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All Journal Lantanida Journal SCIENTIA JOURNAL Jurnal Prima Medika Sains AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Buletin Kedokteran dan Kesehatan Prima
Suyono, Tan
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Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin Virgoh, Livia; Suyono, Tan; Chiuman, Linda; Nurlaela, Lia; Kosasih, Michaela; lister , Clarissa
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.430

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or action. Diabetic nephropathy, a microvascular complication of type 2 DM, causes damage to kidney function due to progressive hyperglycemia. This study analyzed the potential of durian seed extract in reducing blood sugar levels (KGD) and improving kidney function and histopathological features in streptozotocin (STZ)-induced Wistar rats. Rats were divided into six groups: normal, positive control (STZ + metformin), negative control (STZ), and three treatment groups with durian seed extract doses of 150, 300, and 450 mg/kgBB. The extract was given for 14 days, followed by examination of kidney function and histopathology. The results showed that a dose of 450 mg/kgBB was most effective in reducing KGD, equivalent to metformin, which could improve kidney function and histopathology. Durian seed extract 450 mg/kgBB has the potential as an effective antidiabetic in reducing kidney damage.
The Antiacne Activity of Sunkist Peels Methanol Extract in Propionibacterium Acne-Induced Acne Vulgaris Mutia, Maya Sari; Damayanti, Etha Wilda Hasiani; Suyono, Tan; Sihotang, Widya Yanti
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.9 No.2 November 2023
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v9i2.12320

Abstract

Treatment with acne vulgaris is a challenge because the complex pathophysiology of acne vulgaris. One of the natural products that potentially use as a herbal medicine is Sunkist peel. The peel of Sunkist is more inclined to end up as waste from domestic industries. The aim of this study was to investigate the antiacne activity of the Sunkist peel methanol extract gel in vivo study. The experimental study used by applied Sunkist peel extract gel to rats injected intradermally with Propionibacterium acne suspension. One hour before the injection of Propionibacterium acnes suspension, all rats were applied to a topical gel based on the group. Control, standard, Sunkist Peel Extract Gel-I, II, and III groups received gel base, clindamycin, 5%, 10%, and 15% of Sunkist peel extract gel, respectively. This study indicates the methanol extract of Sunkist orange peel with a yield of 8.73% revealed the presence of some phytochemicals, including alkaloids, flavonoids, tannins, and saponins. Sunkist orange peel methanol extract gel significantly reduced the size of acne vulgaris lesions after 7-14 days of extract application (p-value <0.05). It is in line with the histological study that the gel concentration increased, followed by the growth of the epidermal layer. This study sstrongly indicates that Sunkist orange peel methanol extract has an antiacne effect in a physically stable gel form.
Association between dietary patterns and hypertension among older adults at the Medan Johor Community Health Center Waruwu, Inel Hartanti; Ginting, Rapael; Suyono, Tan; Kurniawan, Evan; Sitanggang, Holan Dianju Melva Meinaria; Bestari, Welas; Deseva, Frisca Gemmi; Bangun, Andreas Xaverio
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7793

Abstract

Hypertension is a leading global cause of mortality, with a high prevalence among the elderly. Dietary patterns constitute a modifiable risk factor. This study aimed to analyse the association between dietary patterns and the incidence of hypertension among the elderly. A quantitative study with a cross-sectional design was conducted at the Medan Johor Community Health Centre. A sample of 90 elderly individuals was selected via purposive sampling. Dietary data were collected using a Food Frequency Questionnaire (FFQ), and blood pressure was measured using a sphygmomanometer. Data analysis employed the Chi-Square test. A total of 72.2% of respondents had hypertension, and 65.6% had poor dietary patterns. Bivariate analysis indicated a significant association between dietary patterns and the incidence of hypertension (p-value = 0.022; OR = 0.268). Elderly individuals with poor dietary patterns had a 0.268 times higher risk of hypertension compared to those with good dietary patterns. A significant association exists between poor dietary patterns and the incidence of hypertension among the elderly at the Medan Johor Community Health Centre. Promotive and preventive efforts through balanced nutrition education are essential.
Co-Authors Bangun, Andreas Xaverio Bestari, Welas Bu'ulolo, Christian Siuwandy Chiuman, Linda Damayanti, Etha Wilda Hasiani Deseva, Frisca Gemmi Dwi Puspitasari Edlin, Edlin Felix, Jesslyn Ginting, Chrismis Novalinda Girsang, Ermi Holan Dianju Melva Meinaria Sitanggang Kosasih, Michaela Kurniawan, Evan Levinna, Levinna Liena, Liena lister , Clarissa Lister, Clarissa Lubis, Nurul Sri Finna Mutia, Maya Sari Nasution, Ali Napiah Nurlaela, Lia Oktaviani, Emma Panjaitan, Dian Parapat, Winny G I Rapael Ginting Sembiring, Imelda Sri Lestari Ramadhani Nasution Sulistijanto, Eddy Sumiati Sumiati Suwarno Suwarno Virgoh, Livia Waruwu, Inel Hartanti Widya Yanti Sihotang