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Administration of Eucalyptus to Inhibit the Skin Aging Process of Rats (Rattus Norvegicus) Wistar Strains Exposed to Ultraviolet-B Light Mahrahmi, Asira; Suyono, Tan; Napiah Nasution, Ali
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.340

Abstract

Ageing weakens the skin's protective layer, causing pigmentation, inflammation, and cancer. Environmental hazards like pollution and UV radiation harm the skin. Antioxidants, like Eucalyptus globulus, protect against free radicals, making them valuable in medicinal use. The study aimed to investigate the efficacy of Eucalyptus administration in inhibiting skin ageing in rats exposed to ultraviolet-B light. A true experiment was conducted to examine the effectiveness of Eucalyptus in reducing skin ageing in Wistar rats exposed to ultraviolet-B radiation. The study used the "3R Principle" and SPSS to analyse the relationship between collagen quantity, Eucalyptus, and UVB radiation. The study found normal distribution for the control and treatment groups, with a significance of 0.200 and 0.091, respectively. The Levene test showed homogeneity and a T-test result 0.000, indicating a significant difference. The control group had a moderate collagen density, while the treatment group with Eucalyptus extract had a tighter collagen density. The study concludes that the Eucalyptus tree extracts, including tannins, saponins, and flavonoids, have been found to have anti-ageing and collagen-increasing effects in mice exposed to UVB light. The treatment group showed significantly increased collagen density, indicating potential anti-ageing properties in the treatment group.
Participation of pregnant women in pregnancy exercise: The role of knowledge, attitudes, and husband's support Sembiring, Imelda; Liena, Liena; Suyono, Tan; Lister, Clarissa; Suwarno, Suwarno; Sulistijanto, Eddy
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.6237

Abstract

Pregnancy exercise offers numerous benefits for both mother and child. However, many pregnant women do not participate in this activity. This study aims to identify factors influencing pregnant women's participation in pregnancy exercise at Darussalam Health Center, Medan City. A cross-sectional study was conducted on 60 pregnant women visiting the Darussalam Health Center. Data were collected using a structured questionnaire and analyzed using Chi-square tests and logistic regression. The findings indicate that most pregnant women did not participate in pregnancy exercise. Knowledge of the benefits of prenatal exercise, positive attitudes toward exercise, and partner support were significant predictors of participation. Multivariate analysis confirmed that these three factors were independently associated with exercise participation. This study highlights the importance of knowledge, attitudes, and partner support in promoting prenatal exercise among pregnant women. Health education programs focusing on these factors could encourage more women to engage in regular physical activity during pregnancy.
Effectiveness of Durian Fruit Seed Extract (Durio Zibethinus) on Kidney Function and Histopathology of Rats Induced by Wistar Streptozotocin Virgoh, Livia; Suyono, Tan; Chiuman, Linda; Nurlaela, Lia; Kosasih, Michaela; lister , Clarissa
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.430

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or action. Diabetic nephropathy, a microvascular complication of type 2 DM, causes damage to kidney function due to progressive hyperglycemia. This study analyzed the potential of durian seed extract in reducing blood sugar levels (KGD) and improving kidney function and histopathological features in streptozotocin (STZ)-induced Wistar rats. Rats were divided into six groups: normal, positive control (STZ + metformin), negative control (STZ), and three treatment groups with durian seed extract doses of 150, 300, and 450 mg/kgBB. The extract was given for 14 days, followed by examination of kidney function and histopathology. The results showed that a dose of 450 mg/kgBB was most effective in reducing KGD, equivalent to metformin, which could improve kidney function and histopathology. Durian seed extract 450 mg/kgBB has the potential as an effective antidiabetic in reducing kidney damage.
The Antiacne Activity of Sunkist Peels Methanol Extract in Propionibacterium Acne-Induced Acne Vulgaris Mutia, Maya Sari; Damayanti, Etha Wilda Hasiani; Suyono, Tan; Sihotang, Widya Yanti
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.9 No.2 November 2023
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v9i2.12320

Abstract

Treatment with acne vulgaris is a challenge because the complex pathophysiology of acne vulgaris. One of the natural products that potentially use as a herbal medicine is Sunkist peel. The peel of Sunkist is more inclined to end up as waste from domestic industries. The aim of this study was to investigate the antiacne activity of the Sunkist peel methanol extract gel in vivo study. The experimental study used by applied Sunkist peel extract gel to rats injected intradermally with Propionibacterium acne suspension. One hour before the injection of Propionibacterium acnes suspension, all rats were applied to a topical gel based on the group. Control, standard, Sunkist Peel Extract Gel-I, II, and III groups received gel base, clindamycin, 5%, 10%, and 15% of Sunkist peel extract gel, respectively. This study indicates the methanol extract of Sunkist orange peel with a yield of 8.73% revealed the presence of some phytochemicals, including alkaloids, flavonoids, tannins, and saponins. Sunkist orange peel methanol extract gel significantly reduced the size of acne vulgaris lesions after 7-14 days of extract application (p-value <0.05). It is in line with the histological study that the gel concentration increased, followed by the growth of the epidermal layer. This study sstrongly indicates that Sunkist orange peel methanol extract has an antiacne effect in a physically stable gel form.
Dermapen Action on the Skin of White Rats Wistar Strain (Rattus norvegicus) to Evaluate the Efficacy of Avocado Fruit Ethanol Extract Cream (Persea americana Mill.) in Healing Wounds Suyono, Tan; Mucmaini, Rica; Ginting, Chrismis Novalinda; Pratama, Irza Haicha
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6181

Abstract

Wounds disrupt anatomical and skin functions. Thus, proper treatment and healing are needed. Saponins, tannins, and flavonoids in natural medicinal extracts accelerate wound healing. Plants and natural substances are usually employed in topical therapy. This study tested the efficacy of ethanol extract cream from the avocado pulp (Persea americana Mill.) in treating dermapen-induced lesions on white rats (Rattus norvegicus) Wistar strain. This is a lab study or an experiment. Mouse samples were divided into four treatment groups of five mice each. This study also found that avocado flesh extract (Persea americana Mill.) significantly improved dermapen scar healing compared to base cream. The treatment groups given avocado pulp extract (Persea americana Mill.) exhibited higher healing percentages than the control group: 60.5, 95.7, 97.3, and 100%. Researchers found that 15% avocado flesh extract cream (Persea americana Mill.) healed dermapen scars best. This study found that avocado flesh extract cream (Persea americana Mill.) accelerates skin regeneration and increases fibroblasts more than base creams. The highest and densest number of fibroblast cells was found in treatment group 3 healing wounds. Fibroblasts indicate active dermapen wound healing.
Analysis of Efficiency Of KDT-OAT and Removal Preparations on The Recovery of Pulmonary Tuberculosis Duha, Kristin Berlianta; Lestari Ramadhani Nasution, Sri; Girsang, Ermi; Suyono, Tan
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 2 (2022): May 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (121.099 KB) | DOI: 10.51601/ijhp.v2i2.43

Abstract

Background: Tuberculosis is one of the 10 most common causes of death and is the single most common cause of infection and causes illness every year in millions of people. The etiology of tuberculosis is the bacteria Mycobacterium tuberculosis and Mycobacterium bovis. These germs have a size of 0.5-4 microns x 0.3-0.6 microns with thin rods, straight or slightly bent, granular or have no sheath, but have a thick outer layer consisting of lipoids (especially mycolic acid). Based on data from the Riset Kesehatan Dasar in 2018 conducted by the Kementerian Kesehatan RI, the prevalence rate of pulmonary TB by doctors in Indonesia in 2018 was the same as in 2013 which was 0.4%. Based on the OAT guidelines used in Indonesia, there are two OAT drug preparations, namely OAT-KDT or (FDC) and the Kombipak package. Comparison of the efficacy of this drug in curing pulmonary TB also varies. Objective: To determine the efficacy of KDT-OAT and removal preparations on the cure rate of pulmonary TB. Methods: This type of research is a retrospective cohort study, which is a time-period approach. This study was conducted in October-November 2020. Results: There was no significant difference in treatment outcomes in pulmonary TB patients who received OAT-KDT or OAT-release preparations.
Formulation And Testing Of The Effectiveness Of The Ethanol Extract Lotion Of Rosella Flower (Hibiscus Sabdariffa L.) Lotion As A Skin Moisturizer Kurnia, Felicia; Suyono, Tan; Napiah Nasuyion, Ali; Ferdinan, Sahna
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 4 (2022): November 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.685 KB) | DOI: 10.51601/ijhp.v2i4.103

Abstract

Rosella flowers are able to provide a moisturizing and smoothing effect because they contain many substances that are useful for the skin, rosella flowers are also synonymous with a sour taste so that it gives a fresh sensation. In this study, the ethanolic extract of rosella flowers used was at a concentration of 2%, 2.5%, 3%, and 5%. This type of research is experimental research using a pre-test and post-test control group design. The sample of this research is Rosella flower extract lotion (Hibiscus Sabdariffa L.). Data analysis using ANOVA. The results showed that the entire concentration group of rosella flower (Hibiscus Sabdariffa L.) ethanol extract in this study was effective in moisturizing the skin. Ethanol extract of rosella flower (Hibiscus Sabdariffa L.) which is most effective in moisturizing the skin is ethanol extract with a concentration of 5%. The entireconcentration group of Rosella flower (Hibiscus Sabdariffa L.) ethanol extract in this study was effective in smoothing the skin. The ethanol extract of rosella flower (Hibiscus Sabdariffa L.) which was most effective in smoothing the skin was ethanol extract with a concentration of 5%.
Health Belief Model Effect on Nurses Hand Hygiene Adherence Lestari Ramadhani Nasution, Sri; Suyono, Tan; Khu, Adrian; Pangestu Simarmata, Hans; Happy, Happy
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 2 (2023): May 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i2.118

Abstract

Healthcare acquired infections/HAIs (nosocomial infection) is a growing problem in developing and developed country around the world and one of the contributing factors in the increasing of morbidity, mortality and cost of treatment in hospital. One way to prevent HAIs is by increasing adherence of hand hygiene practice in healthcare workers, including nurses, especially in rooms with high risk of HAIs incidents. This study aims to understand the effect of health belief model (HBM) on the adherence of hand hygiene practice of nurses in rooms with high HAIs risk. A total number of 170 nurses who worked in high HAIs risk enrolled in this study. All nurses then asked to fill questionnaire which consist of demographic factors, experience, personal beliefs, cue to action, and self-efficacy. During this study, all nurses hand hygiene practice also observed directly by researcher. This study found that demographic factor, personal belief, cue to action and self-efficacy have no significant relationship with hand hygiene practice adherence (p>0.05), whilst modifying factor like experience shown to have significant relationship with adherence of hand hygiene practice (p<0.05). Demographic factor, personal belief, cue to action, and self-efficacy component of HBM can’t predict the adherence of hand hygiene practice. However, modifying factor in HBM such as experience can predict the adherence of hand hygiene practice.
Cost And Utilization Analysis In Increasing Cost Recovery Rate (CRR) In Rsu Royal Prima Medan 2022 Wijaya, Franks; Girsang, Ermi; Suyono, Tan
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 3 (2023): August 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i3.186

Abstract

Cost Recovery Rateat the Royal Prima Medan Hospital, there was a surplus every year below 5% and even decreased in 2018 to less than 100%. The CRR surplus is still below 5% and the CRR decline is related to costs, tariffs and utilization. This study aims to analyze tariffs, costs and utilization in increasing the Cost Recovery Rate (CRR) at RSU Royal Prima Medan. This type of research is quantitative and qualitative research is descriptive analytic. The population and sample were the Director, Director of Medical Services, Head of Finance Subdivision, Head of Accounting and Marketing Subdivision at RSU Royal Prima Medan, totaling 5 informants. Data collection with primary and secondary data and data analyzed by data reduction, data display and data verification. The results of the study show that there is a change in the Cost Recovery Rate (CRR) every year, how to determine service product rates at RSU Royal Prima Medan and compare them to rates at competing hospitals in Medan, the number of sick people totaling 4222 people was only about 53 people who came out dead for various reasons, not because of the disease they suffered when they entered and the strategy carried out by RSU Royal Prima Medan in increasing CRR is to carry out promotions for several superior service products. It is recommended that because this research is limited to using only quantitative descriptive methods with a qualitative approach, the authors suggest that the leadership can re-examine the success of this research by opening other researchers using different methodologies and employees need to increase motivation and quality of service from year to year so as to make RSU Royal Prima Medan is indeed a hope for the wider community.
Implementation Of The Workload Indicators Of Staff Needing Method Based On Workload To Determine The Right Number Of Human Resources Requirements At The Medical Rehabilitation Poly Of H.Abdul Manan Simatupang Kisaran Hospital In 2021 Putra Nasution, Pratama; Novalinda Ginting, Chrismis; Suyono, Tan; Lestari Ramadhani Nasution, Sri
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 3 (2023): August 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i3.188

Abstract

A good work program is needed by using the WISN (Workload Indicators of Staff Needing) method, which helps see the workload given to and received by medical workers in health facilities. This study aims to determine the appropriate number of employees using the WISN (Workload Indicators of Staff Needing) method to reduce the workload in the hospital's medical rehabilitation polyclinic. This research is a descriptive study with quantitative data analysis conducted at the H. Abdul Manan Simatupang Hospital in 2021. The data taken is medical record data on the total number of patient visits at the medical rehabilitation polyclinic and staffing data for the rehabilitation polyclinic. H. Abdul Manan Simatupang Kisaran Hospital. We found a relatively high number of visits at the Medical Rehabilitation Polyclinic; the workforce data obtained totaled four employees who handled patients directly. The study's results found that the available work time was not directly proportional to the existing standard workload, where the available work time is 135,360 minutes per year while the Standard Workload is 347,424 minutes per year. The workload in the Medical Rehabilitation Polyclinic is too high, and we can obtain the cause from the number of operational staff on duty.