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All Journal Global Medical and Health Communication Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini Indonesian Journal of Educational Counseling Jurnal Teknik Industri Terintegrasi (JUTIN) GOVERNANCE: Jurnal Ilmiah Kajian Politik Lokal dan Pembangunan INCOME: Indonesian Journal of Community Service and Engagement Innovative: Journal Of Social Science Research Journal of Engineering Science and Technology Management GENIUS: Indonesian Journal of Early Childhood Education JES-TM Social and Community Service
Aliza, Nur
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Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Case Series: Confirmed Diphtheria at Sulianti Saroso Infection Center Hospital in The Post-pandemic Period Nugroho, Anita Puspitasari Dyah; Herlina, Herlina; Hendrawati, Nunung; Aliza, Nur; Hartono, Teguh Sarry; Widiantari, Aninda Dinar; Murtiani, Farida
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 1 (2025): MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4121

Abstract

Background: Diphtheria vaccine coverage decreased during the Covid-19 pandemic. Diphtheria is caused by Corynebacterium diphtheria, which infects the upper respiratory system and produces toxins circulating in the body. The disease was fatal, with a mortality rate higher in children. This study described a case series of confirmed hospitalised diphtheria patients at Sulianti Saroso Infectious Disease Hospital (SSIDH) eighteen months post-pandemic. Objective: to describe epidemiological characteristics, laboratory examinations and outcomes of hospitalised diphtheria patients at SSIDH from January 1st, 2022, to June 31st,2023. Case Presentation: We reported ten confirmed diphtheria cases based on RT-PCR and clinical and epidemiological diagnosis. Of the ten cases, nine were children (<18 years old), six were male patients, and five lived in Jakarta. Based on Albert staining, 9 of 10 samples were found to be bacilli, positive-gram bacteria with metachromatic granular. Result: According to the RT-PCR examination, eight cases were confirmed positive for toxigenic diphtheria, five were a mitis subtype, one was a gravis subtype, and the other four were undetected. Based on clinical examination, eight cases were classified as severe diphtheria, five cases included myocarditis, and three patients passed away. Pediatric cases dominated diphtheria cases. RT-PCR examinations are more accurate and specific to finding toxigenic subtypes in the Jakarta Metropolitan Area. Conclusion: The detection of diphtheria cases in adult’s highlights concerns about adult immunity and awareness of vaccination. Vaccination campaigns and booster shots are essential, alongside continuous surveillance and accurate testing to prevent a resurgence of the disease.
Co-Authors Adeswastoto, Hanantatur Afandes, Muhammad Farhan Afrina, Yeni Amin, Desrinawati Muhammad Anwar, Syifa Fauziyah Aryanto, Dara Tyas Putri Danuarta, Dino Hasibuan, Alfi Syahrin Hendrawati, Nunung Herlina Herlina Irwan Kumala Sari, Resy Lailatul Syifa Tanjung Maemun, Siti Muhammad Alridho Lubis Muhammad Rusdi Murtiani, Farida Nazilah, Mahdatu Bayatina Nugroho, Anita Puspitasari Dyah Rahmah, Miftah Fadhilah Rahmawani, Atika Rustianingrum, Risma Ruzea, Iryne Safira, Azumah Lola Salianty, Syariah Sari, Resy Kumala Sinaga, Indah Erfa Sulastri , Dewi Suzanti, Lizza Syafendra, Mega Oktariena Syahrin Hasibuan, Alfi T. Romi Marnelly Tanjung, Lailatul Syifa Teguh Sarry Hartono, Teguh Sarry Widiantari, Aninda Dinar Widjayatri, Rr. Deni Yoenoes, Dedet Hidayati Yulianti Yulianti Yusmita, Yesi