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FORMULASI SEDIAAN TABLET EKSTRAK ETANOL DAUN SEMBUNG RAMBAT (Mikania micrantha) SEBAGAI ANTIDIARE SERTA PENGUJIAN KANDUNGAN FLAVONOID TOTAL Aslam, M.Muzhil; Estiningsih, Daru; Fatmawati, Annisa
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3044

Prevalensi diare di Indonesia menurut Riskesdas 2018 diperkirakan 9% pada usia kurang dari 1 tahun , 11,5% usia 1 sampai 4 tahun, 6,2% usia 5 sampai 14 tahun, dan 6,7% berusia 15 sampai 24 tahun. Flavonoid pada daun M.micrantha memiliki aktivitas antidiare dengan menghambat motilitas usus. Tujuan penelitian ini adalah untuk mengetahui perbedaan sifat fisik tablet EEDSR 96% dengan beberapa variasi komposisi bahan pengisi (laktosa, amilum, kalium fosfat) dan mengetahui perbedaan nilai kadar flavonoid total yang terkandung di dalamnya. Jenis penelitian ini eksperimental menggunakan metode spektrofotometri UV Vis. Evaluasi sifat fisik tablet ekstrak etanol daun sembung rambat (EEDSR) 96% meliputi keseragaman bobot tablet, keseragaman ukuran, kekerasan, kerapuhan dan waktu hancur tablet. Uji kadar flavonoid total menggunakan metode spektrofotometri UV-Vis pada sediaan tablet dan kuersetin sebagai pembanding. Hasil: Evaluasi sifat fisik tablet EEDSR 96% dari uji granul dan sifat fisik tablet memenuhi persyaratan. Kadar flavonoid total pada tablet EEDSR 96%, formula I, II dan III adalah 1,37±0,04 mgEQ/100mg, 1,61 ± 0,03 mgEQ/100mg, dan 1,58 ± 0,02 mgEQ/100mg. Kesimpulan: Tablet dengan variasi komposisi bahan pengisi memiliki sifat fisik yang berbeda bermakna pada parameter waktu hancur dan kadar total flavonoid total. Kadar flavonoid total pada masing-masing formula tablet EEDSR 96% diperoleh nilai rata-rata yang berbeda makna.

Pengaruh Pemberian Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Kadar Low-Density Lipoprotein (LDL) Tikus Jantan Galur Sprague dawley : Efek Antikolestrol Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Kusumawardani, Nurul; Fauzi, Rizal; Emelda, Emelda; Estiningsih, Daru; Sukma Ananda , RA Dewinta; Nabila , Lathifa
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.9

This study aimed to determine the effect of the n-hexane fraction of Moringa leaf ethanol extract (Moringa oleifera L.) on low-density lipoprotein (LDL) levels in Sprague Dawley male rat strains fed a high-fat diet. This study used a pre-test and post-test control design on male rats of the Sprague Dawley strain. Thirty-six male white rats of the Sprague Dawley strain were given high-fat diet and then divided into six groups: group I was normal group, group II negative control was given CMC Na, Group III positive control was given Simvastatin 10 mg, Group IV, V, VI was given n-hexane fraction of ethanol extract of Moringa leaves (Dose 3,722 mg/kgBW; 7.444 mg/kgBW; 14,888 mg/kgBW). The results of measuring low-density lipoprotein (LDL) levels in animals were measured after 14 days of research as a post-test. Based on statistical analysis, there was no significant difference between the positive control group and the three treatment groups (p=1,000). The results of this study can conclude that the dose of the n-hexane fraction of Moringa leaves has a significant effect on decreasing LDL levels in male Sprague Dawley rats with the best % reduction at a dose of 14.89 mg/kg BW (61.17%), with a linear regression equation y=-0.0408x + 1.079; (R2=0.986). The results of this study indicate that the n-hexane part of Moringa leaves may reduce low-density lipoprotein levels in male white Wistar rats induced by high-fat.

Pengaruh Pemberian Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Kadar Low-Density Lipoprotein (LDL) Tikus Jantan Galur Sprague dawley : Efek Antikolestrol Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Kusumawardani, Nurul; Fauzi, Rizal; Emelda, Emelda; Estiningsih, Daru; Sukma Ananda , RA Dewinta; Nabila , Lathifa
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.9

This study aimed to determine the effect of the n-hexane fraction of Moringa leaf ethanol extract (Moringa oleifera L.) on low-density lipoprotein (LDL) levels in Sprague Dawley male rat strains fed a high-fat diet. This study used a pre-test and post-test control design on male rats of the Sprague Dawley strain. Thirty-six male white rats of the Sprague Dawley strain were given high-fat diet and then divided into six groups: group I was normal group, group II negative control was given CMC Na, Group III positive control was given Simvastatin 10 mg, Group IV, V, VI was given n-hexane fraction of ethanol extract of Moringa leaves (Dose 3,722 mg/kgBW; 7.444 mg/kgBW; 14,888 mg/kgBW). The results of measuring low-density lipoprotein (LDL) levels in animals were measured after 14 days of research as a post-test. Based on statistical analysis, there was no significant difference between the positive control group and the three treatment groups (p=1,000). The results of this study can conclude that the dose of the n-hexane fraction of Moringa leaves has a significant effect on decreasing LDL levels in male Sprague Dawley rats with the best % reduction at a dose of 14.89 mg/kg BW (61.17%), with a linear regression equation y=-0.0408x + 1.079; (R2=0.986). The results of this study indicate that the n-hexane part of Moringa leaves may reduce low-density lipoprotein levels in male white Wistar rats induced by high-fat.

Analysis of Length of Stay (LOS) of Diabetes Mellitus Patients with COVID-19 Confirmed at One of Bantul Private Hospitals Masfiyah, Lukluul; Estiningsih, Daru; Astuti, Witri Susila; Hadi, Ninisita Sri
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6608

Diabetes mellitus (DM) is one of the most common health problems affecting millions of people in the world. Based on data from the Indonesian COVID-19 Handling Task Force, as of May 2021, it is known that the prevalence of DM as a comorbid COVID-19 is 33.6%. The variety of clinical conditions that accompany DM cases makes the complexity of patient care increase, which results in variations in patient LOS as one of the quality indicators to support better management and to improve the quality of service for DM patients confirmed with COVID-19 and not confirmed COVID-19. The purpose of this study was to determine whether or not there is a difference in the Length of Stay (LOS) of DM patients confirmed with COVID-19 and not confirmed with COVID-19 with the type of observational analytic cross-sectional design. Result Research shows that based on the Mann-Whitney test used to determine the difference in length of stay between DM patients confirmed with COVID-19 and not confirmed COVID-19, they get significant results, namely p-value = 0.000 (p<0.050). It can be concluded that there is a difference between the Length Of Stay (LOS) of Diabetes Miletus patients confirmed with COVID-19 and diabetes mellitus patients who are not confirmed with COVID-19.

FORMULASI SEDIAAN TABLET EKSTRAK ETANOL DAUN SEMBUNG RAMBAT (Mikania micrantha) SEBAGAI ANTIDIARE SERTA PENGUJIAN KANDUNGAN FLAVONOID TOTAL Aslam, M.Muzhil; Estiningsih, Daru; Fatmawati, Annisa
Jurnal Ilmiah Farmako Bahari Vol 15 No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3044

Prevalensi diare di Indonesia menurut Riskesdas 2018 diperkirakan 9% pada usia kurang dari 1 tahun , 11,5% usia 1 sampai 4 tahun, 6,2% usia 5 sampai 14 tahun, dan 6,7% berusia 15 sampai 24 tahun. Flavonoid pada daun M.micrantha memiliki aktivitas antidiare dengan menghambat motilitas usus. Tujuan penelitian ini adalah untuk mengetahui perbedaan sifat fisik tablet EEDSR 96% dengan beberapa variasi komposisi bahan pengisi (laktosa, amilum, kalium fosfat) dan mengetahui perbedaan nilai kadar flavonoid total yang terkandung di dalamnya. Jenis penelitian ini eksperimental menggunakan metode spektrofotometri UV Vis. Evaluasi sifat fisik tablet ekstrak etanol daun sembung rambat (EEDSR) 96% meliputi keseragaman bobot tablet, keseragaman ukuran, kekerasan, kerapuhan dan waktu hancur tablet. Uji kadar flavonoid total menggunakan metode spektrofotometri UV-Vis pada sediaan tablet dan kuersetin sebagai pembanding. Hasil: Evaluasi sifat fisik tablet EEDSR 96% dari uji granul dan sifat fisik tablet memenuhi persyaratan. Kadar flavonoid total pada tablet EEDSR 96%, formula I, II dan III adalah 1,37±0,04 mgEQ/100mg, 1,61 ± 0,03 mgEQ/100mg, dan 1,58 ± 0,02 mgEQ/100mg. Kesimpulan: Tablet dengan variasi komposisi bahan pengisi memiliki sifat fisik yang berbeda bermakna pada parameter waktu hancur dan kadar total flavonoid total. Kadar flavonoid total pada masing-masing formula tablet EEDSR 96% diperoleh nilai rata-rata yang berbeda makna.

Analysis of the relationship between treatment patterns based on patient characteristics in cases of hypertension complications at PKU Muhammadiyah Gamping Hospital Ariansyah, Diffa Zahra; Wulandari, Ari Susiana; Estiningsih, Daru; Nurinda, Eva
JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Vol 12, No 3 (2024)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/jnki.2024.12(3).365-378

Background : Hypertensive disease is often referred to as "The Silent Disease" or silent disease. The percentage of complication hypertension in Indonesia is cerebrovascular disease 21.6%, heart disease 40.9%, and kidney disease 33.2%. Yogyakarta is one of the provinces in Indonesia with a prevalence of complication hypertension of 32.86%. Each year, an estimated 9.4 million people die from hypertension and complications.Objective : To analyze the relationship between treatment patterns based on sociodemographic characteristics in complication hypertensive patients in Inpatient PKU Muhammadiyah Gamping Hospital.Methods: This study was analytical research methods using retrospective methods. The sampling technique was in this study is the total sampling technique. The variables used in this study were patterns of antihypertensive drug use associated with sociodemographic factors including gender, age, and patient health insurance (BPJS or non-BPJS). The test analysis was Chi-Square Test and Kendall's tau-b Test for variable blood pressure relationships and drug use patterns.Results: Sociodemographic characteristics of respondents include: adult age (16.7%) and elderly (83.3%), male and female gender (50.0%), BPJS treatment coverage (91.7%) and general (8.3%). Hypertensive disease complications include: stroke (20.8%), myocardial infarction (4.2%), kidney failure (4.2%), heart failure (33.3%), diabetes mellitus (37.5%). Drugs used: Amlodipine (23.10%), Candesartan (30.80%), Nifedipine (11.50%), Bisoprolol (19.20%), Clonidin (5.80%), Captopril (1.90%), Lisinopril (3.80%), and Ramipril (3.80%).Conclusion: There was no relationship between sociodemographic characteristics and treatment patterns and there was a relationship between systolic / diastolic blood pressure with drug use patterns in cases of complication hypertension at PKU Muhammadiyah Gamping Hospital.

Tren Global Penelitian Toll-like receptor 4 pada Penyakit Kardiovaskular: Analisis Bibliometrik 2017-2025 Amukti, Danang; Estiningsih, Daru; Herlina, Tetie; Kusumawardani, Nurul; Puspitasari, Ade; Amalia, Latifa; Suminingtyas, Ifa Aris; Nurinda, Eva; Nuryanti, Sundari Desi; Wulandari, Ari Susiana; Pratami, Ria Indah
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol 9, No 1 (2025)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v9i1.5989

Toll-like receptor 4 (TLR4) memiliki peran penting dalam patogenesis penyakit kardiovaskular (PKV) melalui mediasi respons inflamasi. Meskipun peran molekul ini semakin dikenal, belum ada kajian bibliometrik komprehensif yang mengulas tren global publikasi terkait TLR4 dalam konteks PKV secara sistematis. Tujuan penelitian ini bertujuan untuk menganalisis dinamika publikasi ilmiah global tentang TLR4 pada PKV dalam kurun waktu 2017–2025 menggunakan pendekatan bibliometrik. Data dikumpulkan dari database Scopus dengan kata kunci “Toll-like receptor 4” dan “cardiovascular”, difilter berdasarkan judul, abstrak, dan kata kunci, serta dibatasi pada dokumen berbahasa Inggris. Sebanyak 1.939 dokumen dianalisis menggunakan perangkat lunak Bibliometrix (R) dan VOSviewer untuk mengevaluasi tren publikasi, produktivitas penulis, kontribusi negara dan institusi, pemetaan kata kunci, dan artikel yang paling berpengaruh. Tiongkok mendominasi jumlah publikasi (592 dokumen), sementara Amerika Serikat mencatat pengaruh ilmiah tertinggi melalui kolaborasi internasional dan jumlah sitasi. Penulis paling produktif adalah Li Y dan Wang Y, sedangkan institusi teratas adalah Mashhad University dan Capital Medical University. Peta kata kunci menunjukkan empat klaster utama: inflamasi-imunitas, stres oksidatif-apoptosis, metabolisme, dan model hewan. Artikel paling disitasi berasal dari jurnal bereputasi tinggi seperti Signal Transduction and Targeted Therapy dan Nature Reviews Rheumatology. TLR4 merupakan target utama dalam penelitian multidisipliner dan translasi pada penyakit kardiovaskular. Hasil studi ini dapat menjadi acuan penting untuk perumusan strategi riset lanjutan dan kolaborasi global yang lebih terarah.

FAKTOR-FAKTOR YANG MEMPENGARUHI PEMILIHAN JENIS KONTRASEPSI PADA WANITA USIA SUBUR DI KECAMATAN SEMANU KABUPATEN GUNUNGKIDUL YOGYAKARTA Wijayanti, Adina Nugrahaeni; Febrianti, Yosi; Estiningsih, Daru
Media Farmasi: Jurnal Ilmu Farmasi Vol. 15 No. 2: September 2018
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v15i2.12663

Ledakan penduduk merupakan salah satu masalah yang ada di negara berkembang sepertiIndonesia yang merupakan negara dengan jumlah Wanita Usia Subur (WUS) terbesar di AsiaTenggara. Untuk mengatasi permasalahan ini, pemerintah menerapkan program KeluargaBerencana (KB) untuk mengontrol laju pertumbuhan masyarakat dengan menggunakan alatkontrasepsi yang pemilihannya dipengaruhi oleh beberapa faktor sehingga tercipta sumber dayayang berkualitas. Tujuan dari penelitian ini adalah untuk mengetahui faktor-faktor yangmempengaruhi pemilihan metode kontrasepsi di Kecamatan Semanu Kabupaten GunungkidulYogyakarta. Penelitian ini merupakan penelitian analitik kuantitatif dengan rancangan penelitiancross sectional dengan instrumen penelitian berupa kuesioner yang telah divalidasimenggunakan content validity. Waktu pengambilan sampel dilaksanakan pada bulan Juni 2016.Sampel diambil dengan menggunakan metode accidental sampling dan besarnya sampeldihitung dengan rumus slovin. Analisis data menggunakan analisis bivariat dengan uji chisquare.Hasil penelitian menunjukkan bahwa yang mempengaruhi pemilihan jenis kontrasepsidi Kecamatan Semanu adalah faktor pekerjaan (p=0,033) dan pengalaman efek samping(p=0,000).

Comparison of Clinical Outcomes of Diabetes Mellitus Patients with COVID-19 Confirmed Diabetes Mellitus Patients at One of the Hospital Bantul Nadliroh, Lubabun; Estiningsih, Daru; Sarwadhamana, Raden Jaka; Ninisita Sri Hadi
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

SARS-CoV-2-infected patients with comorbid DM are very likely to experience a significant reduction in glycemic control and eventually require adjustment of antidiabetic treatment to optimize clinical outcomes. The results of data collected by the COVID-19 Handling Task Force, the total number of cases in Indonesia that were confirmed positive for COVID-19 had comorbidities, one of which was Diabetes Mellitus 33.6%. This study aimed to determine whether or not there were differences in clinical outcomes of DM patients with confirmed COVID-19 and DM without confirmed COVID-19 at One of Hospital Bantul. This type of research is observational with a cross-sectional design. Secondary data in the form of medical records. Sampling was carried out using a simple random sampling method with the Lemeshow formula. The data were analyzed using the Mann-Whitney test in bivariate analysis. The results showed that the clinical outcome of type 2 DM patients with confirmed COVID-19 was the GDS target value (38.9%) and the GDS target value (61.1%). The clinical outcome of patients with type 2 diabetes who did not have confirmed COVID-19 was that the GDS target value (55.6%) was achieved and the GDS target value was not reached (44.4%). The results of the Mann-Whitney test showed a significant difference in clinical outcome p=0.046 between DM type 2 confirmed COVID-19 and DM type 2 not confirmed COVID-19. It can be concluded that DM patients with confirmed COVID-19 have different clinical outcomes than DM patients without confirmed COVID-19.

KAJIAN PENGGUNAAN OBAT OFF-LABEL PADA ANAK DI PUSKESMAS SLEMAN Akbar, Rizki; Setyaningrum, Ndaru; Estiningsih, Daru
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol. 1 No. 1 (2017)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v1i1.501

AbstrakOff-label merupakan istilah singkat yang menjelaskan penggunaan obat diluar ketentuan yang berkaitan dengan dosis, kelompok usia, rute pemberian, dan indikasi yang berbeda. Penggunaan obat off-label pada anak terjadi karena tidak lengkapnya data farmakokinetik, farmakodinamik, dan efek samping dari suatu obat karena penelitian klinik pada anak cukup sulit dan tidak sesuai dengan etika dan moral penelitian. Penelitian yang digunakan dalam penelitian ini adalah deskriptif dengan pengambilan data dilakukan secara retrospektif. Data prevalensi penggunaan off-label pada anak diperoleh dengan melakukan telaah catatan medik anak di Puskesmas Sleman selama periode tahun 2015. Selain kajian obat off-label dilakukan juga pengelompokan obat berdasarkan sistem klasifikasi ATC (Anatomical Therapeutic Chemical). Berdasarkan hasil penelitian dari 100 sampel rekam medis pasien anak usia 0-18 tahun selama tahun 2015 terdapat obat-obat off-label sebanyak 25 kasus (8,41%), yang terdiri dari 12 kasus (4,04%) off-label cara pemberian, 8 kasus (2,69%) off-label indikasi, dan 5 kasus (1,68%) off-label usia. Sedangkan untuk kategori off-label dosis dan off-label kontraindikasi tidak ditemukan adanya kasus off-label. Obat yang paling banyak diresepkan secara off-label adalah golongan obat saluran napas sebanyak 13 penggunaan (4,38%) yaitu salbutamol, dan gliseril guaiakolat. Kata Kunci: Obat off-label, Anak, Puskesmas Sleman, ATC. AbstractOff-label is a term to decscribe the usage of drugs agaisnt the regulations in accordance to doses, age groups, distribution routes, and diverse indications. The usage of off-label drugs on children is caused by incomplete pharmacokinetic data, pharmacodynamic, and as a result of side effects due to clinical studies on children are quite complex and incorresponding with ethics and moral of the studies. Method used in this study was evaluative-descriptive using retrospective approach in data collection. Prevelance data of the usage of off-label drugs on children was gathered by examining the children medical records in Sleman Community Health Center within the time period of 2015. Besides research on off-label drug, drug categorization was also done based on the ATC Classification system (Anatomical Therapeutic Chemical). Based on the result of the research, out of 100 sample of patient medical record of the age 0-18 years along 2015, there has been 25 cases of off-label medicines (8,41%), in which 12 cases (4,04%) was distribution way off-label, 8 cases (2,69%) indicated off label, and 5 cased (1.68%) age off-label. While for the category of dose off label and contraindication off label has not been found any case. The most common off label prescription was respiratory drugs of 13 use (4,38%) that is salbutamol, and glyceril guaiacolat. Keyword: Off-label drugs, Children, Sleman Community Health Center, ATC.

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