg/mL. This value is almost three times higher than without adding cinnamon oil and lemongrass. In conclusion, adding cinnamon oil and lemongrass to the roselle tea formulation can increase cytotoxic activity against T47D cancer cells, indicating its potential as a natural anti-cancer agent.Keywords: Chemopreventive, Cinnamon, Lemongrass, Roselle Tea, T47D Cells.
A Cytotoxic Activity of Clitoria ternatea Flower Tea with the Cinnamon and Lemongrass Oil Vapor against T47D Breast Cancer Cells Cahyono, Edy; Handayani, Tri; WH, Nugrahaningsih; Azid, Saffanah Binti Mohd Ab; Alighiri, Dante; Zaky, Adrian Maulana; Aisyah, Sabila; Permatasari, Bella
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 3 (2024): December 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v16i3.8480

Abstract

Breast cancer is a deadly disease for women. It is crucial to take preventive measures, one of which involves using natural ingredients as chemopreventive agents. Clitoria ternatea flowers, cinnamon, and lemongrass oil have been proven to have cytotoxic activity in several studies. This research aims to analyze the effect of adding cinnamon and lemongrass oil vapor to C. ternatea flower tea on the cytotoxic activity of T47D breast cancer cells. Cytotoxic activity testing was carried out colorimetrically using the MTT (3- (4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) assay method. The results of the research showed that there was a decrease in the IC50 value of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor. The IC50 value of C. ternatea flower tea without additional ingredients was the most potent with 14159 μg/mL, compared to 15 g addition of cinnamon with 1164 μg/mL; meanwhile, for 15 seconds of evaporation time for lemongrass, it was at 331 μg/mL, respectively This research shows the potential of C. ternatea flower tea with the addition of cinnamon and lemongrass oil vapor as a chemopreventive agent against breast cancer cells.
Risk analysis of air quality for parameters NO2, SO2, NH3, and Ox from the area around fertilizer industries in Indonesia Alighiri, Dante; Widodo, Naufaldi Bani; Abdullah, Ravely Adhitya; Firnanda, Indah Putri; Drastisianti, Apriliana
Journal of Natural Sciences and Mathematics Research Vol. 11 No. 1 (2025): June
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/jnsmr.v11i1.23331

Abstract

Industrial zones with intensive human activities often experience air-quality degradation, particularly in areas surrounding fertilizer production facilities. This study analyzes the concentrations of nitrogen dioxide (NO₂), sulfur dioxide (SO₂), ammonia (NH₃), and oxidants (Ox) in the ambient air around fertilizer industries in Indonesia and evaluates their potential non-carcinogenic health risks. Air sampling was conducted using an InScienPro US-1012 impinger equipped with selective absorbent solutions. Pollutant concentrations were quantified using UV-Vis spectrophotometry based on the Griess–Saltzman method for NO₂, the pararosaniline method for SO₂, the indophenol method for NH₃, and the neutral buffer potassium iodide method for Ox. Concentrations were compared with national ambient air-quality standards. To strengthen the assessment, a quantitative health-risk evaluation was incorporated using the Hazard Quotient (HQ) and Hazard Index (HI), allowing for the interpretation of long-term exposure impacts. Results show that most pollutant concentrations were below regulatory limits; however, SO₂ levels at one sampling point and NH₃ levels near the production zone were elevated. The HQ–HI analysis revealed that SO₂ at the office-area sampling point (HQ = 0.794) and NH₃ inside the processing plant (HQ = 2.238) were the dominant contributors to cumulative exposure, with HI values exceeding 1 at both locations. These findings indicate potential non-carcinogenic risks for individuals chronically exposed in areas closest to emission sources. Overall, this study highlights the importance of continuous monitoring and risk-based evaluation to identify localised hotspots, inform mitigation strategies, and enhance emission control practices in fertiliser-industrial environments.
Creative Economic Empowerment Tulip Dasawisma Group, Sukorejo Village Through Environmentally Friendly Ecoprint Art Skills Rahayuningsih, Margareta; Widowati, Widowati; Karsinah, Karsinah; Alighiri, Dante; Suwarti, Suwarti
Jurnal Abdimas Vol. 29 No. 2 (2025): December 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/abdimas.v29i2.38584

Abstract

The Dasawisma (Dawis) “Tulip” Family Welfare Empowerment (PKK) Group of RT 13 RW 05 Sukorejo Village need a featured product that can be developed into a pioneering Micro Small Medium Enterprise (MSME/ UMKM). Ecoprint has the potential to be a featured product because the materials are available around the Dawis environment, such as Yellow trumpet tree (tabebuya), Jamaica cherry (kersen), Mahogany, Tropical almond (ketapang), and Cosmos (kenikir). The leaves and bark of these plants can be used as ecoprint materials and natural dyes. On this basis, two solutions are offered: 1) increasing the knowledge of the Dawis members in developing eco-friendly ecoprint, 2) increasing the skills of the Dawis members in making ecoprint as a pioneer to create a business unit. These can be achieved through the introduction of eco-friendly ecoprint, increasing the capacity of skills through training and mentoring, as well as monitoring and evaluation of ecoprint products as a pioneering business unit. The results of community service show that: 1) increased knowledge of Dasawisma group members about ecoprint, 2) an increase in ecoprint-making skills of Dasawisma Tulip members, 3) produced hijab, pashmina, and clutch products. The outputs achieved are 1) news in electronic mass media, 2) copyright on ecoprint making procedures, 3) publication of activity videos, and 5) journal publications that are in the process of being submitted. This community service activity is in line with SDGs 4 (Quality Education) and SDGs 9 (Industry, Innovation, and Infrastructure).
Co-Authors - Jumaeri Abdullah, Ravely Adhitya Aisyah, Sabila Akhmad Darmawan Akhmad Darmawan Anis Susanti Anwar, Ahmad Faisal Azid, Saffanah Binti Mohd Ab Basyirun Budiyanto, Saraswati Putri Choirunnisa, Fadhillah Cici Fatmala Dian Fithra Permana Dian Marini Dian Marini Drastisianti, Apriliana Edy Cahyono Eko Budi Susatyo Endang Susilaningsih Enni Suwarsi Ervan Bagus Haditya F Widhi Mahatmanti Fatmala, Cici Firnanda, Indah Putri Haditya, Ervan Bagus Harjono Humairoh, Lia Intan Iis Naeni Putri Wahyuni Iis Naeni Putri Wahyuni Imam Syafi’i Karsinah - Kirana, Kurnia Galuh Candra Margareta Rahayuningsih Nugroho Edi K Masturi Masturi Mohammad Alauhdin, Mohammad Nasyatal Ula Hawa Hazuwa Nasyatal Ula Hawa Hazuwa Nina Oktarina Ningrum, Lis Setiyo Ni`ma, Neli Syahida Nugrahaningsih WH, Nugrahaningsih Nur Rahayu Utami Permatasari, Bella Pramesti, Citra Pratiwi Dwijananti Rahmaniar, Ranita Samuel Budi Wardhana Kusuma Savitri, Annisa Aulia Setyo Yuwono Sigit Priatmoko Sri Nurini Sri Wahyuni Sucipto, Lukman Suwarti Suwarti Syafi'i, Imam Syafi’i, Imam Tri Handayani Umar Faruq Muttaqiin Umar Faruq Muttaqiin Uswatun Hasanah Wawan Rustyawan Widodo, Naufaldi Bani widowati widowati Willy Tirza Eden, Willy Tirza Wiwik Kartika Sari Zaky, Adrian Maulana