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Efek Antiinflamasi Ekstrak dan Tablet Daun Kenitu (Chrysophyllum cainito L. ) pada Tikus Wistar (Rattus norvegicus) Ma'arif , Burhan; Sholekhah, Syafirda Arma'atu; Fuadi, Muhammad Nauval Nadhirul; Dianti, Meilina Ratna; Suryadinata , Arief; Maulina, Novia
FARMASIS: Jurnal Sains Farmasi Vol 5 No 1 (2024): Farmasis: Jurnal Sains Farmasi Vol 5. No. 1 (2024)
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v5i1.8614

Abstract

Pendahuluan : Inflamasi pada persendian akibat kerusakan tulang rawan merupakan ciri dari osteoarthritis (OA). Osteoarthtritis adalah suatu penyakit degeneratif terkait dengan rendahnya kadar estrogen dalam tubuh. Senyawa fitoestrogen memiliki struktur yang sama seperti estrogen, sehingga fitoestrogen dapat menjadi alternatif dalam meredakan inflamasi pada OA. Daun kenitu (Chrysophyllum cainito L.) salah satu tanaman yang memiliki kandungan senyawa fitoestrogen. Tujuan: Untuk membuktikan ekstrak etanol 70 persen (EDC) dan tablet (TDC) yang diformulasikan dari daun C. cainito  dapat mengurangi efek inflamasi pada tikus wistar jantan. Metode: Aktivitas antiinflamasi EDC dan TDC  kemudian diuji pada tikus menggunakan metode edema kaki tikus yang diinduksi karagenan dengan dosis 4,05, 8,1, dan 16,2 mg tiap 200gBB tikus per hari untuk EDC, sedangkan untuk TDC 24,3, 48,6, dan 97,2 mg tiap 200gBB tikus per hari. Setelah pemberian masing-masing sampel selama 30 menit, tikus diinduksi secara subplantar dengan karagenan 1 persen  kemudian diamati edema pada telapak kaki tikus selama 6 jam.  Hasil: EDC dan TDC menunjukkan aktivitas antiinflamasi, dengan dosis optimal untuk EDC adalah 4,05 mg tiap 200gBB sedangkan, dosis optimal untuk TDC adalah 48,6 mg tiap 200gBB, sehingga menghasilkan persentase penghambatan edema pada tikus. Kesimpulan: Hasil tersebut menunjukkan bahwa CLE dan CLT mempunyai efek anti inflamasi sehingga berpotensi untuk dikembangkan sebagai obat alternatif anti OA.
Overview of The Level of Outpatient Satisfaction with Pharmaceutical Services in The Pharmacy Room Jenggawah Sub-District Public Health Jember Regency Maulina, Novia; Sugihantoro, Hajar; Syahrir, Achmad; Pratiwi, Nurvita Cindy Dwi
Journal of Islamic Pharmacy Vol 8, No 2 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i2.24572

Abstract

Health is one of the important things for human life as a supporting factor of the quality of human life. Public health center is the first health facility for the community as an effort to improve health with several health services. One of the health services at the Public health center is pharmaceutical services whose activities are directly responsible for preventing the misuse of drugs against patients by providing the best service so that patient satisfaction arises. The purpose of this research was to determine the level of satisfaction of outpatients with pharmaceutical services in the pharmacy room of the Public health center at Jenggawah sub- district, Jember Regency. This type of research was descriptive research with a quantitative approach. The sampling method uses a nonprobability sampling method with purposive sampling techniques. Samples were obtained 100 respondents. This study refers to service quality (servqual) questionnaire instrument using a Likert scale satisfaction calculation and processed using SPSS 25. The results of the research on the level of patient satisfaction with pharmaceutical services on the pharmacy room's appearance were 78.95% (very satisfied), drug information services 80.33% (very satisfied), The pharmacist hospitality was 84.75% (very satisfied), the speed and accuracy of the officers were 80% (very satisfied), and at the indicators of drug availability 74.25% (medium). So that the majority of outpatient satisfaction with pharmaceutical services in the Pharmacy Room of the Public health center at Jenggawah Sub-district, Jember Regency is in the satisfied category.
Acute Toxicity of 70% Ethanol Extract of Kenitu (Chrysophyllum cainito L.) Leaves of Wistar Rats (Rattus norvegicus) Maulina, Novia; Fawzia, Rachma Izza; Firdausy, Alif Firman; Quintão, Roberto Doutel; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 9, No 1 (2024): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v9i1.27019

Abstract

The postmenopausal phase, which results in a lack of estrogen levels and is one of the triggers of menopausal symptoms, contributes to the elderly's cognitive function decline. This condition can also cause joint and bone pain, bladder and urinary tract disorders, and sexual problems. Based on several studies, it is known that kenitu (Chrysophyllum cainito L.) contains phytoestrogen compounds with a structure similar to the hormone estrogen, so kenitu has the potential as an alternative treatment for disease conditions with risk factors for estrogen deficiency. The study was conducted to determine the estimated lethal dose 50 (LD50) value based on the Globally Harmonized System (GHS) classification as well as macroscopic (physical, behavioral, and average weight gain per day) and microscopic (liver and kidney histology) values in Wistar rats against the administration of 70% ethanol extract of kenitu leaves at a dose of 2000 mg/kg body weight (BW). The Up-and-Down Procedure (UDP) acute toxicity test method was used for this study. The maximum dose was 2000 mg/kg BW of ethanol extract from 70% kenitu leaves. The study found that the 70% ethanol extract of kenitu leaves had more than 2000 mg/kg BW LD50 value against Wistar rats. Based on the classification of the GHS, it can be concluded that 70% ethanol extract of kenitu leaves against Wistar rats is classified as low toxicity.
The Influence of Perception of Halal Labels and Brand Image on Cosmetic Purchasing Decisions Among Millennials Hakim, Abdul; Sugihantoro, Hajar; Maulina, Novia; Nasichuddin, Achmad; Setiawan, Abdul Malik; Nicotiana, Diah Ayu
Indonesian Journal of Halal Research Vol 6, No 2 (2024): August
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ijhar.v6i2.37077

Abstract

The cosmetics industry consistently requires up-to-date research to develop effective marketing strategies that attract consumers and build their trust. This research aims to analyze how Millennials perceive halal labels and brand image in relation to their purchasing decisions for cosmetics. The study utilized an associative research method with a quantitative approach, employing purposive sampling and a questionnaire as its instrument. Data was processed using structural equation modeling-partial least squares (SEM-PLS) analysis. The findings indicate a strong positive correlation between the perception of halal labels and Millennials' purchasing decisions for cosmetics, as halal certification is a crucial factor for this demographic. Additionally, the study found that a positive brand image also significantly influences purchasing decisions, as consumers prefer products that are recognized for their quality, safety, and popularity. The practical implications for the cosmetics industry are evident: understanding the factors that drive purchasing decisions can help companies make the best strategic choices. It is recommended that companies consistently maintain halal certification on their products and focus on building a strong brand image, as both factors play a critical role in influencing consumer decisions.
Pengaruh Tingkat Pengetahuan terhadap Perilaku dalam Menggunakan Produk Kosmetik Berlabel Halal pada Mahasiswa Teknik Arsitektur UIN Malang Maulina, Novia; Silmy, Nur Fairus; Sugihantoro, Hajar; Syahrir, Achmad
Journal of Islamic Pharmacy Vol 9, No 2 (2024): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v9i2.26879

Abstract

Indonesia sebagai negara dengan mayoritas penduduk muslim, sepatutnya memenuhi kebutuhan yang mengarah pada keadaan kehalalan suatu produk, salah satunya penggunaan kosmetik yang banyak digunakan masyarakat terutama mahasiswa. Kesadaran dalam menggunakan kosmetik halal ini merupakan akibat dari pemahaman agama yang baik serta edukasi produsen terkait sertifikat halal pada produknya, sehingga masyarakat lebih selektif pada pemilihan produk yang digunakan. Pengetahuan tentang kosmetik halal ini akan mempengaruhi perilaku dalam menggunakan produk kosmetik halal. Tujuan penelitian ini adalah untuk mengetahui tingkat pengetahuan dan perilaku mahasiswa Teknik Arsitektur UIN Malang tentang produk kosmetik halal, serta mengetahui pengaruh tingkat pengetahuan terhadap perilaku dalam menggunakan kosmetik berlabel halal pada mahasiswa Teknik Arsitektur UIN Malang. Metode penelitian bersifat deskriptif kuantitatif. Teknik pengambilan sampel menggunakan non probability sampling yaitu teknik purposive sampling. Hasil analisis data pada 104 responden menunjukkan pada tingkat pengetahuan 73 mahasiswa (70%) memiliki pengetahuan tinggi, 30 mahasiswa (29%) memiliki pengetahuan cukup, dan 1 mahasiswa (1%) memiliki pengetahuan rendah. Pada tingkat perilaku 62 (60%) mahasiswa memiliki perilaku tinggi, 27 mahasiswa (26%) memiliki perilaku cukup, dan 15 mahasiswa (14%) memiliki perilaku rendah. Pengetahuan kosmetik halal berpengaruh signifikan (0,006) terhadap perilaku dalam menggunakan produk kosmetik berlabel halal dengan kekuatan pengaruh sedang 0,388 dan arah positif. Kesimpulan penelitian ini adalah terdapat pengaruh antara pengetahuan tentang kosmetik halal dengan perilaku dalam menggunakan produk kosmetik berlabel halal dengan kekuatan pengaruh tinggi dan arah hubungan yang positif.
Consumer Behavior Analysis as a Form of Pre-market Survey for the Black Pule (Alstonia spectabilis) Antimalarial Tablet Prototype: Analisis Perilaku Konsumen Sebagai Bentuk Survei Pre-market Tablet Prototipe Antimalaria Pule Hitam (Alstonia spectabilis) Taek, Maximus Markus; Ma'arif, Burhan; Maulina, Novia; Muslikh, Faisal Akhmal; Lalong, Paulus Risan Funan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16986

Abstract

Malaria is a disease caused by the protozoan parasite Plasmodium with a high incidence of spread that is still found in remote tropical places, especially areas around gardens, swamps, forests, and mines such as eastern Indonesia. The commonly used antimalarial drug chloroquine has experienced resistance, encouraging researchers to look for effective alternative treatments. Formulation development of Standardized Herbal Medicine (OHT) from black pule was carried out as a potential new alternative treatment as an antimalarial. Objectives: The purpose of this study was to determine the level of liking and quality assessment or characteristics of the prototype of antimalarial OHT tablets. Methods: The method used in this research is descriptive quantitative which aims to describe 57 panelists' perspective on the product and to analyze product marketing. In this research method includes hedonic test and hedonic quality test which is a series of organoleptic tests and consumer acceptance tests by tasting and observing the product followed by filling out a form according to what is felt and observed. Results: The results obtained from this research, namely the preference test of the overall characteristics of the prototype of antimalarial black pule tablets (Alstonia spectabilis) showed a good sensory impression and characteristics. The positive results obtained from all aspects have illustrated that the panelists have considerable interest in the prototype sample and assess that the prototype tablets are suitable for dissemination to the public. Conclusions: Based on the research, it can be concluded that the prototype of black pule (Alstonia spectabilis) tablets tested through hedonic and hedonic quality tests produced overall good results, characterized by the tendency of panelists to choose "Like" in the hedonic test of sensory impressions and positive values in the hedonic quality test.
Cost-Effectiveness Analysis Penggunaan Antidiabetik Oral pada Pasien Diabetes Melitus Rawat Jalan di RSU Haji Surabaya Rahmadanita, Fathia Faza; Maulina, Novia; Sugihantoro, Hajar; Muhimmah, Ilmiyatul; Saputra, Azian F.
Pharmaceutical Journal of Indonesia Vol. 8 No. 1 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.008.01.5

Abstract

ABSTRAK Pendahuluan: Diabetes melitus adalah penyakit kronis akibat proses metabolisme dalam tubuh yang tidak normal yang ditandai dengan adanya peningkatan kadar glukosa darah melebihi batas normal dalam tubuh. Diabetes melitus membutuhkan perawatan medis secara terus-menerus sehingga biaya medis yang dikeluarkan besar. Tujuan: Untuk mengetahui dan menganalisis efektivitas biaya penggunaan antidiabetik oral pada pasien diabetes melitus tipe 2 rawat jalan di RSU Haji Surabaya. Metode: Penelitian ini adalah penelitian deskriptif observasional dengan data retrospektif berupa rekam medis dan biaya pengobatan pasien rawat jalan dengan penyakit diabetes melitus tipe 2 di RSU Haji Kota Surabaya Periode Juni-November 2021. Analisis data dilakukan menggunakan rumus Average Cost-Effectiveness Ratio (ACER) dan Incremental Cost-Effectiveness Ratio (ICER). Hasil: Didapatkan 70 pasien diabetes melitus tipe 2 dengan penyakit penyerta yang memenuhi kriteria inklusi. Penggunaan terapi antidiabetik oral monoterapi ditemukan pada 11 pasien dan pada terapi antidiabetik oral kombinasi sebanyak 59 pasien. Antidiabetik oral monoterapi yang paling banyak digunakan adalah glimepiride (8,57%), sedangkan pada antidiabetik oral kombinasi adalah kombinasi metformin dan glimepiride (17,14%). Terapi antidiabetik oral monoterapi yang paling cost-effective adalah gliklazid dengan nilai efektivitas sebesar 100%, nilai ACER sebesar Rp 1.331,15. dan nilai ICER Rp. -641,70 dan Rp. -714.52. Sedangkan terapi antidiabetik oral kombinasi yang paling cost-effective adalah kombinasi pioglitazone, metformin dan glimepiride dengan nilai efektivitas 55,56%, nilai ACER sebesar Rp 3.266,34 dan nilai ICER Rp. 1.491,54 dan Rp. 1.654,43. Kesimpulan: Berdasarkan parameter ACER dan ICER, antidiabetik oral monoterapi yang paling cost-effective adalah gliklazid. Sedangkan antidiabetik oral kombinasi yang paling cost-effective adalah kombinasi pioglitazone, metformin dan glimepiride. Kata Kunci: Diabetes melitus, Cost-effectiveness Analysis, ACER, ICER
O-CITRI Soap: Antibacterial Paper Soap Made from Orange Peel (Citrus sinensis L.) and Basil (Ocimum sanctum L.) Fitriyani, Fitriyani; Bustomi, Mochammad Y. A.; Maulina, Novia; Kinasih, Larasati S.; Arriziq, Muhammad A.
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.52344

Abstract

Basil (Ocimum sanctum L.) have a dominant content of citral compounds with antibacterial activity. Another plant suspected to contain antibacterial bioactive components is orange peel. Orange peel (Citrus sinensis L) contains phenolic compounds (phenolic acids, flavonones, and polymethoxylated flavones), carotenoids, and ascorbic acid. Phenolic compounds are known to have several activities such as antimicrobial, antioxidant, anticancer, anti-inflammatory, and anti- allergic. The aim of this research is to prove that the combination of orange peel and basil extracts has antibacterial effects against Staphylococcus aureus, which can be formulated as paper soap which is named O-Citri. This research method is experimental, involving the physical and chemical evaluation of the formulation, as well as antibacterial activity testing. The research results show that the combination of orange peel and basil extracts in the paper soap formulation has antibacterial effects. The highest concentration combination for antibacterial activity is F1 with a ratio of orange peel and basil extract at 5%:15%.
The Influence of Perception of Halal Labels and Brand Image on Cosmetic Purchasing Decisions Among Millennials Hakim, Abdul; Sugihantoro, Hajar; Maulina, Novia; Nasichuddin, Achmad; Setiawan, Abdul Malik; Nicotiana, Diah Ayu
Indonesian Journal of Halal Research Vol. 6 No. 2 (2024): August
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ijhar.v6i2.37077

Abstract

The cosmetics industry consistently requires up-to-date research to develop effective marketing strategies that attract consumers and build their trust. This research aims to analyze how Millennials perceive halal labels and brand image in relation to their purchasing decisions for cosmetics. The study utilized an associative research method with a quantitative approach, employing purposive sampling and a questionnaire as its instrument. Data was processed using structural equation modeling-partial least squares (SEM-PLS) analysis. The findings indicate a strong positive correlation between the perception of halal labels and Millennials' purchasing decisions for cosmetics, as halal certification is a crucial factor for this demographic. Additionally, the study found that a positive brand image also significantly influences purchasing decisions, as consumers prefer products that are recognized for their quality, safety, and popularity. The practical implications for the cosmetics industry are evident: understanding the factors that drive purchasing decisions can help companies make the best strategic choices. It is recommended that companies consistently maintain halal certification on their products and focus on building a strong brand image, as both factors play a critical role in influencing consumer decisions.
Eksplorasi Hubungan Tingkat Pengetahuan Terhadap Kepatuhan Terapi Pasien Hipertensi di UPT Puskesmas Tanjung Batu Kabupaten Karimun Maulina, Novia; Luthfi, Fitrati Hasanah; Inayatilah, Fidia Rizkiah; muslikh, Faisal akhmal
Journal of Islamic Medicine Vol 9, No 1 (2025): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2025
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v9i1.25921

Abstract

Background: Hypertension is a condition where blood pressure exceeds normal levels (120/80mmHg), with systolic blood pressure above 140 mmHg and diastolic blood pressure above 90mmHg. Termed as the "silent killer," hypertension often manifests without symptoms and is a leading cause of death in Indonesia. The prevalence of hypertension in the Riau Islands Province reached 25.85% in 2018, with Karimun Regency ranking second. Objectif: This study aims to assess the relationship between knowledge and adherence to antihypertensive medication among hypertensive patients at UPT Puskesmas Tanjung Batu, Karimun, in 2022. Methods: This observational study employs a Cross-sectional design. Data were collected from March to May 2022 from 90 respondents using a questionnaire. The sampling method used was consecutive sampling. Data analysis involved univariate and bivariate analyses with the Spearman rank test (significance level 0.005). Results: The majority of respondents were female (71%), aged 46-55 years (43%), with an educational background of elementary school (62%). On average, they had suffered from hypertension for less than 5 years (56%), and the primary source of information was from doctors (81%). Knowledge level was sufficient (49%), while medication adherence was low (83%). Statistical analysis indicated a significant relationship (p=0.001) and alignment between knowledge and adherence among hypertensive patients at UPT Puskesmas Tanjung Batu, Karimun, with a moderate correlation (r=0.343). Conclusion: There is a significant relationship between knowledge and adherence to antihypertensive medication among hypertensive patients.