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All Journal E-Prodenta Journal of Dentistry Indonesian Journal of Dental Medicine JSMARTech : Journal of Smart Bioprospecting and Technology Caring : Jurnal Pengabdian Masyarakat Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Indonesian Health Journal
Widodorini, Trining
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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EFEKTIVITAS EKSTRAK AIR BATANG CIPLUKAN (Physalis minima L.) TERHADAP KADAR MALONDIALDEHID TULANG MANDIBULA TIKUS PUTIH (Rattus norvegicus) Strain Wistar Pasca Ovariectomy Fadhilah, Nadia; Permatasari, Nur; Widodorini, Trining
E-Prodenta Journal of Dentistry Vol 9 No 2 (2025)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2025.009.02.2

Abstract

Estrogen has function as an antioxidant that can reduce free radicals. Hipoestrogen condition will increase oxidative stress in the body. Periodontitis is one of the diseases associated with oxidative stress. Oxidative stress, characterized by increased levels of malondialdehid (MDA). Malondialdehid is usually used to assess the oxidative stress. Phytoestrogens are plant components that have biological activity of estrogen. Ciplukan is a natural ingredient or plant suspected to be a phytoestrogen compound. The theoretical study results showed that ciplukan stem contained physalin, which have a similar effect to estrogen. The purpose of this study is to determine the effectiveness of ciplukan stem extract on malondialdehyde levels in the rat mandibular bone post ovariectomy. Twenty four rats were randomly divided into 6 groups with each 4 rats, that are 3 control groups and 3 groups treated rats that were given the ciplukan stem extract at the end of the first 5 weeks ovariectomy with three different doses: 500 mg/kg BW (K4), 1.500 mg/kg BW (K5), and 2.500 mg/kg BW (K6) for 4 weeks. MDA levels calculated by thiobarbituric acid (TBA) test and read by a spectrophotometer and MDA standard curve created. The results showed the incease of MDA levels can be inhibited at the dose of 500 mg / kg, while at the dose of 1500 mg/kg BW and 2500 mg/kg BW can restore MDA levels similar to normal. There is a strong correlation between the negative direction doses of ciplukan stem extract with MDA levels in mandibular bone (r = -0.507). The conclusion of this study is the ciplukan stem extract can reduce MDA levels in mandibular bone strain of wistar rats after ovariectomy.
Subchronic Exposure of Tofu Processing Wastewater: Effects on Liver Function and Blood Parameters in Wistar Rats Pratamawari, Dyah Nawang Palupi; Permatasari, Nur; Widodorini, Trining; Kusteja, Jilan Namira; Salsabila, Naurah Rana Khansa; Kusumaningrum, Novia Ayu
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 7 No. 1 (2026): Vol. 7 No. 1 (2026): JSMARTech Volume 7, No 1, 2026
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2026.007.01.17

Abstract

Tofu is a major soybean-based food in Indonesia; however, the potentially harmful effects of tofu processing wastewater (TPW) in home-based tofu industries have not been elucidated. This study aimed to analyze the potential hazard components (heavy metals) in TPW and the subchronic toxicity effects on liver and blood parameters in rats. Thirty-six adult male Wistar rats were divided into 6 groups (n=6): control group, TPW 1.6 ml/day (A), TPW 3.2 ml/day (B), and TPW 4.8 ml/day (C) for 28 days, respectively. The remaining two groups were assigned to TPW 1.6 mL/day (D) and TPW 4.8 mL/day (E) for 28 days, and were sacrificed 14 days after the last day of TPW administration. Body weight, liver relative weight, serum SGPT and SGOT levels, and blood count analysis were measured using standard methods. Statistical analysis was performed using one-way analysis of variance (ANOVA) with P<0.05, following Tukey honestly significant difference as the post-hoc test. This study found acceptable levels of cadmium (Cd) and lead (Pb) in TPW samples. The administration of oral TPW induced elevation of serum SGPT and SGPT levels as well as alteration of blood count parameters. This study concluded that TPW had minimal toxic effects in rats; however, further investigation into its long-term safety applications is warranted.
Co-Authors Adilah, Hanifa Fairuz Al Magfiroh, Miftahur Rohmah Alifah, Nisrina Andini Ardiana, Agrisca Salvabella Aulia, Nabila Rizky Akbar Dyah Nawang Palupi Pratamawari Endah Damaryanti, Endah Fadhilah, Nadia Fasa, Fathina Kamilia Fauzia, Malianawati Hamidullah, Achmad Maulidana Hernani M, Yully Endang Istikharoh, Feni Kurniawati, Sari Kusteja, Jilan Namira Kusumaningrum, Novia Ayu Lodra, Ester Handayani Musfira, Naadhira Nayola, Adelia Marta Nur Masita Silviana Nur Permatasari Pra Setya Wati, Ditta Ika Prasasti, Anggani Puspaningtyas, Kristina Linggam Rafie, Mahardhika Ali Rubiyanti, Safira Yusinta Salsabila, Naurah Rana Khansa Sutanti, Viranda Wardhani, Nabilah Kusuma Wijanarko, Grace Vanesa Winara, Jesselyn