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All Journal Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Medicamento Journal of Pharmaceutical and Health Research Jurnal Farmasi Klinik dan Sains Sahabat Sosial: Jurnal Pengabdian Masyarakat Usadha Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Sains dan Kesehatan Journal of Chemistry Sciences and Education Indenesian Journal of Tropical Biology Indenesian Journal of Tropical Biology
Nurhidayati, Lailiana Garna
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Uji Aktivitas Kombinasi Jus Buah Nanas (Ananas comocus L.) dan Jus Pepaya (Carica papaya L.) Sebagai Pencahar terhadap Mencit Putih Jantan (Mus musculus L.) Sapitri, Anis; Nurhidayati, Lailiana Garna; Pramiastuti, Oktariani
KUNIR: JURNAL FARMASI INDONESIA Vol 2 No 1 (2024): JULI
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v2i1.589

Abstract

Obat pencahar merupakan obat yang dapat merangsang gerakan peristaltik dinding usus pada saat sembelit. Buah nanas dan pepaya mengandung serat dan bromelin yang berkhasiat mengatasi sembelit. Bromelin membantu melunakkan makanan di lambung dan serat buah nanas dapat merangsang gerak peristaltik dengan meningkatkan daya cerna pada dinding usus. Penelitian ini bertujuan untuk mengetahui aktifitas dan konsentrasi terbaik kombinasi jus buah nanas dan jus buah pepaya sebagai pencahar. Penelitian ini menggunakan metode eksperimental, dengan sampel buah nanas dan buah pepaya yang diinduksi ke mencit dengan bobot 20-30 gram. Mencit dibagi 5 kelompok perlakuan masing-masing terdiri dari 5 ekor mencit. Kelompok I diberi aquadest sebagai kontrol negatif. Kelompok II diberi bisacodyl (dulcolac tab) sebagai kontrol positif. Kelompok III, IV dan V diberi kombinasi jus buah nanas dan jus buah pepaya perbandingan 1:1 dengan dosis masing-masing uji I 60g, uji II 120g, dan uji III 180g. Metode uji yang di gunakan yaitu metode ANOVA (satu arah) dan Duncan. Hasil penelitian menunjukkan nilai rata – rata feses dari setiap perlakun yaitu kontrol negatif 0,81g, positif 0,97g, kontrol uji 1(60g) 1,081g, kontrol uji ll (120g) 1,15g, kontrol uji lll (180g) 1,62g. Sehingga dapat disimpulkan bahwa kombinasi jus buah nanas dan jus buah pepaya memiliki efek sebagai pencahar dengan memperbanyak berat feses di bandingkan dengan kontrol negatif (CMC) dan dosis paling pada kelompok V dosis 180g dengan berat feses 1,62g.
UJI TOKSISITAS AKUT EKSTRAK ETANOL BUAH DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA IKAN ZEBRA (Danio rerio) Nurhidayati, Lailiana Garna; Alfiraza, Ery Nourika; Diana, Intan Mauli; Krisdiantho, Roos Kemal
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1931

Abstract

Belimbing wuluh (Averrhoa bilimbi L.) adalah tanaman yang banyak ditemui di Indonesia. Buah dan daun belimbing wuluh dikenal banyak memiliki kandungan senyawa bioaktif yang berpotensi salah satunya sebagai agen antikanker. Uji toksisitas akut dapat dilakukan sebagai skrining awal untuk melihat potensi agen antikanker dari suatu senyawa. Penelitian ini bertujuan untuk mengetahui toksisitas akut ekstrak buah dan daun belimbing wuluh (Averrhoa bilimbi L.) pada ikan zebra (Danio rerio). Metode pengujian menggunakan hewan uji ikan zebra (Danio rerio) yang diberi sampel perlakuan konsentrasi 1000, 800, 400, 200 dan 100 ppm dengan medium akuades dan pengamatan selama 96 jam. Hasil yang diperoleh pada ekstrak daun dan buah belimbing wuluh berturut-turut memiliki toksisitas dengan LD50 591,851 ppm dan 41,609 ppm. Hasil tersebut dapat dikategorikan bahwa ekstrak daun dan buah belimbing wuluh memiliki potensi toksisitas yang bersifat toksik. Sehingga dapat disimpulkan bahwa ekstrak buah belimbing wuluh ini dapat dikembangkan menjadi kandidat obat antikanker.
Biomedical Cost Analysis of Tuberculosis Morbidity in Inpatients at dr. Soeselo Slawi Hospital, 2022 fahamsya, arifina; Vandani, Chiara Dhinta; Nurhidayati, Lailiana Garna
Indonesian Journal of Tropical Biology Vol. 1 No. 1 (2025): April
Publisher : Yayasan Siti Widhatul Faeha

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis is one of the deadly infectious diseases worldwide. It is caused by Mycobacterium tuberculosis infection. The cases of tuberculosis in 2022 were reported to be 824,000 with an annual death toll of 93,000. Tuberculosis is a disease caused by long-term treatment and falls under the ICD-10 code 16.2 for national health insurance coverage. The aim of this research is to determine the cost of illness due to tuberculosis from a health perspective and to determine the variables associated with the cost of illness due to tuberculosis at RSUD dr. Soeselo Slawi in 2022. This research method uses observational with a cross sectional research design on 82 patient data, descriptive analysis methods to determine cost estimates and statistical methods to determine the factors that influence the total cost of illness for tuberculosis patients. Based on the research, it shows that the cost of service is the highest cost component compared to other cost components. The average cost of supporting examinations is Rp. 753,827.00; service fee of Rp. 2,133,809.00; and pharmacy costs Rp. 1,873,449.00. The average cost of tuberculosis illness from a healthcare perspective is Rp. 4,761,085.00. The largest component of the illness costs is the service cost. The variables significantly associated with a Sig. (2-tailed) value ˂ 0.05 are the ward class, length of stay, diagnostic test costs, service costs, and pharmacy costs with respect to the total illness costs.
Biomedical Cost Analysis of Tuberculosis Morbidity in Inpatients at dr. Soeselo Slawi Hospital, 2022 fahamsya, arifina; Vandani, Chiara Dhinta; Nurhidayati, Lailiana Garna
Indonesian Journal of Tropical Biology Vol. 1 No. 1 (2025): April
Publisher : Yayasan Siti Widhatul Faeha

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis is one of the deadly infectious diseases worldwide. It is caused by Mycobacterium tuberculosis infection. The cases of tuberculosis in 2022 were reported to be 824,000 with an annual death toll of 93,000. Tuberculosis is a disease caused by long-term treatment and falls under the ICD-10 code 16.2 for national health insurance coverage. The aim of this research is to determine the cost of illness due to tuberculosis from a health perspective and to determine the variables associated with the cost of illness due to tuberculosis at RSUD dr. Soeselo Slawi in 2022. This research method uses observational with a cross sectional research design on 82 patient data, descriptive analysis methods to determine cost estimates and statistical methods to determine the factors that influence the total cost of illness for tuberculosis patients. Based on the research, it shows that the cost of service is the highest cost component compared to other cost components. The average cost of supporting examinations is Rp. 753,827.00; service fee of Rp. 2,133,809.00; and pharmacy costs Rp. 1,873,449.00. The average cost of tuberculosis illness from a healthcare perspective is Rp. 4,761,085.00. The largest component of the illness costs is the service cost. The variables significantly associated with a Sig. (2-tailed) value ˂ 0.05 are the ward class, length of stay, diagnostic test costs, service costs, and pharmacy costs with respect to the total illness costs.
Co-Authors Agung Nur Cahyanta, Agung Nur Ainun Mardiah Alfiraza, Ery Nourika Andi Kamal M. Sallo Anindya, Yuarinda Melly Desi Sri Rejeki Dewi, Amaria Diana, Intan Mauli Fahamsya, Arifina Farida Fakhrunnisa, Farida Fauziah, Silvia Novi Nur Fia, Nela Selfi Nur Okta Fiqih Kartika Murti, Fiqih Kartika Fitriani, Lisna Annisa Hilal, Achmad Krisdiantho, Roos Kemal Listina, Osie Musaidah Musaidah Nida, Laelatun Ningrum, Ayu Puspita Nisa, Sinta Khoiri Nurfauziah, Afina Pramiastuti, Oktariani Rosdiana Rosdiana Rusnita, Rusnita Sapitri, Anis Sardi Anto Vandani, Chiara Dhinta Wahyuningtias, Arum