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Aktivitas Analgetika dan Antiinflamasi Ekstrak Etanol dan Fraksi Daun Jambu Mawar (Syzygium jambos L.) Secara In Vivo: Analgetic and Anti-inflammatory Activity of Ethanol Extract and Fraction of Guava Leaf (Syzygium jambos L.) In Vivo Deden Winda Suwandi; Tita Puspita; Doni Anshar Nuari; Syifa Hamdani
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.279

Syzygium jambos is a plant that has traditionally been used to treat several diseases, especially the leaves as a medicine for rheumatism. In this study, the ethanol extract, fraction of n-hexane, ethyl acetate, and water from its leaves were tested for analgesic and anti-inflammatory activity using the writhing method (Siegmund), hot plate, and the formation of swelling of the soles induced by carrageenan lamda. The results showed that the ethanol extract at doses of 100 and 200 mg/kg BW and fractions of n-hexane, ethyl acetate and water at doses of 50 and 100 mg/kg BW had analgesic and anti-inflammatory activities. The ethanol extract at doses of 100 and 200 mg/kg BW can reduce the amount of writhing every 5 minutes for 60 minutes of observation by 84 and 98 times with percent protection of 58.0 and 52.0%. The Ethyl acetate, n-hexane, and water fractions of 50 and 100 mg/kg BW can reduce the amount of animal writhing by 93 and 35 times, 75 and 100 times, as well as 84 and 124 times with the percent of protection is 54.45 and 82.85, 63.0 and 50.9, as well as 58.47 and 38.02%. The analgesic activity of the hot plate method, ethanol extract can increase the survival time of animals in the hot plate by 154.0 and 95.02%, while the animal survival time of the n-hexane fraction is 95.86 and 105.5, ethyl acetate by 143, 7 and 105.7, and the water fraction of 34.1 and 99.5%. The anti-inflammatory activity of ethanol extract at doses of 100 and 200 mg/kg BW was indicated by a decrease in the volume of rat leg edema at the time of observation for 6 hours with the percent inhibition of edema of 59.2 and 41.12%. The n-hexane, ethyl acetate, and water fractions have relatively the same ability, indicated by the edema inhibition value of the n-hexane fraction of 68.24 and 68.56%, the ethyl acetate fraction of 57.08 and 67.32% and the fraction water of 64.02 and 67.46%. The effective dose of extracts and fractions of n-hexane, ethyl acetate, and water as analgesics and anti-inflammatory is 100 mg/kg BW.

Aktivitas Antiobesitas Ekstrak Etanol Daun Kemuning (Murraya paniculata (L.) Jack) pada Tikus Betina Galur Wistar: Antiobesity Activity of Kemuning Leaf Ethanol Extract (Murraya paniculata (L.) Jack) in Female Wistar Rats Deden Winda Suwandi; Josep Bahari; Anas Subarnas
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1727

Obesity is a condition where there is excessive accumulation of fat due to an imbalance in energy intake with long-term energy expenditure. Serious clinical conditions are often experienced by obese people causing high morbidity and mortality rates at a young age. Efforts to treat obesity pharmacologically are carried out by using synthetic substances that act centrally or peripherally. In addition, many people use natural ingredients that are empirically efficacious in reducing obesity. The aim of this study was to determine the anti-obesity activity of the ethanol extract of Murraya paniculata leaves in female Wistar rats. The test was initiated by induction of animal obesity by subcutaneous administration of monosodium-L-glutamate 2 g/kgbw of rats for the first 5 days and high-carbohydrate diet for 45 days. Parameters observed were body weight, food intake, consistency and weight of faeces, and liver index. The results showed that the ethanol extract of kemuning leaves at doses of 200, 400 and 800 mg/kg of rats has anti-obesity activity by suppressing the increase in body weight of the rats which was significantly different from the positive control (p

Aktivitas Antitukak Lambung Ekstrak Etanol Akar Pakis Tangkur (Polypodium feei., METT) pada Tikus Jantan Galur Wistar yang Diinduksi dengan Asetosal: Antiulcer Activity of Extract of Ethanol of Polypodium feei Roots in Male Rats Induced with Acetosal Suwandi, Deden Winda; Utami, Putri Antiyani; Subarnas, Anas
Jurnal Sains dan Kesehatan Vol. 7 No. 3 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i3.2434

A health problem with a fairly high prevalence in humans is stomach ulcer. This disease is characterized by damage to the mucosal layer by an imbalance of proactive and aggressive factors. This study aims to determine the effect of Pakis tangkur roots as an anti-gastric ulcer. This test was carried out in vivo on male white Wistar mice. The research began by making Pakis tangkur root extract by maceration using 96% ethanol. The extract doses were 100, 200 and 400 mg/kg body weight and Sucralfate 90 mg/kg body weight was used as a positive control. Acetosal 1000 mg/kg bw is used as an ulcer inducer. The parameters observed were the number of ulcers and the severity of the ulcers. The results showed that the ethanol extract of Pakis tangkur roots at 200 mg/kg body weight and a dose of 400 mg/kg body weight had anti-gastric ulcer activity that was significantly different from the control (p<0.05). The effective dose of ethanol extract of Pakis tangkur roots is 200 mg/kg bw. Keywords: Pakis Tangkur, Aspirin, Stomach Ulcer Abstrak Salah satu masalah kesehatan pada manusia dengan prevalensi cukup tinggi adalah tukak lambung. Penyakit ini ditandai dengan rusaknya lapisan mukosa dinding lambung karena adanya ketidakseimbangan faktor proaktif dan agresif pada dinding lambung. Penelitian ini bertujuan untuk mengetahui efek akar pakis tangkur sebagai antitukak lambung. Pengujian ini dilakukan secara in vivo terhadap tikus putih jantan galur wistar. Pengujian diawali dengan membuat ekstrak akar pakis tangkur dengan cara maserasi menggunakan etanol 96%. Ekstrak yang digunakan adalah 100, 200 dan 400 mg/kg bb dan Sukralfat 90 mg/kg bb digunakan sebagai kontrol positif. Asetosal 1000 mg/kg bb digunakan sebagai Penginduksi tukak yang diberikan selama 7 hari. Parameter yang diamati adalah jumlah tukak dan keparahan tukak. Hasil penelitian menunjukkan bahwa ekstrak etanol akar pakis tangkur dosis 200 dan 400 mg/kg bb menunjukkan aktivitas antitukak lambung yang berbeda bermakna terhadap kontrol (p<0,05). Dosis efektif ekstrak etanol akar pakis tangkur adalah 200 mg/kg bb. Kata Kunci: Akar Pakis Tangkur, Aspirin, Tukak Lambung

The Relationship between Knowledge Level and Self-Medication Behavior for Scabies at SMK Plus Al-Istiqomah Sadino, Asman; Suwandi, Deden Winda; Susanti, Risa; Nuari, Doni Anshar; Renggana, Hesti; Rohimah, Vina Siti; Apriliani, Nisa Siti
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 02 (2024): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i2.712

Scabies is a skin disease that is often ignored. Scabies is still common in Islamic boarding schools with a high prevalence rate. Self-medication is used to treat mild to moderate illnesses without consulting a doctor first. This community service aims to determine the relationship between the level of understanding of scabies' self-medication behavior at SMK Plus Al Istiqomah. The method used begins with the distribution of an initial questionnaire (pre-test), presentation of the material with the help of PowerPoint slides, a question and answer session between students (i) and the presenter, and distribution of the final questionnaire (post-test). The results of this community service activity showed an increase in knowledge of scabies from a percentage of 5% to 87.5%. This means that the education provided can be well received by students at SMK Plus Al-Istiqomah.

Mobilizing Putrajawa Village Towards Zero New Stunting Through Educational and Awareness Seminars Suwandi, Deden Winda; Herlina, Lina; bhila, Nayla Shalsa; Salsabila, Hanum; Sapta, Agis; S. Rezeqi, Kayla; Aulia, Nita
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 01 (2024): Indonesian Journal of Community Empowerment (February)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i1.917

The problem of stunting in Indonesia is a challenge faced in almost all regions, including Garut Regency. To overcome the problem of stunting incidence in Garut Regency, a community service program was implemented in Putrajawa Village, Selaawi District. This program aims to reduce stunting rates through educational seminars designed to increase awareness and understanding of pregnant women and mothers of children under 0-24 months about the causes, impacts, and prevention strategies of stunting. The method used was a one-group pre-test and post-test design, which was used to evaluate changes in participants' knowledge before and after the intervention. The results of the seminar showed a significant increase in participants' understanding of stunting and its prevention measures, with the percentage of good knowledge increasing from 78% before the seminar to 94% after the seminar.

Introduction to the Pharmacist Profession and Education on Wise Choice of Snacks and the Dangers of Cigarettes and Drugs for Teenagers Renggana, Hesti; Susanti, Risa; Qowiyyah, Atun; Dewi, Asri; Winda, Deden; Anshar, Doni; Sadino, Asman
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 01 (2024): Indonesian Journal of Community Empowerment (February)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i1.925

Pharmacists are competent health professionals in drug management. Many efforts have been made so that the role of pharmacists in carrying out pharmaceutical work is more felt in the community. Therefore, community service is carried out in the form of education on introducing the pharmacist profession, wisely choosing snacks, and about the dangers of cigarettes and drugs. It is expected that from this service, students who are part of the community can better understand the pharmacist profession and its role in adolescent health. Education was carried out on MIT and MTs Baitul Aziz Majalaya students. Before the education, a pretest was carried out and after the education, a posttest was carried out using a questionnaire related to the material. Data were processed and analyzed using descriptive statistics. The results of the education showed that the level of knowledge of MIT students increased, especially in the good category, from 8% to 76% for knowledge of the pharmacist profession, and from 80% to 95% for knowledge of wisely choosing snacks. In addition, the level of knowledge of MTs students regarding the dangers of cigarettes and drugs also increased, especially in the good category from 13% to 75% after education.

Introduction to the Pharmacist Profession and Education on Wise Choice of Snacks and the Dangers of Cigarettes and Drugs for Teenagers Renggana, Hesti; Susanti, Risa; Qowiyyah, Atun; Dewi, Asri; Winda, Deden; Anshar, Doni; Sadino, Asman
Indonesian Journal of Community Empowerment (IJCE) Vol 5 No 01 (2024): Indonesian Journal of Community Empowerment (February)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v5i1.925

Pharmacists are competent health professionals in drug management. Many efforts have been made so that the role of pharmacists in carrying out pharmaceutical work is more felt in the community. Therefore, community service is carried out in the form of education on introducing the pharmacist profession, wisely choosing snacks, and about the dangers of cigarettes and drugs. It is expected that from this service, students who are part of the community can better understand the pharmacist profession and its role in adolescent health. Education was carried out on MIT and MTs Baitul Aziz Majalaya students. Before the education, a pretest was carried out and after the education, a posttest was carried out using a questionnaire related to the material. Data were processed and analyzed using descriptive statistics. The results of the education showed that the level of knowledge of MIT students increased, especially in the good category, from 8% to 76% for knowledge of the pharmacist profession, and from 80% to 95% for knowledge of wisely choosing snacks. In addition, the level of knowledge of MTs students regarding the dangers of cigarettes and drugs also increased, especially in the good category from 13% to 75% after education.

Analgesic and anti-inflammatory activities of the extract of Polypodium feei mett roots Suwandi, Deden Winda; Renggana, Hesti; Subarnas, Anas; Rostinawati, Tina; Muchtaridi, Muchtaridi; Sadino, Asman
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.25133

The limited scientific evidence on the analgesic and anti-inflammatory effects of Polypodium feei roots, despite their traditional use in rheumatism treatment, highlights the need for pharmacological validation. The study investigates the analgesic and anti-inflammatory properties of Polypodium feei roots, a traditional medicine used to treat rheumatism, in mice and rats with carrageenan-induced paw edema, using acetylsalicylic acid and tramadol as analgesics and diclofenac sodium as an anti-inflammatory. The writhing test results demonstrate that the extract of P. feei roots (EPFR) at dosages of 50 and 100 mg/kgBW lowered the writhing responses of rat significantly (p <0.01). The dose of 100 mg/kgBW provided more protection than acetylsalicylic acid at a level of 65 mg/kgBW. In the hot plate method, the extract increased the latency period significantly (p <0.05) as compared with the control. In the anti-inflammatory examination, the EPFR decreased edema of rat paws induced by carrageenan. The significant effect of the EPFR was shown by the dose of 100 mg/kgBW (p <0.05), but its inhibition was lower than that of a standard agent, diclofenac sodium. This study concluded that the EPFR may have peripherally and centrally analgesic activity and anti-inflammatory activity. This evidence supports the folklore claim of the efficacy of EPFR as traditional medicine for rheumatism.

Strategy for Reducing Stunting Rates in Mandalakasih Village, Pameungpeuk, Kab. Garut Suwandi, Deden Winda; Putri Rachmaida, Nabila; Munawar, Azrina Rival; Kusuma, Erlang Darma; Kusuma, Rahiel Rindu; Dinata, Rizki Wangsa; Ibrahim, Maulana; Farida, Dida
Indonesian Journal of Community Empowerment (IJCE) Vol 4 No 02 (2023): Indonesian Journal of Community Empowerment (May)
Publisher : Fakultas Kewirausahaan Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35899/ijce.v4i02.704

Stunting is a serious problem in many countries, including Indonesia. In Mandalakasih Village, Pameungpeuk, Kab. Garut. The prevalence of stunting is still high, so it has become the village's main program in efforts to overcome health problems. Stunting is a chronic nutritional problem caused by a lack of nutritional intake over a long period of time, which can disrupt growth in children. Efforts to reduce the stunting rate in Mandalakasih Village were carried out through an understanding survey and direct education as an effort to prevent stunting. There were 285 correspondents for this research, consisting of 127 pregnant women and 158 parents with babies aged 0-23 months. The results of this research showed that there was an increase in insight into preventing stunting, namely for pregnant women it was 99.05%, while for parents with children aged 0-23 months it was 84.68%.

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