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Fadhila, Feldha
Institut Kesehatan Rajawali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Effectiveness of Antiseptic Liquid Smoke of Pine Fruit (Pinus merkusii) in Vitro and in Vivo Alfani, Fhadliana; Armela, Diana Rizki; Adzra, Fa’izzah Nur; Fadhila, Feldha; Maryana, Yayan; Rumidatul, Alfi
Biomedika Vol 15 No 2 (2022): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v15i2.1543

Abstract

Hand sanitizers containing alcohol-based components are frequently used to clean hands due to their usage is more effective and efficient. Natural substances, such as pine fruit, can be used to replace alcohol-based components. Pine fruit may be processed into an antibacterial liquid smoke product, making it potentially useful as an antiseptic. The purpose of this research is to see how effective pine fruit liquid smoke is at inhibiting microbial growth in vitro and in vivo. In vitro disc diffusion test against E. coli ATCC 25922 and Staphylococcus aureus ATCC 25923, and employing disc and well diffusion methods on Aspergillus flavus ATCC 9643 and Candida albicans ATCC 10231. The pour plate approach was used in vivo. The in vitro test findings revealed an inhibitory zone on E. coli (5.3 mm) and S. aureus (5.83 mm) from 100% concentration of liquid smoke. The in vitro test results are supported by the in vivo test results, which indicate that the liquid smoke of pine fruit is 100% effective at preventing the growth of bacteria by 75.1% and fungi by 87.7%. The results of the questionnaire indicated that respondents liked the color (50%), and aroma (58%), that the product did not induce dryness (75%), and did not burning effects (83%). The result of this research is that 100% liquid smoke of pine fruit (Pinus merkusii) is effective in inhibiting the growth of E. coli ATCC 25922 and S. aureus ATCC 25923, as well as being effective as antiseptic agents.
Efektifitas Asap Cair Kayu Sengon (Falcataria moluccana) Sebagai Antiseptik Secara In Vivo dan In Vitro Zaenudin Arif, Jihan Ahmad; Amelia, Riska; Fauziah, Anti Zulfitri; Fadhila, Feldha; Maryana, Yayan; Rumidatul, Alfi
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.45381

Abstract

Bakteri dan jamur merupakan penyebab utama penyakit infeksi, pencegahan dapat diatasi dengan penggunaan hand sanitizer, tetapi dapat menimbulkan efek samping iritasi, maka diperlukan bahan alternatif alam. Asap cair kayu sengon memiliki kemampuan sebagai antiseptik. Penelitian ini bertujuan untuk mengetahui efektivitas asap cair kayu sengon sebagai antiseptik terhadap pertumbuhan mikroba secara in vitro dan in vivo. Hasil uji in vitro didapatkan zona hambat tertinggi pada asap cair kayu sengon grade 1 terhadap E. coli ATCC 25922 konsentrasi 75% 5,8 mm.  S. aureus ATCC 25923 konsentrasi 75% 10 mm. A. flavus ATCC 9643 konsentrasi 75% 22,8 mm. C. albicans ATCC 10231 konsentrasi 75% 3,6 mm. Grade 2 terhadap E. coli ATCC 25922 konsentrasi 75% 7,5 mm. S. aureus ATCC 25923 konsentrasi 75% 12 mm. A. flavus ATCC 9643 konsentrasi 75% 27,8 mm. C. albicans ATCC 10231 konsentrasi 75% 5,1 mm. Hasil uji in vivo menunjukan efektivitas asap cair kayu sengon grade 2 pada bakteri sebesar 54,51%, jamur sebesar 84,37%. Dari data kuesioner responden diperoleh 75% menyukai warna, 41% menyukai aroma, 75% tidak menimbulkan efek kekeringan, 92% tidak mendapatkan efek samping. Dapat disimpulkan asap cair kayu grade 2 konsentrasi 75% memiliki kemampuan dalam menghambat pertumbuhan mikroba.
Effectiveness of Sengon Ethyl Acetate Extract and Bamboo Liquid Smoke as Disinfectants Anisa, Divia; Marlina, Rina; Juniar, Fadia Rahma; Nurjaman, Deni; Fadhila, Feldha; Mayuri, Nindya Sekar; Rumidatul, Alfi
BIOEDUPAT: Pattimura Journal of Biology and Learning Vol 5 No 1 (2025): Bioedupat : Pattimura Journal of Biology and Learning
Publisher : Program Studi Pendidikan Biologi, Pascasarjana, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/bioedupat.v5.i1.pp287-293

Abstract

The absence of environmental sanitation can influence the transmission of infectious diseases, exemplified as toilets tainted with dangerous microbes. Prevention typically employs disinfectants; nevertheless, their adverse effects might lead to skin and respiratory discomfort. Flavonoids, tannins, and saponins in sengon wood possess antibacterial properties and can serve as alternative materials. The study aimed to assess the efficacy of combining sengon wood extract and bamboo stem liquid smoke as a disinfectant. The experimental methodology employed in vitro testing through an inhibitory assay and in vivo testing utilizing a swab on the surface, assessing the effects pre- and post-swabbing. The in vitro results indicated that the most substantial inhibitory zone was observed with a 40:60 ratio for Salmonella typhimurium ATCC 25241, measuring 11.8 mm; for Candida albicans ATCC 10231, a 30:70 ratio yielded 5.33 mm; and for Aspergillus flavus ATCC 9643, a 30:70 ratio resulted in 5.5 mm. In vivo, swabs from the table yielded an average reduction of 92% in bacterial colonies and 73% in fungal colonies. Conclusion: The amalgamation of sengon twig wood extract and bamboo stem liquid smoke exhibits potential as a disinfectant. Keywords: Liquid smoke, bamboo sticks, disinfectant, sengon wood
Efektivitas Ekstrak Kayu Sengon (Falcataria moluccana) dan Asap Cair Batang Bambu (Bambusa sp) sebagai Disinfektan: Effectiveness of Sengon Wood Extract (Falcataria moluccana) and Bamboo Stem Liquid Smoke (Bambusa sp) as Disinfectants Anisa, Divia; Marlina, Rina; Juniar, Fadia Rahma; Nurjaman, Deni; Fadhila, Feldha; Mayuri, Nindya Sekar; Rumidatul, Alfi
Jurnal Sains dan Kesehatan Vol. 7 No. 2 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i2.2431

Abstract

Lack of cleanliness of the surrounding environment can influence the spread of infectious diseases, such as toilets being contaminated by pathogenic microorganisms. It is common for prevention to use disinfectants, but the negative impact of using them can cause skin and respiratory irritation. The objective of this research is to determine the effectiveness of the combination of sengon twig wood extract and bamboo stem liquid smoke as a disinfectant. The method of this research is uses an experimental design where testing is carried out in vitro using an inhibition test and in vivo using a swab on a table by looking at the effects before and after the swab. Results: In vitro, the largest inhibition zone was formed in a combination ratio of 40:60 for Salmonella typhimurium ATCC 25241 of 11.8 mm; Candida albicans ATCC 10231 in comparison 30:70 was 5.33 mm; Aspergillus flavus ATCC 9643 in a ratio of 30:70 of 5.5 mm. In vivo, using swabs on the table, the average reduction in the number of bacterial colonies was 92% and in fungi the average was 73%. The combination of sengon twig wood extract and bamboo stem liquid smoke has the potential to be a disinfectant Keywords:          Liquid smoke, bamboo sticks, disinfectant, sengon twigs   Abstrak Kurangnya kebersihan lingkungan sekitar dapat mempengaruhi penyebaran penyakit infeksi, seperti toilet yang tercemari oleh mikroorganisme patogen.  Lumrahnya pencegahan menggunakan disinfektan, namun dampak negatif penggunaanya dapat menyebabkan iritasi kulit dan pernafasan. Tujuan penelitian ini untuk mengetahui efektivitas kombinasi ekstrak kayu ranting sengon dan asap cair batang bambu sebagai disinfektan. Metode penelitian ini menggunakan desain eksperimental dimana dilakukan pengujian secara in vitro menggunakan uji daya hambat dan in vivo menggunakan swab pada meja dengan melihat efek sebelum dan setelah swab. Secara in vitro terbentuk zona hambat paling besar pada kombinasi perbandingan 40:60 untuk Salmonella typhimurium ATCC 25241 sebesar 11.8 mm; Candida albicans ATCC 10231 di perbandinga 30:70 sebesar 5.33 mm; Aspergillus flavus ATCC 9643 di perbandingan 30:70 sebesar 5.5 mm. In vivo melalui swab pada meja diperoleh nilai rata-rata penurunan jumlah koloni bakteri  sebesar 92% dan pada jamur rata-rata sebesar 73%. Kombinasi ekstrak kayu ranting sengon dan asap cair batang bambu berpotensi sebagai disinfektan Kata Kunci:         Asap cair, batang bambu, disinfektan, kayu ranting sengon  
Uji Aktivitas Antimikroba Ekstrak Kulit Ranting dan Kayu Sakit Sengon (Falcataria moluccana) dengan Pelarut Metanol dan Etil Asetat Rumidatul, Alfi; Wahyuniah, Bunga; Zamaludin, Deni; Khusna, Wasiyah; Fadhila, Feldha; Maryana, Yayan
Jurnal Analis Medika Biosains (JAMBS) Vol 8, No 1 (2021): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jambs.v8i1.211

Abstract

Sengon (Falcataria moluccana) memiliki senyawa metabolit yang beragam dan memiliki aktivitas antimikroba baik pada bagian kulit dan daunnya. Penelitian ini bertujuan untuk mengetahui potensi ekstrak Sengon sebagai antimikroba. Metode yang digunakan dalam pembuatan ekstrak adalah maserasi dengan pelarut metanol dan etil asetat dan dibuat menjadi lima varian konsentrasi yaitu 9%, 9,5%, 10%, 10,5%, dan 11% sedangkan untuk pengujian aktivitas antimikroba dilakukan dengan metode difusi cakram atau Kirby bauer terhadap mikroba uji yaitu Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis, Salmonella typhi, Shigella dysenteriae, Klebsiella pneumonia, Escerichia coli, dan Candida albicans. Hasil penelitian menunjukkan konsentrasi optimum ekstrak kulit ranting sakit dengan pelarut metanol yaitu 11% pada S. aureus dengan diameter 8,3 mm, P. mirabilis dengan diameter 4,3 mm, P. aeruginosa dengan diameter 0,5 mm, K. pneumonia dengan diameter 9 mm, dan E. coli dengan diameter 7 mm. Konsentrasi optimum ekstrak kulit ranting sakit dengan pelarut metanol juga terdapat pada konsentrasi 10% dan 11% pada S. dysenteriae dan C. albicans dengan diameter 3 mm, dan pada S. thypi dengan diameter 6 mm. Konsentrasi optimum ekstrak kayu sakit sengon dengan pelarut metanol yaitu 11% pada S. aureus dengan diameter 8,3 mm, P. mirabilis dengan diameter 5,6 mm, dan P. aeruginosa dengan diameter 9 mm. Konsentrasi optimum ekstrak kayu sakit sengon dengan pelarut etil asetat yaitu 10%, 10,5%, dan 11% terhadap C. albicans dengan diameter 2 mm. Hasil yang didapat menunjukkan bahwa ekstrak kulit ranting dan kayu Sengon sakit dengan pelarut metanol dan etil asetat dapat menghambat pertumbuhan mikroba uji dengan konsentrasi optimum ekstrak yang berbeda untuk setiap mikroba uji.
Effectiveness of Tea Twig Liquid Smoke (Camellia sinensis) as an Antiseptic against Microbes in Vivo and In Vitro Ni'am, Ayu Rahayu Nurul; Arrsy, Aulia Nur; Zahroh, Salsabila; Fadhila, Feldha; Mayuri, Nindya Sekar; Rumidatul, Alfi
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 12 No 2 (2025): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol12issue2page94-101

Abstract

Transmission of microorganisms that cause disease in humans occurs directly or indirectly. Prevention efforts can use antiseptics. The content of liquid smoke compounds in tea twigs has the potential to be an antiseptic. The purpose of this study was to determine the effectiveness of liquid smoke from tea twigs (Camellia sinensis) on microbial growth in vitro using the inhibition test method and in vivo swab test on the palms. In the in vitro test, the most effective results were grade 2 liquid smoke with a concentration of 75% with an inhibition zone diameter of 18.1 mm (E. coli ATCC 25922), 15.6 mm (S. aureus ATCC 25923), 32.3 mm (A. flavus ATCC 9643), 4.3 mm (C. albicans ATCC 10231). The results of the in vivo test showed effectiveness in reducing the number of bacterial colonies by an average of 88.33%, and fungal colonies by an average of 91.52%. From the entire questionnaire data, the parameters of aroma, color, dryness are in the criteria of liking and do not cause side effects on the skin. The results of the study showed that liquid smoke from tea twigs has the potential as an antiseptic.
Effectiveness as a Disinfectant of Ethyl Acetate Extracted from Sengon Twig Bark (Falcataria Moluccana) and Bamboo Stem Liquid Smoke (Bambusa sp.) Nabila, Hasna Putri; Yuliani, Septa; Alifah, Aqil; Qomariah, Annisa Nur; Sugara, Yuliannisa; Rumidatul, Alfi; Fadhila, Feldha; Mayuri, Nindya Sekar
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 8 (2025): Volume 12 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i8.19621

Abstract

Penyakit infeksi yang disebabkan oleh mikroba patogen masih menjadi suatu masalah kesehatan utama di seluruh dunia. Pada umumnya, pencegahan dilakukan dengan penyemprotan disinfektan berbahan dasar kimia, namun penggunaananya dapat menimbulkan kerusakan kulit sehingga diperlukan alternatif lain, salah satunya dengan menggunakan bahan alami yaitu ekstrak etil asetat kulit ranting sengon (Falcataria moluccana) dan batang bambu (Bambusa sp.). Mengetahui efektivitas antimikroba ekstrak etil asetat kulit ranting sengon (Falcataria moluccana) dan asap cair batang bambu (Bambusa sp.) sebagai disinfektan. Menggunakan rancangan eksperimental. Data diambil dari 5 perlakuan pada metode difusi menggunakan campuran ekstrak etil asetat kulit ranting sengon (Falcataria moluccana) dan asap cair batang bambu (Bambusa sp.) dengan masing-masing perbandingan 50:50, 40:60, 30:70, 20:80, 10:90 kemudian hasil terbaik dilakukan uji swab pada meja. Pada metode difusi didapatkan hasil terbaik yaitu pada perbandingan 40:60 dan 20:80. Uji swab menghasilkan persentase penurunan bakteri sebesar 78,93% dan persentase penurunan jamur sebesar 83,27%. Ekstrak etil asetat kulit ranting sengon (Falcataria moluccana) dan asap cair batang bambu (Bambusa sp.) memiliki sifat antimikroba sehingga dapat dijadikan sebagai disinfektan.
Efektivitas Asap Cair Kulit Sawit (Elaeis Guineensis Jacq) sebagai Antiseptik terhadap Mikroba Sulistyawati, Annisa Lathifah; Dayanti, Nyimas; Iman, Moch Fajar Anugrah; Fadhila, Feldha; Maryana, Yayan; Rumidatul, Alfi
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.26-35

Abstract

Background Bacteria and fungi that enter through the body get intermediaries from the condition of hands that are not washed clean. Alcohol-based antiseptics are usually used for quick and effective hand washing, but repeated use can cause irritation and dryness of the hands. Natural components can be processed to make non-alcoholic substitutes, such as liquid smoke from palm oil's outer shell (Elais guineensis Jacq). It is known that liquid smoke contains antibacterial phenolic chemicals. Methods This research design is true experimental by testing the effectiveness of palm oil outer shell liquid smoke as an antiseptic, which is carried out in vitro using inhibitory tests and in vivo using palm swabs of respondents by looking at the effects before and after use. In vitro results formed the largest inhibition zone size using grade 2 liquid smoke with a concentration of 75%, with an inhibition zone size of Staphylococcus aureus ATCC 25923 of 15.6 mm; Escherichia coli ATCC 25922 of 5.8 mm; Candida albicans ATCC 10231 of 3.3 mm; and Aspergillus flavus ATCC 9643 of 33.3 mm. Results In vivo, results obtained through the respondent's palm swab showed an average value of 89.84% decrease in bacterial colonies and a 77% decrease in fungal colonies after using liquid smoke antiseptic. The results of the organoleptic assessment showed that 92% of respondents liked the color, 75%  liked the smell, 75% felt that it did not cause dryness, and 92% felt that there were no side effects of use. Conclusions The liquid smoke of the outer shell of palm oil has the potential as an antiseptic.
Effectiveness of Tea Leaf (Camellia sinensis) Liquid Smoke as an Antiseptic Rohmah, Fitriani Nurhidayati; Alamsyah, Muhamad Thamrin; Nurjana, Siti; Fadhila, Feldha; Mayuri, Nindya Sekar; Rumidatul, Alfi
3BIO: Journal of Biological Science, Technology and Management Vol. 6 No. 1 (2024)
Publisher : School of Life Sciences and Technology, Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/3bio.2024.6.1.1

Abstract

Microbes are often the cause of infectious diseases; one method of prevention is to use antiseptics. Excessive use of antisep- tics can cause mild to severe side effects, so an alternative antiseptic is needed. Liquid smoke is an alternative raw material to produce antiseptics because its main component can be used as an inhibitor of microbial growth. This study aims to determine the effectiveness of tea-leaf liquid smoke as an antiseptic against microbial growth in vivo and in vitro. The method for producing liquid smoke via pyrolysis involves distilling grade 3 liquid smoke to generate grade 1 and grade 2 liquid smoke. The in vitro test uses a microbial growth inhibition test with grade 1 and 2 liquid smoke concentrations of 35%, 50%, and 75%. The microbes used were Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Candida albicans ATCC 10231, and Aspergillus flavus ATCC 9643. The in vivo test uses the swab test method on the palm of the hand. The results of the invitro test showed that the largest inhibition zone of tea leaf liquid smoke was obtained using grade 2 liquid smoke with a concentration of 75%.The results of the in vivo test showed that the effectiveness of tea leaf liquid smoke was 80% against bacteria and 85% against fungi. Based onthe results of the study, it can be concluded that tea leaf liquid smoke (Camellia sinensis) has potential as an antiseptic.
Effectiveness of Bamboo Stick Liquid Smoke (Bamboo sp.) With Methanol Extract of Sengon Twig Wood (Falcataria moluccana) as a Disinfectant Nabillah, Hurient Sani; Sonya, Luluil Fajry Thasya; Fitriani, Dilla Saphira; Muzjahidah, Nelly Siti; Vaolina, Putri; Fadhila, Feldha; Rumidatul, Alfi; Mayuri, Nindya Sekar
Jurnal Riset Kesehatan Vol 13 No 1 (2024): MEI 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v13i1.10597

Abstract

Pathogenic microorganisms that cause infectious diseases are widely spread in the environment, especially in public places that allow microorganisms to multiply. Disinfectants are used to prevent the spread of these microorganisms. The use of chemical-based disinfectants can cause side effects, so it is necessary to look for alternatives from natural materials, such as a mixture of bamboo stem liquid smoke and methanol extract from Sengon twig wood. The purpose of this study was to determine the effectiveness of a mixture of bamboo stem liquid smoke and methanol extract of Sengon twig on bacteria and fungi. This research method began with an inhibition test of the disc and well diffusion method with five comparison treatments (50:50, 40:60, 30:70, 20:80, 10:90) to obtain the most effective comparison of the volume of 100% bamboo stem liquid smoke mixture and 11% sengon twig wood methanol extract, then tested using the Total Plate Count (TPC) method with swab samples on wooden tables. The results showed that the most effective comparison of the volume of 100% bamboo stem liquid smoke mixture and 11% sengon twig wood methanol extract was the volume ratio of 50:50 from the results of the inhibition zone on Salmonella typhimurium with a diameter of 10.3 mm. The results of the mixed effectiveness test with a ratio of 50:50 with the swab test on the table showed a decrease in the number of bacteria (51%) and fungi (65%). This shows that the mixture of bamboo stem liquid smoke and methanol extract of Sengon twig wood is effective as a disinfectant.
Co-Authors Adzra, Fa’izzah Nur Al Badri, Muhammad Hilal Alamsyah, Muhamad Thamrin Alfani, Fhadliana Alfi Rumidatul Alfi Rumidatul Alfi Rumidatul Alifah, Aqil Ani Haerani Anisa, Divia Armela, Diana Rizki Arrsy, Aulia Nur Bunga Wahyuniah Dayanti, Nyimas Deni Zamaludin Dheanna P.S Rachmawati Dilla Saphira Fitriani Eki Andini Fadhilah, Wasiyah Khusna Fauziah, Anti Zulfitri Firdausia, Ajeung Dewi Fitriani, Dilla Saphira H.Y, Siti Yesi Hurient Sani Nabillah Iman, Moch Fajar Anugrah Ira Puspa Dewi Juniar, Fadia Rahma Khairin Rabbani Khusna, Wasiyah Luluil Fajry Thasya Sonya Maryana, Yayan Mayuri, Nindya Sekar Muzjahidah, Nelly Siti Nabila, Hasna Putri Nabillah, Hurient Sani Nelly Siti Muzjahidah Ni'am, Ayu Rahayu Nurul Nindya Sekar Mayuri Nurjaman, Deni Nurjana, Siti Nursifah, Devi Pragita, Anisa Sri Purwaeni Purwaeni Putri Vaolina Qomariah, Annisa Nur Raisya Amira Shabira Rina Marlina Riska Amelia Rohmah, Fitriani Nurhidayati Rumidatul, Alfi Shafa, Dheanna Putri Shenny Fitriani Sonya, Luluil Fajry Thasya Sugara, Yuliannisa Sulistyawati, Annisa Lathifah Vaolina, Putri Wahid, Aziz Ansori Wahyuniah, Bunga Wasiyah Khusna Yayan Maryana Yayan Maryana Yuliani, Septa Zaenudin Arif, Jihan Ahmad Zahroh, Salsabila Zamaludin, Deni