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All Journal JURNAL FARMASIMED (JFM) Best Journal (Biology Education, Sains and Technology) PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Jurnal ABDIMAS MUTIARA Jurnal Indah Sains dan Klinis
Asfianti, Vivi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Potensi Antipiretik Ekstrak Metanol Herba Pugun Tanoh (Picria fel-terrae Lour.) pada Tikus Putih Jantan yang Diinduksi 2,4-Dinitrofenol Romansa Sianipar; Asfianti, Vivi; Debi Meylani
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.04

Abstract

Background: Pugun tanoh herb (Picria fel-terrae Lour.) is a medicinal plant belonging to the family Scrophulariaceae and has traditionally been used to treat malaria, promote diuresis, relieve colic, reduce fever, and manage skin diseases. Objective: This study aimed to evaluate the antipyretic activity of the methanol extract of Pugun tanoh herb in male white rats (Rattus norvegicus) induced with 2,4-dinitrophenol and to determine the most effective dose. Methods: This experimental study used a digital thermometer to measure changes in the body temperature of rats. The extract was administered at doses of 50, 100, and 200 mg/kg body weight, with Na-CMC as the negative control and paracetamol at 20 mg/kg body weight as the positive control. Results: The results showed that the methanol extract of Pugun tanoh herb exhibited antipyretic activity. Doses of 50, 100, and 200 mg/kg body weight reduced the body temperature of rats, with mean temperatures of 37.416 °C, 36.776 °C, and 36.388 °C, respectively. Conclusion: The dose of 200 mg/kg body weight demonstrated the strongest antipyretic effect. This activity is presumed to be associated with the flavonoid content of Pugun tanoh herb.
Uji Aktivitas Antioksidan Ekstrak n-Heksan, Etil Asetat dan Metanol Herba Puguntano (Picria fel-terrae Lour.) dengan Metode DPPH Ushbah Safira; Asfianti, Vivi; Samran
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.05

Abstract

Background: Antioxidants are compounds that play a role in inhibiting or reducing oxidative damage caused by free radicals. Objective: This study aimed to evaluate the characteristics of simplicia, phytochemical constituents, reflux extraction process, and antioxidant activity of puguntano herb extract using the DPPH method with UV-Vis spectrophotometry. Methods: Simplicia characterization included macroscopic examination, moisture content, water-soluble extractive value, ethanol-soluble extractive value, and total ash content. Phytochemical screening was performed using thin-layer chromatography to detect alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. Puguntano herb was extracted by reflux using n-hexane, ethyl acetate, and methanol as solvents, followed by concentration with a rotary evaporator to obtain thick extracts. Antioxidant activity was assessed using the DPPH method after 60 minutes of incubation at a wavelength of 516 nm. Results: The simplicia characterization showed a moisture content of 7.23%, water-soluble extractive value of 38.6%, ethanol-soluble extractive value of 5%, and total ash content of 10.71%. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. Conclusion: The IC50 values of the n-hexane, ethyl acetate, methanol extracts, and quercetin were 216.8478, 30.6781, 21.3478, and 4.973 µg/mL, respectively
FORMULASI SEDIAAN KRIM TABIR SURYA EKSTRAK ETANOL DAUN PECUT KUDA (Stachytarpheta jamaicensis L) DAN UJI Surya Protection Factor (SPF) SECARA IN VITRO Marbun, Eva Diansari; Sapitri, Alfi; Sianipar, Artha Yuliana; Asfianti, Vivi
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10697

Abstract

Tabir surya merupakan suatu bahan topikal yang berfungsi untuk mengurangi dampak radiasi yang di sebabkan oleh sinar UV. Daun pecut kuda (Stachytarpetha jamaicensis L) merupakan tanaman yang banyak di manfaatkan untuk menjaga kesehatan dan sebagai obat tradisisonal. Tujuan dari penelitian ini Untuk mengetahui ekstrak etanol daun pecut kuda (Stachytarpheta jamaicensis L) dapat di formulasikan menjadi sediaan krim tabir surya, dan Untuk mengetahui nilai SPF (Sun Protector Factor) dari ekstrak daun pecut kuda (Stachytarpheta jamaicensis L). Metode peneleitian ini menggunakan metode eksperimental atau percobaan yang di mulai dari pengambilan sampel, sortasi basah, pengeringan, sortasi kering, penimbangan, penghalusan simplisia, perkolasi, dan rotary hingga menjadi ekstrak. Hasil penelitian uji mutu fisik krim tabir surya ekstrak etanol daun pecut kuda dengan konsetrasi 1%,2%,3% berbentuk setengah padat, warna cokelat, dan berbau khas rossae. Homogenitas pada sediaan yaitu homogen, Uji pH pada ketiga konsentrasi yaitu 5,9, 6,3, 6,5. Uji tipe krim menunjukkan ketiga konsentrasi yang termasuk tipe m/a. Uji daya lekat pada ketiga konsentrasi memenuhi syarat uji yaitu lebih dari 1 detik. Uji daya sebar pada ketiga konsentrasi memenuhi syarat uji yaitu 5-7cm. Uji iritasi pada ketiga konsentrasi tidak memberikan efek iritasi pada kulit. Uji Viskositas pada ketiga konsentrasi rata-rata 14300. Uji hiodonik dapat di simpulkan bahwa sedian yang paling di sukai panelis adalah konsentrasi 2%. Dan uji nili SPF di dapat hasil F1:1,97(minimal, F2:3,25(minimal), F3:6,41(Ekstra). Kesimpulan pana penelitian ini adalah formulasi ekstrak etanol daun pecut kuda(Stachytarpetha jamaicenis L) dapat di formulasikan sebagai sediaan tabir surya, dan ekstrak etanol daun pecut kuda (Stachytarpetha jamaicensis L) mempunyai nilai SPF(Surya Protection Factor).
Co-Authors Aminah Dalimunthe Antonius Wilson Sembiring Daely, Ruth Christiani N Debi Meylani Dewi Pertiwi Dian Arisetya, Dian Febriady, Andy Harianja, Ester Saripati Hariman, Hariman Marbun, Eva Diansari Purba, Hana Ike Dameira Purba, Sri Dearmaita Retnita Ernayani Lubis Romansa Sianipar Sagala, Vanny Yosepha Samran, Samran Sapitri*, Alfi Sapitri, Alfi Sianipar, Artha Yuliana Simangunsong, Irene Siti Maimunah Sitorus, Binsar Sondang Purba Suprianto Suprianto Syarifuddin, Shofian Ushbah Safira