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All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Kesehatan Andalas Journal of Midwifery Majalah Kedokteran Andalas Andalas obstetrics and gynecology journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal EduHealth Detector: Jurnal Inovasi Riset Ilmu Kesehatan
Elly Usman
Bagian Farmakologi FK Unand
Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Gambaran Polimorfisme Gen SLC22A1 rs683369 pada Pasien Diabetes Melitus Tipe 2 yang Mendapatkan Terapi Metformin Rahmatul Firdaushty; Elly Usman; Linosefa Linosefa
Jurnal Kesehatan Andalas Vol 9, No 1S (2020): Online January 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i1S.1160

Abstract

Mekanisme kerja metformin dipengaruhi oleh Organic Cation Transporter 1 (OCT1) yang dikode oleh gen SLC22A1. Variasi atau polimorfisme pada gen SLC22A1 mempengaruhi uptake metformin ke hati sehingga berhubungan dengan efek metformin dalam menurunkan glukosa darah. Rs683369 merupakan salah satu polimorfisme dari gen SLC22A1. Tujuan: Melihat gambaran polimorfisme gen SLC22A1 rs683369 pada pasien diabetes melitus tipe 2 yang mendapatkan terapi metfomin. Metode: Penelitian ini merupakan studi deskriptif dengan teknik consequtive sampling. Sampel berasal dari 44 pasien DM tipe 2 yang mendapatkan terapi tunggal metformin yang diambil darahnya melalui pembuluh vena untuk dilakukan pemeriksaan genotip dengan cara isolasi DNA, PCR dan sekuensing. Hasil: Didapatkan pasien DM tipe 2 yang mendapatkan terapi tunggal metformin sebagian besar adalah perempuan 63,6%, dan rerata umur 55,77±7,77 tahun. Pemerikaan genotip didapatkan hasil wild type (GG) 4,5%, mutan heterozigot (GC) 22,%, dan mutan homozigot (CC) 72,7%. Simpulan: Ditemukan polimorfisme gen SLC22A1 rs683369 pada pasien DM tipe 2 yang mendapatkan terapi metformin. Perlu penelitian lebih lanjut mengenai variasi lain pada gen SLC22A1 dan efeknya terhadap gula darah pasien.
Azithromycin and the Outcome of Treated COVID-19 Patients: A Hospital-Based Study Elly Usman
Journal of Midwifery Vol 7, No 1 (2022): Published on June 2022
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.7.1.76-81.2022

Abstract

COVID-19 is an infectious disease that has been declared a pandemic. Currently, there is no validated pharmacological treatment for use in COVID-19 disease and is still in the clinical trial stage. The aim of this study to determine the association of azithromycin and the outcome of treated COVID-19 patients. This study used a retrospective cohort.  The number of samples in this study were 40 subjects in each group of azithromycin and non-azithromycin. The research sample was all COVID-19 patients who were treated at Dr. M Djamil Hospital Padang with moderate and severe grades receiving treatment with azithromycin and non-azithromycin. The inclusion criteria in this study were moderate and severe COVID-19 patients and data related to research variables were complete and well-documented. Sampling technique with convenience sampling. Data analysis was performed using the Chi-square test. P < 0.05 was significant, and the data were analyzed using the SPSS version 21.0 program. The mortality of COVID-19 patients in patients receiving azithromycin therapy (80.0%) compared to non-azithromycin (85.0%). The results of the statistical test showed that there was no relationship of azithromycin administration with the outcome of COVID-19 patients (p>0.05), with OR (0.71, 95% CI 0.22-2.26). In this study, it is hoped that the decision on the use of azithromycin should consider the potential benefits and risks, evaluated that the possibility of the drug being effective is greater than the risk to the patient.
Correlation of ApoE Gene Polymorphism with Coronary Heart Disease Severity in Patients with Acute Coronary Syndrome Who Receive Statin Therapy, Padang, Indonesia Elly Usman; Gestina Aliska; Masrul Syafri
Journal of Midwifery Vol 7, No 1 (2022): Published on June 2022
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.7.1.1-7.2022

Abstract

Coronary Heart Disease (CHD) is still the most common cause of death. Ischemic heart disease causes more than 7 million (12.8%) deaths worldwide. It is estimated that 3,750,000 Indonesians have CHD. CHD is a disease with many risk factors. ApoE gene polymorphism is associated with atherosclerosis and plays a role in lipid metabolism, which is 2-16% affecting variability in LDL levels. This study aims to look at the relationship between ApoE gene polymorphism and the severity of coronary heart disease. Data regarding ApoE gene polymorphism was obtained using polymerase chain reaction (PCR). DNA was isolated from white blood cells using DNA purification kit. ApoE2, ApoE3, ApoE4 alleles were detected by DNA sequencing. Data on the severity of coronary heart disease were obtained from angiography and were calculated based on SYNTAX scores. In this study, ApoE was obtained with e2 allele frequencies (4.63%), e3 (78.70%), and e4 (16.67%) with E2 / 2 (0%), E2 / 3 (3.70%), E2 / 4 (5.56%), E3 / 3 (64.81%), E3 / 4 (24.07%), and E4 / 4 (1.85%). The relationship between the SYNTAX score and the ApoE genotype has no significant difference. ApoE3 / 4 genotype has the highest SYNTAX score and the e4 allele has the most influence on CHD despite the influence of statin therapy.
Peningkatan Pengetahuan Masyarakat tentang Bahaya Paparan Mikroplastik dan Dampaknya bagi Kesehatan Ilmiawati Ilmiawati; Liganda Endo Mahata; Gestina Aliska; Erlina Rustam; Yusticia Katar; Rahmatini Rahmatini; Julizar Julizar; Elly Usman
Warta Pengabdian Andalas Vol 29 No 3 (2022)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.29.3.305-311.2022

Abstract

Plastic is a global problem; plastic pollution production reaches 350 million tons annually. This plastic pollution will be degraded into microplastic. This microplastic will pollute the environment and negatively impacted health if exposed too much. Recent research has found microplastics in clothes, toys, and even food. The Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Andalas conducts outreach to the public to enhance the general public's understanding of microplastics and their impact on health. The outreach activity began with filling out a pre-test to assess the public's understanding of microplastics. Followed by education about microplastic exposure, the dangers of microplastics, and education about a healthy lifestyle to reduce sources of microplastic exposure. The event ended with filling out a post-test by participants. Paired t-test analysis on pre-test and post-test data showed an increase in public understanding regarding microplastics, sources of exposure, health impacts and ways to reduce microplastic exposure. Based on these results, it can be concluded that the provision of public service can increase public understanding regarding the sources of microplastics and their impact on health and encourage people to live a healthy lifestyle that minimizes exposure to microplastics.
Edukasi Masyarakat Mengenai Toksikan Abadi (Forever Chemicals) dalam Kosmetik Bersifat Waterproof Ilmiawati Ilmiawati; Liganda Endo Mahata; Gestina Aliska; Rahmatini Rahmatini; Julizar Julizar; Yusticia Katar; Erlina Rustam; Elly Usman
Warta Pengabdian Andalas Vol 30 No 4 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.4.708-714.2023

Abstract

Per- and poly-fluoroalkyl substances (PFAS) are synthetic chemicals added to cosmetics for their waterproof property to obtain a long-lasting application. PFAS is highly persistent, hence called the forever chemicals. This community outreach was aimed to educate the public on PFAS exposure through waterproof cosmetics and its health implications. Our webinar was attended by 84 people, 50 of whom responded to the pre-and post-test. An expert delivered the presentation of the educational content. There was an increase in attendees’ test scores from 56.4±21.3 to 88.4±19.0 (mean±SD; paired t-test, p<0.05). The webinar improved attendees’ knowledge of PFAS exposure from waterproof cosmetics and its potential effects on health.
Efficacy of EMCO Therapy on Serum β-hCG Levels in Case of Gestational Trophoblastic Neoplasm (GTN) at Dr. M. Djamil Hospital Padang 2019-2021 Siregar, Attahhal Fikrian Syadiq; Syamel Muhammad; Elly Usman
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.754-762.2024

Abstract

Backgrounds: Etoposide, Methotrexate, Cyclophosphamide, and Vincristine (EMCO) Chemotherapy is used as an alternative therapy for patients with a diagnosis of Gestational Trophoblastic Neoplasm (GTN) at Dr. M. Djamil Hospital Padang because Actinomycin D has not been included in the National Formulation (FORNAS). Purpose: To determine the efficacy of EMCO therapy with limited Actinomycin D on serum β-hCG levels in Gestational Trophoblastic Neoplasm (GTN) cases at Dr. M. Djamil Padang Hospital in 2019-2021. Methods: The type of research used is numerical comparative analytics with a cross sectional approach. The number of samples was 17 GTN patients who had done EMCO chemotherapy and checked β-hCG levels before and after chemotherapy. The research was conducted from April to October 2022 at Dr. M. Djamil Hospital Padang. Data processing using total sampling technique and tested using Wilcoxon Test. Results: Most GTN patients were found to be <40 years old (64,7%), history of molar hydatidiform pregnancy (47,1%), last pregnancy interval <4 months (58,8%), β-hCG level before chemotherapy ranged from 104-105 mIU/mL (52,9%), tumor size >5 cm (58,8%), metastasis location in the internal genital tract (35,5%), and patients who did not have metastasis (52,9%). Conclusion: There was a significant decrease in β-hCG levels after chemotherapy using EMCO for three cycles in patients with a diagnosis of GTN.
KONSUMSIPISANG EMAS (MUSA Sp ) UNTUK PENCEGAHAN OSTEOPOROSIS Elly Usman
Jurnal Kesehatan Masyarakat Andalas Vol 3 No 1 (2008): Jurnal Kesehatan Masyarakat Andalas
Publisher : Faculty of Public Health, Andalas University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24893/jkma.v3i1.52

Abstract

Osteoporosis merupakan akibat dari kombinasi berkurangnya masa puncak tulang dan meningkatnya masa otot yang hilang. Masa puncak tulang hiasanya dicapai pada usia 20 -an dan tergantung pada faktor masa kanak-kanak dan remaja. Tingkat masa tulang yang hilang ketika dewasa juga tergantung pada pemasukan kalsoium dan olah raga. Sekarang untuk mencegah osteoporosis dibutuhkan pemasukan kalsium dan vitamin D yang memadai dengan mengkonsumsipisang emas (Musa Sp) terutama untuk wanita pasca menaupause disamping olah raga teratur, Disain penelitian ini bersifat experimental dan sampel diambil secara acak di pasar di kota Padang. Sampel yang telah dikeringkan kemudian diserbuk dan didestruksi basah dengan pelarut asam nitrat dan hidrogen peroksida. Serapan larutan diukur dengan menggunakan Spektrofotometer Serapan Atom pada panjang gelombang 232,0 nm Dari hasil penelitian ini didapatkan kadar calsium dalam pisang emas ( Musa Sp) ini sebesar 28,06 ug
Bacterial Patterns and Sensitivity to Antibiotics in Neonatorum Sepsis Patients at Dr. M. Djamil Padang General Hospital in the Period 2018–2021 Fenty Primadhani; Linosefa, Linosefa; Fitrisia Amelin; Almurdi, Almurdi; Elly Usman; Rahmi Lestari
Jurnal EduHealth Vol. 16 No. 02 (2025): Jurnal EduHealt, Edition April - June , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Neonatal sepsis is one of the leading causes of morbidity and mortality in neonates. Bacteria are the most common cause of neonatal sepsis. The appropriate empirical therapy is given based on the bacterial pattern and sensitivity at the site. The appropriate use of empirical antibiotics can help reduce the neonatal mortality rate. This study aimed to evaluate bacterial patterns and antibiotic sensitivity in neonatal sepsis patients at RSUP Dr. M. Djamil Padang period 2018-2021. This study is a descriptive study that used a total sampling method with 63 samples that met the inclusion criteria. The results showed that neonatal sepsis was most commonly found in neonates aged 4-28 days, which were mostly male, had a birth weight < 2500 grams, had a mortality rate of 25.4%, and neonatal pneumonia was the most comorbid disease. The most common causative bacteria were Klebsiella pneumoniae and Staphylococcus haemolyticus. Klebsiella pneumoniae is sensitive to amikacin, tigecycline, meropenem, and ertapenem. Staphylococcus haemolyticus was sensitive to tigecycline, nitrofurantoin, vancomycin, linezolid, and quinupristin / dalfopristin. This study concluded that the most common bacteria causing neonatal sepsis were Klebsiella pneumoniae and Staphylococcus haemolyticus. Klebsiella pneumoniae was sensitive to amikacin, tigecycline, meropenem, and ertapenem. Staphylococcus haemolyticus was sensitive to tigecycline, nitrofurantoin, vancomycin, linezolid, and quinupristin / dalfopristin. Clinicians are expected to review the clinical practice guidelines for neonatal sepsis to suit bacterial patterns and their sensitivity to antibiotics.
Peranan Kortikosteroid Terhadap Luaran Pasien COVID-19: Sebuah Tinjauan Literatur Ahmad Rafid; Elly Usman; Deddy Herman
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 2 No. 3 (2024): Agustus : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v2i3.4008

Abstract

Corticosteroid is one of the COVID-19 drug agents that has a pros and cons of its use because there has been a research that shows this drug had a negative impact and also there has been a research that recommend its use.This literature study conducted to discuss about role of corticosteroid towards COVID-19 patient’s outcome. This paper is a literature review that evaluates variant journals of original research with clinical study design about role of corticosteroid towards COVID-19 patient's outcome by selecting through electronic database such as PubMed, ScienceDirect, and CENTRAL with designated keywords. There are 16 literatures of clinical study design found through PubMed, ScienceDirect, and CENTRAL. It is know that the role of corticosteroid depend on patient's clinical characteristic and time given to the patients. It can be concluded that corticosteroid had role on improving oxygenation on patients with moderate-critical symptoms, reducing mortality rate on critical patients with hyperinflammation, and reducing the lenght of stay in the hospital.
Hubungan Konsumsi Kopi Dengan Kejadian Dismenore : Sebuah Tinjauan Literatur Aisyah Ramadhini; Elly Usman; Aladin Aladin
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 2 No. 3 (2024): Agustus : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v2i3.4009

Abstract

Coffee is a widely consumed beverage especially for Indonesian. Its consumption continues to increase. There is not much information and researches on the relationship between coffee consumption and dysmenorrhea. This literature study was conducted to find out more about the relationship between coffee consumption and the incidence of dysmenorrhea. This literature study is a narrative literature review, delves into the literature with an analytical observational design regarding the relationship between coffee consumption and the incidence of dysmenorrhea. The literature search was carried out through the PubMed, Proquest and ScienceDirect electronic databases based on predetermined inclusion and exclusion criteria. A total of 12 literatures were reviewed. From the results of the literature review, there are six literatures which state that coffee consumption is associated with dysmenorrhea and six other literatures state that coffee consumption is not associated with dysmenorrhea. The conclusion of this literature study is that the relationship between coffee consumption and the incidence of dysmenorrhea is still debatable .
Co-Authors Ahmad Muhtar Ahmad Rafid Aisyah Ramadhini ALADIN ALADIN Almurdi Almurdi Amelin, Fitrisia Aziz Djamal Erlina Rustam Erly Erly Fadhila Aini Fenty Primadhani Gestina Aliska Gestina Aliska Herman, Deddy Iis Rahayu Ilmiawati, Ilmiawati Inez Amelinda Ismail Fajri Ivan Putra Siswanto Julizar Julizar Linosefa Linosefa Mahata, Liganda Endo Masrul Syafri Mohamad Reza Muhammad Gamal Eddin Nadjmir Nadjmir Nency Agustia Oea Khairsyaf Rahmatini . Rahmatul Firdaushty Rahmi Lestari Ramadani, Indah Rauza Sukma Rita Rizanda Machmud Rizky Erizka Siregar, Attahhal Fikrian Syadiq Syamel Muhammad Ulya Uti Fasrini Yanwirasti Yanwirasti Yusticia Katar