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All Journal Jurnal Peluang INDONESIAN JOURNAL OF PHARMACY Jurnal Ilmiah Mahasiswa Pendidikan Matematika Benchmarking: Jurnal Manajemen Pendidikan Islam Buletin Eboni METIK JURNAL Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Geuthee Indian Journal of Forensic Medicine & Toxicology Land Journal Jurnal Lingkar Mutu Pendidikan Land Journal Prosiding Seminar Nasional COSMIC Kedokteran
Suhartati Suhartati
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
PHARMACODYNAMICS STUDY OF ETHANOL EXTRACT OF CYCLEA BARBATA (MIERS.) LEAVES ON SRF AND COX-2 GASTRIC MICE WITH NSAID GASTROPATHY Florence Pribadi; Suhartati Suhartati; Achmad Basori
Indonesian Journal of Pharmacy Vol 28 No 3, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (880.862 KB) | DOI: 10.14499/indonesianjpharm28iss3pp131

Abstract

Epidemiology of NSAIDs gastropathy is increasing as increase number of usage. From arthritis to cardiovascular events and cancer prevention, the versatility of NSAIDs is not questioned. However, no dose of NSAIDs is safe. No matter low dose, or single use, NSAIDs will cause gastric damage upto 3-7 days after use. In inflammation and healing process of gastropathy there are various proteins involved, but treatment with COX-2 and SRF are associated with an immediate healing and better quality of gastric mucosa. Cyclea barbata (miers.) has been declared as functional food for preventing and treatment gastropathy yet, its mechanism of actions have not yet clearly discovered. Hence the aim of this study is to analyze the effects of Cyclea barbata (miers.) ethanol extract to COX-2 and SRF in gastric tissue, in time series basis. Laboratory mice was induced with aspirin to produce gastropathy and then treated with Cyclea barbata (miers.) extract for 1, 3, 7, 10 or 14 days. Gastric tissue then harvested and analysed with elisa procedure to determine tissue SRF and COX-2 level. Treatment was proven to increase COX-2 and SRF higher than control group. This concludes one of Cyclea barbata (miers.) mechanism for NSAIDs gastropathy is by increasing tissue COX-2 and SRF. 
Co-Authors Achmad Basori, Achmad Annisa Dewi Chenny A Wiyono Cut Morina Zubainur Dwi Fadhiliani Florence Pribadi Gwenny I.P Gwenny IP Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Harianto N HERAWATI, LILIK Herliani, Olivia Ira Humairah Jaka Maulana Jannatul Alyana khairul Umam Lana Sunarto Lukitasari, Lina M Hasbi M Hasbi Masfufatun Masfufatun Mukhlis Hidayat Noer Kumala Indahsari, Noer Kumala Pratika Yuhyi Hernanda Rejeki, Purwo Sri Reza Arta BN Siti Khaerunnisa Siti Khaerunnisa Suciati Suciati Sukina B Suryawati Suryawati Susi Wahyuning Asih Sutji Kuswarini Syahfitri Nur Afifah Yeyen Dwi Atma