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All Journal Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Klinik dan Riset Kesehatan Jurnal Info Kesehatan
Dewi, Rose Khasana
Department Of Anatomical Pathology, Brawijaya University, Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Effect of Flavonoids of Phaleria macrocarpa Fruit Extract on Aortic Diameter Mice Menopause Model Khoirinda, Ani; Fadilah, R. A. Rahmawati Nurul; Sutrisno, Sutrisno; Irwanto, Yahya; Dewi, R. A. Rose Khasana
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1554

Abstract

Menopause is a phase experienced by women with an age range of 45-55 years. Menopause is a condition where menstruation stops for a minimum of 12 consecutive months due to the decline in ovarian function, leading to a reduction in estrogen levels. A decrease in estrogen can lead to impaired fat metabolism resulting in atherosclerosis. This study aimed to illustrate the influence of flavonoid extract derived from Phaleria Macrocarpa on the enlargement of the aorta's diameter of mice with a menopause condition. The method of this study is a genuine experimental laboratory setting with a research design of a Randomized Post Test Only Control Group setting. Using 32 female mice divided into 6 groups: K- (without ovariectomy and flavonoid extract Phaleria Macrocarpa), K + (ovariectomy without treatment), P1 (ovariectomy + dose 3.75 mg/mice/day), P2 (ovariectomy + dose 7.5 mg/mice/day), P3 (ovariectomy + dose 11.25 mg/mice/day), and P4 (ovariectomy + dose 15 mg/mice/day). Administration of flavonoid extract Phaleria Macrocarpa was carried out for 14 days. Data analysis using statistical analysis. The results showed that in a post-hoc test, namely the administration of Phaleria macrocarpa flavonoid extract at a dose of 11.25 mg/mice/day and 15 mg/mice/day showed that it could increase the dilation of the aortic diameter of mice model menopause. The study concludes that the flavonoid fruit extract from Phaleria Macrocarpa has the ability to increase the width of the aorta in mice with a menopause condition. In future studies, it is recommended to investigate various variables in order to identify the factors that contribute to the narrowing of the aorta. Additionally, it is suggested to perform further research specifically focusing on women going through menopause.
Co-Authors Agustin Iskandar Aina Angelina Ani Khoirinda Arianto, Onni Dwi Berlian Anggraeni Putri Dhani, Fauzan Kurniawan Diah Prabawati Edy Mustofa Ekaputra, Aditya Airlangga Ery Olivianto Eviana Norahmawati Fabrianta, Dio Mafazi Fadilah, R. A. Rahmawati Nurul Hardika, Arif Satria Harun Al Rasyid Hendy Setyo Yudhanto Hery Susilo Holipah Holipah Ihda Dian Kusuma Kenty Wantri Anita Kenty Wantri Anita, Kenty Wantri Khoirinda, Ani Kurnia Penta Seputra Nurseta , Tatit Putri, Anggie Sasmita Kharisma R. A. Rahmawati Nurul Fadilah Rambe, Annisa Fadhila Aurelia Retnani, Diah Prabawati Rofifa, Amira Fithri Sutrisno Sutrisno Sutrisno, Sutrisno Taufiq Nur Budaya Teguh Prihantoro Widodo, Robby Rinaldi Yahya Irwanto Yahya Irwanto