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All Journal Medali Jurnal : Media Dental Intelektual STOMATOGNATIC- Jurnal Kedokteran Gigi MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Jurnal Kedokteran Gigi Universitas Padjadjaran MDJ (Makassar Dental Journal) Makara Journal of Science Mandala of Health : A Scientific Journal Medical and Health Journal Biomedika
Fanni Kusuma Djati
Universitas Jenderal Soedirman
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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EFFECT OF KECOMBRANG ETHANOL EXTRACT (ETLINGERA ELATIOR) ON FUSOBACTERIUM NUCLEATUM BIOFILM DEGRAGATION Djati, Fanni Kusuma; Ichsyani, Meylida; Widodo, A. Haris Budi; Dewi, Aisha Tiara
Biomedika Vol 17, No 1 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.12008

Abstract

Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that plays a crucial role in periodontal disease progression through biofilm formation. Kecombrang (Etlingera elatior) is a traditional medicinal plant containing bioactive compounds with antimicrobial properties. This study aimed to evaluate the effect of kecombrang extract on F. nucleatum biofilm degradation. This experimental study used ethanolic extracts from three parts of kecombrang (leaves, stems, and flowers) at concentrations of 1.56, 3.12, 6.25, 12.50, 25, and 50 mg/mL. F. nucleatum biofilm was formed and treated with various extract concentrations. Chlorhexidine 0.2% was used as positive control and DMSO 1% as negative control. Biofilm degradation percentage was measured using crystal violet assay at 490 nm wavelength. Data were analyzed using Two-Way ANOVA to evaluate the main effects of plant parts and extract concentrations, followed by Tukey’s HSD post-hoc test. All kecombrang extracts showed dose-dependent biofilm degradation activity. Flower extract demonstrated the highest efficacy with degradation percentages ranging from 36.37% to 86.22% at concentrations 1.56-25 mg/mL. Leaf extract showed degradation of 38.2—82.08%, while the stem extract achieved 34.00-80.22% degradation at the same concentration range. The MBEC50 values were 2.62 mg/mL for flower extract, 3.68 mg/mL for leaf extract, and 4.99 mg/mL for stem extract. Kecombrang extracts possess significant biofilm degradation activity against F. nucleatum, with flower extract showing the most promising results comparable to chlorhexidine positive control
Manifestasi oral pada pasien gagal ginjal kronis di Rumah Sakit Umum Daerah Prof. Dr. Margono Soekarjo, Banyumas Djati, Fanni Kusuma; Naim, Cantika Nadrotan; Ramadhanti, Dian Praba; Kinasih, Amelia Sekar; Berlianza, Activira; Nugroho, Yunanto Dwi
MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Vol 11, No 2 (2025)
Publisher : Fakultas Kedokteran Gigi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mkgk.106128

Abstract

Gagal ginjal kronis (GGK) adalah suatu kondisi penurunan fungsi ginjal secara bertahap yang disebabkan karena terjadinya kerusakan pada ginjal. Gagal ginjal kronis biasanya terjadi dalam waktu lama (tahunan) yang ditandai dengan penurunan nilai glomerular filtration rate (GFR) <60 mL/menit per 1,73 m2. Prevalensi GGK di Indonesia mengalami peningkatan dari tahun 2013 yaitu 0,2% menjadi 0,38% pada tahun 2018. Etiologi GGK tergolong sangat bervariasi seperti diabetes, glomerulonefritis, hipertensi, dan penyakit ginjal kistik. Laporan ini bertujuan untuk mengidentifikasi berbagai manifestasi oral pada pasien GGK dengan mempertimbangkan keterkaitan klinisnya sebagai bahan refleksi diagnostik pada praktik kedokteran gigi. Laporan ini menunjukkan variasi manifestasi oral pada pasien GGK mencakup periodontitis uremik, hiperpigmentasi, oral hairy leukoplakia, cheilitis, stomatitis nekrotikan, coated tongue, dan kandidiasis kronis. Beberapa manifestasi oral pada kasus GGK kemungkinan berkaitan langsung dengan kondisi uremik, sementara manifestasi oral lainnya dipengaruhi oleh faktor xerostomia, gangguan imun, nutrisi, dan penggunaan obat-obatan. Kompleksitas sistemik pada GGK dapat memperburuk kesehatan rongga mulutsecara umum. Temuan pada laporan kasus ini menegaskan pentingnya peran dokter gigi untuk mengenali tanda sistemik yang tampak di rongga mulut serta perlunya pendekatan multidisipliner pada manajemen pasien GGK.
ORAL HYPERPIGMENTATION IN END-STAGE CKD PATIENTS UNDERGOING HEMODIALYSIS: A CASE REPORT Djati, Fanni Kusuma; Minullah, Nanda Asta; Octivany, Sherly; Febriharsari, Niken; Aditiawarman, Aditiawarman; Nugroho, Yunanto Dwi
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.15743

Abstract

Chronic kidney disease (CKD) is a progressive disease characterized by gradual and irreversible loss of kidney function over several months or years. According to Riskesdas 2018, the incidence of CKD in Indonesia is 0.38% (713,783 people) with 19.33% (2,850 people) undergoing hemodialysis therapy. Many CKD patients have related oral lesions, but attention to oral healthcare remains insufficient, especially in developing countries with higher rates of CKD patients. Several oral manifestations of CKD described in the literature include mucosal inflammation, mucosal petechiae, ecchymosis, skin and mucosal hyperpigmentation, fissured tongue, and coated tongue. A 51-year-old male with CKD was hospitalized in Mawar ward, Prof. Dr. Margono Soekarjo Regional Public Hospital. The patient presented of brown patches on his lips and oral cavity. Intraoral examination revealed lesions presenting as irregularly shaped macules with smooth brown margins on the lips and buccal mucosa. The patient was diagnosed with oral hyperpigmentation. Another case involved a 48-year-old female with stage 5 CKD who routinely underwent hemodialysis, presenting with brown patches on the lips, indented lesions on the lateral and dorsal tongue, and yellowish coloration on the dorsal tongue, diagnosed as fissured tongue and coated tongue. The manifestations that appear may be influenced by the kidney disease itself, consumed medications, or the therapy provided. Oral hyperpigmentation, coated tongue, and fissured tongue are some of the oral manifestations commonly found in end-stage CKD patients undergoing hemodialysis, with therapy aimed at improving patients' quality of life.
Co-Authors A Haris Budi Widodo A. Haris Budi Widodo Aditiawarman Aditiawarman, Aditiawarman Aditiyono Ady Soesetijo Affan Wirutomo Amilia Ramadhani Andini, Restian Febi Annida Fatiya Zahra Annida Fatiya Zahra Ario Ditto Primandaru Bagus, Zahran Uzla Attaqi Bambang Sunendar Berlianza, Activira Christiana Cahyani Prihastuti Chrystina Kusuma Dewi Dewi, Aisha Tiara Dwi Nur Indah Sari Dwi Utami Anjarwati Eliska Reza Mulitasari Febriharsari, Niken Harmaji, Andrie Helmi Hirawan Ichsyani, Meylida Kinasih, Amelia Sekar Laksitasari, Anindita Minullah, Nanda Asta Naim, Cantika Nadrotan Nugroho, Yunanto Dwi Octivany, Sherly Rahmah, Faza Faizah Nur Rakhmawati, Widya Ramadhanti, Dian Praba Rinawati Satrio Rosyada, Alya Ghina Sarah, Putri Tuti Sri Suhesti