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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL SIPIL STATIK Majalah Kedokteran Bandung The Indonesian Journal of Occupational Safety and Health Indonesian Journal of Obstetrics & Gynecology Science Manuju : Malahayati Nursing Journal Jurnal Respirasi (JR) Medica Hospitalia JOURNAL LA MEDIHEALTICO Indonesian Health Journal Jurnal Indonesia Sosial Teknologi
Isa, Mohamad
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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The Effect Of Nigella Sativa Administration In Reducing Oxidative Damage In Covid-19 Patients: A Clinical And In Silico Study Diany, Holly; Nurrasyidah, Ira; Haryati, Haryati; Isa, Mohamad; Kusumawardhani, Erna
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.552

Abstract

The COVID-19 pandemic has posed significant challenges to public health, particularly about the oxidative damage caused by infection. Nigella sativa, known for its antioxidant properties, has been extensively studied as a potential therapeutic agent to reduce oxidative damage. This study aims to evaluate the effects of Nigella sativa administration in reducing oxidative damage in COVID-19 patients through a clinical and in silico approach. The research methods include a clinical trial on COVID-19 patients supplemented with Nigella sativa and in silico molecular analysis to identify the interaction mechanisms between the active components of Nigella sativa and SARS-CoV-2 proteins. The results showed that Nigella sativa significantly reduced oxidative stress biomarkers in patients, and in silico results revealed the potential of its active components to inhibit critical enzymes of the SARS-CoV-2 virus. Based on these findings, it is concluded that Nigella sativa has potential as an adjunct therapy in reducing oxidative damage in COVID-19 patients. Further research is required to confirm these results through broader, more in-depth clinical trials.
Vitamin D, Body Mass Index, and Total Lymphocyte Count in Drug-Sensitive and Drug-Resistant Tuberculosis Patients in Banjarmasin Riefani, Soraya; Juhairina, Juhairina; Isa, Mohamad; Kusumawardhani, Erna; Haryati, Haryati; Syam, Shaogi; Nurrasyidah, Ira
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.14-22

Abstract

Introduction: Tuberculosis (TB) remains a global health problem that causes high morbidity and mortality. Based on its classification, TB is divided into drug-sensitive (DS) and drug-resistant (DR). Several risk factors susceptible to TB are malnutrition with low body mass index (BMI), vitamin D deficiency (VDD), and low total lymphocyte count (TLC) related to low immune status. This study aimed to examine the relationship between vitamin D (VD), BMI, and TLC in the TB population in Banjarmasin. Methods: This was an analytic observational study with a cross-sectional design. The total study sample was 42 patients, confirmed by rapid molecular testing, who had not been treated for TB in Banjarmasin from January to May 2023 and met the inclusion and exclusion criteria. Chi-Square and Fisher's exact statistical tests were used to see the relationship between VD, BMI, and TLC in DS TB and DR TB. Results: The median age of DS TB was 38 (24-52) years old, and DR TB was 51 (37-58) years old. Most of the gender was male (24 patients/57.1%). There was a statistically significant difference between VD and BMI in DS TB and DR TB (p = 0.048; p = 0.019). There was a significant relationship between VD and TLC in DS TB and DR TB (p = 0.048). Conclusion: VD and BMI significantly differed in DS TB and DR TB. There was a significant correlation between VD and TLC in TB patients.
Effect of Omega-3 Addition on Sputum Conversion, Body Mass Index, Interleukin-6, and Lymphocyte Monocyte Ratio in the Treatment of Pulmonary Tuberculosis Ferryansyah, Ferryansyah; Isa, Mohamad; Juhairina, Juhairina; Haryati, Haryati; Assagaf, Ali; Kusumawardhani, Erna
Jurnal Indonesia Sosial Teknologi Vol. 6 No. 3 (2025): Jurnal Indonesia Sosial Teknologi
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jist.v6i3.7050

Abstract

This research aims to investigate the impact of omega-3 supplementation on sputum conversion, body mass index (BMI), interleukin-6 (IL-6) levels, and lymphocyte-monocyte ratio (LMR) in patients with pulmonary tuberculosis (TB). Tuberculosis is a significant health problem in Indonesia, with high incidence and mortality rates. Omega-3 fatty acids are known to have anti-inflammatory effects and may enhance the immune response, potentially supporting tuberculosis (TB) therapy. The research methods included bacteriological examination of the sputum, measurement of BMI, IL-6 levels, and MLR in patients who received additional Omega-3 compared to the control group. The results are expected to provide an overview of the effectiveness of Omega-3 as a supportive therapy in treating TB, as well as its contribution to improving patients' nutritional status and immune response. This research is expected to serve as a reference for developing more effective and affordable tuberculosis therapies.
Pregnancy With Multidrug-Resistant Pulmonary Tuberculosis and Autoimmune Hemolytic Anemia Complicated by Intrauterine Growth Restriction - A Case Report Permata, Putri Indah; Aditya, Renny; Putri, Ruth Widhiati Raharjo; Isa, Mohamad; Kurniawan, Sigit Prasetia; Nurrasyidah, Ira
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.878

Abstract

AbstractIntroductionIntrauterine growth restriction (IUGR) is a major obstetric complication often caused by maternal infections and anemia. We present a case of IUGR in a pregnant woman caused by multidrug-resistant tuberculosis (MDR-TB) and autoimmune hemolytic anemia (AIHA).Case presentationA 37-year-old G5P2A2 woman with confirmed MDR-TB and AIHA was treated with levofloxacin, clofazimine, cycloserine, ethambutol, bedaquiline, and methylprednisolone. Fetal biometry showed estimated fetal weight below the 10th percentile, with a significantly declining growth curve thereafter. After administration of fetal lung maturation at 33 – 34 weeks, she underwent an elective cesarean section at 35 – 36 weeks. A female infant weighing 1,840g was delivered. The treatment for MDR-TB and AIHA in the mother was continued afterward.ConclusionPregnancies complicated by MDR-TB and AIHA require strict monitoring and individualized multidisciplinary treatment. Further research is needed to establish treatment strategies that improve maternal and fetal outcomes in similar cases.Keywords : Autoimmune hemolytic anemia; intrauterine growth restriction; multidrug resistance; pregnancy; tuberculosis. Kehamilan dengan Tuberkulosis Paru Resisten Obat Ganda dan Anemia Hemolitik Autoimun yang Diperberat oleh Pertumbuhan Janin Terhambat – Laporan Kasus AbstrakPendahuluanIUGR adalah komplikasi obstetrik yang dapat disebabkan infeksi dan anemia pada maternal. Pada kasus ini dipresentasikan kasus wanita hamil dengan IUGR yang disebabkan multidrug resistant TB (MDR-TB) dan autoimmune hemolytic anemia (AIHA).Ilustrasi kasusIbu hamil 37 tahun G5P2A2 datang dengan TB-MDR dan AIHA. Pasien menjalani terapi TB-MDR dengan levofloksasin, klofazimin, sikloserin, etambutol, dan bedaquiline, serta metilprednisolon untuk AIHA. Pada fetal biometri ditemukan estimated fetal weight (EFW) di bawah 10 persentil dengan kurva pertumbuhan janin menurun signifikan setelahnya. Setelah dilakukan induksi pematangan paru janin pada usia kehamilan 33 - 34 minggu,  operasi sesar elektif dilakukan pada usia kehamilan 35 – 36 minggu melahirkan bayi perempuan dengan berat janin 1840gram. Pengobatan TB-MDR dan AIHA pada ibu dilanjutkan setelahnya.KesimpulanKehamilan dengan TB dan AIHA memerlukan pemantauan ketat dan terapi multidisiplin yang terindividualisasi. Penelitian lebih lanjut diperlukan.Kata kunci : Hemolitik anemia autoimun; kehamilan; pertumbuhan janin terhambat; resisten obat; tuberkulosis.
Co-Authors Ali Assagaf Arganita, Fidya Rahmadhany Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diany, Holly Eko Suhartono Ferryansyah, Ferryansyah Harnoto, Yulia Octaviany Haryati Haryati Ika Kustiyah Oktaviyanti Ira Nurrasyidah Isa Ansori Jeffry Swingly Frans Sumarauw Juhairina, Juhairina Kurniawan, Sigit Prasetia Kusumawardhani, Erna Lenie Marlinae Liany Amelia Hendratta Madargerong, Vincentius Adrian Meitria Syahadatina Noor Mohammad Rudiansyah Muhamad Taufiqurrahman, Muhamad Nia Kania Noor, Meitria Syahdatina Nor, Muhamad Permata, Putri Indah Putri, Ruth Widhiati Raharjo Renny Aditya Riefani, Soraya Risnawati Risnawati Rosihan Adhani, Rosihan Sai'ah, Sai'ah Silvia Kristanti Tri Febriana Syafa’ah, Irmi Syam, Shaogi Syamsul Arifin