Article Per Year (5 Year)
p-Index From 2021 - 2026
1.686
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmasi Jurnal SOLMA Jurnal Kesehatan Al-Irsyad Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Jurnal Pengabdian Dharma Bakti Poltekita: Jurnal Pengabdian Masyarakat Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Nusantara
yunadi, frisca dewi
Unknown Affiliation
Humanities Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Formulation of spray gel and the evaluation of anti-inflammatory activity or effect to relieve diaper rash Utami, Tri Fitri Yana; Tajudin, Tatang; Indratmoko, Septiana; Yunadi, Frisca Dewi; Rinanda, Intan Frisshin
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art12

Abstract

Background: Diaper rash requires topical preparation that minimizes friction on inflamed infant skin. A spray gel was selected for hygienic, low-contact application, while peppermint oil, Virgin Coconut Oil (VCO), and lemon oil were combined for their complementary anti-inflammatory, skin-barrier-supporting, and antioxidant properties.Objective: This study aimed to formulate and evaluate an anti-inflammatory spray gel containing peppermint oil, VCO, and lemon oil, with a focus on the relationship between formula composition, physical quality, and in vitro anti-inflammatory activity. Method: This laboratory-based experimental study prepared seven spray gel formulations using Carbopol-940 and HPMC as gel-forming agents. Data were collected through organoleptic observation, homogeneity, pH, spray pattern, adhesion-spreadability, mechanical stability, and anti-inflammatory activity testing using the bovine-serum-albumin method for inhibiting protein denaturation. The data were analyzed descriptively, while anti-inflammatory activity was assessed based on percentage inhibition and IC₅₀ values. Results: The results indicated that all formulations were homogeneous, mechanically stable, and had pH values ranging from 5.38 to 6.98. All formulations demonstrated anti-inflammatory activity, with Formula F3 showing the strongest effect, indicated by the lowest IC₅₀ value of 1.933 µg/mL. Conclusion: These findings suggest that spray gel containing natural bioactive ingredients has potential as a topical anti-inflammatory candidate for diaper rash and contributes to the development of natural-based pharmaceutical formulations.
Co-Authors Ajeng Puspo Aji Elisa Issusilaningtyas FAHMI HAKAM Imam Agus Faizal Kusumawati, Dhiah Dwi Lisa Savitri Mika Tri Kumala Swandari, Mika Tri Kumala Mubarak, Zulfikar Yusya Muslimah, Gadizza Mutia Wulandari, Mutia Norif Didik Nur Imanah Nugroho, Yusuf Eko Nurmala, Laifa Rinanda, Intan Frisshin Rizkya, Dayna Rizqi, Titis Alvanur Salsabila, Wilda Adelia Septiyaningsih, Rochany Sohimah sohimah, sohimah Tahya, Khofifah Tajudin, Tatang Triyadi Hendra Wijaya Utami, Tri Fitri Yana Yelli Yani Rusyani Yuki Fitria Maatisya