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All Journal Jurnal Pangan dan Gizi Journal of Nutrition College Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Penelitian Kesehatan Suara Forikes GIZI INDONESIA Ilmu Gizi Indonesia Jurnal Kedokteran dan Kesehatan Argipa (Arsip gizi dan Pangan) ARKESMAS [Arsip Kesehatan Masyarakat] Window of Health : Jurnal Kesehatan GHIDZA: Jurnal Gizi dan Kesehatan Jurnal Aplikasi Teknologi Pangan Amerta Nutrition Jurnal Abdi Insani Jurnal Bisnis Indonesia Journal SAGO Gizi dan Kesehatan Nutriology: Jurnal Pangan, Gizi, Kesehatan Jurnal Abmas Negeri (JAGRI) Jurnal Ilmiah Kesehatan (JIKA)
A'immatul Fauziyah
Fakultas Ilmu Kesehatan, Universitas Pembangunan Nasional ”Veteran” Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The effectiveness of Fibraurea tinctoria as anticancer properties: A literature review Nabila Fatihah Raihana; A’immatul Fauziyah
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 1 (2025): April
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i1.2342

Abstract

Background: Cancer remains a leading cause of mortality globally, necessitating the exploration of natural compounds for therapeutic interventions. Fibraurea tinctoria Lour (FT), an indigenous herb in Asia, has shown potential anticancer properties, but its efficacy and mechanisms require further elucidation.Objectives: This review aims to synthesize existing literature on FT's anticancer effects, focusing on its bioactive components, mechanisms of action, and the quantitative impact of FT extracts on various cancer cell lines.Methods: A systematic literature search was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria across databases including Google Scholar, PubMed, and ScienceDirect, yielding six eligible studies from an initial pool of 321. These studies assessed both in vitro and in vivo effects, differing in extract types, dosages, and treatment durations.Results: FT extracts exhibited notable antitumor effects, with palmatine hydrochloride (PaH) demonstrating significant inhibitory activity against cancer cell proliferation. Quantitative data indicate that FT extracts can reduce cancer cell viability by 28-82.79%, with PaH-PDT emerging as a promising therapeutic strategy, effectively inducing apoptosis in multiple cancer cell lines.Conclusion:  FT extracts possess substantial anticancer potential, primarily through mechanisms involving DNA damage and apoptosis induction.
Penurunan Imunitas Pasien Terinfeksi Human Immunodeficiency Virus Akibat Disbiosis Mikrobiota di Usus Aisyah, Yonita Laty; Octaria, Yessi Crosita; Fauziyah, A'immatul; Prambudi, Muhammad Rayhan Mahardika
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 16, No 1 (2025): Januari-Maret 2025
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf16153

Abstract

Gut microbiota dysbiosis is common in HIV-infected patients. Gut dysbiosis can reduce the body's ability to overcome inflammation in the gastrointestinal tract, thus affecting the immune response and disease complications in HIV-infected patients. The purpose of this review is to describe changes in the composition of the gut microbiota and its influence on the immune response in HIV-infected patients. This study is a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Articles were obtained from Elsevier, PubMed, MDPI, and Scopus between 2014 and 2024. Finally, 478 articles were obtained, which were then selected gradually according to predetermined criteria, successfully obtained 6 articles. The obtained articles were compiled, analyzed, and concluded by looking for similarities, differences, providing insights, comparing, and summarizing. The results of this review indicate that gut dysbiosis occurs in HIV-positive patients with or without ART treatment, which can trigger the body's immune response and worsen disease complications in HIV-infected patients. HIV infection can cause gut microbial dysbiosis because the HIV virus attacks CD4+ T cells in the gastrointestinal tract, resulting in loss of immune function. Gut dysbiosis can also exacerbate HIV infection, as one sign of gut dysbiosis is an increase in Prevotella bacteria, which enhances CD4+ T cell activation in the colonic mucosa and triggers a chronic inflammatory response. In conclusion, understanding the role, effects, and molecular mechanisms between gut dysbiosis and HIV infection can provide new insights into the relationship between the microbiota and HIV infection and associated comorbidities.Keywords: gut dysbiosis; Human Immunodeficiency Virus; gut immunity  ABSTRAK Disbiosis mikrobiota usus sering terjadi pada pasien infeksi HIV. Disbiosis usus dapat mengurangi kemampuan tubuh dalam mengatasi peradangan pada saluran cerna sehingga berpengaruh terhadap respon imun dan komplikasi penyakit pada pasien infeksi HIV. Tujuan dari tinjauan ini adalah untuk menggambarkan perubahan dalam komposisi mikrobiota usus dan pengaruhnya terhadap respon imun pada pasien infeksi HIV. Studi ini merupakan systematic review menggunakan Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Artikel didapatkan dari Elsevier, PubMed, MDPI dan Scopus dalam rentang waktu 2014 sampai 2024. Akhirnya diperoleh 478 artikel yang kemudian diseleksi secara bertahap sesuai dengan kriteria yang telah ditentukan berhasil didapatkan 6 artikel. Artikel yang diperolah disusun, dianalisis, dan disimpulkan dengan mencari persamaan, perbedaan, memberikan pandangan, membandingkan dan merangkum. Hasil dari tinjauan ini menunjukkan bahwa disbiosis usus terjadi pada pasien HIV+ dengan atau tanpa penanganan ART yang dapat memicu respon imun pada tubuh dan memperburuk komplikasi penyakit pada pasien infeksi HIV. Infeksi HIV dapat menyebabkan disbiosis mikrobiota usus karena virus HIV menyerang sel T CD4+ di saluran pencernaan dan hal tersebut berakibat pada hilangnya fungsi imunitas. Disbiosis usus juga dapat memperburuk infeksi HIV karena salah satu tanda terjadinya disbiosis usus adalah peningkatan bakteri Prevotella yang meningkatkan aktivasi sel T CD4+ di mukosa usus besar dan memicu respon inflamasi kronis. Dapat disimpulkan bahwa memahami peran, efek, dan mekanisme molekuler antara disbiosis usus dan infeksi HIV dapat memberikan pemahaman baru terkait dengan hubungan mikrobiota pada infeksi HIV dan komorbiditas yang terkait. Kata kunci: disbiosis usus; Human Immunodeficiency Virus; imunitas usus 
Snack Bar Tepung Sorgum dan Tepung Kelapa sebagai Pangan Fungsional untuk Penderita Diabetes Melitus Tipe 2: Sorghum Flour and Coconut Flour Snack Bars as Functional Foods for Type 2 Diabetes Mellitus Zahra, Raisa Siti; Fauziyah, A'immatul; Ilmi, Ibnu Malkan Bakhrul
Amerta Nutrition Vol. 9 No. 2 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i2.2025.278-290

Abstract

Background: People with type 2 diabetes mellitus (T2DM) can control blood sugar levels through adequate fiber consumption. Sorghum flour and coconut flour are non-gluten flours that have high fiber content. Developing functional foods, such as snack bars made from these flours, could help regulate blood glucose levels. Objectives: This study aimed to examine the effect of the proportion of sorghum flour and coconut flour on the nutritional content, dietary fiber content, and organoleptic properties of snack bars. Methods: This study used a completely randomized design with 3 formulations (70:30, 50:50, and 30:70 ratios of sorghum to coconut flour) and 2 repetitions. The gravimetric method was used to analyze water content and ash content. The Kjeldahl and Soxhlet extraction methods were employed to analyze the protein and fat content, respectively. Carbohydrate content was determined using by difference method, and fiber content was evaluated using the enzymatic method. ANOVA and the Kruskal-Wallis test were used to see the differences in proximate, fiber, and organoleptic properties, respectively. Results: The results showed significant differences in ash content (p-value<0.001), protein (p-value=0.002), fat (p-value=0.047), carbohydrates (p-value=0.049), and dietary fiber (p-value<0.001). Taste is one of the hedonic test parameters that has a significant difference (p-value=0.005). The selected snack bar formula was F3 with energy, fat, protein, carbohydrate, and fiber content was 108 kcal, 5.18 g, 4.56 g, 10.85 g, and 10.91 g respectively. Conclusions: Snack bars made from sorghum and coconut flour are rich in dietary fiber and suitable for consumption by individuals with T2DM.
Pengaruh Proporsi Tepung Sagu (Metroxylon sagu Rottb.) dan Tepung Sorgum (Sorghum bicolor L. Moench) terhadap Pati Resistan, Kandungan Gizi, dan Sifat Organoleptik Kukis untuk Diabetes Melitus Tipe 2: The Effect of Sago (Metroxylon sagu Rottb.) Flour and Sorghum (Sorghum bicolor L. Moench) Flour Proportion on Resistant Starch, Nutrient, and Organoleptic Properties of Cookies for Type 2 Diabetes Mellitus Lestari, Hana Tri; Fauziyah, A'immatul; Nasrulloh, Nanang
Amerta Nutrition Vol. 9 No. 1 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1.2025.64-75

Abstract

Background: Basic Health Research (2018) reported that the prevalence of diabetes mellitus (DM) among individuals aged 15 years and older is 8.5%, with 90–95% of them being type 2 diabetes mellitus (DMT2). Therefore, corrective action through food modification is needed to control blood glucose. Sago and sorghum contain resistant starches that can enhance glycemic and insulin response. Objectives: To analyse the effect of the proportion of sago flour and sorghum flour on resistant starch, nutritional content, and organoleptic properties of cookies designated for T2DM. Methods: This study employed a Complete Randomised Design with 5 variations of sago flour and sorghum flour treatment, namely F1 (100%:0%), F2 (75%:25%), F3 (50%:50%), F4 (25%:75%), and F5 (0%:100%), each replicated twice. The analysis of resistant starch and nutritional content utilised a one-way ANOVA test, followed by the Duncan test for significant differences. Organoleptic properties were assessed using the Kruskal Wallis test. The best formulations were determined based on the De Garmo method. Results: The results revealed significant differences in resistant starch (p-value=0.002), protein (p-value<0.001), carbohydrate (p-value=0.012), and ash content (p-value=0.005). No significant differences were observed in fat (p-value=0.514), moisture content (p-value=0.881), colour (p-value=0.891), aroma (p-value=0.061), texture (p-value=0.164), and taste (p-value=0.421). The F2 formulation emerged as the best, containing 6.31% resistant starch, 7.34% protein, 23.69% fat, 50.95% carbohydrates, 16.19% moisture content, and 1.84% ash content. Conclusions: The proportion of sago flour and sorghum flour significantly affected the content of resistant starch, protein, carbohydrates, and ash content, but not fat, moisture content, and organoleptic properties.
Co-Authors Agung Kurniawan Aisyah, Yonita Laty Ardian, Ikhwan Luthfi Astagina Sekar Sakti Atikah Ammar Hanif aufik Maryusman Avliya Quratul Marjan Avliya Quratul Marjan Cantika, Rista Carissa Wira Amadea Chalida Irma Akbar Daniel Happy Putra Dhiya Agis Ghazalah Dita Hesti Rahayu Dodik Briawan Ezra Luga Famawati, Iin Firlia Ayu Arini Haniyyah Prastia Putri Haniyyah Prastia Putri Hardinsyah Herada Putri, Melin Novidinisa Ikeu Tanziha Ilmi, Ibnu Malkan Bakhrul Laeli Lutfiani Lestari, Hana Tri Lusia Handayani Melin Novidinisa Herada Putri Melin Novidinisa Herada Putri Mudiati Nisa Utami Muhajirin, Rahmah Nadea Fitriyani Nabila Fatihah Raihana Nadiya Rahmah Qurnaini Naritsa Rihansjah Nasrulloh, Nanang Nida Amalia Nur Indah Firdausa Nur Intania Sofianita Nurlitta Shafitri Octaria, Yessi Crosita Prambudi, Muhammad Rayhan Mahardika Puspareni, Luh Desi Rahmah Nadea Fitriyani Muhajirin Rahmah Nadea Fitriyani Muhajirin Rahmawati Rahmawati Ramzy Arif Satriyo Bima Anggara Retno Yuliyanti Rica Ervienia Sukianto Rizkia Rachmi Rosali Sembiring Sherly Permata Sintha Fransiske Simanungkalit Siti Imtihanah Sofia Wardhani Sofia Wardhani Sofia Wardhani Syifa Chairunnisa Taufik Maryusman Tiara Permatasari Tri Arina Hanura Trista, Nesa Utami Wahyuningsih Utami Wahyuningsih Vina Mahdalena Widayani Wahyuningsih Widayani Wahyuningtyas Wilda Khoirunnisa Zahra, Raisa Siti