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All Journal Jurnal Biotek Medisiana Indonesia Medical Journal of Indonesia The Indonesian Biomedical Journal Majalah Patologi Indonesia Jurnal Biomedika dan Kesehatan Majalah Sainstekes Jurnal Health Sains Muhammadiyah Journal of Geriatric eJournal Kedokteran Indonesia
Jusman, Sri Widia Azraki
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : eJournal Kedokteran Indonesia

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Mitochondrial Adaptations of Obese Adult Rat Visceral Adipocytes which Differ in Nutritional Status during Childhood Lailan Safina Nasution; Ahmad Aulia; Sri Widia A. Jusman; Mohamad Sadikin
eJournal Kedokteran Indonesia Vol 9, No. 3 - Desember 2021
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.296 KB) | DOI: 10.23886/ejki.9.48.197-202

Abstract

Mitochondria are highly dynamic organelles that can adapt to different environmental stimuli. This study aims to analyze differences in the function and biogenesis of mitochondria and anaerobic glycolysis activity between obese adult rats that were undernourished in childhood (LCD28) and those which were normal (SD28) or already fat (HFD28). Sprague-dawley rats were assigned groups and given diet treatments from December 2017 until August 2018 in the Laboratory Animal Management Unit, Faculty of Veterinary Medicine, Bogor Agricultural Institute. To observe mitochondrial function and biogenesis, MnSOD activity and PGC1α levels were analyzed using ELISA. To investigate the existence of anaerobic glycolysis, LDH activity was analyzed using a spectrophotometry method. The results showed that MnSOD activity and PGC1α levels of LCD28 increased compared to the other groups, signifying higher mitochondrial function and biogenesis. Meanwhile, no significant difference in LDH activity was found, signifying similar levels of anaerobic glycolysis.
Co-Authors Abdul Halim Agus Setiyono Ahmad Aulia Andriani Andriani Angelina Stevany Regina Masengi Ani Retno Prijanti Desdiani Dewi Sukmawati Ernie Purwaningsih Fanny Septiani Farhan Frans Ferdinal H, Novi Silvia Heri Wibowo Iris Rengganis Lailan Safina Nasution Lio, Tiara Mayang Pratiwi Mohamad Sadikin Mohamad Saekhu Mohammad Sadikin Ninik Mudjihartini Nurhadi Ibrahim Nurjati Chairani Siregar Putri C. Eyanoer Retno Kuntarti Samsuridjal Djauzi Saptuti Chunaeni, Saptuti Sarsanti, Pungguri Ayu Nega Satriotomo, Irawan Sri Sukmaniah Suradi Wardaya Wardaya Wawaimuli Arozal Wawan Mulyawan Wawan Mulyawan Werdhasari, Asri Wido Sari Nawangsih, Idah Yastani, Deasyka