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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik JFL : Jurnal Farmasi Lampung Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy
Rahmawati, Fita
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia 55281
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Nurses' knowledge and management of incompatibility issues in intravenous pharmaceutical preparations Fita Rahmawati; Erna Prasetya Ningrum; Marlyn Dian Laksitorini; Endang Lukitaningsih
Media Farmasi Indonesia Vol. 20 No. 2 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i2.312

Abstract

Administering multiple intravenous (IV) preparations through a single catheter line can lead to incompatibility issues, such as precipitation. Precipitation can be avoided with sufficient knowledge by nurses during the administration of IV preparations to patients. This research aims to assess nurses' knowledge and management of incompatibility issues in IV pharmaceutical preparations. This non-experimental research collected data through interviews with healthcare professionals (nurses). The research was conducted at Sultan Agung Islamic Hospital, Semarang. A total of 14 healthcare professionals (nurses) who reconstituted and administered IV pharmaceutical preparations to patients in the Intensive Care Unit (ICU) participated in the research. The results revealed that 13 nurses (92.9%) encountered incompatibility incidents with seven types of drugs. Five nurses (29.4%) reported incompatibility issues with cefoperazone. The most frequently observed incompatibility was color change, reported by seven nurses (53.8%), such as white spots appearing during phenytoin reconstitution and discoloration in IV pharmaceutical preparations of cefoperazone and ceftriaxone. The most common approach to addressing incompatibility was replacing the preparation, reported by six nurses (46.2%). The management of incompatibility issues varied among nurses, even when dealing with the same pharmaceutical preparation. Therefore, training on sterile preparation incompatibility should be provided to all healthcare professionals to establish a standardized operational procedure (SOP) for handling incompatibility in IV pharmaceutical preparations.
GAMBARAN BIAYA LANGSUNG PADA PASIEN KRISIS HIPERTENSI RAWAT INAP DI RSUP DR. SARDJITO, YOGYAKARTA: OVERVIEW OF DIRECT COSTS IN INPATIENTS WITH HYPERTENSIVE CRISIS AT RSUP DR. SARDJITO, YOGYAKARTA Dwi Ismayati; Dwi Endarti; Fita Rahmawati
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/q6e13y53

Abstract

Hypertensive crisis imposes a substantial economic burden on healthcare systems. In Indonesia, rising service costs necessitate health economic evaluations to optimize hospital management. This study aims to analyze the direct costs of hypertensive crisis patients at RSUP Dr. Sardjito, Yogyakarta. A descriptive observational study with a retrospective cohort design was conducted on hypertensive crisis patients from January 2018 to July 2022. A total of 37 subjects were selected using a purposive sampling technique. Patients were divided into Calcium Channel Blocker (CCB) therapy groups (n=31) and non-CCB therapy groups (n=6). Cost components analyzed included medication costs, accommodation, inpatient / ER care, and radiodiagnostics. Statistical analysis used an independent sample t-test. The average total direct cost was IDR 3,282,080. The largest cost component for all subjects was inpatient/ER care costs of IDR 1,154,261 (35.17%). The average total cost in the CCB group was IDR 3,068,395, while in the non-CCB group it was IDR 4,386,119. Despite the cost difference, statistical tests showed no significant difference between the two therapy groups (p = 0.127). There was no significant difference in costs between the use of CCB and non-CCB therapy. These results can be used as a reference in budget planning and management of hypertensive crisis therapy in hospitals. Keywords:  CCB, Direct costs, Hypertensive crisis, Pharmacoeconomics
Evaluation of Amikacin Regimens, Cmax/MIC Ratios, and Clinical Outcomes in a Hospital at Yogyakarta, Indonesia Firdhani Satia Primasari; Nidya Afriana Fitria Dewi; Fita Rahmawati; Arief Rahman Hakim
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.9782

Abstract

Amikacin is widely used to treat infections caused by gram-negative bacteria. Its narrow therapeutic range necessitates plasma concentration monitoring through Therapeutic Drug Monitoring (TDM). However, limited infrastructure has restricted TDM implementation in many Indonesian healthcare settings. This study aims to evaluate amikacin dosing, estimate blood concentrations using pharmacokinetic equations, assess the PK/PD profile, and analyze clinical outcomes. This descriptive-analytic study employed a retrospective cross-sectional design. It was conducted at a hospital in Yogyakarta by collecting data on amikacin dosing regimens, patient clinical outcomes, serum creatinine levels, and antibiotic sensitivity test results. The study subjects were hospitalized patients with infections who received amikacin therapy. Descriptive analysis was performed on patient characteristics, while estimated blood drug levels and PK/PD profiles were calculated using pharmacokinetic formulas and analyzed descriptively. A total of 44 amikacin dosing regimens from 40 patients met the inclusion and exclusion criteria. Of these, 39 regimens were appropriate according to dosing guidelines, and 26 (66.7%) resulted in favorable clinical outcomes. In contrast, five inappropriate regimens were associated with poor clinical outcomes. Among the 39 appropriate regimens, only 18 (46.2%) achieved the target peak plasma concentration (Cmax). Furthermore, of these 18 regimens, only two (11.1%) achieved the target Cmax/MIC ratio, with one associated with a favorable clinical outcome and one without improvement. These findings suggest that, despite appropriate dosing, most amikacin regimens failed to achieve the optimal Cmax/MIC ratio required for effective clinical outcomes, highlighting the potential value of TDM and individualized dosing strategies to optimize amikacin therapy.
Co-Authors Ana Amalia Ardhanarishwari Umi Salamah Arianti Arianti Arief Rahman Hakim Arroyani Asa Dilaga Dita marina Lupitaningrum Djoko Wahyono Djoko Wahyono Djoko Wahyono Dwi Ismayati Emerentiana Wikan Endang Lukitaningsih Erna Prasetya Ningrum Febriana Trisnaputri Rahajeng Fef Rukminingsih Firdhani Satia Primasari I Dewa P. Pramantara I Dewa Putu Pramantara I Dewa Putu Pramantara I Dewa Putu Pramantara Izyan Abdul Wahab Kartika Widayati Taroeno Hariadi Kurniawati, Fivy Lily Annisa Lina Wati Lubis Lukman Hakim Marlyn Dian Laksitorini Meilia Nhadia Amalia Nanang M. Yasin Nanang Munif Yasin Nanang Munif Yasin Nidya Afriana Fitria Dewi Nurlena Ikawati Probosuseno Probosuseno Putra, Aditya Maulana Perdana Santi Andriani Sari, Ratih Pratiwi Siti Rouchmana Tista Ayu Fortuna Titik Nuryastuti Tri Murti Andayani Tri Murti Andayani Vidiya Gunarsih Widyaningrum Utami Willi Wahyu Timur Winda Dwi Puspitasari Yuhansyah Nurfauzi