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All Journal Jurnal Kedokteran Meditek Cermin Dunia Kedokteran
Asri, Rizkia Chairani
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Onikomikosis yang Disebabkan oleh Kodamaea ohmeri pada Seorang Pasien dengan Virus Imunodefisiensi Manusia (HIV) – Laporan Kasus: Laporan Kasus Nadliroh, Siti; Wahid, Mardiastuti; Sjatha, Fithriyah; Haliman, Cliff Clarence; Widaty, Sandra; Mutiara, Rizka; Pratama, Aditya Indra; Asri, Rizkia Chairani; Adawiyah, Robiatul; Kusumaningrum, Ardiana
Cermin Dunia Kedokteran Vol 53 No 07 (2026): Juli 2026
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i07.1895

Abstract

Introduction: Onychomycosis is a fungal nail infection usually caused by dermatophytes. Kodamaea ohmeri is a rare fungus that has been reported as a pathogen capable of causing onychomycosis and systemic infections. This yeast-like fungus is often misidentified as Candida sp. A complete identification is required for accurate results. Case: A 40-year-old male with HIV presented with yellow and brittle fingernails for 2 months. KOH examination of nail scrapings was performed, followed by fungal culture. The isolate was identified in parallel using the Integral System Yeast Plus, Vitek-2, MALDI-TOF (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry), and sequencing, and the result was Kodamaea ohmeri. The patient received oral itraconazole and topical ketoconazole. Discussion: Onychomycosis in HIV patients is caused by low immunity, high viral load, and low CD4 values. In this case, K. ohmeri was successfully identified using Vitek-2, MALDI-TOF, and ITS (Internal Transcribed Spacer) area sequencing, while the Integral System Yeast Plus misidentified the isolate as Candida tropicalis. There was clinical improvement in the nail after treatment. Conclusion: Onychomycosis in HIV patients can be caused by Kodamaea ohmeri. Identification can be done with Vitek-2 and MALDI-TOF.
Mycosis Fungoides dengan TampilanTumor D’Emblee:Laporan Kasus Langka Asri, Rizkia Chairani; Sukarata, I Ketut; Putri, Nadia Andini
Jurnal Kedokteran Meditek Vol 32 No 4 (2026): JULI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i4.4148

Abstract

Introduction: Cutaneous T-cell lymphoma (CTCL) is a rare malignancy with mycosis fungoides (MF) being the most common subtype. Classic MF typically presents with patches that may progress over years into plaques and tumors. In rare instances, the tumor d'emblee variant can be found, with initial appearance of tumors without prior patches or plaques. Case: A 37-year-old male presented with a one-month history of multiple cutaneous nodules involving the face, scalp and trunk, accompanied by a five-month history of progressive left testicular enlargement. There was a history of weight loss and severe anemia. Physical examination revealed multiple firm, grouped tumors with smooth surfaces, brownish to violaceous in color, distributed across the scalp, face, back, neck, thorax, abdomen, and bilateral upper extremities. Laboratory findings included pancytopenia, electrolyte imbalance, hypoalbuminemia, and elevated urea and creatinine. Histopathological examination showed diffuse infiltrates of large atypical lymphoid cells with atypical mitoses from superficial to deep dermis. The patient deteriorated rapidly during hospitalization and died three days after diagnosis was established. Conclusion: Tumor d'emblee is a rare and aggressive MF variant with a lower survival rate than the classic MF. It is crucial to establish a diagnosis based on clinical appearance, histopathological examination and immunohistochemistry.
Co-Authors Ardiana Kusumaningrum Haliman, Cliff Clarence Mutiara, Rizka Nadliroh, Siti Pratama, Aditya Indra Putri, Nadia Andini Robiatul Adawiyah Sandra Widaty SJATHA, FITHRIYAH Sukarata, I Ketut Wahid, Mardiastuti