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All Journal Jurnal Kesehatan Andalas Jurnal Biologi Tropis Majalah Kedokteran Andalas Health and Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Journal Orthopaedi and Traumatology Surabaya (JOINTS) Indonesian Journal of Multidisciplinary Science
Rahmadian, Rizki
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Public Health Social Sciences

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Journal : Indonesian Journal of Multidisciplinary Science

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The Efficacy of Application of Oral Antibiotic Loaded Polymethyl Methacrylate Against Staphylococcus aureus Rahmadian, Rizki; Edison, Ebill Fuji; Kaharudin, Kaharudin; Irrahmah, Miftah; Putra, Andani Eka
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 9 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v2i9.543

Abstract

Chronic osteomyelitis is still common in the developing world and presents a continuing therapeutic challenge. Local antibiotic therapy is performed as the first stage treatment algorithm for 4 to 8 weeks. Given the high patient morbidity, mortality, and economic burden caused by osteomyelitis and its treatment, it is important to find another effective and efficient treatment.  Intravenous antibiotics and polymethylmethacrylate (PMMA) combination have shown effectiveness, but the potential of oral antibiotics and PMMA combination is still rare and is debatable. It aimed to compare efficacy among oral antibiotic-loaded PMMA in many concentrations (5%, 10%, 20%) and controls (0%) against Staphylococcus aureus. This experimental study was conducted in the Microbiology Department of Andalas University. The object was S. aureus. We used ten oral antibiotics and compared among its many concentrations (5%, 10%, 20%) and controls (0%).  Data were analyzed by analysis of variance (ANOVA) test. The lowest counts of S. aureus were found in ciprofloxacin 20%, followed by tetracycline 10%, erythromycin 5%, rifampicin 10%, ofloxacin 20%, clindamycin 20%, amoxiclav 20%, cefixime 5%, cotrimoxazole 20%, and chloramphenicol 20% consecutively. All oral antibiotics loaded PMMA in each concentration might reduce the number of colonies up to 90%. A study in 2013 revealed that a combination of several antibiotics and PMMA was proven to be effective. The oral antibiotics loaded PMMA in various concentrations have a significant bactericidal effect on the growth of S. aureus and able to reduce the number of S. aureus.
Co-Authors Akbar, Inasa Faiza Ananda, Gita Putri Andani Eka Putra Arni Amir Dessy Arisanty Dina Arfiani Rusjdi Edison, Ebill Fuji Eka Fithra Elfi, Eka Fithra Eka Sahputra, Roni Eti Yerizel Firdawati, Firdawati Fortuna, Fory Hanum, Fathiya Juwita Hirowati Ali, Hirowati Ida Rahmah Burhan Intan, Shinta Ayu Irrahmah, Miftah Kaharudin Kaharudin Lili Irawati Marlina Meksiko, Riki Mustafa Noer Rahmatini . Rahmawati, Meilisa Ramda Ilhami, Yose Rasya, Salsabila Faiha Wiendra Rikarni Rikarni Rinaldiansyah Sahputra, Roni Eka Selfi Renita Rusjdi Selfi Renita Rusjdi, Selfi Shafira, Zahra Silvia, Nelmi Siregar, Muhammad Abi Ghoffari Siti Nurhajjah, Siti Yanti, Farah Sevnell