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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL SIPIL STATIK Majalah Kedokteran Bandung The Indonesian Journal of Occupational Safety and Health Indonesian Journal of Obstetrics & Gynecology Science Jurnal Respirasi (JR) Medica Hospitalia JOURNAL LA MEDIHEALTICO Indonesian Health Journal
Isa, Mohamad
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Pregnancy With Multidrug-Resistant Pulmonary Tuberculosis and Autoimmune Hemolytic Anemia Complicated by Intrauterine Growth Restriction - A Case Report Permata, Putri Indah; Aditya, Renny; Putri, Ruth Widhiati Raharjo; Isa, Mohamad; Kurniawan, Sigit Prasetia; Nurrasyidah, Ira
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.878

Abstract

AbstractIntroductionIntrauterine growth restriction (IUGR) is a major obstetric complication often caused by maternal infections and anemia. We present a case of IUGR in a pregnant woman caused by multidrug-resistant tuberculosis (MDR-TB) and autoimmune hemolytic anemia (AIHA).Case presentationA 37-year-old G5P2A2 woman with confirmed MDR-TB and AIHA was treated with levofloxacin, clofazimine, cycloserine, ethambutol, bedaquiline, and methylprednisolone. Fetal biometry showed estimated fetal weight below the 10th percentile, with a significantly declining growth curve thereafter. After administration of fetal lung maturation at 33 – 34 weeks, she underwent an elective cesarean section at 35 – 36 weeks. A female infant weighing 1,840g was delivered. The treatment for MDR-TB and AIHA in the mother was continued afterward.ConclusionPregnancies complicated by MDR-TB and AIHA require strict monitoring and individualized multidisciplinary treatment. Further research is needed to establish treatment strategies that improve maternal and fetal outcomes in similar cases.Keywords : Autoimmune hemolytic anemia; intrauterine growth restriction; multidrug resistance; pregnancy; tuberculosis. Kehamilan dengan Tuberkulosis Paru Resisten Obat Ganda dan Anemia Hemolitik Autoimun yang Diperberat oleh Pertumbuhan Janin Terhambat – Laporan Kasus AbstrakPendahuluanIUGR adalah komplikasi obstetrik yang dapat disebabkan infeksi dan anemia pada maternal. Pada kasus ini dipresentasikan kasus wanita hamil dengan IUGR yang disebabkan multidrug resistant TB (MDR-TB) dan autoimmune hemolytic anemia (AIHA).Ilustrasi kasusIbu hamil 37 tahun G5P2A2 datang dengan TB-MDR dan AIHA. Pasien menjalani terapi TB-MDR dengan levofloksasin, klofazimin, sikloserin, etambutol, dan bedaquiline, serta metilprednisolon untuk AIHA. Pada fetal biometri ditemukan estimated fetal weight (EFW) di bawah 10 persentil dengan kurva pertumbuhan janin menurun signifikan setelahnya. Setelah dilakukan induksi pematangan paru janin pada usia kehamilan 33 - 34 minggu,  operasi sesar elektif dilakukan pada usia kehamilan 35 – 36 minggu melahirkan bayi perempuan dengan berat janin 1840gram. Pengobatan TB-MDR dan AIHA pada ibu dilanjutkan setelahnya.KesimpulanKehamilan dengan TB dan AIHA memerlukan pemantauan ketat dan terapi multidisiplin yang terindividualisasi. Penelitian lebih lanjut diperlukan.Kata kunci : Hemolitik anemia autoimun; kehamilan; pertumbuhan janin terhambat; resisten obat; tuberkulosis.
Adjunctive Effects of Bajakah Wood (Spatholobus littoralis Hassk.) on Cholesterol and Triglyceride in EGFR Wild Type Lung Adenocarcinoma Patients Nikmah, Elok Hikmatun; Kusumawardhani, Erna; Suhartono, Eko; Nurrasyidah, Ira; Ansori, Isa; Assagaf, Ali; Isa, Mohamad; Haryati, Haryati; Oktaviyanti, Ika Kustiyah
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.13-19

Abstract

Introduction: Lung cancer is the leading cause of cancer mortality, influenced by uncontrolled cell proliferation, migration, metastasis, and mutations. The imbalance of high-density lipoprotein (HDL) and triglycerides (TG) has an important role. Spatholobus littoralis Hassk., or Bajakah wood, has antioxidant effects due to dihydrokaempferol, which lowers cholesterol levels and increases HDL. This additional therapy is expected to have a positive impact, supporting treatment for patients with wild-type lung adenocarcinoma. Methods: This was a single-blind clinical trial conducted at Ulin General Hospital, Banjarmasin, Indonesia, in patients with epidermal growth factor receptor (EGFR)-wild-type lung adenocarcinoma at a minimum stage IIIA, from June 2023 to July 2024. The participants were divided into two groups: the treatment group (adjunctive Bajakah wood 1,000 mg) and the control group. Cholesterol, low-density lipoprotein (LDL), HDL, and TG were measured twice before starting chemotherapy and after the third chemotherapy cycle. The resulting data were analyzed using the independent t-test and the Mann-Whitney test through the Statistical Package for the Social Sciences (SPSS) version 26. Results: For the 21 total patients, the cholesterol and TG levels in the treatment group before and after the third chemotherapy were 200.55±42.65 to 184.45±24.20 and 131.27±44.76 to 112.73±34.74, respectively. The control group results were 185.10±51.98 to 168.30±32.89 and 118.30±51.30 to 104.10±12.53, respectively. The comparison of changes between the two groups was not significant (p-value > 0.005). Conclusion: Cholesterol and TG levels were reduced, but there were no statistically significant differences after the addition of therapy with Bajakah wood.
Analysis of Factors Associated with the Utilization of the Kotabaru Community Health Center in the Era of Primary Care Integration Pura, Satria Tanjung; Arifin, Syamsul; Isa, Mohamad; Istiqomah, Ermina; Silapurna, Endah Labati
Journal La Medihealtico Vol. 7 No. 2 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i2.3225

Abstract

Health constitutes a fundamental investment in both human well-being and economic development. Strengthening the primary healthcare system through the Primary Care Integration (PCI) program has therefore emerged as a national priority aimed at delivering comprehensive, accessible, and affordable services. This study seeks to examine the factors associated with the utilization of the Kotabaru Community Health Center (Puskesmas) in the PCI era, with particular emphasis on the relationships among access to healthcare services, health status, and educational attainment in shaping community health-seeking behavior. Employing a literature review approach based on scientific publications from the past five years, the findings indicate that access to healthcare services in the PCI era extends beyond mere geographical proximity, encompassing affordability, administrative simplicity, and the integration of electronic medical records. These dimensions collectively influence the frequency of community visits. Subjective health status emerges as the most dominant determinant, as the PCI system has effectively shifted service utilization patterns from reactive, curative practices toward continuous, life-cycle-based health risk monitoring. Educational level functions as a critical predisposing factor, shaping health literacy and the cognitive capacity of individuals to navigate the newly implemented cluster-based service system. The utilization of the Kotabaru Community Health Center within the PCI framework is therefore significantly shaped by the interplay between accessibility, risk-based health awareness, and the level of community health literacy in making informed medical decisions.
Co-Authors Ali Assagaf Arganita, Fidya Rahmadhany Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diany, Holly Eko Suhartono Ermina Istiqomah, Ermina Ferryansyah, Ferryansyah Harnoto, Yulia Octaviany Haryati Haryati Ika Kustiyah Oktaviyanti Ira Nurrasyidah Isa Ansori Jeffry Swingly Frans Sumarauw Juhairina, Juhairina Kurniawan, Sigit Prasetia Kusumawardhani, Erna Liany Amelia Hendratta Madargerong, Vincentius Adrian Meitria Syahadatina Noor Mohammad Rudiansyah Muhamad Taufiqurrahman, Muhamad Nikmah, Elok Hikmatun Nor, Muhamad Permata, Putri Indah Pura, Satria Tanjung Putri, Ruth Widhiati Raharjo Renny Aditya Riefani, Soraya Silapurna, Endah Labati Syafa’ah, Irmi Syam, Shaogi Syamsul Arifin