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All Journal Jurnal Ilmu Pertanian Indonesia FaST : Jurnal Sains dan Teknologi Indonesia Natural Research Pharmaceutical Journal (INRPJ) Bioinformatics and Biomedical Research Journal Berdikari : Jurnal Pengabdian kepada Masyarakat Pharmacy Action Journal Indonesian Journal of Pharmaceutical Research Jurnal Adiguna Pengabdian Masyarakat
Sagala, Zuraida
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Formulasi dan Uji Iritasi Gel Antibakteri Dari Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi Linn) Terhadap Bakteri Staphylococcus aureus dan Pseudomonas aeruginosa [Formulation and Irritation Test of Antibacterial Gel from Star Furit Leaves (Averrhoa bilimbi Linn.) Ethanol Extract Againts Bacteria Staphylococcus aureus and Pseudomonas aeruginosa] Sutriningsih, Sutriningsih; Sagala, Zuraida; Marhamah, Marhamah
FaST - Jurnal Sains dan Teknologi (Journal of Science and Technology) Vol. 1 No. 2 (2018): MAY
Publisher : Universitas Pelita Harapan

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Abstract

Starfruit (Averrhoa bilimbi Linn.) is containing several chemical contents including tannins, alkaloids, flavonoids, polyphenols and saponins, which can be efficacious as an antibacterial. The purpose of this study is determine stability of  gel and the effect of gel formulation ethanol extracted from leaves starfruit (Averrhoa bilimbi Linn.) against the antibacterial activity of Staphylococcus aureus and Pseudomonas aeruginosa. This is an experimental laboratory research where the formulation of ethanol extracted from the leaves of starfruit (Averrhoa bilimbi Linn.) which  obtained from the process of maceration with 96% of ethanol solvent formulated in a gel dosage form. Gel formulations of the ethanol extracted from leaves starfruit was made with various concentration of the extract including 35%, 50% and 65% with hidroksi propil metil cellulose ( HPMC) as the base. We used without-extract as the negative control and  0.1% of gentamicin ointment as the positive control. The result gel from antibacterial activity was then processed using the agar diffusion method .The use of a gel formulation  ethanol extracted from leaves starfruit affected the antibacterial activity of Staphylococcus aureus and Pseudomonas aeruginosa . The results showed that the ethanol gel extracted from leaves starfruit (Averrhoa bilimbi Linn.) had the best antibacterial activity, indicated by 65% gel concentration containing the ethanol extracted from leaves starfruit being able to inhibit the growth of Staphylococcus aureus that for 28.62 mm with greater barrier diameter and Pseudomonas aeruginosa for 19 mm. Irritation test to 20 female with age 20 - 30 years old man and woman with put it on the back of hands for 2 hours in 3 days and the result is no irritation indication happend . Gel stability was had test for 4 weeks and nothing change happend 
Co-Authors , Triadiati Andini, Fazri Angely Septihany, Elisabeth ardilla khoirotun, ismi Aryanilo, Aryanilo Atisi, Atisi Ayu Wulandari Azzahra, Taysa Zifa Clara, Clara Dunggio, Vivin Dyah Iswantini Harahap, Chairunnisa Indra Yani, Satya Candra Irawati, Juwita Khoiriza, Syifa Nur Lailatusaadah, Nuke Marhamah Marhamah Palensina, Gea Ocktiah Panjaitan, Riong seulina Pramesti, Junaida Purwati Purwati Putri, Zaskia Fahmi Rambu L, Liany Carolina Resmi, Juniar Kalpika Ria Anggraeni Rosita, Leni Seulina Panjaitan, Riong Sulitijorini, Sulitijorini Sutriningsih, Sutriningsih Theodorus Rexa Handoyo Zahira, Rayzha Firya