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All Journal JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jambura Journal of Health Sciences and Research Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO Buletin Kedokteran dan Kesehatan Prima
Wardhani, Fiska Maya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Efek Ekstrak Kunyit Putih (Curcuma Zedoaria) Sebagai Nefroprotektor Pada Tikus Putih Jantan Galur Wistar yang Diinduksi Tembaga Wardhani, Fiska Maya; Chiuman, Linda; Ginting, Chrismis Novalinda; Ginting, Sahna Ferdinand; Nasution, Ali Napiah
Majalah Kedokteran Indonesia Vol 69 No 8 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.8-2019-186

Abstract

Background: Metal pollution increases along with increasing industrial development. Exposure to copper in large quantities can cause kidney and liver damage. Curcuma zedoaria has benefits as an antioxidant, anti-inflammatory, antiproliferation, anticancer, and antimicrobial. Curcumin which contained in white turmeric rhizomes in previous studies was used as a nephroprotective variation. Objective: This study is used to know wether white turmeric rhizome (Curcuma zedoaria had a nephroprotective effect with exposure to CuSO4 pentahydrate. Methods: This is an experimental study by designing post test only control group design. The sampling is using simple random sampling technique. Male white wistar rats are divided into six groups; normal control, control of white turmeric (45 mg / 200 g), control of CuSO4 pentahydrate, and co-treatment group (curcumin for 14 days followed by CuSO4 for 5 days).Results: Data were analyzed using One Way test. For group 4 (preventive group) serum urea creatinine level was not different from group 1 and 2 (p greater than 0.05) with mild histological structure damage. However, differences were obtained (p less than 0.05) in Groups 3, 5, and 6. Conclusion: The dose of 45 mg / 200 g white turmeric extract showed a percentage decrease in serum creatinine urea level and mild histological damage to kidney tissue.
Cerebral Histopathology in Acute Toxicity Test of Curcuma Zedoria Lubis, Adhayani; Wardhani, Fiska Maya; Lubis, Anisa Taqwa; Tandanu , Erny
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.5482

Abstract

This research aims to determine the effect of the acute toxicity test of white turmeric extract (Curcuma zedoaria) on the brain organ. This research is experimental research with a Post Test Only Control Group Design. This research was conducted at the Pharmacy and Histology Laboratory. Faculty of Medicine. University of North Sumatra. The research was carried out from January to March 2023. The population in this research involved male white rats (Rattus norvegicus). The results of the acute toxicity test of white turmeric extract for 14 days showed no signs of toxicity or death in rats given the smallest to largest doses, resulting in an apparent LD50 value of white turmeric extract is >2 g/kgBW, and is classified in the practically non-toxic category. Rats that received white turmeric extract showed movement or activity, appearing more energetic by the end of the second week with increasing doses. Histopathological examination of the brain in the acute toxicity test revealed minimal changes, such as edema and congestion in line with increasing doses.
Co-Authors Amanda, Carissa Asthariq, Miftah Azizoğlu, Azizoğlu Chiuman, Linda Dita, Bunga Tiara Erny Tandanu Florenza, Audrey Gracella Ginting, Audi Torry Ginting, Chrismis Novalinda Ginting, Sahna Ferdinand Hasibuan, Selly Rahmadiah Hsb, Selly Rahmadiah Hyachinta, Izdihar Putri Hyacintha, Izdihar Putri Iskandar, Ari Rahman Juliana, Lina Lina, Juliana Loren, Jeff Lubis, Adhayani Lubis, Anisa Taqwa Muchtar, Muhammad Arafat Nasution, Ali Napiah Nasution, Prenan Dito Perdana Putri, Nabila Dwi Sembiring, Mediana Br. Sri Amelia SUHARTOMI . Tandanu , Erny Yunata, Kianie Engaline