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Ariani, Rizka
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Journal : Biomedika

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THE ASSOCIATION OF INTERLEUKIN-6 AND PROCALCITONIN LEVELS WITH CLINICAL OUTCOME OF COVID-19 DISEASE Ramadhani, Renata Evelyn; Solikhah, Amanatus; Ariani, Rizka
Biomedika Vol 17, No 1 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.12261

Abstract

Severe and potentially fatal complications can arise from COVID-19, especially when the immune system triggers an exaggerated inflammatory reaction. This study examines the possible relationship between serum levels of Interleukin-6, Procalcitonin and clinical outcomes in hospitalized COVID-19 patients. Using a retrospective cross-sectional design, this study evaluated data from 71 patients hospitalized at RSUD Wates in 2021. Biomarker level differences between survivors and non-survivors were assessed using the Mann-Whitney U test and binary logistic regression. IL-6 concentrations were significantly higher in non-surviving patients and continued to serve as an independent predictor of mortality after adjustment. Conversely, while PCT levels were higher in non-survivors, they did not retain independent prognostic significance in multivariate analysis. IL-6 is crucial in forecasting severe outcomes, likely because of its role in cytokine storms and immune dysregulation. Initial IL-6 measurement may help detect patients at higher risk and support decisions regarding intensive care. Meanwhile, raised PCT levels require careful interpretation within the broader clinical picture. Additional research involving larger sample sizes and robust methodologies is required to determine the value of combined biomarkers in COVID-19 risk evaluation.
Co-Authors Alvin, Jeck Thomas Ardiani, Ni Putu Vidya Aristiani, Windy Awisarita, Wiwara Budi Rahayu, Ana Cristie, Lidya Dewi, Beti E Festiyed Jasiah Jasiah Jeffry Simson Supardi Meldi, Meldi Muhammad Farid Nadila Nisa, Afifah Khoiru Palangi, Mispayati Prisilla, Elvina Putri, Ratna Aprillia Eka Ramadhani, Renata Evelyn Ramadhania, Widya Aryana Rastrani, Ardestya Rizkita, Leonny Dwi Rizky Firmansyah rusita rusita Salsabila, Fitriannisa Saputra, Vigo Sarrin Solikhah, Amanatus Sudiro, Tjahjani M Sukirto, Novi Umam Kurniawan, Nurcholid Wijanarko, Janu Annas Winati, Rachel Yase, I Kadek Kartika Yuniasih, Dewi