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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL SIPIL STATIK Majalah Kedokteran Bandung The Indonesian Journal of Occupational Safety and Health Jurnal Respirasi (JR) Medica Hospitalia JOURNAL LA MEDIHEALTICO Indonesian Health Journal
Isa, Mohamad
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Effect of Vitamin D Supplementation on Sputum Conversion, Erythrocyte Sedimentation Rate and Neutrophil-Lymphocyte Ratio in Pulmonary Tuberculosis Patients – A Randomized Controlled Trial Sonjaya, Muchamad Regi; Isa, Mohamad; Yasmina, Alfi; Ansori, Isa; Nurrasyidah, Ira; Kusumawardhani , Erna
Medica Hospitalia : Journal of Clinical Medicine Vol. 13 No. 1 (2026): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v13i1.1290

Abstract

BACKGROUND : The health issue of pulmonary tuberculosis (TB) remains a concern in Indonesia. Vitamin D supplementation is one way to manage tuberculosis, which is a crucial case control metric. It is anticipated that vitamin D's anti-inflammatory properties will lower erythrocyte sedimentation rate (ESR) and inflammatory indicators, hence speeding up sputum conversion. AIMS :  To analyze the effect of vitamin D supplementation on sputum conversion, ESR and neutrophil-lymphocyte ratio (NLR) among pulmonary tuberculosis patients METHOD : Patients with pulmonary tuberculosis who were treated as outpatients at Ulin Banjarmasin Hospital and Pekauman Health Centre between May-July 2024 and who satisfied the study's inclusion requirements were included in the randomised controlled trial. Subjects were randomly divided into 2 groups (19 subjects in the treatment group and 19 subjects in the control group) using random selection with sealed envelopes. The treatment group received antituberculosis drugs (ATD) and vitamin D supplementation at a dose of 10,000 IU/day for eight weeks after the initiation of TB therapy, while the control group received ATD and a placebo. ESR and NLR examinations were performed prior to treatment, in weeks 4 and 8, whereas sputum evaluations were conducted at weeks 2, 4, 6, and 8. Statistical Product and Service Solutions (SPSS) was used for data analysis. P-value <0,05 was significant statistically. RESULT :  The study subjects were 38 pulmonary TB patients, most of whom were women (65.0%) with an average age of 50.42 ± 18.61 years. Overall, during the 8 weeks of intervention, there was a significant effect of vitamin D supplementation on sputum conversion (OR = 1.61, 95%CI = 0.030-0.931, p = 0.037). There was no significant effect of vitamin D supplementation on NLR (regression coefficient = 0.549, 95%CI = -1.769-2.858, p = 0.641) and ESR (regression coefficient = -5.529, 95%CI = -20.658-9.599, p = 0.474). CONCLUSION : Vitamin D supplementation significantly affects sputum conversion. In the 8th week, almost all subjects who initially had positive BTA became negative. But does not significantly affect ESR and NLR.
Co-Authors Alfi Yasmina Ali Assagaf Arganita, Fidya Rahmadhany Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diany, Holly Eko Suhartono Ferryansyah, Ferryansyah Harnoto, Yulia Octaviany Haryati Haryati Ika Kustiyah Oktaviyanti Ira Nurrasyidah Isa Ansori Jeffry Swingly Frans Sumarauw Juhairina, Juhairina Kusumawardhani , Erna Kusumawardhani, Erna Liany Amelia Hendratta Madargerong, Vincentius Adrian Meitria Syahadatina Noor Mohammad Rudiansyah Muhamad Taufiqurrahman, Muhamad Nor, Muhamad Riefani, Soraya Sonjaya, Muchamad Regi Syafa’ah, Irmi Syam, Shaogi