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All Journal Jurnal Kimia Mulawarman Pharmascience Jurnal Biologi Tropis Jurnal Sehat Mandiri INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Best Journal (Biology Education, Sains and Technology) Journal of Pharmaceutical and Health Research Jurnal EduHealth Jurnal Pijar MIPA Jurnal Matematika Dan Ilmu Pengetahuan Alam LLDikti Wilayah 1 (JUMPA) Jurnal Kedokteran Hewan
Mierza, Vriezka
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Literature Review: Standardization of Rutin Compounds in Several Plant Types Mierza, Vriezka; Odhia, Febry Nola; Tyasna, Putri Setya; Nisa, Dila Qhoirul; Andriani, Nadia
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.87 KB)

Abstract

Rutin is a compound derived from flavonoids. Rutin is a quercetin glycoside with a disaccharide consisting of glucose and rhamnose. Rutin is known to have activity as an antioxidant, anti-radical, estrogenic, anti-inflammatory, antiviral, antitumor, cytotoxic and protects against organ damage. The manufacture of herbal medicines must first go through a standardization process. This review was conducted to identify the rutin contained in an extract by means of Visible Light, KLT, HPLC, and LCMS. This research uses the literature review method by collecting and identifying relevant research data sources or articles published online, through the Google Scholar web database and Science Direct.  
EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE Nerdy, Nerdy; Meliala, Linta; Barus, Bunga Rimta; Lestari, Puji; Ginting, Selamat; Ariani, Peny; Mierza, Vriezka; Bakri, Tedy Kurniawan
Jurnal Kedokteran Hewan Vol 15, No 1 (2021): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i1.18406

Abstract

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.
Literature Review: Identification of Chemical Components and Antibacterial Activity of Cinnamon Bark Essential Oil (Cinnamomum burmanii) Clarissa, Yesa Prilia; Mierza, Vriezka
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10795

Abstract

Bacterial infections remain a major global health concern, particularly with the growing incidence of antibiotic resistance. This situation has encouraged the search for alternative antibacterial agents derived from natural sources, including essential oils extracted from cinnamon bark. This review article aims to summarize current findings on the chemical characterization of cinnamon bark essential oil and the compounds responsible for its antibacterial activity, providing a foundation for its potential development as a natural antibacterial agent. Literature selection was conducted using specific inclusion and exclusion criteria, covering original research published between 2015 and 2025 and retrieved from PubMed and Google Scholar using the keywords “essential oil,” “Cinnamomum burmanii,” “bark,” and “antibacterial.” Based on this screening process, seven research articles met the established criteria. The reviewed data indicate that cinnamaldehyde is the predominant component of cinnamon bark essential oil and plays a major role in its broad spectrum antibacterial activity, including against resistant bacterial strains.
Literature Review: The Antimicrobial Potential of Xanthorrhizoland and Curcuminoids from the Rhizomes of Curcuma Xanthorrhiza (Temulawak) Habibah, Habibah; Mierza, Vriezka
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.10810

Abstract

Antimicrobial resistance is a global threat that drives the search for new antimicrobial agents derived from natural sources. Temulawak (Curcuma xanthorrhiza) contains two major active compounds, xanthorrhizol and curcuminoid, known for their antimicrobial properties. This review aims to analyze and compare the antimicrobial potential of these compounds to determine the most prospective candidate for development as an active natural antimicrobial agent in Indonesia. A systematic literature review was conducted using the PRISMA guideline on articles published between 2015 and 2025, obtained from Google Scholar and PubMed. Of the 251 articles identified, 10 met the inclusion criteria and were analyzed. The results indicate that xanthorrhizol exhibits stronger and broader antimicrobial activity, with a Minimum Inhibitory Concentration (MIC) of 16 µg/mL, inhibition zones of 12–14 mm, and inhibition rates exceeding 90% against Candida albicans and Enterococcus faecalis. In contrast, curcuminoid shows variable activity (inhibition zones of 0–16 mm) and its effectiveness increases after photodynamic activation (Photodynamic Therapy, PDT) through the formation of Reactive Oxygen Species (ROS). In conclusion, xanthorrhizol is more promising as a primary natural antimicrobial agent, while curcuminoid serves as a complementary compound to enhance antimicrobial effectiveness.
A Penggunaan Spektrofotometri UV-Vis dan Spektrometri Massa Terhadap Penentuan Struktur Senyawa Metabolit Sekunder: Tinjauan Literatur Terhadap Aplikasi Metode Analisis untuk Identifikasi Struktur Senyawa Metabolit Sekunder Fitriana, Nariyyah; Mierza, Vriezka
JURNAL KIMIA MULAWARMAN Vol 22 No 2 (2025)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v22i2.1490

Abstract

Metabolit sekunder merupakan molekul bioaktif yang diproduksi organisme sebagai hasil adaptasi terhadap lingkungan, memiliki peran penting dalam ekosistem dan potensi aplikasi dalam berbagai bidang. Penelitian ini bertujuan mengkaji prinsip dan aplikasi spektrofotometri UV-Vis dan spektrometri massa (MS) dalam analisis metabolit sekunder. Metodologi penelitian menggunakan pendekatan systematic review literature dari 25 artikel terpilih periode 2015-2024 melalui database PubMed dan Google Scholar, dengan analisis konten terstruktur tiga fase. Hasil menunjukkan bahwa spektrofotometri UV-Vis efektif dalam analisis kuantitatif berdasarkan interaksi cahaya dengan molekul, memberikan informasi tentang transisi elektronik dan konsentrasi senyawa. Spektrometri massa berkontribusi dalam identifikasi struktur molekul melalui analisis ion molekul, pola fragmentasi, dan isotop. Pemilihan pelarut yang tepat dan pemahaman mekanisme transisi elektron pada UV-Vis, serta interpretasi pola fragmentasi pada MS, menjadi kunci keberhasilan analisis. Disimpulkan bahwa kombinasi kedua teknik memberikan pendekatan komprehensif dalam analisis metabolit sekunder, dengan UV-Vis fokus pada deteksi dan kuantifikasi, sementara MS memberikan informasi struktural yang detail.
Penggunaan Spektrofotometri Inframerah dan Nuclear Magnetic Resonance Terhadap Penentuan Struktur Senyawa Metabolit Sekunder Ilmi, Yuniar Fathil; Mierza, Vriezka
JURNAL KIMIA MULAWARMAN Vol 22 No 2 (2025)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v22i2.1492

Abstract

Spektroskopi Inframerah (IR) dan Nuclear Magnetic Resonance (NMR) adalah dua teknik analisis yang digunakan secara luas dalam penentuan struktur metabolit sekunder. Metabolit sekunder merupakan senyawa organik dalam aplikasi farmasi yang signifikan, namun hanya sebagian kecil yang telah dikarakterisasi secara mendalam. Tinjauan ini bertujuan untuk mengeksplorasi prinsip kerja, metode interpretasi data, serta keunggulan dan keterbatasan teknik IR dan NMR dalam karakterisasi struktur metabolit sekunder. Metode yang digunakan adalah studi literatur sistematis dengan menganalisis artikel dalam rentang waktu 2013-2023, meliputi penerapan spektroskopi IR dan NMR secara individual maupun kombinasi keduanya. Hasil menunjukkan bahwa IR efektif dalam identifikasi gugus fungsi melalui analisis spektrum serapan inframerah, sedangkan NMR memberikan detail struktur molekul, seperti konektivitas atom dan stereokimia. Kombinasi kedua teknik ini meningkatkan efisiensi dan analisis akurasi dengan memanfaatkan keunggulan masing-masing. Studi kasus pada karakterisasi α-Mangostin menunjukkan keberhasilan penerapan integrasi IR dan NMR dalam menentukan struktur senyawa kompleks. Kesimpulannya, kombinasi IR dan NMR merupakan pendekatan strategi untuk karakterisasi metabolit sekunder, memberikan panduan praktis bagi penelitian lanjutan, serta berpotensi diterapkan dalam pengembangan obat berbasis senyawa bioaktif.
Studi Literatur : Potensi Antikanker Ekstrak Kulit Manggis (Garcinia mangostana L.) Faiza Setyawan, Najwa Adiva; Mierza, Vriezka
Jurnal Sehat Mandiri Vol 21 No 1 (2026): Jurnal Sehat Mandiri, Volume 21, No.1 Juni 2026
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v21i1.2571

Abstract

Cancer is a leading cause of death worldwide. Cancer therapy methods such as surgery, radiotherapy, and chemotherapy often cause serious side effects. Active compounds derived from natural sources are considered a promising alternative in the search for new anticancer agents because they are believed to have minimal adverse effects. This study aims to scientifically examine the anticancer potential of mangosteen peel extract. A systematic literature review was conducted using the PubMed database. The search was restricted to articles published between 2015 and 2025, and article selection followed predefined inclusion and exclusion criteria. The inclusion criteria consisted of original full-text research articles written in English that investigated mangosteen peel extract or xanthone compounds in relation to anticancer activity. Articles were excluded if they were not original studies, not full text, not written in English, published before 2015, or did not examine the anticancer activity of mangosteen peel. A total of 440 articles were identified, and 9 studies met the inclusion criteria. The results of the literature review show that mangosteen peel extract has demonstrated anticancer potential against cervical, ovarian, liver, lung, tongue, oral cavity, and glioma cancer cells. Conclusion: Mangosteen peel extract contains xanthones with strong anticancer potential via apoptosis induction, proliferation inhibition, and promising development as natural therapy.
Co-Authors Advaita, Chalisya Vanya Aisiyah, Adella Ananda, Meisya Dwi Andri, Ihsan Alfi Andriani, Nadia Apriani, Risa Dwi Ardhita, Intan Ariani, Peny Arsylrakhmatika, Giga Anugrah BAKRI, TEDY KURNIAWAN Barus, Bunga Rimta Clarissa, Yesa Prilia Debora, Priscinya Christiana Faiza Setyawan, Najwa Adiva Fitriana, Nariyyah GINTING, SELAMAT Habibah Habibah Hasna, Vina Luthfiana Ilmi, Yuniar Fathil Irwansyah, Silvana Lestari Iskandar, Putri Mutiara Jekmal Malau Khaerunisa, Aulia Khuriyah . Meliala, Linta Muhammad Hanafi Munir Alinu Mulki Nailuvar, Regita Nerdy, Nerdy Nilsya Febrika Zebua, Nilsya Febrika Nisa, Dila Qhoirul Odhia, Febry Nola Pandiangan, Martina Panjaitan, M Ridho Pangestu PUJI LESTARI Razali, Mariany Sakinah, Irene Virda Saputri, Muharni Septimar, Elviza Sudarjat, Hadi Tyasna, Putri Setya Urbaningrum , Lestari Mahardika Yessi Febriani