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All Journal Majalah Farmaseutik Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian Masyarakat (ABDIRA) Duta Pharma Journal Jurnal Ilmiah Kesehatan Journal of Biotropical Research and Nature Technology
Sandi Mahesa Yudhantara
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Pengaruh Konsentrasi Pelarut Terhadap Kandungan Flavonoid Total Daun Binahong (Anredera cordifolia) Menggunakan Metode Microwave Assisted Extraction Yudhantara, Sandi Mahesa; Rohmawati, Lili
Journal of Biotropical Research and Nature Technology Vol. 1 No. 2 (2023): Borneo
Publisher : Prodi Biologi FMIPA Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/borneo.v1i2.8583

Abstract

Binahong (Anredera cordifolia) merupakan tumbuhan yang secara empiris dipercaya memiliki beragam khasiat. Salah satu kandungan senyawa dalam daun binahong adalah flavonoid. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi pelarut etanol pada proses ekstraksi berbantu microwave terhadap kadar flavonoid total ekstrak daun binahong. Variasi konsentrasi pelarut etanol yang digunakan adalah 60%, 70% dan 96%. Proses ekstraksi menggunakan metode microwave assisted extraction (MAE). Penetapan kadar flavonoid total menggunakan spektrofotometri uv-vis. Kadar flavonoid total ekstrak etanol daun binahong pada konsentrasi pelarut 60%, 70% dan 96% masing-masing sebesar 0,103%; 0,138% dan 0,061%. Hasil analisis menunjukkan adanya pengaruh variasi konsentrasi pelarut terhadap kadar flavonoid total ekstrak daun binahong.
Pengaruh Metode Maserasi dan Soxhletasi Terhadap Kandungan Senyawa Penangkap Radikal Bebas Daun Kersen Menggunakan LC-MS Muadifah, Afidatul; Putri, Amalia Eka; Rahmawati, Desti Linda Dwi; Yudhantara, Sandi Mahesa
Majalah Farmaseutik Vol 21, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i2.99625

Abstract

Daun Kersen (Muntingia Calabura L.) mempunyai senyawa metabolit sekunder seperti fenol, flavonoid, terpenoid, tanin, saponin dan alkaloid yang berpotensi menjadi penangkap radikal bebas alami. Penelitian ini bertujuan untuk membandingkan kandungan senyawa penangkap radikal bebas di daun kersen (Muntingia Calabura L.) yang diekstraksi secara maserasi dan soxhletasi. Analisis senyawa pada daun kersen (Muntingia Calabura L.)  menggunakan Liquid Chromatograph Mass Spectrometry (LCMS). Hasil analisis LCMS ekstrak maserasi daun kersen (Muntingia Calabura L.) yaitu terdapat 85 senyawa terdiri dari flavonoid 68,63%, fenol 11,67%, terpenoid 2,77%, alkaloid 0,3%, saponin 2,2%, dan tanin 1,3%. Pada ekstrak soxhletasi terdapat 92 senyawa terdiri dari flavonoid 71,47%, fenol 10,16%, terpenoid 23,91%, alkaloid 1,04%, tanin 1,4%, dan saponin 1,5%. Analisis senyawa LCMS juga diperkuat dengan uji aktivitas penangkapan radikal bebas menggunakan DPPH pada ekstrak soxhletasi nilai  69,428 ppm sedangkan ekstrak maserasi 74,407 ppm, kedua ekstrak dikategorikan penangkap radikal bebas kuat. Dengan demikian, kandungan senyawa penangkap radikal bebas hasil analisis dengan LC-MS pada daun kersen (Muntingia Calabura L.) dari metode ekstraksi soxhletasi memperoleh persentase (% kadar) yang lebih tinggi dibandingkan dengan ekstraksi maserasi, didukung dengan uji DPPH ekstraksi soxhletasi dapat menghasilkan nilai  lebih kecil dari pada metode maserasi.
PERBANDINGAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL 70% DAUN PEPAYA MUDA DAN TUA (CARICA PAPAYA L.) MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Mahesa Yudhantara, Sandi; Christina , Odilea Dea; Hastuti, Fitri
Duta Pharma Journal Vol. 4 No. 1 (2024): DUTA PHARMA JOURNAL
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v4i1.3808

Abstract

The content of secondary metabolite compounds flavonoid that contained in papaya leaves (Carica papaya Leaf) has various benefits for treatment, but the utilization of flavonoid compounds contained in papaya leaves wasn't optimal due to the selection of sources that hasn't been optimal. One consideration that can be used as a benchmark for obtaining maximum benefits from papaya leaves is the age of the leaves. The aim of this study is to determine the effect of papaya leaf age on flavonoid content. The samples used in this research were young and old papaya leaves, where the extraction process used the maceration method using ethanol 70% as a solvent. Flavonoid content analysis was carried out qualitatively using thin layer chromatography and quantitatively using UV-Vis spectrophotometry. The results of determining total flavonoid between young and old papaya leaves resulted in lower levels in young leaves, where young leaves had a content of 8.15% w/w QE, while old leaves had a content of 17.41% w/w QE.
PENETAPAN KADAR VITAMIN C PADA BUAH NANAS KALENG (Ananas comocus L.) DENGAN METODE SPEKTROFOTOMETRI UV-Vis DAN TITRASI IODIMETRI Ruwista, Anista; Sugiyo, Warlan; Mahesa, Sandi
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Vitamin C has an important role in the human body, namely carrying out its functions such as in the synthesis of collagen, the formation of carnitine, is involved in cholesterol metabolism, become bile acids, and plays an important role in the formation of the neurotransmitter norepinephrine. Vitamin C intake must be obtained from outside the body because this vitamin cannot be synthesized in the body through the biosynthetic pathway. Pineapple fruit is one of the fruits that contain vitamin C. The purpose of this study was to analyze the levels of vitamin C in canned pineapples for which the result of vitamin C on the AKB value on the packaging label were not known using UV-Vis spectrophotometry and iodimetric titration. The method used in the qualitative analysis of vitamin C is identification by color raction using Fehling A and B reagents and KMnO4 reagent. Quantitative analysis of vitamin C using the UV-Vis spectrophotometry method with a wavelength of 0,0031 % while the results from the iodimetric titration methode obtained an average % of vitamin C levels from canned pineapple samples of 0,050 % w/w.
Co-Authors Aditya Nuryanto Saputra Alfanaar, Rokiy Atalia Tamo Ina Bulu Ayu Ina Solichah Ayuningtyas, Nurista Dida Buanasari, Buanasari Christina , Odilea Dea Elsa, Limpat Fatiqin, Awalul Ferika Indrasari Fitri Hastuti I Nyoman, Sudyana, Kamilla Sekar margareta retno Margareta Retno Priamsari Metrikana Novembrina Muadifah, Afidatul Mu’afa Purwa Arsana Odilia Dea Christina Putri, Amalia Eka Rahman, Sudarman Rahmawati, Desti Linda Dwi Rohmawati, Lili Ruwista, Anista Shesanti Citra Riana Subarjo, Nonik Triliana Warianti Thathit Suprayogi Wahyu Setiyaningsih Warlan Sugiyo Wirawati, Ninik Yahya Febrianto Yohanes Edi Gunawan