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All Journal JURNAL FARMASIMED (JFM) International Conference on Health Science, Green Economics, Educational Review and Technology (IHERT) Jurnal Pengmas Kestra (JPK) Jurnal Indah Sains dan Klinis
Syarifuddin, Shofian
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Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : JURNAL FARMASIMED (JFM)

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Test of the Anti-Inflammatory Effectiveness of Ethanol Extract Gel Preparation of Sabrang Onion Bulb (Eleutherine bulbosa) on Incisional Wounds in Wistar Rats Harahap, Hasni Yaturramadhan; Syarifuddin, Shofian; Cahya, Cucu Arum Dwi; Br Sinaga, Irma Suryani Kristina
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2317

Abstract

Background: The use of medicinal plants is increasingly widespread among the community, especially due to their properties in healing various diseases. One of the developing medicinal plants is bawang sabrang (Eleutherine bulbosa), which has been proven to accelerate the healing process of wounds. Objective: To evaluate the effectiveness of administering gel extract from bawang dayak tubers on the healing process of incised wounds in rats. The test subjects used were 25 male rats. Incisions measuring 2 cm were made on the backs of the rats using a surgical knife. Method: Laboratory experimental study with a Completely Randomized Design (CRD) consisting of five treatments: one positive control (bioplacenton gel), one negative control (gel base), and three graduated concentrations of gel extract, namely 5%, 10%, and 15%. Treatments were administered twice daily for 14 days. Results: Measurement of wound diameter showed that the gel extract of bawang sabrang at a concentration of 15% and the positive control provided a more effective healing effect compared to the gel extract at concentrations of 5%, 10%, and the negative control (gel base). Conclusion: Ethanol extract of bawang sabrang is effective as a gel for healing incised wounds in rats at a concentration of 15%. The physical properties of the gel show a characteristic aroma and a golden red color, homogenous without grains or lumps, a pH of 4.9, and a spreadability of 5 cm.Keywords: Bawang sabrang tuber, Anti-inflammatory, rats, Edema.
Formulation and Stability Evaluation of Antioxidant Sunscreen Gel Containing Green Tea Leaf (Camellia sinensis) Extract Using the DPPH Method Sinurat, Jhon Patar; Fitria, Zahara; Br Karo, Reh Malem; Syarifuddin, Shofian
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/f66vym74

Abstract

Sunscreen formulations are designed to protect the skin from exposure to ultraviolet (UV) radiation; however, excessive use of synthetic ingredients may lead to adverse effects on the skin. The utilization of natural ingredients as alternatives has gained increasing attention, one of which is green tea leaves (Camellia sinensis), known for their rich antioxidant content. This study aimed to formulate and evaluate the stability and antioxidant activity of a sunscreen gel based on green tea leaf extract. This research was a laboratory-based experimental study employing a quantitative approach with a post-test only control group design. The gel formulations were prepared in four variations of extract concentration, namely 0% (F0), 5% (F1), 10% (F2), and 15% (F3). The preparations were then evaluated for physical characteristics, irritation potential, and antioxidant activity using the DPPH method. The results showed that 392 g of extract was obtained from 3.8 kg of dried simplicia, yielding a 10.32% extraction yield. Phytochemical screening indicated the presence of flavonoids, tannins, saponins, and alkaloids. All formulations exhibited a semi-solid form, good homogeneity, and stable pH values ranging from 6.0 to 6.3, which are compatible with skin pH. Furthermore, no irritation reactions were observed among the 12 volunteers. Antioxidant activity increased with higher extract concentrations, with IC₅₀ values of 28.86 ppm (F0), 22.11 ppm (F1), 21.25 ppm (F2), and 20.72 ppm (F3). In addition, the percentage of inhibition for F0–F3 also showed an increasing trend, namely 8.24–17.50%, 15.79–26.28%, 13.30–24.89%, and 14.82–26.25%, respectively. In conclusion, green tea leaf extract demonstrates strong potential as an active ingredient in sunscreen gel formulations that are safe, stable, and possess significant antioxidant activity.
Co-Authors Aritonang, Barita Asfianti, Vivi Br Sinaga, Irma Suryani Kristina Cahya, Cucu Arum Dwi Debi Meilani Dicky Yuswardi Wiratma Febriady, Andy Fitria, Zahara Frimpong Oppong, Richard Hanindiya, Beta Harahap, Hasni Yaturramadhan Hendri Kurniawan, Hendri Mustaruddin Panjaitan, Delita Pitriani, Pitriani Purnama Sari, Dian Reh Malem br Karo Sagala, Vanny Yosepha Sanjaya, Muhartri Sinurat, Jhon Patar Sitepu, Rahmadani Suprianto Suprianto Tony Sohdin Martua Simanjuntak, Edwin Widyaningsih, Fadlilah