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The Impact of Chronic Pain on Epilepsy: A Systematic Review Yaffie Noor Rochim; Raras Windaswara; Kuswanto; Frida puspitasari; Yaffie Mohammad Rizaq
The International Journal of Medical Science and Health Research Vol. 15 No. 5 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/8m669990

Abstract

Introduction: Epilepsy and chronic pain represent two of the most burdensome neurological conditions globally, each contributing significantly to disability and reduced quality of life. Emerging evidence suggests a clinical and pathophysiological overlap that is far greater than coincidental, pointing toward a synergistic negative impact when they co-occur. This systematic review aims to comprehensively evaluate the multifaceted impact of chronic pain on the clinical course, psychosocial well-being, and overall burden of epilepsy. Methods: A systematic search of PubMed, Scopus, and the Cochrane Library was conducted to identify relevant literature, including systematic reviews, meta-analyses, randomized controlled trials, and observational cohort studies. Search terms encompassed epilepsy, seizure disorders, chronic pain, neuropathic pain, migraine, and fibromyalgia. Studies were selected based on predefined eligibility criteria, and data were extracted and synthesized across key outcome domains, including epidemiology, pathophysiology, seizure control, quality of life, neuropsychiatric status, cognitive function, and socioeconomic burden. Results: The epidemiological data reveal a stark disparity: 40.2% of adults with active epilepsy report chronic pain, a rate double that of the general population (20.0%). This comorbidity is associated with adverse clinical outcomes, including the potential for increased seizure frequency, mediated by pain-induced chronic stress. The impact on patient well-being is profound, with comorbid pain compounding the already significant reduction in health-related quality of life (HRQoL) seen in epilepsy. The neuropsychiatric burden is dramatically amplified; notably, the presence of chronic pain is associated with a nearly four-fold increased risk of suicidal ideation in individuals with epilepsy (OR=3.86). This dyad also exacerbates cognitive deficits, sleep disturbances, and challenges in treatment adherence due to polypharmacy and increased side-effect burden. Consequently, the socioeconomic costs, both direct and indirect, are substantially magnified. Discussion: The findings underscore a complex, bidirectional relationship between chronic pain and epilepsy, likely driven by shared neurobiological mechanisms including neuronal hyperexcitability, central sensitization, and dysfunction of inhibitory GABAergic pathways. The therapeutic overlap of certain antiepileptic drugs further supports this mechanistic link. The clinical implications are significant, highlighting the inadequacy of treating epilepsy in isolation when chronic pain is present. The synergistic negative effects on mental health, QoL, and even suicide risk necessitate a paradigm shift in clinical practice. Conclusion: Chronic pain is not merely a passive comorbidity but a critical, disease-modifying factor that actively worsens the clinical trajectory and overall burden of epilepsy. Its presence undermines treatment efficacy and dramatically increases patient suffering and mortality risk. These findings advocate for the universal screening of pain and associated psychiatric conditions in epilepsy care and the implementation of integrated, multidisciplinary management strategies to improve patient outcomes.
Implementasi Desain Pembelajaran Literasi Di SDN Kayumpia, Sigi Dan SDN Lemahduhur, Bogor Rahmat Hidayat, Asep; Kuswanto; Wicaksono, Dirgantara
Jurnal Manajemen, Ekonomi, Hukum, Kewirausahaan, Kesehatan, Pendidikan dan Informatika Vol 3 No 4 : Juni (2025): Jurnal Manajemen, Ekonomi, Hukum, Kewirausahaan, Kesehatan, Pendidikan dan
Publisher : Shofanah Media Berkah

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Abstract

This study examines the implementation of literacy learning design at SDN Kayumpia, Sigi, and SD N Lemahduhur, Bogor, using a qualitative narrative approach. It aims to understand the context, challenges, and impacts of literacy learning design on students’ skills in these rural schools. Data were collected through in-depth interviews with 4 teachers, 2 principals, and 10 students, classroom observations, and RPP document analysis. Narrative analysis revealed that key needs include culturally relevant reading materials, teacher training in literacy strategies, and integration of local context in learning. Major challenges include limited resources, such as a lack of reading books, and insufficient teacher professional development for cross-curricular literacy integration. However, a local wisdom-based approach, such as using folktales, enhanced student engagement. The findings indicate improved student motivation and reading skills, though implementation is hindered by a rigid curriculum. The study recommends developing contextual literacy resources, ongoing teacher training, and curriculum flexibility to support the School Literacy Movement. This research contributes to the development of relevant literacy practices in rural schools.
Identifikasi Preferensi Konsumen Terhadap 20 Karakter Morfologi Anggrek Dendrobium Spp. Siswanto; Noer Rahmi Ardiarini; Kuswanto
Produksi Tanaman Vol. 13 No. 08 (2025): Agustus
Publisher : Jurusan Budidaya Pertanian Fakultas Pertanian Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.protan.2025.013.08.03

Abstract

Karakter morfologi merupakan atribut penting yang mempengaruhi preferensi konsumen terhadap komoditas tanaman hias, khususnya pada anggrek Dendrobium. Informasi terkait preferensi konsumen dapat membantu pemulia tanaman dalam mengembangkan dan menghasilkan varietas Dendrobium baru dengan karakter unggul yang disukai oleh konsumen. Tujuan penelitian ini yaitu untuk mengidentifikasi preferensi konsumen terhadap 20 karakter morfologi anggrek Dendrobium Spp. Penelitian dilaksanakan pada bulan Juli 2023 – Oktober 2023 menggunakan metode survei dengan menyebarkan kuisioner melalui sosial media. Hasil survei dianalisis menggunakan Chi-Square. Hasil analisis Chi-Square menunjukkan terdapat 17 karakter morfologi yang mempengaruhi preferensi konsumen secara signifikan. Preferensi konsumen terhadap anggrek Dendrobium menunjukkan bahwa karakter morfologi yang disukai oleh konsumen yaitu ukuran tanaman sedang dengan bentuk daun lonjong, tipe tangkai bunga tegak dan panjang, posisi pembungaan di samping, jumlah bunga banyak dengan arah hadap bunga ke segala arah, lebar bunga sedang dan tebal, bentuk bunga keriting, bunga memiliki 2 kombinasi warna, serta memiliki aroma harum.
The Effect of Selling Prices on the Income of Vegetable Traders in Nipah Panjang District Husairi, Ridwan; Abidin, Zaenal; Kuswanto
Zabags International Journal of Economy Vol. 3 No. 2 (2025): Economic Studies
Publisher : CV. Zabags Qu Publish

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61233/zijec.v3i2.101

Abstract

This study aims to examine 2 (two) variables using path analysis. The purpose of this study is to reveal the effect of selling price on the income of vegetable traders. In this study, the researcher uses quantitative research because the researcher views human behavior as predictable and social reality; objective and measurable. Therefore, the use of quantitative research with valid and reliable instruments and appropriate and appropriate statistical analysis causes the results of the research achieved not to deviate from the actual conditions. The data of this study was obtained from primary data in the form of questionnaires distributed to the population and samples. The population and sample in this study the author used sample size of 130 respondents. The sampling technique used was Accidental sampling. Based on the results of the hypothesis test, the significance value is known to be Sig value 0.000 <0.05, t count value> t table (6.947> 1.656). Thus, it can be concluded that the selling price variable has a positive and significant effect on income. Based on the results of the Determination Coefficient test, it can be concluded that the magnitude of the influence of the Selling Price Variable on income is 27.40%, while the remaining 72.60% is influenced by other factors.
The Influence of Promotion Strategies on the Sales Level of Food Products at Kedai JAM Sindi; Abidin, Zaenal; Kuswanto; Ikhlas, Muhammad
Zabags International Journal of Economy Vol. 3 No. 2 (2025): Economic Studies
Publisher : CV. Zabags Qu Publish

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61233/zijec.v3i2.114

Abstract

In the face of increasing digital competition, micro, small, and medium enterprises (MSMEs) are required to adapt by implementing technology-based promotional strategies to strengthen their market presence and boost sales performance. This study aims to examine the influence of digital promotional strategies on the sales of food products at Kedai JAM, an MSME located in Muara Sabak Timur, Jambi. Utilizing a quantitative approach with a causal research design, primary data were collected through questionnaires from 90 consumers who had been exposed to the business’s promotional content on Facebook. The instrument measured key dimensions of promotional strategy namely attractiveness, promotional media, consistency, and creativity while sales performance was evaluated based on sales volume, revenue, purchase frequency, and new customer acquisition. The results of the regression equation obtained were Y = 6.604 + 0.880X, with a significance value of 0.000 and thitung 12.243 > ttabel 1.662, which means that there is a significant influence of promotional strategies on sales levels. A determination coefficient (R²) value of 0.630 indicates that 63% of sales variations were influenced by promotional strategies, while 37% were influenced by other factors outside the study. These findings suggest that Facebook functions not only as an efficient promotional medium but also as a strategic marketing platform capable of influencing consumer behavior and expanding market reach. This study offers practical insights for MSME promotion strategies and contributes to the theoretical discourse on digital marketing within the context of community-based entrepreneurship.
Assisting MSME Traders in Pandan Lagan Village in Complying with Halal Products Andini, Sukma Tri; Kuswanto; Safitri, Ria Astuti
Media for Empowerment, Mobilization, and Innovation in Research & Community Vol. 1 No. 2 (2025): July-December
Publisher : Future Tecno-Science Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59535/bn1hhy20

Abstract

Micro, Small, and Medium Enterprises (MSMEs) play a crucial role in the local economy, including in Pandan Lagan Village, Geragai District, Tanjung Jabung Timur Regency. However, many MSME actors still lack awareness regarding compliance with halal product standards as part of their moral and legal responsibilities. This community service project aims to enhance MSME actors’ understanding, awareness, and capability in the halal certification process and the application of halal principles in production and distribution. The program includes halal regulation socialization, technical training on halal certification documentation, and consultative assistance for registration with BPJPH. The results show an 85% increase in MSME knowledge of halal principles and growing commitment to registering their products for halal certification. The program also established a village halal companion group to sustain the halal economy movement locally.
KAJIAN KONSEP OPEN-AIR MUSEUM: STUDI KASUS KAWASAN CAGAR BUDAYA TROWULAN Wahyudi, Wany Raharjo; Kuswanto
Berkala Arkeologi Vol. 34 No. 1 (2014)
Publisher : BRIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30883/jba.v34i1.17

Abstract

This article discusses the concept of open-air museum as a kind of museum based on the new museology paradigm, within the heritage region of Trowulan. Research location is in the Heritage Region of Trowulan, Mojokerto, East Java Province. This study is a qualitative research with case studies strategy, and the research stages include data collection, data processing, and data integration (conclusion). The research results can formulate concepts and models of open-air museum that can be developed in the Cultural Heritage Regions of Trowulan. Principally, it is an open-air museum in the form of monumental buildings that located on the original site (in situ) equipped with the interpretation of human activities and integrated in an exhibition layout theme. The exhibition layout theme presented is about multicultural aspects from the Majapahit Kingdom.
SITUS BESOLE: SISA-SISA PINTU GERBANG DARI MASA KADIRI Kuswanto
Berkala Arkeologi Vol. 29 No. 2 (2009)
Publisher : BRIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30883/jba.v29i2.378

Abstract

Besole is a site wher remants of a brick gateway were found. This site is assumed to be dated from Kadiri Kingdom period (1041 AD – 1222 AD), though it exists in Blitar district. The gateway is an important element in a building complex or a city. The existence of a gateway can show the complexity of the neighbourhood. This article will discuss about the invention, rescue, and interpretation of the remmants in Besole as a contribution to reconstruct the nation civilization history.
Pendampingan Manajerial Rumah Makan Dua Putri dalam Upaya Peningkatan Efisiensi dan Produktivitas di Kecamatan Dendang, Kabupaten Tanjung Jabung Timur Sophia Nurelita Dewi; Kuswanto; Ria Astuti Safitri
Swakarya: Jurnal Penelitian Sosial dan Pengabdian Masyarakat Vol. 4 No. 2 (2026): Swakarya: Jurnal Penelitian Sosial dan Pengabdian Masyarakat
Publisher : Pusat Studi Penelitian dan Evaluasi Pembelajaran

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Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan efisiensi dan produktivitas operasional pada Rumah Makan Dua Putri yang berlokasi di Kecamatan Dendang, Kabupaten Tanjung Jabung Timur. Permasalahan utama yang dihadapi mitra adalah rendahnya efektivitas manajemen usaha, kurang optimalnya pembagian tugas karyawan, serta belum adanya sistem pencatatan keuangan yang terstruktur. Melalui program pendampingan manajerial, tim pelaksana melakukan serangkaian kegiatan meliputi analisis kebutuhan, pelatihan manajemen usaha, penerapan sistem pencatatan keuangan sederhana, serta evaluasi kinerja produktivitas. Metode pelaksanaan yang digunakan adalah pendekatan partisipatif dengan melibatkan pemilik dan karyawan rumah makan secara aktif. Hasil kegiatan menunjukkan adanya peningkatan kemampuan manajerial mitra, efisiensi waktu kerja, dan pengelolaan keuangan yang lebih transparan. Selain itu, produktivitas usaha meningkat yang ditandai dengan peningkatan jumlah pelanggan dan pendapatan harian. Kegiatan pendampingan ini diharapkan dapat menjadi model pemberdayaan usaha mikro kuliner dalam mengembangkan manajemen usaha yang lebih efektif dan berkelanjutan.
Strategi Pendidikan Kewirausahaan Untuk Meningkatkan Kreativitas, Kemandirian, dan Daya Saing Peserta Didik Kuswanto; Ridwan Rifai; Ahmad Nofiyadi; Amirudin; Ahmad Nasi'in; Ari Kurniawan; Susilo; Kois
Jurnal Pendidikan Dasar Islam Vol. 4 No. 2 (2026): Juni
Publisher : putrapublisher.org

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58540/jurpendis.v4i2.1815

Abstract

Pendidikan kewirausahaan merupakan salah satu strategi penting dalam mempersiapkan peserta didik menghadapi tantangan abad ke-21 yang ditandai oleh globalisasi, transformasi digital, dan perubahan kebutuhan dunia kerja. Penelitian ini bertujuan untuk menganalisis strategi pengembangan kewirausahaan dalam pendidikan serta implikasinya terhadap kreativitas, kemandirian, dan daya saing peserta didik. Penelitian menggunakan pendekatan kualitatif dengan metode studi kepustakaan (library research). Data diperoleh dari buku, jurnal ilmiah, hasil penelitian terdahulu, dan dokumen lain yang relevan dengan pendidikan kewirausahaan. Analisis data dilakukan secara deskriptif kualitatif melalui tahapan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil kajian menunjukkan bahwa pengembangan kewirausahaan dalam pendidikan dapat dilakukan melalui integrasi nilai-nilai kewirausahaan dalam kurikulum, penerapan Project Based Learning, pengembangan budaya kewirausahaan di sekolah, pemanfaatan teknologi digital, penguatan kemitraan dengan dunia usaha dan dunia industri, serta peningkatan kompetensi pendidik. Strategi tersebut berkaitan dengan peningkatan kreativitas peserta didik, penguatan kemandirian, dan pengembangan daya saing melalui keterampilan abad ke-21, seperti berpikir kritis, komunikasi, kolaborasi, dan literasi digital. Dengan demikian, pendidikan kewirausahaan memiliki peran strategis dalam mendukung terbentuknya generasi yang inovatif, adaptif, dan siap menghadapi perubahan sosial, ekonomi, dan teknologi di masa depan.