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All Journal The Indonesian Biomedical Journal JMM (Jurnal Masyarakat Mandiri) Jurnal Pengabdian Masyarakat AbdiMas Jurnal Pengabdian kepada Masyarakat Archives Pharmacia Journal of Applied Nursing and Health Pharmaceutical Sciences and Research (PSR) Jurnal Medika: Medika E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu
Hurit, Hermanus Ehe
Universitas Esa Unggul
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Promosi Kesehatan Melalui Edukasi dan Skrining Sebagai Upaya Peningkatan Literasi Masyarakat Tentang Pencegahan Diabetes Melitus Inherni Marti Abna; Anna Yuliana; Mellova Amir; Hermanus Ehe Hurit; Mashuri Yusuf; Sri Teguh Rahayu; Ayu Puspitalena; Lintang Purwara Dewanti; Putri Ronitawati
Jurnal Medika: Medika in progres
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/dbg59r66

Abstract

Diabetes melitus merupakan penyakit tidak menular yang jumlah penderitanya terus meningkat dan dapat menimbulkan berbagai komplikasi apabila tidak dicegah sejak dini. Salah satu tantangan dalam pengendalian penyakit ini adalah masih terbatasnya pengetahuan masyarakat mengenai faktor risiko dan pentingnya deteksi awal. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pemahaman masyarakat tentang faktor risiko dan upaya pencegahan diabetes melitus melalui program promosi kesehatan di RW 008 Kelurahan Cibodas, Kota Tangerang. Kegiatan dilaksanakan dengan pendekatan edukatif dan partisipatif yang mencakup identifikasi permasalahan, skrining kesehatan sederhana, penyuluhan kesehatan, sesi tanya jawab, serta penilaian pengetahuan menggunakan pre-test dan post-test. Skrining meliputi pemeriksaan tekanan darah, kadar gula darah, dan kadar asam urat. Hasil evaluasi menunjukkan bahwa rata-rata nilai pengetahuan peserta meningkat dari 86,67% sebelum penyuluhan menjadi 93,33% setelah kegiatan. Selain itu, hasil skrining menemukan beberapa peserta dengan tekanan darah dan kadar gula darah di atas batas normal sehingga memerlukan tindak lanjut dan pemantauan kesehatan. Keterlibatan aktif peserta selama penyuluhan dan sesi tanya jawab menunjukkan bahwa pendekatan partisipatif dapat mendukung penyampaian informasi kesehatan kepada masyarakat. Dengan demikian, promosi kesehatan yang dipadukan dengan skrining kesehatan sederhana berpotensi menjadi salah satu intervensi berbasis komunitas untuk mendukung pencegahan dan deteksi dini diabetes melitus.
Formulation of Antioxidant Cream from Mung Bean (Vigna radiata L.) Seed Coat Extract Hermanus Ehe Hurit; Linda Handayani; Reinaldo Pradana; Dara Andini Putri
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.475

Abstract

The skin is the body’s primary barrier against free radicals, which can induce oxidative stress and premature ageing. Antioxidants neutralize these radicals. This study aims to formulate and evaluate a cream containing ethanol extract of mung bean (Vigna radiata L.) seed coat. Four formulations were prepared with extract concentrations of 10%, 15%, 20%, and 25%. Physical evaluations included organoleptic tests, homogeneity, pH, viscosity, cream type, spreadability, and adhesiveness. Antioxidant activity was measured using the DPPH method. All formulations met physical standards, and formula F4 (25%) showed the highest antioxidant activity with an IC₅₀ value of 79.49 ppm. These findings indicate the potential of mung bean seed coat extract as an active antioxidant agent in topical preparations.
Network Pharmacology and Molecular Docking Analysis of Zingiberaceae Bioactive Compounds as Candidate Adjuncts for Hypertension Therapy Asarini Asarini; Gemini Alam; Hermanus Ehe Hurit
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.541

Abstract

Hypertension remains a major cardiovascular risk factor, and plant-derived compounds may provide leads for adjunctive therapeutic development. This study evaluated bioactive compounds from six Zingiberaceae species using ADMET screening, network pharmacology, and molecular docking. Thirty-two compounds were screened with DeepPK using predicted human oral bioavailability (≥20%) and selected toxicity endpoints. Six compounds met the screening criteria: zingerone, isoborneol, terpinyl acetate, 1,8-cineole, linalool, and α-terpineol. SwissTargetPrediction, GeneCards, STRING, and Cytoscape analyses identified TNF as the highest-ranked hub by both degree and bottleneck metrics. Three independent native-ligand redocking runs against human TNF-α (PDB ID: 6OP0) yielded RMSD values below 2 Å. Pentoxifylline showed a Rerank Score of -43.846, whereas zingerone had the most favorable score among the selected plant compounds (-36.2546) and was predicted non-toxic for the screened endpoints. These computational findings prioritize zingerone for further experimental validation as a potential antihypertensive adjunct candidate.
Asiatic Acid Modulates Il6 and Tgfb1 mRNA Expression and Soluble Collagen Levels in RAW 264.7–NIH 3T3 Co-culture Cells under High-Glucose and LPS Stimulation Rizki Awaluddin; Dwi Aris Agung Nugrahaningsih; Eti Nurwening Sholikhah; Hermanus Ehe Hurit
The Indonesian Biomedical Journal Vol 18, No 4 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i4.4296

Abstract

BACKGROUND: Chronic inflammation contributes to diabetes-associated fibrosis, through persistent hyperglycemia, leading to increased interleukin-6 (IL-6), transforming growth factor-β (TGF-β), and collagen levels. While metformin effectively controls blood glucose, it may not adequately suppress these pathogenic pathways. Asiatic acid has demonstrated anti-inflammatory and antifibrotic properties, although its effects within a direct-contact macrophage–fibroblast microenvironment such as in co-culture models remain unclear. This study was conducted to evaluate the effects of asiatic acid on Il6, Tgfb1, and soluble collagen levels in a RAW 264.7–NIH 3T3 co-culture under high-glucose and lipopolysaccharide (HG–LPS) stimulation.METHODS: RAW 264.7 and NIH 3T3 cells were co-cultured at ratios of 1:1–1:6, and the selected co-culture was treated with asiatic acid (2.5, 5.0, and 10.0 µg/mL) for 24 h while HG–LPS stimulation was maintained. Unstimulated NIH 3T3 monocultures and untreated HG–LPS co-cultures served as controls. The inflammatory and profibrotic markers such as Il6 and Tgfb1 mRNA expression were quantified by polymerase chain reaction (PCR), and soluble collagen was measured using a modified Sirius Red assay.RESULTS: Among the tested ratios, the 1:1 co-culture exhibited the highest Tgfb1 mRNA expression (0.35±0.02) and soluble collagen level (1.30±0.00) and was selected for subsequent experiments, whereas Il6 mRNA expression did not differ significantly among co-culture ratios. Under HG–LPS stimulation, Il6 and Tgfb1 mRNA expression increased 3.5-fold and 10.3-fold, respectively, compared with unstimulated NIH 3T3 monocultures. Asiatic acid significantly reduced Il6 mRNA expression at 5.0 and 10.0 µg/mL, Tgfb1 mRNA expression at 2.5 µg/mL, and soluble collagen levels at all tested concentrations, indicating a non-monotonic concentration–response pattern.CONCLUSION: The 1:1 RAW 264.7–NIH 3T3 co-culture was the most responsive under HG–LPS stimulation and could be in vitro platform for investigating macrophage–fibroblast interactions under hyperglycemic inflammatory conditions. Asiatic acid modulated Il6 and Tgfb1 mRNA expression and soluble collagen levels in RAW 264.7–NIH 3T3 co-culture, which suggest that Asiatic acid may be potential for the management of fibrotic inflammation.KEYWORDS: co-culture, collagen, fibroblast dysfunction, NIH 3T3 fibroblast, RAW 264.7 macrophage
Co-Authors Abdul Karim Zailani Abna, Inherni Marti Adelia Eka Sutomo Putry Agung Setiawan agung setiawan Alfiyah, Siti Alno Kaldicson Alvianto Gautama Anantya, Catur Andani, Dhea Julia Anggi Nuraini Anisa Aulia Pratiwi Anna Yuliana, Anna Antonius Dewanto Purnomo Aprilita Rina Yanti Aprilita Rinayanti Ari Suko Pratiwi Asarini Atilah, Niken Tri Rachmah Ayu Pertiwi, Reza Ayu Puspitalena Ayu Puspitalena Ayu Puspitalena Ayuni, Dewi Sartika Azzuhra, Hanifah Nur Dara Andini Putri Devina Elsha Dominica Zebua Dewanti, Lintang Purwara Dimas Inggar Pramudya Dwi Aris Agung Nugrahaningsih Eden, Yonatan Eden, Yonathan Eti Nurwening Sholikhah Eva Mardiana Ompusunggu FAJRIANI, NUZUL Fayza Maghfira Solachudin Gemini Alam Ghozaly, Muchammad Reza HILHAMI, HILHAMI Imanuel, Imanuel Isda Kana Limas, Ayu Linda Handayani Manuelim, Karin Mellova Amir Mellova Amir Michelle Miftahul Hassanahl Miftahul Ilmy Setiawan Muda, Cut Alia Keumala Muh Dewa Putra Muhammat Khairun Nafa Nafa, Muhammat Khairun Nanda Dwi Septiani Putri Nur, Syurya Muhammad Nurfadhilah Shofi. A Nurjannah Bachri Pertiwi, Ratih Dyah Pingkan Febriana Pingkan Irlanda Puspitalena, Ayu Putra, Muh Dewa Putri Ronitawati Putri, Andini Adinda Ramadhani, Rizki Dwi Refo Ananta Lim Reinaldo Pradana Reinaldo Pradana Reza Apriliani Rizki Awaluddin Robby Rijal Sauri Salsabilla, Ersa Salsabillah, Salsabillah Sauri, Robby Rijal Setiawan, Miftahul Ilmy Shinta Dewi gita Amalia Sri Teguh Rahayu, Sri Teguh Surjana, Vernant Tyas Putri Utami Widyan Dana Dwi Ratri Conita Winda Amelia Sari Yasmin Zabarij Yuni Rahayu Yusuf, Mashuri