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Molecular Docking and Molecular Dynamic Simulation of 1,5-Benzothiazepine Chalcone Derivative Compounds as Potential Inhibitors for Zika Virus Helicase Frimayanti, Neni; Nasution, Musyirna Rahmah; Etavianti, Elsa
Jurnal Riset Kimia Vol 12, No 1 (2021): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i1.365

Zika virus caused of the emerging infections characterized by fever, Guillain-BarrÃ© syndrome (GBS) for adults. In the current work, we aimed to study the binding orientation of 1,5-benzothiazepine compounds as new potential agent against Zika virus inhibitor through molecular docking and molecular dynamic simulation. Since, 1-5-Benzothiazepines are particular interest for drug discovery and they also has some biological activities. However, their antiviral activities and in silico studies of the binding to their biological targets have not been extensively investigated. Molecular docking study of 1,5-benzothiazepine chalcone derivatives compounds with protein target 5GJB (PDB ID) and this protein was taken from the crystallographic structure. In this study, twelve 1,5-benzothiazepine chalcone derivative compounds were docked to the protein with the grid box along x, y and z radius of 26.85, 28.17 and 24.43 Ã…, respectively. Suramin was used as positive control. Thus, it can be used as a reference for design new inhibitors for Zika virus helicase. Based on the docking results, it is observed that compounds MA3 and MA8 are estimated to have activity as inhibitors for Zika virus helicase with binding free energy values of -4.6490 and -4.9291 kcal/mol, respectively. MA3 and MA8 were also stable during the MD simulations with the hydrogen bonding are still maintained before and after MD simulation. Furthermore, both of these compounds can be used an early stage for drug design and drug delivery process.

Aktivitas Antibakteri dan Antijamur Fraksi Etil Asetat Kulit Buah Jeruk Manis (Citrus sinensis (L.) Osbeck) Octaviani, Melzi; Masnun, Lidiatil; Nasution, Musyirna Rahmah; Susanti, Emma; Utami, Rahayu; Furi, Mustika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.140

The sweet orange (Citrus sinensis (L.) Osbeck) is a popular fruit. The part of the sweet orange that is consumed is only the fruit flesh, while the orange peel is only thrown away and not utilized. The sweet orange peel contains several secondary metabolites, namely alkaloids, flavonoids, tannins, phenols, saponins, and steroids, which have antimicrobial properties. This study aims to determine the effect of the concentration of the ethyl acetate fraction of sweet orange peel on antibacterial and antifungal activity in Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Salmonella typhi, and Candida albicans fungi using the disc diffusion method. The ethyl acetate fraction was prepared in several concentration series, namely 50%, 25%, 12.5%, 6.25%, 3.125%, and 1.5625% w/v. The results obtained showed that all concentrations of the ethyl acetate fraction series showed activity in inhibiting the growth of Salmonella typhi bacteria. Series concentrations of 3.125% to 50% have activity in inhibiting the growth of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Candida albicans fungi. The results of the data analysis using statistical one-way ANOVA showed that the antibacterial and antifungal activities between the concentration series were significantly different (p<0.05) from the negative control.

Ciplukan (Physalis angulata L.): Review Tanaman Liar yang Berpotensi Sebagai Tanaman Obat Fadhli, Haiyul; Ruska, Shinta Liana; Furi, Mustika; Suhery, Wira Noviana; Susanti, Emma; Nasution, Musyirna Rahmah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.144

Ciplukan (Physalis angulata L.) has been widely used as a traditional medicine in several countries and regions in Indonesia, such as to increase blood flow and relieve body aches, asthma, diabetes, chickenpox, cough medicine, fever, diarrhea, hypertension, and back pain. This article reviews the potential of ciplukan to overcome various health problems. The preparation of this review article uses references from research articles related to the results of phytochemical screening, the isolation of secondary metabolites, and biological activity tests (pharmacology) of Physalis angulata plants reported in the last 10 (ten) years. This plant contains many secondary metabolite compounds isolated from its roots, leaves, stems, and fruits, such as physalin, withanolide, and flavonoid glycoside compounds. Several studies have reported that this plant has biological and pharmacological activities such as antioxidants, toxicity, anticancer, anti-inflammatory, antidiabetic, antidiarrheal, antibacterial, antifibrotic, and anti-hypercholesterolemia.

Antimicrobial of Ethanolic Extract from Marpuyan Stem Bark (Rhodamnia cinerea Jack) Nasution, Musyirna Rahmah; Cahyani, Ardhia Regita; Aqilla, Alya; Fitri, Valentina; Triani, Leni
Acta Chimica Asiana Vol. 7 No. 1 (2024)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v7i1.193

The Bark of Marpuyan Tree (Rhodamnia cinerea Jack) is a plant that has been empirically used by communities in Indonesia for the treatment of infectious diseases caused by bacteria and fungi. The bark of Marpuyan contains flavonoids, phenolics, and saponins. This study aimed to evaluate the antibacterial and antifungal activities of the ethanol extract of the bark of Marpuyan using the disc diffusion method at various extract concentrations, namely 30%, 25%, 15%, 10%, and 5%. The results of the antibacterial activity test against Gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus subtilis) showed inhibitory zones with respective diameters of 11.67±0.21 mm, 12.29±0.43 mm, and 12.78±0.14 mm. These results indicate weak antibacterial activity. In the antibacterial activity test against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi), inhibitory zones were found with respective diameters of 13.05±0.05 mm, 12.58±1.78 mm, and 10.98±0.21 mm. These results also indicate weak antibacterial activity. However, in the antifungal activity test, no activity was found against Candida albicans and Malassezia furfur. Nevertheless, the ethanol extract of Marpuyan bark showed moderate antifungal activity against Trichophyton mentagrophytes, with an inhibitory zone diameter of 15.44±2.02 mm.

UJI VALIDASI METODE DAN PENETAPAN KADAR RANITIDIN DALAM SEDIAAN TABLET SECARA SPEKTROFOTOMETRI UV: METHOD VALIDATION TEST AND DETERMINATION OF RANITIDINE CONTENT IN TABLET PREPARATIONS BY UV SPECTROPHOTOMETRY Dona, Rahma; Ningrum, Tilar Eka Widia; Nasution, Musyirna Rahmah; Fernando, Armon; Syahbandi, Ilham; Milianty, Jesy
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1805

This study aims to determine the levels of ranitidine in generic and trade name tablet preparations by UV spectrophotometry. Based on the results obtained linearity value of r = 0.9999 with limit of detection (LOD) 0.1667 ppm and limit of quantitation (LOQ) 0.5558 ppm. Precision obtained RSD results of 0.641% and in accuracy obtained % recovery at 3 concentrations of 9, 12 and 15 ppm respectively 101.05; 100.63; and 100.33%. The results of the determination of levels in ranitidine tablet preparations with five generic tablets and five trade name tablets have met the requirements for levels in medicinal preparations for ranitidine tablet preparations according to the Indonesian Pharmacopoeia VI Edition, which contains ranitidine not less than 90.0% and not more than 110.0%. It can be concluded that the UV spectrophotometric method used in the study has met the parameters set in the validation test so that this method can be applied to the analysis of determining ranitidine levels in a laboratory. Keywords: Ranitidine, UV Spectrophotometry, Method validation

IDENTIFIKASI KANDUNGAN FORMALIN PADA BAKSO MENGGUNAKAN METODE RAPID TEST KIT Nasution, Musyirna Rahmah; Pardede, Depa Gloria Kristin
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 4 No. 1 (2025): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v4i1.102

Telah dilakukan penelitian tentang identifikasi kandungan formalin pada bakso menggunakan metode rapid test kit. Formalin merupakan salah satu bahan pengawet berbahaya yang sering digunakan sebagai bahan tambahan pangan. Bakso merupakan makanan yang sangat populer di Indonesia yang terbuat dari tepung kanji dan daging. Rapid test kit adalah uji cepat yang digunakan untuk identifikasi bahan-bahan berbahaya pada produk. Tujuan penelitian ini adalah untuk mengetahui ada atau tidaknya formalin dalam bakso yang beredar di jalan Garuda Sakti km 1-12. Pengambilan sampel dilakukan pertama dengan metode purposive sampling kemudian diambil secara acak dengan metode simple ramdom sampling. Hasil pengujian ketujuh sampel bakso menunjukan bahwa terdapat 14,28% sampel positif mengandung formalin dan 85,72% sampel negatif mengandung formalin. Hasil identifikasi ini ditunjukan dengan adanya perubahan warna ungu pada sampel bakso setelah direaksikan dengan test kit formalin

Shrimp Cracker Making Business in Indragiri Hilir Bathara, Lamun; Nugroho, Firman; Nasution, Tio Afandi; Simanjuntak, Asnika Putri; Nasution, Musyirna Rahmah
Jurnal Perikanan dan Kelautan Vol. 30 No. 2 (2025): June
Publisher : Fakultas Perikanan dan Kelautan Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jpk.30.2.252-256

Indragiri Hilir is one of the districts with extensive waters and abundant fishery production. The potential for capture fisheries in Indragiri Hilir Regency is very large. In 2021, the potential for capture fisheries was 53,057.13 tons. Shrimp is a fishery commodity with high economic value and a favorite of Indonesian exports in the fisheries sector. Shrimp crackers are a series of food processing processes that combine tapioca flour with fresh shrimp to produce crispy snacks with a distinctive flavor. This process involves several critical stages that must be carried out carefully to produce high-quality products. Shrimp crackers are one of Indonesia's traditional snacks that have a distinctive taste and are in demand by various groups. Based on this, this study aims to determine how the shrimp cracker-making business process in Indragiri Hilir will be carried out in 2024. The research results obtained from this study are the shrimp cracker-making business in Indragiri Hilir, precisely in Tanah Merah Village, starting from the preparation, processing, and packaging stages. Shrimp crackers have been marketed to regions including Irian Jaya, Batam, Pekanbaru, Palembang, and Java. The development of the shrimp cracker processing business not only increases the livelihood of local people but also contributes to reducing unemployment in the area.

The Isolatıon, Characterızatıon, and Antıfungal Assay of Lactıc Acıd Bacterıa Isolated from Green Glutınous Rıce Tape Agaınst Aspergillus flavus Nasution, Musyirna Rahmah; Aulya, Nurliza; Dona, Rahma; Ningsih, Yozi Fiedya
Medical Laboratory Technology Journal Vol. 11 No. 1 (2025): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i1.645

Green glutinous rice tape is a fermented food made from glutinous rice, katuk leaves (Sauropus androgynus), and yeast, originating from Tembilahan, Riau Province. This product can serve as a source of lactic acid bacteria (LAB) capable of producing antimicrobial compounds to inhibit pathogenic microorganisms, including Aspergillus flavus, a well-known spoilage fungus in food products. However, to date, no reports have explored the ability of LAB from green glutinous rice tape to inhibit the growth of Aspergillus flavus. This study aimed to isolate LAB from green glutinous rice tape, conduct macroscopic, microscopic, and biochemical characterizations, and evaluate the antifungal activity of the LAB isolates against Aspergillus flavus using the good diffusion method. The isolation process yielded four LAB isolates from Tembilahan green tape (TKHT-2, TKHT-3, TKHT-5, and TKHT-7), which were identified as members of the genus Lactobacillus sp., with antifungal activities of 25.50 ± 5.78 mm, 24.33 ± 0.62 mm, 22.16 ± 6.56 mm, and 18.66 ± 4.28 mm, respectively. The corresponding cell-free supernatants (CFS) from these isolates (TKHT-S2, TKHT-S3, TKHT-S5, and TKHT-S7) also demonstrated antifungal activity with inhibition zones of 19.83 ± 3.47 mm, 19.83 ± 4.24 mm, and 14.50 ± 3.26 mm, respectively. LAB cells and their cell-free supernatants partially inhibited Aspergillus flavus, indicating a fungistatic effect. These findings suggest the potential application of LAB from green glutinous rice tape as a natural preservative or antifungal agent in food products.

MEMANFAATAN INFUSED WATER UNTUK MENCEGAH DEHIDRASI DAN DETOKSIFIKASI TUBUH Dewi, Ratna Sari; Nasution, Musyirna Rahmah; Agustini, Tiara Tri; Arundita, Silvy; Anggraini, Annisa Fitri; Febrian, Dyan; Manik, Dhea Putri Bertuah Br; Ramadhani, Elsha Fadhika Dwi; Hanifa, Elvi; Afnita, Fakhiratunnisa; Diwa, Resi Oktamara; Nabilla, Vivi Gita; Amnan, Wekis Raya; Azhari, Weriska Restu
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 5 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i5.1263

Infused water merupakan salah satu cara untuk menjaga kesehatan dengan mudah. Memperbanyak meminum air dan mengonsumsi buah-buahan merupakan salah satu cara menjaga kesehatan. Tujuan kegiatan ini adalah memberikan pemahaman kepada masyarakat tentang manfaat infused water serta mengedukasi masyarakat bagaimana cara pembuatan infused water yang benar sehingga diharapkan program pengabdian masyarakat ini dapat meningkatkan derajat kesehatan masyarakat. Kegiatan pengabdian ini dilaksanakan pada haru minggu, 13 oktober 2024 di Car Free Day, Jalan Sudirman Pekanbaru, dengan tema “Pemanfaatan Infused Water Untuk Mencegah Dehidrasi Dan Detoksifikasi Tubuh” dengan pembagian leaflet, edukasi secara lisan terkait judul diangkat dan diakhiri dengan pembagian infused water. Hasil dari pemberian edukasi yang signifikan mengenai Infused Water kepada Masyarakat. Berdasarkan hasil pre-test dan post-test yang melibatkan 55 responden. Dari hasil uji statistic Wilcoxon juga menunjukan perbedaan yang signifikan antara tingkat pengetahuan sebelum dan sesudah edukasi (p-value < 0,05). Secara tidak langsung penyuluhan ini memberikan dampak yang baik untuk Masyarakat agar dapat selalu menerapkan mengkonsumsi infused water setiap hari.

Shrimp Cracker Making Business in Indragiri Hilir Bathara, Lamun; Nugroho, Firman; Nasution, Tio Afandi; Simanjuntak, Asnika Putri; Nasution, Musyirna Rahmah
Jurnal Perikanan dan Kelautan Vol. 30 No. 2 (2025): June
Publisher : Fakultas Perikanan dan Kelautan Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jpk.30.2.252-256

Indragiri Hilir is one of the districts with extensive waters and abundant fishery production. The potential for capture fisheries in Indragiri Hilir Regency is very large. In 2021, the potential for capture fisheries was 53,057.13 tons. Shrimp is a fishery commodity with high economic value and a favorite of Indonesian exports in the fisheries sector. Shrimp crackers are a series of food processing processes that combine tapioca flour with fresh shrimp to produce crispy snacks with a distinctive flavor. This process involves several critical stages that must be carried out carefully to produce high-quality products. Shrimp crackers are one of Indonesia's traditional snacks that have a distinctive taste and are in demand by various groups. Based on this, this study aims to determine how the shrimp cracker-making business process in Indragiri Hilir will be carried out in 2024. The research results obtained from this study are the shrimp cracker-making business in Indragiri Hilir, precisely in Tanah Merah Village, starting from the preparation, processing, and packaging stages. Shrimp crackers have been marketed to regions including Irian Jaya, Batam, Pekanbaru, Palembang, and Java. The development of the shrimp cracker processing business not only increases the livelihood of local people but also contributes to reducing unemployment in the area.

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