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Histopathological Difference of Inflammatory Cells Infiltration into Fetal Membranes of PROM and Non-PROM SUDIARTA, KETUT EDY; FABIOLLA, FABIOLLA; HERDIYANTINI, MITA
Nusantara Medical Science Journal Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i1.36072

Abstract

Introduction: Premature rupture of membranes (PROM) remains one of several causes of premature birth that increases both maternal mortality ratio and neonatal mortality rate. Inflammation of fetal membranes leads to release of inflammatory mediators and resulting in weakness of fetal membranes, particularly the amniotic membrane. The amniotic membrane in PROM has a focal weakness, which differs from the membrane in non-premature rupture of membrane (non-PROM) that has a generalized weakness. This research aimed to determine histopathological difference of inflammatory cells infiltration into fetal membranes of PROM and non-PROM.   Methods:  Quantitative observation was applied to this research. Cross-sectional design was used for analyzing data. Primary data was collected from the delivery room and operating theater of Emergency Department in dr. Ramelan Central Naval Hospital (RSPAL dr. Ramelan) Surabaya. Data collection started from August to November 2019 using total population sampling technique. Results: A total of 40 samples histopathologically examined showed that 11 out of 20 (55%) fetal membranes in PROM had polymorphonuclear (PMN) cells infiltration and 9 (45%) did not have PMN cells infiltration, 1 out of 20 (5%) fetal membranes in non-PROM had PMN cells infiltration and 19 (95%) did not have PMN cells infiltration. The prevalence ratio (PR) of PROM based upon the presence of PMN cells infiltration into fetal membranes was 2.85 (PR>1). The significance level of Chi-square test was 0.001 (ρ>0.05). Conclusions: The difference of inflammatory cells infiltration into fetal membranes of PROM and non-PROM was statistically significant.
KEJADIAN DEPRESI PADA IBU POST PARTUM GEMELI DI RSUD Dr. SOEROTO NGAWI Mita Herdiyantini; Wienta Diarsvitri
Surabaya Biomedical Journal Vol. 1 No. 2 (2022): January
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.20

Abstract

Tujuan Penelitian: Perubahan biologis selama kehamilan dapat menjadi penctus terjadinya gangguan psikologis mulai dari yang ringan hingga gangguan jiwa. Penelitian ini memberikan gambaran kejadian depresi pada ibu post partum yang melahirkan bayi kembar (gemeli) di RSUDD Dr. Soeroto Ngawi selama bulan Januari 2016-Maret 2016. Metode : Penelitian deskriptif ini menggunakan kuesioner Edinburgh Postnatal Depresion Scale (EPDS) pada 12 ibu post partum yang melahirkan gemeli di Ruang Nifas Wijaya Kusuma dan kontrol nifas di Poli Hamil/Kandungan Rumah Sakit Umum Dr. Soeroto, Ngawi selama bulan Januari 2016-Maret 2016. Hasil : Sebagian besar responden (75%) berpendidikan SD-SMP, 67% responden berusia 20-24 tahun, 67% responden tidak bekerja, 58% tidak pernah kontrol rutin selama kehamilan. Enam responden (50%) menyatakan jarang mengalami gangguan tidur, 33% menyatakan bahwa hampir setiap waktu mengalami gangguan tidur karena kecemasan yang dialami, 17% tidak pernah mengalami gangguan tidur. Mayoritas responden (58%) tidak pernah mengalami kejadian/peristiwa berat pada satu tahun sebelum hamil. Berdasarkan hasil Kuesioner EPDS didapatkan 58% responden kemungkinan tidak mengalami depresi, 25% responden kemungkinannya sedang untuk mengalami depresi, 17% responden kemungkinannya tinggi untuk mengalami depresi. Kesimpulan : Sebagian besar responden post partum gemeli yang kemungkinan mengalami depresi berasal dari kelompok usia 20-24 tahun, mempunyai anak lebih dari tiga, dan tidak rutin kontrol di poli RSUDD Dr. Soeroto Ngawi. Oleh karena itu diperlukan kerjasama lintas sektor untuk mencegah terjadinya depresi pada ibu post partum gemelli.
Correlation Between 25-Hydroxyvitamin D Levels ND Preeclampsia among Primigravida Mothers Keysha Amalia Fitrah Adrian; Agung Sunarko Putra; Dian Ardiana; Mita Herdiyantini
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1206

Abstract

Maternal Mortality Rate (MMR) is still a health challenge at the global and national levels. One of the main causes of maternal mortality is preeclampsia, which can cause serious complications in both the mother and the fetus. Risk factors for preeclampsia include reproductive status, health conditions, and nutritional deficiencies, including vitamin D. Vitamin D has an important role in placental implantation and function through angiogenic, anti-inflammatory, and immunomodulatory effects. Some studies suggest low levels of vitamin D are associated with an increased risk of preeclampsia. In addition, primigravida is known to be more prone to preeclampsia than multigravidae. This study aims to determine the correlation between vitamin D 25-OH levels and the incidence of preeclampsia in primigravida mothers at the Obstetrics and Gynecology Polyclinic RSPAL dr. Ramelan Surabaya for the 2023-2025 period. Cross-sectional research was carried out at RSPAL dr. Ramelan Surabaya. A total of 66 primigravida mothers were selected by total sampling. The dependent variable is the occurrence of preeclampsia. The independent variable is the vitamin D 25-OH level. Data in the form of medical records of the Obstetrics and Gynecology Polyclinic RSPAL dr. Ramelan Surabaya for the 2023-2025 period. The data were analyzed by the Kendall's Tau-b test. The results of Kendall's Tau-b test showed that the age variable showed a weak positive association with the incidence of preeclampsia but was not statistically significant (τ = 0.195; p = 0.116). Body mass index (BMI) had a positive association with moderate strength and significant to the incidence of preeclampsia (τ = 0.334; p = 0.005), suggesting that an increase in BMI was associated with an increased incidence of preeclampsia. Mean Arterial Pressure (MAP) showed a very strong and significant positive association with the incidence of preeclampsia (τ = 1.000; p < 0.001), confirming the role of blood pressure as a factor strongly related to preeclampsia. Meanwhile, vitamin D 25-OH levels showed a weak and statistically insignificant positive association with the incidence of preeclampsia (τ = 0.217; p = 1,000). There is no correlation between vitamin D 25-OH levels and the incidence of preeclampsia in primigravida mothers at the Obstetrics and Gynecology Polyclinic RSPAL dr. Ramelan Surabaya for the 2023-2025 period.
Vesicovaginal fistula with surgical interventions at Dr. Ramelan Naval Hospital, Surabaya, Indonesia Sahika Nisandi Ayudelvi; Risa Najmi; Ritma Visi Amala; Rizka Indah Ramadina; Salma Inas Konitatunisa; Mita Herdiyantini; Dian Ardiana
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.249-261

Abstract

HIGHLIGHTS Vesicovaginal fistula (VVF) cases in this study were primarily caused by hysterectomy, post-caesarean section surgery, and radiation therapy for cervical cancer. Symptoms experienced by patients included urine leakage from the vagina, foul odor, and pain during urination. The success rate of fistula repair using cystography and fistula repair procedures was very high. The patients were able to urinate normally without pain or vaginal leakage.   ABSTRACT Objective: Evaluating the risk factors and outcomes of surgical interventions in patients with vesicovaginal fistula at Dr. Ramelan Naval Hospital Surabaya, Indonesia, from January 2019 to December 2023. Case Series: There were 6 cases of vesicovaginal fistula that underwent surgical interventions at Dr. Ramelan Naval Hospital, Surabaya, from 2019 to 2023 that met the inclusion criteria. The majority of vesicovaginal fistula cases occurred as a result of hysterectomy, accounting for 4 cases (67%), followed by caesarean section surgery (16%) and radiation therapy for cervical cancer (17%). Symptoms experienced by the patients included urine leakage from the vagina, foul odor, and pain during urination. The vesicovaginal fistulas that underwent surgical interventions were typically 0.5 to 3 cm in size. Most of the cases involved simple-type fistulas. A total of 5 cases (83%) were successfully repaired. These patients were able to urinate normally, without pain or vaginal leakage. However, 1 case (17%) experienced recurrent fistula with an increase in the number of fistulas and continued to experience pain during urination and leakage from the vagina, particularly during strenuous activities. Conclusion: The vesicovaginal fistula cases at Dr. Ramelan Naval Hospital Surabaya, Indonesia, from 2019 to 2023 showed a high therapeutic success rate. Among 6 patients that we studied, the majority of cases were caused by hysterectomy, characterized as simple-type fistulas, with 83% of the cases were successfully repaired.