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Journal : JOURNAL LA MEDIHEALTICO

Serum Interleukin-6 Levels are Positively Correlated with the Severity of Acne Vulgaris Triatmakusuma, Yogi; Praharsini, I Gusti Ayu Agung; Darmaputra, I Gusti Nyoman; Winaya, Ketut Kwartantaya; Karna, Ni Luh Putu Ratih Vibriyanti; Puspawati, Ni Made Dwi
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1056

Abstract

Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. This disease occurs on the skin of the face, body, back, and other areas of the body, and can leave scars on the skin which can be temporary or permanent. Recent data shows that the inflammatory process is the initial process in the pathogenesis of acne, several pro-inflammatory cytokines, one of which is interleukin 6 (IL-6), which plays a role in acne vulgaris. Analytical observational study with a cross-sectional approach. The research was carried out from February - November 2023 at the Skin and Venereology Polyclinic, RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar and the Clinical Pathology Laboratory of Prof IGNG Ngoerah Hospital. The sample consisted of 47 samples of patients with acne and 20 samples without acne aged 8 - 45 years who were selected through consecutive sampling according to inclusion and exclusion criteria. A sample of 3 milliliters of venous blood is taken which will then be checked for IL-6 with an ELISA kit. Data analysis with SPSS version 24 and p value <0.05 is significant. The mean IL-6 serum levels in the acne group was 110.2 ± 88.3 pg/ml while in the non-acne group it was 26.7 ± 23.7 pg/ml. There was a significant difference in the category of IL-6 levels in the acne and non-acne groups (95% CI 55.1 - 155.3, p<0.001). The correlation analysis of IL-6 levels with the severity of acne was strongly positive (r=0.951, p<0.001).
Co-Authors Agiel Fahlevie Choirunanda Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Indah Jayanthi Batan, Putu Nila Wardhani Cita Rosita Sigit Prakoeswa Daarshawnee Segar Darmaputra, I Gusti Nyoman Devi, Putu Akopita Elice Wijaya Elis Indira, I Gusti Ayu Agung Febrina D Pratiwi Hasri Dewi Henny Wijaya Hosea, Felicia Emiliana I Dewa Made Rendy Sanjaya I Gde Nengah Adhilaksman I Gde Nengah Adhilaksman Sunyamurti Wirawan I Gede Raditya Narayana I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Nyoman Darmaputra I Komang Arimbawa IGNA Wisnu Kresnan Dana Indira, I Gusti Ayu Agung Elis Jihan Prani Wibowo Ketut Kwartantaya Winaya Khathreen, Corry Laksmi, I Gusti Ayu Agung Mini Luh Gede Melia Puspita Sari Luh Made Mas Rusyati Luh Putu Sustiana Kartika Sari Made Wardhana Martalova AJ, Adelia Marvin Giantoro Muhammad Hidayatullah Syukri Ni Kadek Setyawati, Ni Kadek Ni Kadek Yunita Arsita Dewi Ni Luh Putu Ratih Vibriyanti Karna Ni Made Adi Tarini Ni Made Dwi Puspawati Ni Nengah Dwi Fatmawati Ni Wayan Evita Pradnya Dharmesti Nyoman Suryawati Nyoman Yoga Maya Pramita Nyoman Yoga Maya Pramita Pramita, I Gusti Ayu Sattwika Prima Saraswati Sanjiwani Sudarsa Putu Nanda Tediantini Putu Nila Wardhani Batan Putu Nila Wardhani Batan Putu Raisha Vishkariana Dewi Ratih Purnamasari Nukana Ricky Fernando Maharis Rikcy Fernando Maharis Riyana Noor Oktaviyanti Salonika Sutiawan, Indry Setyono, Alfred Stefani Nurhadi Tiara Evangelista Triatmakusuma, Yogi Wicaksono, Rafael Lilik Winaya, Ketut Kwartantaya Wisnu Triadi Nugroho