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All Journal Pharmasipha Jurnal Delima Harapan Jurnal Dunia Farmasi Abdi Masyarakat Jurnal Peduli Masyarakat Jurnal Kesehatan Tambusai Journal of Fundamental and Applied Pharmaceutical Science Ahmar Metastasis Health Journal (AMHJ) Proceedings of the International Conference on Nursing and Health Sciences Journal of Applied Nursing and Health Prosiding Seminar Informasi Kesehatan Nasional Inovasi Jurnal Pengabdian Masyarakat (IJPM) Parapemikir Jurnal Ilmiah Farmasi
Artini, Kusumaningtyas Siwi
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Energy Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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AKTIVITAS EKSTRAK ETANOL SERAI (Cymbopogon citratus (DC.) Stapf) SEBAGAI ANALGESIK PADA MENCIT PUTIH (Mus musculus) JANTAN YANG DIINDUKSI ASAM ASETAT Kota, Hildagardis Mbula; Artini, Kusumaningtyas Siwi; Rohmana, Vivin Marwiyanti
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.44695

Abstract

Nyeri  merupakan  pertanda  bahwa  terjadinya  kerusakan  pada  jaringan  atau  tubuh  manusia  yang dapat menyebabkan perasaan yang tidak menyenangkan. Analgesik merupakan obat yang dapat digunakan untuk menekan dan mengurangi rasa sakit (nyeri) tanpa menyebabkan seseorang kehilangan kesadaran . Serai (Cymbopogon citratus (DC.) Stapf) banyak digunakan dalam pengobatan tradisional dengan berbagai indikasi, seperti gangguan pencernaan dan saraf, peradangan, nyeri, demam dan diabetes. Flavonoid adalah senyawa yang dapat melindungi membran lipid dari kerusakan dan mekanisme kerjanya menghambat enzim cyclooxygenase I yang merupakan jalur pertama sintesis mediator nyeri seperti prostaglandin. Penelitian ini dilakukan untuk mengetahui ekstrak etanol serai (Cymbopogon citratus DC. Stapf) memiliki efektivitas analgesik pada mencit putih (Mus musculus) dengan metode writhing test  dan pada dosis berapakah ekstrak etanol serai (Cymbopogon citratus DC. Stapf) yang paling efektif dapat memberikan aktivitas analgesik pada mencit putih (Mus musculus). Ekstraksi tanaman serai dilaksanakan dengan menggunakan maserasi memakai etanol 70% sebagai larutan dasar. Uji aktivitas analgesik melibatkan lima kelompok hewan uji dengan metode writhing test, mencit diinduksi asam asetat untuk memicu respon nyeri, dengan jumlah geliat yang timbul dijadikan sebagai indikator intensitas nyeri. Data yang didapatkan kemudian dipelajari secara statistik menggunakan uji Anova satu arah (One Way ANOVA). Hasil memperlihatkan bahwasannya serai dengan dosis 700 mg/kgBB meberikan sensasi anti nyeri yang hampir setara dengan asam mefenamat, bahwa tercatat persentase proteksi analgesik sebesar 70,05%. Sementara itu, dosis 500 mg/kgBB dan 300 mg/kgBB menunjukkan efek analgesik yang lebih rendah. Diduga bahwa kandungan flavonoid dalam serai berperan sebagai analgesik yang efektif.
Training on Processing Used Cooking Waste into Solid Soap and Liquid Soap at the Karang Taruna of Palur Village. Wardani, Tatiana siska; Suhatmi, Erna Chotidjah; Artini, Kusumaningtyas Siwi; Dewi, Belinda Arbitya; Erikania, Susanti
Abdi Masyarakat Vol 7, No 1 (2025): Abdi Masyarakat
Publisher : Lembaga Penelitian dan Pendidikan (LPP) Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58258/abdi.v7i1.8714

Abstract

Karang Taruna Saras Muda Palur Village in creating a clean environment, one of which is collecting used cooking oil so that it does not pollute the environment and can have a bad impact on health. One of the uses of used cooking oil that can be turned into a product that has a selling value is soap. The purpose of this PKM is to increase understanding and training in liquid soap and solid soap that can be sold to increase the income of Karang Taruna Saras Muda Palur Village. The methods used are socialization, soap making training and entrepreneurship training. This PKM produces a processed product from used cooking oil waste and increases partner understanding after the pretest and posttest. From the activities above, it can be concluded that the results of the PKM related to the utilization of used cooking oil waste carried out by Karang Taruna Saras Muda Palur Mojolaban Sukoharjo have been carried out well and smoothly.
Formulation and Activity Test of Anti-Acne Toner Containing Lemongrass Essential Oil (Cymbopogon nardus) against Propionibacterium acnes Bacteria Wijayanti, Devi Nur; Permata, Bangkit Riska; Artini, Kusumaningtyas Siwi
Ahmar Metastasis Health Journal Vol. 5 No. 2 (2025): Ahmar Metastasis Health Journal
Publisher : Yayasan Ahmad Mansyur Nasirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/amhj.v5i2.496

Abstract

Acne (Acne vulgaris) is caused by colonization of Propionibacterium acnes bacteria on the skin. The use of natural ingredients with antimicrobial activity for acne medication is an attractive alternative because it is considered safer than chemical ingredients. Lemongrass shows antibacterial activity. Lemongrass acne gel preparations can inhibit the growth of Propionibacterium acnes bacteria. This study aims to formulate the preparation and antibacterial activity of lemongrass essential oil toner. The method used is an experimental method. Variations in the concentration of lemongrass essential oil (Cymbopogon nardus) were tested at 10%, 20%, and 30%. The essential oil was produced using steam distillation. The physical quality of the toner formulation was tested using organoleptic testing, homogeneity testing, pH testing, and viscosity testing. This was followed by irritation testing, hedonic testing, and antibacterial activity testing of the toner formulation. Data analysis was performed using One-way ANOVA and Post Hoc. The acne-fighting toner based on lemongrass essential oil exhibited good physical characteristics, including a slightly opaque white color, a distinctive lemongrass aroma, a liquid texture that absorbs easily into the skin, and visual homogeneity. pH and viscosity tests showed significant differences between formulations, but all remained within safe ranges. Irritation tests showed that all formulations are safe for use as they did not cause negative reactions on the volunteers' skin. Based on hedonic testing, the formulation with a 20% concentration was most preferred by panelists in terms of aroma and color. Antibacterial activity testing showed that all concentrations (10%, 20%, and 30%) were able to inhibit the growth of Propionibacterium acnes, with effectiveness increasing as the concentration increased. The 10% formulation already demonstrated moderate antibacterial activity, while the 20% and 30% formulations fall into the strong category. Therefore, the lemongrass essential oil toner is effective and safe for use as an acne treatment, with an optimal concentration of 20%.
ANALISIS MINIMAL BIAYA PASIEN DIABETES MELITUS TIPE 2 DI INSTALASI RAWAT JALAN RSUD DR. MOEWARDI SURAKARTA PERIODE JANUARI- MARET 2023 Wardhani, Annisa Kusuma; Artini, Kusumaningtyas Siwi; Wardani, Tatiana Siska
Prosiding Seminar Informasi Kesehatan Nasional 2023 : SIKesNas 2023
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/sikenas.vi.2821

Abstract

Diabetes melitus merupakan suatu penyakit kelainan metabolik yang ditandai dengan hiperglikemia karena sekresi insulin yang rusak. Diabetes melitus tipe 2 ditandai dengan resistensi insulin perifer dan penurunan produksi insulin. Data RISKESDAS 2018 menjelaskan prevalensi diabetes melitus nasional adalah sebesar 8,5 % atau sekitar 20,4 juta orang Indonesia terdiagnosis diabetes melitus tipe 2. Analisis farmakoekonomi dalam peningkatan efisiensi atau penggunaan biaya secara lebih rasional sangat diperlukan. Pasien diabetes melitus tipe 2 juga memerlukan terapi seumur hidupnya sehingga membutuhkan biaya yang cukup besar untuk terapi pengobatannya. Untuk itu, penelitian ini bertujuan untuk memberikan informasi mengenai minimal biaya terapi kepada pasien diabetes melitus tipe 2 di instalasi rawat jalan RSUD Dr. Moewardi Surakarta pada periode Januari – Maret 2023. Metode yang digunakan dalam analisis biaya penelitian ini adalah Cost Minimization Analysis (CMA). Hasil penelitian ini diketahui distribusi pengobatan hiperglikemik yang paling banyak digunakan untuk pasien diabetes melitus tipe 2 di instalasi rawat jalan RSUD Dr. Moewardi Surakarta adalah terapi kombinasi insulin analog basal dan insulin analog prandial/premixed sebanyak 30 pasien (33%) serta monoterapi insulin analog basal/prandial/premixed sebanyak 11 pasien (12%). Hasil analisis biaya dengan metode Cost Minimization Analysis (CMA) didapatkan hasil Rp 1.282.626,- dan Rp 1.173.120,-
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN ANTIBIOTIK PASIEN DEMAM TIFOID RAWAT INAP RSAU DR.SISWANTO LANUD ADI SOEMARMO TAHUN 2022 Sahadatun, Angga Aulia; Artini, Kusumaningtyas Siwi; Wardani, Tatiana Siska
Prosiding Seminar Informasi Kesehatan Nasional 2023 : SIKesNas 2023
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/sikenas.vi.2827

Abstract

Demam tifoid merupakan penyakit infeksi sistemik yang menyerang usus halus disebabkan oleh bakteri Salmonella typhi. Terapi awal yang diberikan pada penderita yaitu antibiotik, pilihan antimikroba pilihan Kemenkes yaitu seftriakson, sefotaksim, thiamphenikol dan sefiksim. Ketidak tepatan terapi menyebabkan lama perawatan sehingga biaya pengobatan semakin mahal. Cost Effectiveness Analysis (CEA) merupakan salah satu langkah untuk memulai menilai perbandingan manfaat kesehatan. Tujuan dari penelitian ini untuk mengetahui pola penggunaan antibiotik, besar biaya penggunaan antibiotik dan antibiotik mana yang paling efektif digunakan dilihat dari lama rawat inap dan penurunan suhu. Metode yang digunakan dalam penelitian ini yaitu Cost Effectiveness Analysis (CEA) dengan metode noneksperimental. Hasil dari penelitian ini yaitu antibiotik yang paling banyak digunakan yaitu kombinasi antibiotik inj seftriakson + thiamphenikol 500mg, besar biaya penggunaan antibiotik Rp.924.800, dan antibiotik yang paling cost effectiveness yaitu kombinasi antibiotik inj seftriakson + sefiksim 100 mg.
EVALUASI RASIONALITAS ANTIDIABETIK PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2 DI RSAU DR. SISWANTO TAHUN 2022 Anisawati, Amanda; Pratama, Kharisma Jayak; Artini, Kusumaningtyas Siwi
Prosiding Seminar Informasi Kesehatan Nasional 2023 : SIKesNas 2023
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/sikenas.vi.2835

Abstract

Diabetes melitus tipe 2 merupakan penyakit kronis akibat keabnormalan pada proses sekresi insulin, resistensi insulin ataupun akibat faktor pola hidup yang kurang sehat, sehingga perlu adanya terapi untuk menunjang kualitas hidup penderita. Terapi rasional antidiabetik menjadi salah satu parameter keberhasilan terapi optimal bagi pasien diabetes. Ketepatan terapi dapat dilihat berdasarkan kondisi pasien dan hasil tes gula darah HbA1c ≥6,5%. Penelitian ini dilaksanakan di RSAU dr. Siswanto terhadap pasien diabetes melitus tipe 2 di tahun 2022. Adapun tujuan penelitian ini untuk mengevaluasi profil pengobatan diabetik dan kerasionalitasan terapi antidiabetik yang meliputi 3 indikator ketepatan yaitu tepat indikasi, tepat obat, dan tepat dosis. Penelitian ini termasuk non eksperimental dengan pendekatan deskriptif menggunakan resep dan data rekam medis. Hasil penelitian menunjukkan bahwa dari 114 sampel yang terdiri dari 73 perempuan dan 41 laki-laki dimana seluruhnya memenuhi kriteria inklusi dan eksklusi, dan menunjukkan pravalensi umur yang mendominasi adalah sekitar 56-65 tahun (39,3%), tercatat memiliki ketepatan indikasi sebesar 81,74%, tepat obat 81,74%, dan tepat dosis 100% yang masing-masing diolah menggunakan Microsoft Excel.
ANALISIS Gap PENGARUH PELAYANAN INFORMASI OBAT TERHADAP KEPUASAN PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT PKU MUHAMMADIYAH SURAKARTA Rohmana, Vivin Marwiyati; Artini, Kusumaningtyas Siwi; A, Ferlinda Ayu
Prosiding Seminar Informasi Kesehatan Nasional 2024: SIKesNas 2024
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Studi ini bertujuan untuk mengetahui tingkat kesesuaian antara kinerja tenaga farmasi dengan harapan pasien rawat jalan di Instalasi Farmasi Rumah Sakit PKU Muhammadiyah Surakarta. Untuk mengetahui pengaruh kualitas pelayanan terhadap kepuasan pasien rawat jalan di instalasi farmasi rumah sakit PKU Muhammadiyah Surakarta. Penelitian ini dilakukan dengan menggunakan kuesioner yang diberikan pada 333 konsumen dengan metode purposive sampling di Instalasi Farmasi Rumah Sakit PKU Muhammadiyah Surakarta. Data dari korelasi antara variabel bebas (jenis informasi obat, sikap tenaga farmasi, kinerja tenaga farmasi, kemampuan berkomunikasi tenaga farmasi dan lama waktu pelayanan informasi obat) dengan variabel tergantung (kepuasan pasien) dianalisis dengan analisis regresi linier sederhana, analisis regresi berganda dan analisis Gap. Hasil penelitian menunjukkan bahwa presentase kepuasan pasien rawat jalan di Instalasi Farmasi Rumah Sakit PKU Muhammadiyah Surakarta faktor jenis informasi obat, sikap dan kinerja tenaga farmasi, kemampuan berkomunikasi tenaga farmasi dan lama waktu pelayanan informasi obat secara berurutan sebagai berikut 97,1%; 96,9%; 97,4%; 96,5% dan 97,1% yang berarti skor presentasi kepuasan sangat tinggi. Dan menunjukkan urutan nilai Gap dari yang terbesar hingga yang terkecil pada kelima dimensi sebagai berikut, sikap tenaga farmasi (-0,11); kinerja tenaga farmasi (-0,09); kemampuan berkomunikasi tenaga farmasi (0,06); jenis informasi obat (-0,1) dan lama waktu pelayanan informasi obat (-0,1).
Effectiveness of a Culturally Adapted Mindfulness-Based Intervention on Blood Pressure, Medication Adherence, and Self-Management: A Quasi-Experimental Study Ady Irawan.AM; Artini, Kusumaningtyas Siwi; Putri, Anggie Pradana
Journal of Applied Nursing and Health Vol. 8 No. 2 (2026): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/janh.v8i2.427

Abstract

Background: Hypertension is a leading global health problem, with poor adherence to treatment remaining a major barrier to effective control. Mindfulness has emerged as a supportive strategy for improving adherence and self-care. However, the effectiveness in non-Western hypertensive populations remains unclear. This study aimed to evaluate the effectiveness of a culturally adapted mindfulness intervention on blood pressure, medication adherence, and self-care in patients with hypertension in Indonesia. Methods: A nonrandomized quasi-experimental pretest-posttest control group design was employed. 40 adults aged 18-40 years with stage 1 hypertension were recruited through purposive sampling, and the minimum sample size was determined using power analysis (G*Power 3.1), resulting in a minimum of 15 participants per group. To account for attrition, 20 participants were recruited per group. We excluded adults with coronary heart disease, pregnancy, concurrent complementary therapies, or prior mindfulness experience. The study followed the TREND guideline for nonrandomized evaluations. Participants were allocated to an intervention group (n = 20) that received an eight-week culturally adapted mindfulness program delivered in group and individual sessions, or to a control group (n = 20) that received standard care. Data were collected at baseline, post-intervention, and one-month follow-up, using a validated digital sphygmomanometer (blood pressure), the Morisky Medication Adherence Scale-8 (medication adherence), and the Self-Care of Hypertension Inventory (self-care). Ethical clearance was obtained from the institutional review board (No. 109/VII/AUEC/2024), and data were analysed using repeated-measures ANOVA and independent t-tests. Results: Participants in the intervention group experienced significant reductions in systolic and diastolic blood pressure and improved medication adherence compared with the control group, with effects sustained at follow-up (time x group interaction: SBP F = 8.33, p < 0.001, η² = 0.15; DBP F = 7.01, p = 0.002, η² = 0.13; MMAS-8 F = 15.27, p < 0.001, η² = 0.24). Self-care scores increased significantly post-intervention (p = 0.030) but declined at follow-up, with no significant group difference at T2 (p > 0.05). Baseline characteristics were comparable between groups, ensuring equivalence. Conclusion: A culturally adapted mindfulness program effectively improved blood pressure control and medication adherence in Indonesian patients with hypertension, although self-care benefits diminished over time. These findings suggest that mindfulness-based interventions can be a feasible, low-cost complement to standard care, particularly in resource-limited settings. Future studies with larger samples, longer follow-up, and reinforcement strategies are recommended to sustain self-care behaviours.
Total Flavonoid Content of Lemongrass Leaf (Cymbogoncitratus (DC.) Stapf) Extract and Antioxidant Activity with Frap Nurinnafi'a, Ahda Maulida Ulufan; Artini, Kusumaningtyas Siwi; Permatasari, Desy Ayu Irma
Journal of Fundamental and Applied Pharmaceutical Science Vol. 3 No. 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15556

Abstract

Lemongrass (Cymbogoncitratus (DC.) Stapf) leaves contain alkaloids, saponins, tannins, anthraquinones, steroids, phenols and flavonoids. Flavonoids act as antioxidants as they can reduce free radicals. This study aims to determine the total flavonoid content, antioxidant activity, and IC50 value of lemongrass leaf extract (Cymbogoncitratus (DC.) Stapf). Extracts were made by maceration using 96% ethanol as solvent. Testing of total flavonoid content with the AlCl3 method using UV-Vis spectrophotometry was carried out three times. The antioxidant activity test used the FRAP (ferric reducing antioxidant power) method on extracts containing 100, 200, 300, 400, and 500 ppm. The test results showed that the leaf extract of citronella (Cymbogoncitratus (DC.) Stapf) had a total flavonoid content of 22,60 mg QE/g extract. Furthermore, there was antioxidant activity in the leaf extract of lemongrass (Cymbogoncitratus (DC.) Stapf indicated by the formation of a blue color purplish when reacted with FRAP solution, and IC50 extract value was 71,59 ppm and included in the category of strong antioxidants.
Antibacterial Activity of Abrus precatorius L. Leaves Against Streptococcus mutans ATCC 25175 Bacteria Andika, Nadia Aisy; Artini, Kusumaningtyas Siwi; Wardani, Tatiana Siska
Journal of Fundamental and Applied Pharmaceutical Science Vol. 3 No. 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.16206

Abstract

One of the herbal plants that have medicinal properties is Abrus precatorius L or commonly known as Saga in Indonesia. Empirically, the boiled water of saga leaves is widely used as an ingredient in cough medicine, cancer sores and swollen tonsils. The chemical constituents of antibacterial activity in the saga leaves are glycosides (abrusoside AD and abrusgenin), flavonoids and saponins (glycerin). This study aims to determine the antibacterial activity of extracts and fractions from saga leaves and the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the most active fraction of saga leaves on the growth of Streptococcus mutans ATCC 25175. Saga leaf powder was macerated using 96% ethanol, then fractionated using n-hexane, ethyl acetate, water as solvent, 96% ethanol extract, and n-hexane fraction. The antibacterial activity test using the diffusion method showed that the extract, n-hexane fraction, ethyl acetate fraction, and water fraction of saga leaves had antibacterial activity against Streptococcus mutans. The most active fraction was the ethyl acetate fraction, with a concentration of 50% with an average inhibition zone diameter of 12.2 mm. The ethyl acetate fraction from saga leaves had the most active antibacterial activity compared to ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction, as seen from the average diameter of the inhibition zone obtained. The test results of the dilution method of the ethyl acetate fraction of saga leaves showed a Minimum Inhibitory Concentration of 12.5% and a Minimum Killing Concentration of 25%.
Co-Authors A, Ferlinda Ayu Ady Irawan.AM Andika, Nadia Aisy Anisawati, Amanda Annisa Kusuma Wardhani Belinda Arbitya Dewi Dewi Plasmawati, Kadek Erikania, Susanti Hazir, Nur Shukriyah Binti Mohamad Jayak P, Kharisma Kota, Hildagardis Mbula Listyani, Tiara Ajeng Nurinnafi'a, Ahda Maulida Ulufan Pahlawaningrum, Intan Malla Permata, Bangkit Riska Permatasari, Desy Ayu Irma Pratama, Kharisma Jayak Puguh Ika Listyorini Putri, Anggie Pradana Rahadyana, Riskaldila Zahra Rohmana, Vivin Marwiyanti Rohmana, Vivin Marwiyati Sahadatun, Angga Aulia Saifana, Cindy Septia Saryadi Sejati, Siti Laila Utari Septian Maulid Wicahyo Suhatmi, Erna Chotidjah Verentika, Jumini Wardani, Tatiana Siska Wijayanti, Devi Nur