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All Journal Paediatrica Indonesiana AcTion: Aceh Nutrition Journal Jurnal Ilmu Kedokteran dan Kesehatan journal of Basic Medical Veterinary Future Academia : The Journal of Multidisciplinary Research on Scientific and Advanced
Amna, Eka Yunita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Vitamin D and calcium status in children with thalassemia beta major: A cross sectional study in Banda Aceh Fiska, RR. Rima Aulia; Edward, Eka Destianti; Amna, Eka Yunita; Herdata, Heru Noviat; Sovira, Nora; Ismy, Jufitriani
AcTion: Aceh Nutrition Journal Vol 10, No 3 (2025): September
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i3.2486

Abstract

Frequent blood transfusions in children with beta-thalassemia major result in iron overload, leading to hemosiderosis in various body tissues, and impair the function of these organs, disrupting vitamin D metabolism, which contributes to osteoporosis and other morbidities, which are believed to be associated with hypocalcemia, which significantly affects growth. This study aimed to investigate the relationship between vitamin D and calcium status in children with β-thalassemia major at dr. Zainoel Abidin Public Hospital in Banda Aceh, Indonesia. Methods: An analytical observational study employed a cross-sectional design involving 40 children aged 2–18 years with a beta-thalassemia major attending the Children's Thalassemia Clinic at dr. Zainoel Abidin Public Hospital in Banda Aceh, Indonesia. from July to November, 2024. Categorical data were analyzed using the Spearman test, with a p-value of <0,05. Results, of the 40 subjects, 55% subjects were male, in 45% of subjects, there was Vitamin D deficiency, 25% was vitamin D insufficiency, hypocalcemia in 77,5% subjects. Among subjects with vitamin D deficiency, 94,4% also had hypocalcemia (r = 0,037, p = 0,017). In conclusion, there was a significant association between vitamin D and calcium status in children with beta-thalassemia major.
Co-Authors Anidar Anidar, Anidar Bakhtiar Bakhtiar Chalisah, Lilis Edward, Eka Destianti Fadhil, Iziddin Fajar, Sukmawan Fajri, Fauzan Fajri, Rizky Fiska, RR. Rima Aulia Gunawan, Aris Halsa, Ulliya Permata Hasan, Denny Irmawati Herlina Dimiati, Herlina Heru Noviat Herdata, Heru Noviat Ismy, Jufitriani Julinar Julinar Julinar Mahara, Cut Mudarris, Muhammad Raisul Mulya Safri, Mulya Nadia, Nurul Nandita, Aisya Shaka Nora Sovira, Nora Rusdi Andid, Rusdi Sari, Eva Devita Silvia Yasmin Lubis, Silvia Yasmin Sulaiman Yusuf Syafruddin Haris, Syafruddin Thaib, T.M. Zakia, Fitri