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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Biomedical Journal of Indonesia INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Clinical and Pharmaceutical Sciences Journal
Pratami, Ria Indah
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Tren Global Penelitian Toll-like receptor 4 pada Penyakit Kardiovaskular: Analisis Bibliometrik 2017-2025 Amukti, Danang; Estiningsih, Daru; Herlina, Tetie; Kusumawardani, Nurul; Puspitasari, Ade; Amalia, Latifa; Suminingtyas, Ifa Aris; Nurinda, Eva; Nuryanti, Sundari Desi; Wulandari, Ari Susiana; Pratami, Ria Indah
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol 9, No 1 (2025)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v9i1.5989

Abstract

Toll-like receptor 4 (TLR4) memiliki peran penting dalam patogenesis penyakit kardiovaskular (PKV) melalui mediasi respons inflamasi. Meskipun peran molekul ini semakin dikenal, belum ada kajian bibliometrik komprehensif yang mengulas tren global publikasi terkait TLR4 dalam konteks PKV secara sistematis. Tujuan penelitian ini bertujuan untuk menganalisis dinamika publikasi ilmiah global tentang TLR4 pada PKV dalam kurun waktu 2017–2025 menggunakan pendekatan bibliometrik. Data dikumpulkan dari database Scopus dengan kata kunci “Toll-like receptor 4” dan “cardiovascular”, difilter berdasarkan judul, abstrak, dan kata kunci, serta dibatasi pada dokumen berbahasa Inggris. Sebanyak 1.939 dokumen dianalisis menggunakan perangkat lunak Bibliometrix (R) dan VOSviewer untuk mengevaluasi tren publikasi, produktivitas penulis, kontribusi negara dan institusi, pemetaan kata kunci, dan artikel yang paling berpengaruh. Tiongkok mendominasi jumlah publikasi (592 dokumen), sementara Amerika Serikat mencatat pengaruh ilmiah tertinggi melalui kolaborasi internasional dan jumlah sitasi. Penulis paling produktif adalah Li Y dan Wang Y, sedangkan institusi teratas adalah Mashhad University dan Capital Medical University. Peta kata kunci menunjukkan empat klaster utama: inflamasi-imunitas, stres oksidatif-apoptosis, metabolisme, dan model hewan. Artikel paling disitasi berasal dari jurnal bereputasi tinggi seperti Signal Transduction and Targeted Therapy dan Nature Reviews Rheumatology. TLR4 merupakan target utama dalam penelitian multidisipliner dan translasi pada penyakit kardiovaskular. Hasil studi ini dapat menjadi acuan penting untuk perumusan strategi riset lanjutan dan kolaborasi global yang lebih terarah.
Worldwide Bibliometric Analysis of Antibiotic Resistance Research Trends Amukti, Danang Prasetyaning; Pratami, Ria Indah; Kaffah, Silmi; Ningsih, Novita Fitria; Evelin; Nurdevi, Aldise Indah; Liani, Fega; Panduwinata, Revina; Nurshintya, Agnes; Andre, Muhamad; Nurfaizah, Eka
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.264

Abstract

Introduction. Antibiotic resistance (AR) is a critical issue in global health, characterized by the increasing number of resistant pathogens that threaten the effectiveness of infection therapy. Although there has been a significant increase in the number of scientific publications related to AR, there are not many studies that systematically map the dynamics and direction of global research. This study aims to evaluate the global trend of antibiotic resistance research in the period 2022–2025 through a bibliometric approach. Methods. This is a quantitative bibliometric study with a descriptive design. Data were taken from 1,845 indexed international scientific sources, covering 18,786 documents. The analysis was carried out using the Bibliometrix R-package , focusing on publication growth, scientific collaboration, dominant keywords, and identification of the most contributing authors, institutions, and countries. Results. The study showed that despite a -28.01% decline in the annual publication growth rate, research volume remained high, with 27.62% cross-border collaboration and 87,959 authors involved. China and the United States dominated both in terms of publications and citations, while frequent keywords reflected a laboratory approach and focus on major pathogens. The most influential articles were published in leading journals such as The Lancet, Gut, and Clinical Infectious Diseases. Conclusion. This study confirms that antibiotic resistance remains a major focus of the global scientific community, characterized by extensive, collaborative, and evidence-based research activities. These findings provide an important scientific basis for designing more effective, adaptive, and sustainable AR research and policy strategies at the global level.
Tren Global Penelitian Toll-like receptor 4 pada Penyakit Kardiovaskular: Analisis Bibliometrik 2017-2025 Amukti, Danang; Estiningsih, Daru; Herlina, Tetie; Kusumawardani, Nurul; Puspitasari, Ade; Amalia, Latifa; Suminingtyas, Ifa Aris; Nurinda, Eva; Nuryanti, Sundari Desi; Wulandari, Ari Susiana; Pratami, Ria Indah
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol. 9 No. 1 (2025)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v9i1.5989

Abstract

Toll-like receptor 4 (TLR4) memiliki peran penting dalam patogenesis penyakit kardiovaskular (PKV) melalui mediasi respons inflamasi. Meskipun peran molekul ini semakin dikenal, belum ada kajian bibliometrik komprehensif yang mengulas tren global publikasi terkait TLR4 dalam konteks PKV secara sistematis. Tujuan penelitian ini bertujuan untuk menganalisis dinamika publikasi ilmiah global tentang TLR4 pada PKV dalam kurun waktu 2017–2025 menggunakan pendekatan bibliometrik. Data dikumpulkan dari database Scopus dengan kata kunci “Toll-like receptor 4” dan “cardiovascular”, difilter berdasarkan judul, abstrak, dan kata kunci, serta dibatasi pada dokumen berbahasa Inggris. Sebanyak 1.939 dokumen dianalisis menggunakan perangkat lunak Bibliometrix (R) dan VOSviewer untuk mengevaluasi tren publikasi, produktivitas penulis, kontribusi negara dan institusi, pemetaan kata kunci, dan artikel yang paling berpengaruh. Tiongkok mendominasi jumlah publikasi (592 dokumen), sementara Amerika Serikat mencatat pengaruh ilmiah tertinggi melalui kolaborasi internasional dan jumlah sitasi. Penulis paling produktif adalah Li Y dan Wang Y, sedangkan institusi teratas adalah Mashhad University dan Capital Medical University. Peta kata kunci menunjukkan empat klaster utama: inflamasi-imunitas, stres oksidatif-apoptosis, metabolisme, dan model hewan. Artikel paling disitasi berasal dari jurnal bereputasi tinggi seperti Signal Transduction and Targeted Therapy dan Nature Reviews Rheumatology. TLR4 merupakan target utama dalam penelitian multidisipliner dan translasi pada penyakit kardiovaskular. Hasil studi ini dapat menjadi acuan penting untuk perumusan strategi riset lanjutan dan kolaborasi global yang lebih terarah.
Unveiling Global Research Trends and Collaboration Patterns in Alzheimer’s Disease: A Bibliometric Perspective Prasetyaning Amukti, Danang; Pratami, Ria Indah; Estiningsih, Daru; Saiful Bachri, Moch; Muhammad Ma’ruf; Djaka Purwanto, Barkah; Sukma Ananda, RA Dewinta; Suminingtyas, Ifa Aris; Akbar, Imam
Clinical and Pharmaceutical Sciences Journal Vol. 2 No. 1 (2026)
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/clips.v2i1.556

Abstract

Alzheimer's disease is one of the most common forms of dementia and poses a major challenge to global health, especially as the aging population increases. With the high research interest in this topic, a scientific mapping is needed to identify trends, major contributors, and current research focuses in the field of Alzheimer's. This study uses a bibliometric approach with a Scopus database published in the period 2023 to 2025, then the data is analyzed using bibliometrix software. The results show an annual publication growth rate of 19.67% with an average of citations per document of 3,524. The most productive journals are alzheimer's and dementia (1,093 documents), followed by Journal of Alzheimer's Disease (817 documents). The most active authors are Wang Y (493 documents), Zhang Y (437), and Li Y (410). The most affiliations come from University of California And Harvard Medical School, while the countries with the largest contributions are the United States, China, and India. Alzheimer's research shows rapid development in terms of quantity and international collaboration. The United States and China are the main centers of scientific contribution, both in terms of the number of publications and citations. These results are important as a basis for making research policies, cross-country collaborations, and determining the direction of future research in efforts to overcome alzheimer's disease.
Genetic Variants Influencing Spironolactone Effectiveness: A Pharmacogenomic Perspective Amukti, Danang Prasetyaning; Pratami, Ria Indah; Ananda, RA Dewinta Sukma
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 14 No. 1 (2026): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v14i1.43475

Abstract

Background: Spironolactone, a mineralocorticoid receptor antagonist, is widely used to treat resistant hypertension, heart failure, and primary aldosteronism. However, significant interindividual variability in therapeutic response suggests a genetic contribution to its effectiveness. Method: This study employed a bioinformatics approach using secondary data from PharmGKB, GTEx Portal, and HaploReg v4.2 to identify genetic variants and gene expression profiles potentially influencing spironolactone response. Result: Seven variants were identified as associated with spironolactone effectiveness: rs1799752 (ACE), rs3890011 and rs1126742 (CYP4A11), rs1801253 (ADRB1), rs1799983 (NOS3), rs4961 (ADD1), and rs1042713 (ADRB2). Tissue-specific expression analysis showed ACE highly expressed in testis, CYP4A11 in liver, ADRB1 in lung, NOS3 in spleen, ADD1 in tibial artery, and ADRB2 in skin. Functional predictions indicated that missense variants (rs1126742, rs1799983, rs4961) may affect protein structure, while intronic variants (rs1799752, rs3890011) may influence gene regulation. Conclusion: These findings suggest that pharmacogenomic profiling may help predict spironolactone response and support the development of personalized treatment strategies. Further clinical validation is required to establish the therapeutic relevance of these variants
Co-Authors Amalia, Latifa Amukti, Danang Amukti, Danang Andre, Muhamad Danang Prasetyaning Amukti Djaka Purwanto, Barkah Estiningsih, Daru Evelin Herlina, Tetie Imam Akbar, Imam Kaffah, Silmi Kusumawardani, Nurul Liani, Fega Muhammad Ma’ruf Ningsih, Novita Fitria Nurdevi, Aldise Indah Nurfaizah, Eka Nurinda, Eva Nurshintya, Agnes Nuryanti, Sundari Desi Panduwinata, Revina Prasetyaning Amukti, Danang Puspitasari, Ade Saiful Bachri, Moch Sukma Ananda , RA Dewinta Sukma Ananda, RA Dewinta Suminingtyas, Ifa Aris Wulandari, Ari Susiana