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Saputro, Sutiyo Dani
Fakultas Ilmu Kesehatan, Universitas Kusuma Husada Surakarta
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THE EFFECTIVENESS OF GALENIC CREAM OF DURIAN PEEL EXTRACT AND CHITOSAN FOR TREATMENT OF DIABETIC ULCERS Agustin, Wahyu Rima; Harti, Agnes Sri; Crisdian S, Hanugrah Ardya; Saputro, Sutiyo Dani; Saelan, Saelan
INDONESIAN NURSING JOURNAL OF EDUCATION AND CLINIC (INJEC) Vol 8, No 2 (2023): INJEC
Publisher : Asosiasi Institusi Pendidikan Ners Indonesia (AIPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24990/injec.v8i2.597

Abstract

Introduction: The chemical substance of durian peel (Durio zibethinus L.) is a polysaccharide polymer of D-galacturonic acid which is polar and anti-microbial. Chitosan is a derivative of chitin from the peels of Crustaceae animals, which is polycationic and antimicrobial; biodegradable, and biocompatible wit animal tissues. Diabetic ulcers are chronic wounds due to neurological disorders and vascular disorder in the legs, causing tissue damage. The purpose of the study was to analyze the effectiveness of galeni preparations of durian peel extract and chitosan for the treatment of diabetic ulcers.Method: This research is experimental including testing the quality of 5% durian peel extract cream preparations; 2% chitosan, a mixture of both ratio = 1:1; 1:2 physically, chemically, and microbiologically,and the rate of wound healing in test animals. Statistical data analysis of One Way Anova parametric test.Results: The results showed that the preparation of galenic durian peel extract cream and chitosan and their combination ratio (1:1), (1:2) could be formulated and met the quality test of cream preparations physically, chemically, and microbiologically according to the requirements of BPOM No. 32 of 2019 and is effective for healing diabetic ulcers on the 8th day.Conclusions: The preparation of galenic durian peel extract cream and chitosan and their combination ratio (1:1), (1:2) can potentially be developed as a cream preparation for healing diabetic ulcers.
Co-Authors Afni, Anissa Cindy Nurul Agnes Sri Harti Anissa Cindy Nurul Afni Anissa Cindy Nurul Afni Anissa Cindy Nurul Afni Anissa Cindy Nurul Afni Bambang Abdul Syukur Barros, Carmelita Berna Detha Meilyana Bintari Ratih Kusumaningrum, Bintari Ratih Budi Prasetyo Budiman, Amin Aji Crisdian S, Hanugrah Ardya Dewanto, Dany Ekwantoro Ekwantoro Endang Zulaicha Susilaningsih Fakhrudin Nasrul Sani Gatot Suparmanto Heri Suroso, Heri Meri Oktariani Meri Oktariani Mila Wahyu Utami Muhammad Nur Rahmad Musta’in Muzaroah Ermawati Ulkhasanah Nikma Alfi Rosida Noviana Nur Zaidah Rahmad, Muhamad Nur Ratih Ayu Puspasari S Susilowati S.Dwi Sulisetyawati Saelan, Saelan Saputri, Mareta Nawang Singgih Nugroho Suparmanto, Gatot Teguh Kurniawan, Sahuri Wahyu Rima Agustin Wahyu Rima Agustin