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All Journal Jurnal Kesehatan Masyarakat SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Ilmu Kesehatan Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Jurnal Sains dan Kesehatan
Bariroh, Tahyatul
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Kidney and Liver Disorders Due to Microplastic Exposure: Chronic in Vivo Study in Male White Rats Hidayat Ramli Inaku, Awaluddin; Hadiyanto, Hadiyanto; Rya Abdurachim, Henna; Bariroh, Tahyatul; Matin, Hashfi Hawali Abdul
Jurnal Kesehatan Masyarakat Vol 20, No 1 (2024)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i1.48781

Abstract

The increasing use of plastics has caused severe environmental pollution, especially by microplastics with plastic particles of 5 mm or less in diameter. These particles are formed by environmental factors such as weathering and ultraviolet irradiation, thus making environmental pollution worse. This environmental pollution increases human exposure to microplastics through the food chain. Many studies have now reported the adverse effects of exposure to microplastics in food and aquatic organisms. However, relatively few studies have used white rats. the entry of microplastics into white rats can affect two important organs, namely the liver and kidneys, in this study we conducted an in-vivo experimental test of male white rats by giving acute and chronic exposure to pure microplastic PE (polyethylene) for 28 days respectively. repeated with an adjusted dose. Toxicological effects were comprehensively evaluated in white rats by looking at clinical signs, body weight, and kidney and liver activity through examination of blood parameters creatinine, SGOT, SGPT, and further kidney and liver abnormalities were analyzed through histopathological tests. Based on the results of the experiments conducted, it was found that PE-type microplastics had a significant impact on changes in body weight, increased functional activity of the kidneys and livers of white rats, and chronic histopathological abnormalities in male white rats, so it is hoped that this study can clarify that PE type microplastics greatly affect organs for those who consume it in the long term.
Aktivitas Antiinflamasi Ekstrak Etanol 96% Batang Apel Beludru (Diospyros Blancoi A.Dc.) terhadap Jumlah Limfosit, Monosit, dan Neutrofil pada Tikus Putih Jantan Galur Wistar yang Diinduksi Karagenan: Antiinflammatory Activity of 96% Ethanol Extract of Apel Beludru Stems (Diospyros Blancoi A.Dc.) to the Number of Lymphocytes, Monocytes, and Neutrophils in Carrageenan-induced Wistar Rats Rusdi, Numlil Khaira; Bariroh, Tahyatul; Isra, Rafiq Al; Rahmat, Amalia; Fujianti, Fujianti; Prastiwi, Rini; Sunaryo, Hadi; Hariyanti, Hariyanti
Jurnal Sains dan Kesehatan Vol. 7 No. 4 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i4.2437

Abstract

The potential of velvet apple plants (Diospyros blancoi A. DC) is large, further research is still needed to determine the anti-inflammatory effect on velvet apple stems (Diospyros blancoi A. DC). The purpose of this study was to determine the anti-inflammatory activity of 96% ethanol extract of velvet apple stems against the reduction of lymphocytes, monocytes, and neutrophils. A total of 25 male white rats of wistar strain were divided into 5 groups, namely the negative control group, the positive control group (Na diclofenac), the group given 96% ethanol extract of velvet apple stems with several doses, namely doses of 125 mg / kg BB, 250 mg / kg BB and 500 mg / kg BB. All test animals were made air bags on days 1 and 3, then on day 6 test preparations and carrageenan induction were carried out. On the 7th day blood was taken through the retroorbital sinuses, then the calculation of lymphocytes, monocytes, neutrophils using a microscope was carried out and the data were analyzed using One-way Anova and Kruskal Wallis test. The results showed a higher percentage of negative lymphocytes, monocytes, and neutrophils compared to the treatment group. In the treatment group, the dose of 500mg/kgBB had a significant decrease in the percentage of lymphocytes, monocytes, neutrophils compared to the negative group (p<0.05) and was not significantly different from the positive control group. Ethanol extract 96% velvet apple stem dose 500 mg/kg body weight has the greatest anti-inflammatory activity against decreasing the percentage of lymphocytes, monocytes, and neutrophils. Keywords:          anti-inflammatory, apel beludru, Diospyros blancoi A. DC, lymphosite, monosite, neutrophil   Abstrak Potensi tanaman apel beludru (Diospyros blancoi A. DC) yang besar, sehingga perlu penelitian lebih lanjut untuk mengetahui efek antiinflamasi pada batang apel beludru (Diospyros blancoi A. DC). Tujuan penelitian ini untuk mengetahui aktivitas antiinflamasi ekstrak etanol 96% batang apel beludru terhadap penurunan limfosit, monosit, dan neutrofil. Sebanyak 25 ekor Tikus putih jantan galur wistar dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif, kelompok kontrol positif (Na diklofenak), kelompok yang diberi ekstrak etanol 96% batang apel beludru dengan beberapa dosis yaitu dosis 125 mg/kgBB, 250 mg/kgBB dan 500 mg/kgBB. Semua hewan uji dibuat kantung udara pada hari ke-1 dan ke-3, lalu pada hari ke-6 dilakukan pemberian sediaan uji dan induksi karagenan. Pada hari ke-7 diambil darah melalui sinus retroorbitalis, kemudian dilakukan perhitungan sel limfosit, monosit, dan neutrofil menggunakan mikroskop. Data dianalisis menggunakan One-way Anova dan uji Kruskal Wallis. Hasil penelitian menunjukkan jumlah limfosit, monosit, dan neutrophil kelompok kontrol negatif lebih tinggi dibandingkan dengan kelompok perlakuan. Pada kelompok perlakuan, pemberian ekstrak dosis 500mg/kgBB mengalami penurunan persentase jumlah limfosit, monosit, neutrofil terbesar secara signifikan dibandingkan kelompok negatif (p<0,05) dan tidak berbeda bermakna dengan kelompok kontrol positif. Ekstrak etanol 96% batang apel beludru dosis 500 mg/kg BB memiliki aktivitas antiinflamasi terbesar terhadap penurunan persentase jumah limfosit, monosit, dan neutrophil. Kata Kunci:         antiinflamasi, apel beludru (Diospyros blancoi A. DC), limfosit, monosit, neutrophil
Inovasi pengharum ruangan sustainable: pelatihan lilin aromaterapi dan soy wax sachet di Rusunawa Rorotan Siska, Siska; Bariroh, Tahyatul; Fatmawati, Sofia; Rindita, Rindita; Riyanti, Hurip Budi; Yati, Kori
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 5 (2025): September
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i5.30886

Abstract

Abstrak Aromaterapi merupakan terapi pelengkap yang memanfaatkan minyak atsiri dari tanaman beraroma yang mudah menguap dan memberikan efek relaksasi serta manfaat kesehatan. Rusunawa Rorotan memiliki unit hunian terbatas sekitar 30 m², sehingga warga memerlukan kegiatan yang dapat menghilangkan kejenuhan sekaligus meningkatkan keterampilan. Tujuan utama kegiatan ini meliputi peningkatan pemahaman, penerapan gaya hiudp berkelanjutan, pengembangan keterampilan kreatif, penciptaan peluang ekonomi mikro, serta peningkatan kesejahteraan psikologis melalui stimulus olfaktori dan visual. Kegiatan meliputi registrasi, penyampaian materi, praktik pembuatan produk, serta evaluasi melalui pre dan post test. Hasil evaluasi menunjukkan peningkatan signifikan dalam pengetahuan peserta, terlihat dari nilai rata-rata pre-test dan post-test yang berturut-turut mencapai 65,8 dan 82,57, serta respons positif peserta terhadap produk yang mudah dibuat (100%), bentuk produk menarik (74%), dan  memiliki aroma wangi (67%) yang berdampak pada peningkatan mood.  Kesimpulan dari kegiatan ini, secara keseluruhan pelatihan aromaterapi tidak hanya mengurangi kejenuhan di lingkungan padat, tetapi juga mendorong transformasi kearifan lokal menjadi solusi kreatif dna berkelanjutan secara ekonomi bagi warga Rusunawa Rorotan.    Kata kunci: aromaterapi; dekoratif; essential oil; sustainable. Abstract Aromatherapy is a complementary therapy that utilizes essential oils from aromatic plants, which are volatile and provide relaxation and helath benefits. Rusunawa Rorotan has limited living units of approximately and health benefits. Rusunawa Rorotan has limited living units of approximately 30 m², residents face challenges related to psychological well-being and limited opportunities for skill development. This community-based training program aimed to enhance participants’ understanding of sustainable lifestyles, promote the practical application of aromatherapy, foster creative skills, generate microeconomic opportunities, and improve psychological well-being through olfactory and visual stimuli. The program consisted of registration, theoretical sessions, hands-on product-making workshops, and evaluation via pre- and post-tests. Results indicated a significant improvement in participants’ knowledge, with average pre-test and post-test scores rising from 65.8 to 82.57, respectively. Furthermore, participant feedback revealed that 100% found the products easy to make, 74% appreciated the attractive design, and 67% noted pleasant aromas that positively influenced mood. In conclusion, the aromatherapy training effectively alleviated mental fatigue in a densely populated environment and successfully transformed local traditional knowledge into innovative, sustainable, and economically viable solutions for the community of Rusunawa Rorotan. Keywords: aromatherahy; decorative; essential oil; sustainable.
Effect of Extraction Time And GC-MS Analysis of Fresh and Dry Frangipani Flower (Plumeria rubra L.) using Ultrasonic Assisted Extraction Fatmawati, Sofia; Astari, Zhafirah; Bariroh, Tahyatul
Jurnal Ilmu Kesehatan Vol 11 No 1 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i1.3609

Abstract

Frangipani flower (Plumeria rubra) is one of the plants that has a role in perfume and aromatherapy technology which have essential compounds that are the main cause of fragrant smelling flowers. Optimization of extract production needs to be done to obtain a high content of active substances. Ultrasonic assisted extraction is a widely used method for extraction of active compounds in certain products due to shorter operating times. This study aims to determine the effect of variations in extraction time 30,45,60 minutes from fresh and dry frangipani flowers using ultrasonic methods on extract yield values ​​and chemical compositions using the GC-MS method. The results showed that the 60 minutes extraction produced the highest yield values, namely 5.11% for fresh yellow frangipani flower extract and 3.43% for dried yellow frangipani flower. The results of the chemical content study using GC-MS showed that the constituent compounds of fresh yellow frangipani flower essential oil consisted of fatty acids (6.59%), alkanoic acids (4.43%), triterpenoids (1.42%) and floral compound groups. Dry frangipani consists of alkanes (7.47%), alcohol (13.31%), fatty acids (1.00%).
Pelatihan Pembuatan Sabun Kertas Untuk Meningkatkan Kesadaran Sanitasi Di Pca Bukit Duri, Jakarta Selatan Fatmawati, Sofia; Rindita, Rindita; Bariroh, Tahyatul
Jurnal Dimas Vol 5 No 2 (2023): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/dimas.v5i2.75

Abstract

Lingkungan yang padat cenderung memiliki sanitasi lingkungan yang kurang baik, dikarenakan terbatasnya fasilitas, kurangnya pengetahuan serta kesadaran masyarakat sekitar terhadap perilaku hidup bersih dan sehat. Sanitasi lingkungan yang kurang baik dapat menyebabkan timbulnya berbagai penyakit, salah satunya adalah penyakit yang disebabkan infeksi mikroorganisme yang hidup di lingkungan dengan sanitasi yang kurang baik, seperti diare, tipes, atau iritasi pada kulit. Tangan merupakan organ yang banyak tercemar dan banyak digunakan untuk melakukan aktivitas sehari-hari seperti untuk makan, mengambil sesuatu, berjabat tangan, dan menyentuh benda-benda yang mudah terkontaminasi mikroorganisme seperti handphone, laptop, atau fasilitas umum lainnya. Mitra yang kami ajak kolaborasi terhadap kegiatan ini adalah Pengurus Cabang Aisyiyah (PCA) Bukit Duri, Jakarta Selatan. PCA ini terletak di lingkungan yang padat penduduk dan terbilang dekat dengan wilayah yang sanitasinya kurang baik karena terdapat kali/saluran air yang berbau, dekat dengan pangkalan angkutan umum yang masih banyak sampah dan berbau. Salah satu kegiatannya adalah menyampaikan tentang pentingnya sanitasi lingkungan yang baik, kesadaran cuci tangan pakai sabun (CTPS), salah satunya menggunakan sabun kertas yang akan kami buat agar lebih menarik, praktis, bisa dibawa kemana-mana, mudah disimpan sehingga tidak segan mencuci tangan dengan sabun. Mitra juga mengatakan belum ada yang melakukan kegiatan yang serupa sebelumnya di wilayah mereka. Kegiatan ini didukung adanya pre-test dan post-test yang menunjukkan hasil post-test lebih tinggi di semua soal yang diberikan dibandingkan dengan hasil pre-test. Kegiatan ini telah dipublikasikan melalui media massa online yaitu pada situs kabar pendidikan dan video pelaksaanaan yang sudah diunggah dalam kanal youtube.
Co-Authors Astari, Zhafirah Fatmawati, Sofia Fujianti, Fujianti Hadi Sunaryo Hadiyanto Hadiyanto Hariyanti Hariyanti Hidayat Ramli Inaku, Awaluddin Isra, Rafiq Al Kori Yati Matin, Hashfi Hawali Abdul Numlil Khaira Rusdi, Numlil Khaira Rahmat, Amalia Rindita, Rindita Rini Prastiwi Riyanti, Hurip Budi Rya Abdurachim, Henna Siska Siska