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All Journal Majalah Obat Tradisional Warta Penelitian Perhubungan Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology International Journal Of Science, Technology & Management (IJSTM) Jurnal Farmanesia Warta Penelitian Perhubungan
Sitorus, Panal
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Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride Lubis, Meiva Amelia; Dalimunthe, Aminah; Sitorus, Panal; Satria, Denny; Lubis, Arga
Viva Medika Vol 17 No 3 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i3.1490

Abstract

This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Additionally, liver macropathology observations indicated improved liver conditions in the treatment group. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended to validate these findings and explore the extract's therapeutic applications.
Evaluation of Antyhipercholesterolemic Effect of Allium cepa L. var cepa in Atherogenic Induced Rats Lumban Gaol, Nurahmi; Yuandani; Sitorus, Panal
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5381

Abstract

Fermented onion is a type of onion that produced by heating onion bulbs at high temperature for 15 days by fermenter machine. This research is expected to produce new alternatives therapy for reducing cholesterol from onions especially Allium cepa L. var cepa. In this experimental laboratory used 25 male white rats that divided into five groups, group I: negatif control, group II: positif control (Atorvastatin), group III: 100 mg/Kg body weight (bw) of fermented onion extact, group IV: 200 mg/Kg bw of fermented onion extract and group V: 300 mg/Kg bw of fermented onion extract. The Rats was feeding by an atherogenic diet to makes them hypercholesterolemia before treatment for 7th days, 14th days and 21st days. All of data were analyzed by ANOVA method (significant 0,05). The result concludes that of all the doses tested, fermented onion extract of Allium cepa L. var cepa with a dose of 200 mg/Kg bw has the highest effect in decreasing total cholesterol levels of hypercholesterolemia rats (Rattus novergicus).
Antibacterial Activity of Ethanol Extract and Fraction of Daemonorops draco (Willd.) Blume. Fruit Samaniyah, Siti; Masfria; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 3 No. 4 (2022): July 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i4.544

Abstract

Daemonorops draco is a type of draco (Willd.) Blume fruit is well-known as an antiseptic, increases blood circulation, anti-microbial, anti-viral, anti-tumor, wound medicine, diarrhea, fractures, gonorrhea, mild burns, and other traditional medicines. Daemonorops draco is a type of draco (Willd.) Blume belongs to the Arecaceae family and contains alkaloids, flavonoids, tannins, saponins, steroids / triterpenoids, and glycosides, among other chemical components. Chemical compounds such as flavonoid compounds, saponins, and tannins have antibacterial and antiviral properties. Simplicia features, phytochemical screening, and antibacterial activity testing of ethanol extract and fruit fractions of Daemonorops draco (Willd.) Blume are all part of this study. Organoleptic, macroscopic, and microscopic tests were performed on the simplicia, as well as water content measurement on ethanol extracts. Maceration with ethanol as the solvent was followed by fractionation with n-hexane and ethylacetate as solvents. The phytochemical screening was done on Daemonorops draco (Willd.) Blume simplicia powder, extract, and fruit fraction. The antibacterial activity of each fraction was determined by examining the zone of inhibition against different test species, including Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and Salmonella typhi (ATCC 25923). (ATCC 6539). The water content of the simplicia was 4.65 percent, and the ethanol extract was 5.98 percent, according to the results of the characterisation. Alkaloids, flavonoids, glycosides, saponins, tannins, and steroids/triterpenoids were found in the phytochemical screening test of the ethanol extract. At a concentration of 25 mg/ml, Staphylococcus aureus had the highest antibacterial activity with an effective inhibitory diameter of 15.3 mm, Escherichia coli had the highest antibacterial activity with an effective inhibitory diameter of 14.2 mm, and Salmonella typhi had the highest antibacterial activity with an effective inhibitory diameter of 14.5 mm.
Antibacterial Activity Of Daemonorops Draco (Willd) Blume Fruit Ethanol Extract Against Some Bacterial Pathogens Apriani, Aida; Masfria, Masfria; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 3 No. 4 (2022): July 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i4.545

Abstract

Daemonorops draco (Willd.) Blume fruit has been used as a traditional medicine which is well-known as an antiseptic, stimulates blood circulation, anti-microbial, anti-viral, anti-tumor, wound medicine, diarrhea, fractures, gonorrhea, minor burns and others. Daemonorops draco (Willd.) Blume belonging to the Arecaceae tribe contains a class of chemical compounds such as alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and glycosides. Flavonoid compounds, saponins and tannins are chemical compounds that have potential as antibacterial and antiviral. This study aims to determine the characteristics of simplicia, phytochemical screening, antibacterial activity test of the ethanol extract of Daemonorops draco (Willd.) Blume fruit.Simplicia characterization includes organoleptic, macroscopic, microscopic examination, determination of water content. Extraction was carried out by maceration using ethanol as a solvent. Phytochemical screening was carried out on simplicia powder, fruit ethanol extract Daemonorops draco (Willd.) Blume, assay of antibacterial activity of extract using diffusion methodagar by observing the zone of inhibition against several test bacteria: Staphylococcus aureus, Escherichia coli, Salmonella thypi. The results of simplicia characterization obtained water content of 4.65%. The results of the phytochemical screening test of simplicia and ethanolic extracts contained groups of alkaloids, flavonoids, glycosides, saponins, tannins, steroids/triterpenoids. Having the highest antibacterial activity was ethanol extract from Gram positive Staphylococcus aureus bacteria followed by Gram negative bacteria Escherichia coli and Salmonella thypi at a concentration of 500 mg/ml with an effective inhibitory diameter of 15.5 mm, Escherichia coli at 14.3 mm, Salmonella typhi at 14, 8 mm.
Phytochemical Screening and Antibacterial Activity Ethanolic Extract of Solanum mauritianum Scop Leaves Against Staphylococcus aureus and Pseudomonas aeruginosa BR PA, Ayu Meta Sari; Masfria; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.648

Abstract

According to the Karo people, Solanum mauritianum Scop leaves are widely used as traditional medicine, which is used topically to treat sprains, wounds, and bruises because of their high phenol content. The purpose of this study was to identify the content of secondary metabolites (alkaloids, flavonoids, saponins, tannins, steroids, triterpenoids, and glycosides) that inhibit the antibacterial activity of Staphylococcus aureus and Pseudomonas aeruginosa by the diffusion method using paper discs from the ethanolic extract of Solanum mauritianum Scop leaves. The results of phytochemical screening showed that Solanum mauritianum Scop leaves were positive for alkaloids, flavonoids, glycosides, saponins, tannins, and steroids. Results The antibacterial activity test of the ethanolic extract of Solanum mauritianum Scop leaves showed effective results at a concentration of 80 mg/mL on Staphylococcus aureus with an inhibition zone diameter of 14.54 ± 0.13 mm. Meanwhile, Pseudomonas aeruginosa showed effective results at a concentration of 300 mg/mL with an inhibition zone diameter of 15.70 ± 0.09 mm. Both bacteria showed activity in the strong category. Conclusion The ethanolic extract of Solanum mauritianum Scop leaves has antibacterial activity against both test bacteria with a strong category
Phytochemical Screening of Phaleria macrocarpa (Scheff.) Boerl.) and Antibacterial Activity Test of Ethanol Extract Against Staphylococcus aureus Bacteria Rizki, Muhammad; Harahap, Urip; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.781

Abstract

Phaleria macrocarpa is known as one of the medicinal plants in Indonesia. Almost all parts of the plant have chemical content that is useful for being used as medicine. The growing use of crown plants by the community for various diseases requires a series of tests to obtain traditional medicine preparations that are safe for human use. The purpose of this study was to identify the content of secondary metabolite compounds (alkaloids, flavonoids, saponins, tannins, steroids, triterpenoids, and glycosides) and the antibacterial activity of Staphylococcus aureus with the good method because the good method has the advantage that it is easier to measure the area of the inhibition zone formed because an antibacterial activity is not only on the upper surface of nutrient agar but also at the bottom. The results of phytochemical screening showed that the flesh of Phaleria macrocarpa (Scheff). The results of testing the antibacterial activity of an ethanol extract of crown Phaleria macrocarpa (Scheff) fruit flesh (Boerl) were positive for alkaloids, flavonoids, glycosides, saponins, tannins, and steroids. Boerl.) showed effective results at a concentration of 40 mg/ml against Staphylococcus aureus bacteria with an inhibition zone diameter of 14 mm; the antibacterial activity was categorized as strong.
Phytochemical Screening Of Ethanol Extract Of Temu Kunci (Boesenbergia Rotunda (L.) Mansf) Rhizome Extract And Testing Of Bilirubin Levels In Male White Mice Harahap, Mawandha Sari; Harahap, Urip; Sitorus, Panal
International Journal of Science, Technology & Management Vol. 4 No. 3 (2023): May 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i3.819

Abstract

Liver Disease Is A Deadly Disease That Has Attacked Many People. Liver Disease Is A Disease That Occurs As A Result Of An Unhealthy Lifestyle. Usually, The Patient Will Consume Drugs With Chemical Compounds To Overcome The Problem Of This Disease. The Long-Term Use Of Chemical Drugs Will Certainly Cause Side Effects Or, Even Worse, Cause New Diseases. Therefore, The Latest Treatment Methods Must Be Developed To Minimize Side Effects, Namely The Use Of Traditional Medicines. The Purpose Of This Study Was To Determine The Use Of Temu Kunci Rhizome As An Alternative To Reduce Total Bilirubin Levels In Rats As Experimental Animals. This Study Used Rats As Experimental Animals, Which Were Divided Into 6 Test Groups, Namely Group 1 Without Treatment, Group 2 With 0.5% CMC Suspension, Group 3 With 200 Mg Acetylcysteine, Group 4 With 250 Mg/Kg BW Ethanol Extract Of Temukunci, Group 5 Treated With A 500 Mg/Kg BW Dose Of Ethanol Extract Of Temukunci, And Group 6 With A 750 Mg/Kg BW Ethanol Extract Of Temukunci. From The Results Of The Research Conducted, The Ethanol Extract Of Temu Kunci At A Dose Of 750 Mg/Kg BW Was The Best Treatment For Reducing Total Bilirubin Levels In Rats As Experimental Animals.
Co-Authors Aida Apriani Aminah Dalimunthe BR PA, Ayu Meta Sari Chandra, Devina Denny Satria, Denny Eka Margareta Sinaga Harahap, Mawandha Sari Lubis, Arga Lubis, Meiva Amelia Lumban Gaol, Nurahmi Marpaung, Jon Kenedy Masfria Muhammad Rizki Muhammad Wahyu, Muhammad Munthe, Bernadetta R. Nasution, Pandapotan Sitanggang, Berton Siti Nurbaya Siti Samaniyah Suharyanisa Supartiningsih - - Syukur Berkat Waruwu Urip Harahap Vadhila, Mumtaz Vevariantina, Ayu Yanti, Roma Devina Yuandani