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All Journal Medali Jurnal : Media Dental Intelektual STOMATOGNATIC- Jurnal Kedokteran Gigi MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Jurnal Kedokteran Gigi Universitas Padjadjaran MDJ (Makassar Dental Journal) Makara Journal of Science Mandala of Health : A Scientific Journal Medical and Health Journal Journal of Dental and Biosciences
Fanni Kusuma Djati
Universitas Jenderal Soedirman
Dentistry Health Professions Medicine & Pharmacology Public Health

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Manifestasi oral pada pasien gagal ginjal kronis di Rumah Sakit Umum Daerah Prof. Dr. Margono Soekarjo, Banyumas Djati, Fanni Kusuma; Naim, Cantika Nadrotan; Ramadhanti, Dian Praba; Kinasih, Amelia Sekar; Berlianza, Activira; Nugroho, Yunanto Dwi
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 11, No 2 (2025)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.106128

Abstract

Gagal ginjal kronis (GGK) adalah suatu kondisi penurunan fungsi ginjal secara bertahap yang disebabkan karena terjadinya kerusakan pada ginjal. Gagal ginjal kronis biasanya terjadi dalam waktu lama (tahunan) yang ditandai dengan penurunan nilai glomerular filtration rate (GFR) <60 mL/menit per 1,73 m2. Prevalensi GGK di Indonesia mengalami peningkatan dari tahun 2013 yaitu 0,2% menjadi 0,38% pada tahun 2018. Etiologi GGK tergolong sangat bervariasi seperti diabetes, glomerulonefritis, hipertensi, dan penyakit ginjal kistik. Laporan ini bertujuan untuk mengidentifikasi berbagai manifestasi oral pada pasien GGK dengan mempertimbangkan keterkaitan klinisnya sebagai bahan refleksi diagnostik pada praktik kedokteran gigi. Laporan ini menunjukkan variasi manifestasi oral pada pasien GGK mencakup periodontitis uremik, hiperpigmentasi, oral hairy leukoplakia, cheilitis, stomatitis nekrotikan, coated tongue, dan kandidiasis kronis. Beberapa manifestasi oral pada kasus GGK kemungkinan berkaitan langsung dengan kondisi uremik, sementara manifestasi oral lainnya dipengaruhi oleh faktor xerostomia, gangguan imun, nutrisi, dan penggunaan obat-obatan. Kompleksitas sistemik pada GGK dapat memperburuk kesehatan rongga mulutsecara umum. Temuan pada laporan kasus ini menegaskan pentingnya peran dokter gigi untuk mengenali tanda sistemik yang tampak di rongga mulut serta perlunya pendekatan multidisipliner pada manajemen pasien GGK.
ORAL HYPERPIGMENTATION IN END-STAGE CKD PATIENTS UNDERGOING HEMODIALYSIS: A CASE REPORT Djati, Fanni Kusuma; Minullah, Nanda Asta; Octivany, Sherly; Febriharsari, Niken; Aditiawarman, Aditiawarman; Nugroho, Yunanto Dwi
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.15743

Abstract

Chronic kidney disease (CKD) is a progressive disease characterized by gradual and irreversible loss of kidney function over several months or years. According to Riskesdas 2018, the incidence of CKD in Indonesia is 0.38% (713,783 people) with 19.33% (2,850 people) undergoing hemodialysis therapy. Many CKD patients have related oral lesions, but attention to oral healthcare remains insufficient, especially in developing countries with higher rates of CKD patients. Several oral manifestations of CKD described in the literature include mucosal inflammation, mucosal petechiae, ecchymosis, skin and mucosal hyperpigmentation, fissured tongue, and coated tongue. A 51-year-old male with CKD was hospitalized in Mawar ward, Prof. Dr. Margono Soekarjo Regional Public Hospital. The patient presented of brown patches on his lips and oral cavity. Intraoral examination revealed lesions presenting as irregularly shaped macules with smooth brown margins on the lips and buccal mucosa. The patient was diagnosed with oral hyperpigmentation. Another case involved a 48-year-old female with stage 5 CKD who routinely underwent hemodialysis, presenting with brown patches on the lips, indented lesions on the lateral and dorsal tongue, and yellowish coloration on the dorsal tongue, diagnosed as fissured tongue and coated tongue. The manifestations that appear may be influenced by the kidney disease itself, consumed medications, or the therapy provided. Oral hyperpigmentation, coated tongue, and fissured tongue are some of the oral manifestations commonly found in end-stage CKD patients undergoing hemodialysis, with therapy aimed at improving patients' quality of life.
The activity of saga leaf (Abrus precatorius) ethanol extract fractions on biofilm degradation of Fusobacterium nucleatum Satya Maharani br. Simatupang; Fanni Kusuma Djati; Meylida Ichsyani; Eka Prasasti Nur Rachmani; Maulina Triani
Journal of Dental and Biosciences Vol 3 No 02 (2026): Journal of Dental and Biosciences
Publisher : Jurusan Kedokteran Gigi Fakultas Kedoketaran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jdentbios.2026.3.02.14766

Abstract

Periodontitis is a chronic inflammatory disease causing permanent destruction of periodontal tissues. Fusobacterium nucleatum is a key bacterium involved in periodontitis biofilm formation. Biofilm degradation is crucial for periodontitis treatment. This study aimed to investigate the antibiofilm activity of ethanol extract fractions from Abrus precatorius leaves against F. Nucleatum. An in vitro experimental study was conducted using nine treatment groups, consisting of three fractions (n-hexane, ethyl acetate, and residual) at three concentrations (3.125, 6.25, and 12.5 mg/mL). Chlorhexidine gluconate 0.2% and metronidazole served as positive controls, while 1% DMSO was used as a negative control. Biofilm degradation was assessed using microtiter plate assay with crystal violet 1% staining and Microplate Reader at 600 nm. Data analysis employed one-way and two-way ANOVA, followed by post-hoc LSD and Tukey HSD tests. Results showed that all fractions at various concentrations effectively degraded biofilm (p≤0,05) compared to the negative control, except for the residual fraction at 3,125 mg/mL. Two-way ANOVA revealed significant differences between concentrations and fractions. The n-hexane fraction at 3.125 mg/mL demonstrated the highest biofilm degradation efficacy, comparable to chlorhexidine gluconate 0.2%. This study concludes that Abrus precatorius leaf ethanol extract fractions exhibit antibiofilm activity against F. Nucleatum.
Co-Authors A Haris Budi Widodo Aditiawarman Aditiawarman, Aditiawarman Aditiyono Ady Soesetijo Affan Wirutomo Amilia Ramadhani Andini, Restian Febi Annida Fatiya Zahra Annida Fatiya Zahra Ario Ditto Primandaru Bagus, Zahran Uzla Attaqi Bambang Sunendar P Berlianza, Activira Christiana Cahyani Prihastuti Chrystina Kusuma Dewi Dwi Nur Indah Sari Dwi Utami Anjarwati Eka Prasasti Nur Rachmani Eliska Reza Mulitasari Febriharsari, Niken Harmaji, Andrie Helmi Hirawan Kinasih, Amelia Sekar Laksitasari, Anindita Maulina Triani Meylida Ichsyani Minullah, Nanda Asta Naim, Cantika Nadrotan Nugroho, Yunanto Dwi Octivany, Sherly Rahmah, Faza Faizah Nur Rakhmawati, Widya Ramadhanti, Dian Praba Rinawati Satrio Rosyada, Alya Ghina Sarah, Putri Satya Maharani br. Simatupang Tuti Sri Suhesti