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All Journal Buletin Farmatera Sumatera Medical Journal SCRIPTA SCORE Scientific Medical Journal Indonesian Journal of Global Health research Cermin Dunia Kedokteran The Journal of Society Medicine (JSOCMED) Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia Cermin Dunia Kedokteran
Jusuf, Nelva Karmila
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Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : The Journal of Society Medicine (JSOCMED)

 1 
Relationship between Thioredoxin Reductase (TrxR) Levels and Melasma Risanti, Rinda Chindra; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of Society Medicine Vol. 3 No. 3 (2024): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i3.131

Abstract

Introduction: Melasma is a common condition of acquired hypermelanosis in dermatology that often occurs in areas of the body exposed to sunlight, especially the face. Thioredoxin Reductase (TrxR) is a key antioxidant system in defense against oxidative stress through disulfide reductase activity that regulates dithiol/disulfide protein balance. High levels/activity of TrxR correlate with melanin formation and tyrosinase activity which provides additional information about the role of cellular antioxidant proteins in melanogenesis which is suspected to be related to the occurrence of melasma. The aim of this study was to determine the relationship between TrxR levels and melasma Method: This study was an observational analytical study with cross-sectional design on 30 melasma patients and 30 controls. Each patient underwent anamnesis, dermatological examination, and blood sampling to assess TrxR levels by ELISA test. These data were analyzed statistically using the Mann Whitney test. Results: This study shows that the most common distribution pattern of melasma was centrofacial in 24 people (80%). The mean TrxR level in melasma was 12.73±11.66 ng/ml. The results of the study showed that there was a relationship between high TrxR levels and melasma (p<0.001). The TrxR mean level based on the duration of suffering from melasma at <5 years was 11.4±2.89, and ≥ 5 years was 14.0±3,18 Conclusion: There is a relationship between TrxR levels and melasma.
Relationship between Angiotensin Converting Enzyme (ACE) and Cellulite Annisa Astari; Putra, Imam Budi; Jusuf, Nelva Karmila
Journal of Society Medicine Vol. 3 No. 3 (2024): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i3.133

Abstract

Introduction: Cellulite is a local metabolic disorder in subcutaneous tissue characterized by changes in skin topography, occurring in parts of the body with a large accumulation of fat tissue, especially thighs, buttocks, hips, and abdomen. Angiotensin converting enzyme is a zinc metallopeptidase, distributed on the surface of endothelial cells. Increased ACE levels cause microcirculation disorders, adipocyte hypertrophy, increased extracellular matrix, and stimulate the emergence of inflammatory cytokines which will cause an increase in the inflammatory response in the tissue, stimulate fibrogenic response and influences the appearance of cellulite. The aim of this study was too determine the relationship between ACE and cellulite. Method: This study was an observational study with a cross-sectional design of 40 cellulite patients and 40 controls. Each patient underwent history, dermatological examination, and blood sampling to assess ACE levels by ELISA test. These data were analyzed statistically using the Chi square test. Results: The mean ACE level in cellulite was 66.78±15.38 µg/ml. The highest age with cellulite was 26–35 years 17 subjects (42.5%). Most of them had a family history of cellulite from their mother 22 subjects (55%). The majority of cellulite are located on the femoral and gluteus regions by 27 subjects (67.5%). The result of this study showed that there was a relationship between high ACE levels causing a risk of 4.5 times for cellulite (p = 0.002). Conclusion: There is a relationship between ACE levels and cellulite.
The Aryl Hydrocarbon Receptor (AhR) Level Based on Age and Clinical Type of Melasma Danil, Rezkyana; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of Society Medicine Vol. 3 No. 7 (2024): July
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i7.153

Abstract

Introduction: Melasma is the most common pigmentation condition on the face due to excessive melanin production and release. The main predisposing factor for melasma is UV exposure. Aryl Hydrocarbon Receptor (AhR) is a ligand-dependent transcription factor that regulates the expression of a very large number of target genes in humans. Facial hyperpigmentation is increased in people living in air-polluted areas with particulate matter2.5  (PM2.5) concentrations. Dioxin compounds contained in PM2.5  can activate AhR signaling. This study aims to determine the aryl hydrocarbon receptor (AhR) level based on age and clinical type of melasma. Methods: This study was an observational study with a cross-sectional design of 30 women with melasma at Prof. CPL Hospital. This study was conducted after obtaining ethical clearance from the Research Ethics Commission of the University of North Sumatra and has obtained permission from the research field of Prof. Chairuddin Panusunan Lubis Hospital. All subjects underwent history taking, physical examination, dermatological examination, and blood sampling to assess AhR levels by ELISA test. Data were analyzed with Chi square test to assess AhR levels based on age, and to assess AhR levels based on clinical type of melasma with Kruskal Wallis test. Results: This study shows that the majority of melasma age is 41-50 years with the highest mean AhR level is 882,61 ng/mL, while the lowest AhR level is in the age range of 20-30 years with a mean of 271,5 ng/mL. Chi square test showed that there was a significant relationship between AhR levels and age (p < 0,001). The highest mean AhR levels in melasma subjects were centrofacial type with a mean of 795,50 ng/mL, while the lowest mean AhR levels were found in melasma subjects with malar type with a mean of 623,36 ng/mL. The Kruskal Wallis test showed that there was no significant difference in AhR levels based on the clinical type of melasma (p = 0,930). Conclusion: That increased the age, the highest AhR levels. The highest average AhR level was centrofacial type of melasma. There was no significant difference in AhR levels based on the clinical type of melasma.
Co-Authors Al Hafiz, OK Muhammad Amalia, Rina Annisa Astari Danil, Rezkyana Deliana, Rizka Dhillon, Jesryn Eka Zhaki Safira Lubis Fitri Puspita Kartayana, Johan Khairina, Fadilah Oliv Kusumawati, R. Lia Lubis, Ade Fitriyani Lubis, Nabila Adani Meutia, Nanda Muhammad Ichwan Mutia Fadhila Sy Nasution, Khairina Oentari, Widyaningsih Putra, Imam Budi Rina Amelia Risanti, Rinda Chindra Rosyada, Rahma Sari, Lovena Setio Wati, Sri Karunia Siahaan, Ade Gustina Sutrisno, Angie Regina Tamba, Asnita Bella Putri Tasmil, Adina Miltania Tengku, Nabila Nurhafizha Utama, Putri Wahdiah utami, dina rizki Wiryadana, Michelle Wulandari, Puteri Yosi, Ariyati Zulfa, Riefka Ananda