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All Journal Jurnal NERS MNJ (Malang Neurology Journal) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology AKSONA Asian Journal of Health Research Folia Medica Indonesiana
Machin, Abdulloh
3Departement Of Neuorology, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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A Study on Knowledge Towards Brain Death among Residents in Indonesia Fauzi, Asra Al; Waloejo, Christrijogo Sumartono; Machin, Abdulloh; Shodiq, Muhammad Ja'far
Folia Medica Indonesiana Vol. 56, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

This research was conducted to evaluate the knowledge and diagnosis of brain death among resident in Indonesia. This study used an observational analytic study with a cross-sectional study design using a questionnaire. The research subjects consisted of 132 level 2 (after 2 years of residency) and level 3 (after 4 years of residency) residents, the total sampling for which was taken from the departments of Neurosurgery, Anesthesiology, and Neurology at Dr. Soetomo Academic Medical Center Hospital, Surabaya, Indonesia. Data were taken from November 2018 to January 2019. A total of 132 residents of Neurosurgery, Neurology, and Anesthesiology participated in this study. From the series of studies, residents' knowledge of the concept of brain death was in the sufficient category (41.7%), residents' knowledge of the technical diagnosis of brain death was in the good category (40.2%), residents' knowledge of brain death examination was in the less category (43.2%), and finally, it was found that the resident's knowledge of brain death was in a good category (35.6%). There were also significant differences in knowledge of brain death between Neurosurgery, Neurology, and Anesthesiologist Resident (P <0.001) and knowledge of brain death between level 2 and level 3 residents (P=0.032). In general, the Indonesian resident doctors' knowledge of brain death is adequate, but knowledge of the clinical examination of brain death is still lacking. Further research must be carried out to promote knowledge of brain death in residents as well as professional doctors/specialists, so that the number of organ transplants, especially in Indonesia, will increase.
Effects of Minocycline as a Neuroprotective Agent for Stroke on Mmp-9 Levels, Functional Outcome, and Mortality Nisa, Ayu Imamatun; Damayanti, Arlia Ayu; Nagasastra, Jeffri; Machin, Abdulloh; Qorib, Mohammad Fathul; , Retnaningsih; Hamidi, Baarid Luqman
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Highlights: 1. As minocycline plays an important role in stroke microglia activation and iron chelation, it is important to further analyze its effects on stroke treatment. 2. This meta-analysis revealed a significant effect of minocycline therapy, as evidenced by improved functional outcomes and inhibited matrix metalloproteinase-9 (MMP-9) activity. Abstract Stroke is the most common and devastating cerebrovascular disease. Many neuroprotective medications, such as scale and minocycline, have been developed to help the nervous system recover or regenerate after a stroke. However, it remains unclear whether minocycline provides a beneficial effect on stroke. We conducted this systematic review and meta-analysis to synthesize the effects of minocycline in stroke treatment. The systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), with registration number CRD42023485168. The quality of the eligible studies was assessed using the Jadad scale. This systematic review included three ischemic stroke trials, seven intracerebral hemorrhage trials, and one study on acute stroke. There was a significant association between minocycline intervention and stroke severity according to the National Institute of Health Stroke Scale (NIHSS), with a pooled mean difference (MD) of -1.92, a 95% confidence interval (CI) of -3.39 to -0.45, and a value of p=0.01. In the subgroup of ischemic stroke, the modified Rankin Scale (mRS) was significantly lower in the minocycline treatment group compared to the control group (MD=-0.89, 95% CI=-1.54 to -0.25, p=0.007). Additionally, matrix metalloproteinase-9 (MMP-9) levels for the intracerebral hemorrhage subgroup were significantly lower in the minocycline treatment group compared to the control group (MD=-19.93, 95% CI=-36.9 to -2.96, p=0.02). The analysis revealed that minocycline intervention was not significantly associated with hematoma volume, mortality, or stroke recurrence. Our findings indicate that minocycline supplementation is a potential intervention strategy for treating ischemic stroke and intracerebral hemorrhage.
The Profile of Glioma Patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, 2018-2022 Fauzan, Rizki Ahmad; Ardiansyah, Djohan; Fauziah, Dyah; Haryono, Yudha
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 1 (2026): JANUARY 2026 (IN-PROGRESS ISSUE)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I12026.76-83

Abstract

Highlights: This study provides updated insights into glioma profiles in Indonesia, focusing on a large patient cohort from a major referral hospital. Most gliomas were large tumors located in the cerebrum, with midline shift and heterogeneous contrast enhancement being the primary radiological features observed. Glioblastoma was the predominant type, yet no significant correlation was found between radiological features and histopathological grading, highlighting a potential gap in predictive diagnostics.   Abstract Introduction: Glioma is a common brain tumor that significantly impacts patients’ quality of life by affecting motor, sensory, cognitive, and emotional functions. This study aimed to provide a holistic and comprehensive analysis of glioma characteristics by examining clinical, radiological, and histopathological data from patients treated at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, over five years from 2018 to 2022. Methods: This retrospective cross-sectional study analyzed records of 204 glioma patients from Dr. Soetomo General Academic Hospital, Surabaya, Indonesia (2018-2022). Data included demographics, clinical symptoms, tumor size and location, radiological features, and histopathological grading. Statistical analysis used Fisher’s exact test (p<0.05), and data were processed using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 23.0. Results: The most affected age group was 30-39 years old (19.1%), and it was dominated by male patients (59.8%). Headache was the most common presenting symptom (33.8%). Tumors were predominantly located in the cerebrum (75.9%), and most lesions measured >4 cm (76.9%). Midline shift was observed in 69.1% of cases. Contrast enhancement was described as heterogeneous in 35.8% and homogeneous in 1.5%, while 62.7% of cases lacked enhancement data. Histopathologically, the World Health Organization (WHO) grade 4 gliomas (glioblastoma) were the most frequent (39.22%). No significant association was found between radiological features (midline shift or contrast enhancement) and histopathological grading (p>0.05). Conclusion: Gliomas were predominantly found in male patients and were most common among individuals in their younger adult years. The primary clinical symptom was headache, with tumors frequently located in the cerebrum and typically presenting as large masses. Histopathologically, glioblastoma represented the most frequent and aggressive type identified.
Inhibition of Neurogenesis and Induction of Glial Scar Formation by Neuroinflammation Following Ischemic Stroke: Evaluation of BDNF, GFAP, HMGB1 and TNF-α Expressions Aris Widayati; Fedik Abdul Rantam; Abdulloh Machin; Wibi Riawan
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3439

Abstract

BACKGROUND: Ischemic stroke remains as a major health problem and one important process in Ischemic Stroke is neuroinflammation which has a principal role to maintain the balance of neurogenesis and neurodegeneration process in the brain. Neuroinflammation can lead to glial scar and inhibit neurogenesis processes which is needed for recovery neuron function. This study was conducted to observe the role of high mobility group box 1 (HMGB1) and tumor necrosis factor-α (TNF-α) as neuroinflammation markers to glial fibrillary acidic protein (GFAP) as glial scar marker and to brain-derived neurotrophic factor (BDNF) as neurogenesis marker in brain tissue following ischemic stroke.METHODS: Fifteen male Wistar rats were randomized to three groups; sham group, rats receiving occlusion and terminated 180 minutes later (group A), and rats receiving occlusion and terminated after 7 days (group B). Expressions of BDNF and BDNF mRNA were examined using immunohistochemistry (IHC) and Reverse Transcription Polymerase Chain Reaction (RT-PCR), respectively. While GFAP, HMGB1, TNF-α were assessed using IHC.RESULTS: Expression of BDNF was found lower in group A and group B than in sham group (5.20±1.924, 5.00±1.581, and 7.80±1.304, respectively; p=0.032). Expression of BNDF mRNA was found lower in group A and B than in sham group as well. While expression of GFAP was found higher in group A and B than in sham group (9.60±1.517, 11.40±2.074, and 5.20±1.48, respectively; p=0.000). Higher level of HMGB1 and TNF-α expressions were also found to in group A and group B than in sham group (9.3±1.528, 11.67±1.528, and 2.00±1.000, respectively; p=0.000 for HMGB1 and 6.33±1.155, 9.33±1.528, and 3.00±1.000, respectively; p=0.002 for TNF-α).CONCLUSION: The presence of low BDNF levels and high levels of GFAP, HMGB1 and TNF-α markers, possibly reflects inhibition of the neurogenesis process by neuroinflammation, and induced glial scar formation in ischemic stroke conditions after than 180 hours until 7 days. KEYWORDS: ischemic stroke, BDNF, GFAP, TNF-α, HMGB1
Co-Authors , Retnaningsih Afif Nurul Hidayati, Afif Nurul Alia, Safia Ardiansyah, Djohan Aris Widayati Arlia Ayu Damayanti Ayu Imamatun Nisa Baarid Luqman Hamidi Basuki, Mudjiani Christrijogo Soemartono Waloejo Damayanti, Arlia Ayu Dedy Kurniawan Dewi Sekarsari Didik Hasmono Dienanta, Savira DYAH FAUZIAH, DYAH Edfina Rahmarini Fahmi Achmad Faisal Fahmi, Achmad Farmindo Hartono Farmindo Hartono Fatihuddin, M Fata Fauzan, Rizki Ahmad Fauzi, Asra Al Fedik Abdul Rantam Firdha, Azizah Amimathul Hamidi, Baarid Luqman Hanifah, Anny Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Husni, Nadya Imami, Nabilah Hasna Jeffri Nagasastra Jenar Harumi Jovian Philip Swatan Kim, Beom Joon Meo, Maria Lettisia Mohammad Fathul Qorib Muhammad Hamdan Muhammad Hamdan Muhammad Ja'far Shodiq Muhammad Ja'far Shodiq Nabilah Hasna Imami Nadiva, Shafa Karin Nagasastra, Jeffri Nisa, Ayu Imamatun Nugraha, Priya Paulus Sugianto Paulus Sugianto, Paulus Pearl Dhodik Wirasman Prastiya I. Gunawan Priya Nugraha Qorib, Mohammad Fathul Rahmarini, Edfina Retnaningsih Safia Alia Sensusiati, Anggraini Dwi Setjaputra, Vina Lidya Shodiq, Jakfar Shodiq, Muhammad Ja'far Siti Khaerunnisa Siti Khaerunnisa SOETJIPTO . Steven Christian Susianto Sudibyo, Devi Ariani Sugondo, Alexander Tikara Suharjanti, Isti Suprapto, Djoko Agus Susianto, Steven Christian Swatan, Jovian Philip Talaway, Athalia Anastasia Turchan, Agus Vina Lidya Setjaputra Viskasari P. Kalanjati Wibi Riawan