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All Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal SEPA (Social Economic and Agribusiness Journal) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JRST (Jurnal Riset Sains dan Teknologi) Journal of Pharmacopolium JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) DedikasiMU: Journal of Community Service JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Indonesian Journal of Medical and Pharmaceutical Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Pharmacon: Jurnal Farmasi Indonesia Journal of Pharmascience
Ika Yuni Astuti
Universitas Muhammadiyah Purwokerto
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Efektivitas Jamu Saintifik terhadap Kadar Gula Darah Sewaktu dan HbA1c pada Pasien Diabetes Melitus tipe 2 di Klinik Saintifikasi Jamu Kabupaten Tegal Priadiatna, Aziz; Astuti, Ika Yuni; Wahyuningrum, Retno
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 3 (2021): J Sains Farm Klin 8(3), Desember 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.3.264-270.2021

Abstract

Diabetes melitus (DM) adalah penyakit metabolik yang ditandai dengan peningkatan kadar glukosa darah. Selain pengobatan menggunakan obat-obat antidiabetik, masyarakat banyak yang menggunakan bahan alam, khususnya tanaman untuk mengobati penyakit DM. Penelitian ini bertujuan untuk membandingkan kadar gula darah sewaktu (GDS) dan HbA1c pada pasien DM tipe 2 yang mendapat terapi jamu saintifik (JS) di klinik saintifikasi jamu WKJ Kabupaten Tegal dengan pasien DM tipe 2 yang mendapat terapi antidiabetik oral di puskesmas pada tahun 2020. Rancangan penelitian adalah eksperimental dengan teknik consecutive sampling menggunakan subjek uji yang memenuhi kriteria. Subjek uji penelitian ini adalah 19 pasien dengan terapi antidiabetik oral (ADO) dari Puskesmas dan 9 pasien dengan terapi jamu saintifik dari Klinik WKJ. Uji independent t-test digunakan untuk membandingkan rata-rata GDS dan kadar HbA1c pada kedua kelompok, dengan nilai signifikansi p < 0,05. Kuesioner digunakan untuk mengukur tingkat kepatuhan minum obat. Hasil penelitian menunjukkan rata-rata nilai GDS pasien terapi antidiabetik oral (ADO) dan jamu saintifik (JS) setelah terapi berturut-turut adalah 282,95 mg/dL dan 267,56 mg/dL. Rata-rata HbA1c pasien terapi ADO dan JS setelah terapi berturut-turut adalah 9,83% dan 10,11%. Kadar GDS dan HbA1c setelah terapi pada kelompok pasien dengan terapi ADO tidak berbeda bermakna dengan kelompok pasien dengan terapi JS. Berdasarkan pengukuran analisis tingkat kepatuhan, diketahui tidak terdapat hubungan antara tingkat kepatuhan pasien terhadap kadar GDS dan HbA1c pasien
Optimization of Microgel Formula Combination of Snail Mucus and Catechin to Accelerate Wound Closure Azizah, Adinda Fayi; Astuti, Ika Yuni; Syarifah, Arini; Kumalasari, Raudia; Agistya, Lusyahaura; Talitarahma, Anindya Tian
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.7562

Abstract

Incised wound healing is a crucial process that requires effective treatment solutions. A microgel containing snail mucus and catechin seems a promising approach to accelerate healing and improve recovery outcomes. This study aimed to develop a microgel preparation contain snail mucus (Achatina fulica) and catechin. Formulation design is assisted using the Design Expert SLD method. The optimum formula was achieved with a carbopol to TEA ratio of 1.589:0.411, with estimated values of pH (4.506), viscosity (18,873 cPs), spread ability (5.477 cm), and adhesion (2.068 second). These estimated values showed no significant difference from the actual values obtained in the laboratory experiments. To evaluate the quality of the preparation, in vivo testing was performed on white mice, and the data were analysed using one-way ANOVA. The snail mucus and catechin microgels were proven to be effective in treating deep incision wounds.
Optimasi Formula Facial Wash Gell Antipolutan Ekstrak Bunga Rosella Ungu (Hibiscuss sabdariffa L. Var. Roselindo2) Anisa Fitri, Hidayah; Falahdin, Fadita Iza; Astuti, Ika Yuni
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 12 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v12i1.17127

Abstract

Exposure to Particulate Matter (PM) and other airborne pollutants can lead to various skin issues. The anthocyanin compounds in purple roselle flower extract exhibit antipollution activity, making the extract a promising candidate for the development of a facial wash gel formulation, optimised with carbopol 940 and triethanolamine (TEA). These two ingredients were selected due to their influence on the physical properties of the formulation, which is expected to help maintain the physicochemical stability of anthocyanins. This study aimed to determine the optimal concentrations of these components as gel base-forming agents, such as viscosity, pH, and spreadability. The optimum formula was designed using Design Expert 13 software with a Simple Lattice Design (SLD) model, while statistical analyses were conducted using one-way ANOVA and T-test to verify the predicted and actual optimum formula. The physical evaluation results confirmed that the optimum formula met the required viscosity (3826±28.67 cPs), dispersibility (6.07±0.45 cm), and exhibited an acidic pH (6.53±0.07) suitable for a facial cleansing gel. Based on the conducted tests and analyses, the optimum formula contained 2% carbopol 940 and 2% TEA, with a desirability value of 0.993. Verification testing indicated no significant differences between the predicted and actual optimum formula.
Peningkatan Higiene dan Sanitasi Proses Produksi Jamu “Golden Milk” di Buana Al-Faza PCNA Rawalo, Banyumas, Jawa Tengah Diniatik, Diniatik; Astuti, Ika Yuni; Annisa, Rully; Rusman, Ade
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 4 No 3 (2025): Juli
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jipmi.v4i3.744

Abstract

Latar belakang: Rawalo merupakan salah satu kecamatan di Kabupaten Banyumas yang memiliki banyak pelaku usaha rumahan yang memproduksi makanan dan minuman. Salah satunya Buana Al-Faza milik Pimpinan Cabang Nasyiatul Aisyah (PCNA) Rawalo yang memproduksi minuman jamu susu “Golden MilK”. Minuman jamu “Golden Milk” memiliki 4 varian rasa yaitu: original, teh, kayu manis dan lemon. Proses produksi masih menggunakan peralatan produksi sederhana. Tujuan: Untuk meningkatkan higiene dan sanitasi proses produksi minuman jamu “Golden Milk” Buana Al-Faza PCNA Rawalo. Metode: Presentasi penyampaian materi, diskusi pendalaman materi dan praktek. Dilakukan pre-test dan post-test untuk mengukur peningkatan pengetahuan peserta. Hasil: Hasil kegiatan pelatihan mampu meningkatkan pengetahuan anggota kelompok dengan nilai pre-test (59,375±8,634), nilai post-test (81,25±4,432) (p= 0,001). Kesimpulan: Pelatihan peningkatan higiene dan sanitasi proses produksi jamu  susu “Golden Milk” Buana Al-Faza PCNA Rawalo mampu meningkatkan pengetahuan dan keterampilan peserta. Kata kunci: banyumas, higiene, sanitasi, jamu _________________________________________________________________________ Abstract Background: Rawalo is a sub-district in Banyumas Regency, where many home-based businesses produce food and beverages. One of them is Buana Al-Faza, owned by the Nasyiatul Aisyah Branch (PCNA) Rawalo, which produces the herbal milk drink "Golden Milk". The herbal drink "Golden Milk" has four flavors: original, tea, cinnamon, and lemon. The production process still uses simple production equipment. Objective: To improve hygiene and sanitation in the production process of the herbal drink "Golden Milk" Buana Al-Faza PCNA Rawalo. Method: Presentation of material delivery, in-depth discussion of the material, and practice. Pre-test and post-test were conducted to measure the increase in participants' knowledge. Result: The training activities increased the knowledge of group members from pre-test scores (59.375±8.634) to post-test scores (81.25±4.432) (p= 0.001). Conclusion: The training on improving hygiene and sanitation in the production process of Buana Al-Faza PCNA Rawalo's "Golden Milk" herbal medicine (jamu) improved participants' knowledge and skills. Keywords: banyumas, hygiene, sanitation, herbal medicine
Optimization of Phosphatidylcholine and Tween 80 Composition in the Formulation of Icariin Transfersome as a Transdermal Delivery System using Design-Expert Setiyawan, Sukamto Jodi; Astuti, Ika Yuni; Hariyanti, Hariyanti
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Icariin is the main flavonoid of Epimedium sp. and has phosphodiesterase type-5 inhibitor (PDE5I) activity; however, its low water solubility and membrane permeability limit its oral bioavailability. The transferosome-based transdermal drug delivery system approach is considered promising because it can increase skin penetration and avoid the first-pass metabolism. This study aims to optimize the composition of phosphatidylcholine and Tween 80 in icariin-loaded transfersome vesicles to produce optimal physicochemical characteristics for transdermal applications. Method: Icariin transfersome was formulated using a thin-film hydration method with variations in phosphatidylcholine and Tween 80 concentrations. Optimization is performed using the Simplex Lattice Design (SLD) in Design Expert 13 software. The observed responses included particle size, polydispersity index (PDI), zeta potential, and Entrapment efficiency (EE%). The results of this study are the optimal formula of icariin transfersome, with a ratio of phosphatidylcholine and Tween 80 of 95%: 5%, resulting in ideal vesicle characteristics, namely a particle size of 106.15 nm, a zeta potential of -22.67 mV, a Polydispersity Index (PDI) of 0.37, and an Entrapment efficiency of 86.96%.
Optimization of Kolang-Kaling Seed Galactomannan Serum Using Response Surface Methodology Anggraeni, Rosiana Sofia; Nurulita, Nunuk Aries; Astuti, Ika Yuni
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.573

Abstract

Background: Ultraviolet (UV) exposure promotes free radical formation, leading to oxidative stress, lipid peroxidation, inflammation, and hyperpigmentation. Galactomannan derived from kolang-kaling (Arenga pinnata) exhibits antioxidant activity with potential protective effects against UV-induced damage. In serum formulations, carbomer and triethanolamine (TEA) are commonly combined as gelling agents to achieve desirable physicochemical properties. Objective: This study aimed to optimize a galactomannan-based facial serum by determining the most effective Carbomer–TEA concentration combination using Response Surface Methodology (RSM). Methods: A formulation optimization study was conducted employing the RSM approach with Design Expert software to evaluate the interaction effects of Carbomer and TEA concentrations on serum characteristics. Results: The optimal formulation predicted by the model consisted of 0.100% (w/v) Carbomer and 1.047% (w/v) TEA. Conclusion: Response Surface Methodology successfully optimized the galactomannan facial serum formulation. The identified combination of Carbomer and TEA is expected to provide suitable serum properties while supporting the antioxidant potential of galactomannan against UV-induced oxidative damage.
Optimasi Formula Micellar water Antipolutan Mengandung Ekstrak Bunga Rosella Merah (Hibiscus sabdariffa L. var. roselindo1) Hidayah Anisa Fitri; Fajrina Maulani; Ika Yuni Astuti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 02 Desember 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i2.24516

Abstract

Paparan polusi udara secara terus menerus menyebabkan berbagai macam permasalahan pada kulit wajah. Antosianin dalam ekstrak bunga rosella merah diketahui memiliki aktifitas sebagai antipolutan sehingga berpotensi untuk dikembangkan menjadi produk micellar water. Micellar water yang mengandung surfaktan dan antosianin dalam ekstrak bunga rosella diharapkan dapat meningkatkan efektifitas dalam pembersihan. Namun demikian perlu dilakukan pertimbangan dalam pemilihan dan penentuan konsentrasi surfaktan yang digunakan karena dapat mempengaruhi parameter fisik krusial akhir sediaan seperti pH; yang dapat mempengaruhi stabilitas sifat fisika kimia senyawa antosianin, serta viskositas dan kejernihan sediaan. PEG-6 caprylic/capryic glycerides (PEG-6 caprylic), dan disodium cocoamphodiacetate (DCC) merupakan dua surfaktan yang dapat digunakan dan dioptimasi agar menghasilkan formula optimum micellar water yang memenuhi syarat dan diharapkan dapat mempertahankan stabilitas antosianin di dalamnya. Penelitian ini bertujuan untuk melakukan optimasi formula micellar water ekstrak bunga rosella dengan menggunakan kedua surfaktan tersebut. Rancangan formula optimum dibuat dengan bantuan software design expert model SLD (Simple Lattice Design). Data diolah dan dianalisis secara statistik menggunakan one-way ANOVA serta T-Test. Berdasarkan pada hasil pengujian yang telah dilakukan didapatkan formula optimum micellar  water dengan PEG-6 caprylic dan DCC sebesar 6,972 % dan  4,028 % yang memiliki nilai desirabilitas 0,875. Formula optimum yang dibuat memenuhi seluruh ketentuan parameter pH, viskositas dan kejernihan dan telah diverifikasi tidak berbeda signifikan terhadap hasil prediksi formula yang sebelumnya telah dirancang.
Formula Optimization of Roselle Flower Extract as Clay Facial Soap Hidayah Anisa Fitri; Ghaliyah Kusuma Wardani; Ika Yuni Astuti; Indri Hapsari
JRST (Jurnal Riset Sains dan Teknologi) Volume 9 No. 2 September 2025: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/jrst.v9i2.24495

Abstract

Roselle flower is known rich in anthocyanin compounds that has activities as antipollutants, so it has potential to be developed as clay facial soap. Soap is formed by the saponification reaction between fatty acids and strong bases which generally has high pH properties. The anthocyanin compound in roselle extract is unstable at base pH. In addition, there are crucial parameters such as pH, viscosity and foam stability that must be eligible to be accepted as cleanser product for facial skin. This study aimed to obtain an optimal formula for clay facial soap containing roselle flower extract by optimizing concentration of surfactant SLES and KOH as soap-forming components. Soap basis was made by mixing the base with fatty acid phase. Design Expert 13 software, one-way ANOVA, and T-Test SPSS were used to design, analyze the effect and predict optimum mixed components in the formula so the final product met the ideal parameters. The data of study showed that the optimal formula of roselle flower clay facial soap should have 9.5% of SLES and 5.25% KOH with a desirability value of 1. The optimum formula had organoleptic, homogeneity, pH, viscosity and foam stability parameters that met the requirements.
Optimasi Granul Effervescent Kombinasi Ekstrak Daun Kepel, Kulit Manggis dan Rimpang Kunyit Husein, Zulaikhah; diniatik, diniatik; Astuti, Ika Yuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.48085

Abstract

Hiperurisemia adalah suatu keadaan dimana kadar asam urat dalam tubuh lebih dari 7,0 mg/dL. Daun Stelechocarpus burahol, kulit Garcinia mangostana, dan rimpang temulawak memiliki aktivitas antihiperurisemia. Obat herbal yang mengandung ekstrak tumbuhan biasanya memiliki rasa pahit, sehingga dibuat butiran effervescent yang dapat meningkatkan rasa tidak enak dan memiliki efek menyegarkan. Penelitian ini bertujuan untuk menentukan formula optimum kombinasi ekstrak granul effervescent daun kepel, kulit manggis dan rimpang kunyit. Optimasi Metode Faktorial 22 (Design Expert 13) dengan variabel bebas asam sitrat dan natrium bikarbonat. Kelembaban, waktu larut dan kecepatan alir sebagai variabel terikat. Hasil penelitian menunjukkan bahwa granul dengan komposisi asam sitrat 1800 mg dan natrium bikarbonat 2160 mg merupakan formula optimum dengan nilai prediksi kelembaban 1,435%, waktu larut 90,8 detik dan laju alir 12,64 g/detik dengan nilai desirability. dari 0,859. Formula optimum grnul effervescent memiliki nilai kadar air 1,21%, waktu larut 99,92 detik dan laju alir 11,69 g/detik.
Potensi Biji Orok-orok (Crotalaria juncea L.) sebagai Kandidat Obat Insomnia Asmiyenti Djaliasrin Djalil; Siti Musyarofah; Bayu Satria Nugroho Putra; Erza Genatrika; Ika Yuni Astuti
Journal of Pharmascience Vol. 4 No. 1 (2017): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i1.5749

Abstract

ABSTRAK Insomnia merupakan gangguan yang menyebabkan penderita mengalami ketidakmampuan untuk mencukupi kebutuhan tidur. Pemilihan terapi insomnia di Desa Lembarawa, Brebes, secara empiris biasanya menggunakan biji orok-orok (Crotalaria juncea L.) sebagai sedatif. Penelitian ini bertujuan untuk membuktikan bahwa biji orok-orok memiliki potensi sebagai sedatif dengan dosis yang tepat. Biji orok-orok diekstrak menggunakan pelarut metanol. Ekstrak yang diperoleh selanjutnya difraksinasi dengan pelarut etil asetat dan metanol. Ekstrak dan fraksi yang diperoleh kemudian diujikan terhadap mencit. Mencit dibagi menjadi 12 kelompok, kelompok I kontrol positif (fenobarbital 60 mg/Kg BB) kelompok II kontrol negatif (NaCMC 1%), kelompok III-IV merupakan kelompok perlakuan ekstrak metanol dengan konsentrasi 50 dan 200 mg/Kg BB, kelompok V-VIII merupakan fraksi etil asetat dengan konsentrasi berturut-turut 7,5; 15; 22,5; dan 30 mg/Kg BB, kelompok IX-XII merupakan fraksi metanol dengan konsentrasi berturut-turut 25, 50, 75, dan 100 mg/Kg BB. Parameter yang digunakan adalah daya cengkeram mencit, reflek balik badan mencit, diameter pupil mata, serta daya jatuh menit. Hasil uji menunjukkan bahwa fraksi etil asetat dan metanol memiliki efek sedatif. Efek sedatif paling baik ditunjukkan oleh fraksi metanol 100 mg/Kg BB yang mendukung terapi untuk insomnia. Kata kunci: biji orok-orok, Crotalaria juncea L., sedatif. ABSTRACT Insomnia is a disruption that can not supply the needs of sleeping. In Lembarawa, Brebes, insomnia was treated empirically using Crotalaria Juncea L. (orok-orok). The purpose of this study was to prove that the seeds of Crotalaria juncea L. had potential as a sedative. Orok-orok seeds methanolic extract, ethyl acetate fraction, and methanolic fraction were observed as a sedative. Mice were divided into 12 groups: positive control group (phenobarbital 60 mg/Kg BW), negative control group (Na CMC 1%), methanolic extract of orok-orok seeds with doses of 50 and 100 mg/Kg BW, ethyl acetate fraction with doses of 7.5; 15; 22.5; and 30 mg/Kg BW, methanolic extract with doses of 25; 50; 75; and 100 mg/Kg BW. The sedative activity was investigated in mice including diameter mouse’s pupil, grip strange performances, return mice reflect, and rotarod performances. The results suggest that methanolic extract, ethyl acetate fraction, and methanolic fraction of orok-orok seeds possess potent sedative activity. The highest activity was obtained by using 100 mg/Kg BW of methanolic fraction, which supported its therapeutic use for insomnia. Keywords: Crotalaria juncea L., Orok-orok seeds, a sedative.
Co-Authors Adi Garnadi Rahman, Adi Garnadi Agistya, Lusyahaura Agung Endro Nugroho Anggraeni, Rosiana Sofia Ani Aminiati, Ani Anisa Fitri, Hidayah Annisa, Rully Arif Mulyanto Arini Syarifah Asmiyenti Djaliasrin Djalil Aziz Priadiatna Azizah, Adinda Fayi Bayu Satria Nugroho Putra Binar Asrining Dhiani Didik Setiawan Diniatik Dwi Hartanti Dwi Saesar Nur Syafril, Dwi Saesar Nur Endang Sari, Endang Faesol Amin, Faesol Fajrina Maulani Falahdin, Fadita Iza Feni Nurul Hidayanti, Feni Nurul Frisky Almuksiti, Frisky Ganjar Taufik Genatrika, Erza Ghaliyah Kusuma Wardani Gigih Iryoto, Gigih Hariyanti , Hariyanti Hariyanti Hariyanti Hidayah Anisa Fitri Husein, Zulaikhah Ika Puspitasari Indri Hapsari Indri Hapsari Iryani, Yeyen Dwi Iskandar Soedirman, Iskandar kartono, Teguh hari Kristanti Kristanti Kumalasari, Raudia Luthvia Novita Sari, Luthvia Novita M. Dafit Mulyadi Marchaban, Marchaban Martien, Ronny Nimas Mahataranti Nova Astrit Natalia, Nova Astrit Nunuk Aries Nurulita Priadiatna, Aziz Puspitaningrum, Dwi Aulia Rahma, Nur Anisa Ranti Kartikasari, Ranti Regawa Bayu Pamungkas Reny Apriani, Reny Retno Wahyuningrum Rusman, Ade Setiyawan, Sukamto Jodi Siti Musyarofah Suparman Suparman Talitarahma, Anindya Tian Titik Sunarti, Titik Tri Setyo Bayuaji, Tri Setyo Unik Fajriyah, Unik Wahyunita Yulia Sari, Wahyunita Yulia Wiranti Sri Rahayu Yeyen Dwi Iryani Yohanes Khristantyo, Yohanes