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Evaluasi Hasil Histerosalpingografi Pasien Infertil dengan Nyeri dan Laparoskopi di Rumkital Dr. Ramelan Surabaya Nanda Putra Prakasa; Mita Herdiyantini; Dody Taruna
HANG TUAH MEDICAL JOURNAL Vol 16 No 2 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRACT Background: Infertility can caused factors of cervix, uterine, tubal and peritoneal, ovulation and sperm factors in men. Abnormality of tubal factor and primary peritoneum factors are endometriosis and PID, which clinically give complain of pain. Checkup of tubal and peritoneum factors are difficult to conduct. It needs laparoscopic equipment and laparoscopic specialist doctors. Whereas the most convenient, cheapest, not invasive and large equipment which are used to find tubal factor is by checking-up Hysterosalpingography (HSG). HSG only can find tubal potential and peritoneal factor. Objective: to measure the relation between pain and checkup result of hysterosalpingography with laparoscopic examination results. Method: observational analytic which was retrospective longitudinal using secondary data and medical record infertile women who had been conducted HSG test before, which were conducted laparoscopy and registered in obstetrician at Rumkital dr. Ramelan Surabaya in Januari 2013 - December 2017 as population. The samples were 30 respondents. Furthermore, data analysis were calculated using Chi-square test, Fisher Exact Test. It was carried out the descriptive analysis for data by valuing Sensitivity, Specificity, Positive Predictive Value and Negative Divination Value. Result: data showed that there was relation between pain and the result of laparoscopy test in infertile patient and there was relation between the result of HSG test and the result of laparoscopy test in infertile paitients at Rumkital dr. Ramelan Surabaya. Conclusion: there is a relation between pain complain and the result of hysterosalpingography with laparoscopic examination results.

Karakteristik Pasien Tuberkulosis Paru Dengan HIV di Rumah Sakit Umum Daerah Dr Harjono Ponorogo Periode Januari 2018 - Desember 2022 Anindya Zalfaa Kusuma Dewi; Ronald Pratama A.; Dody Taruna; Irmawati M. Dikman; Soedarsono Soedarsono; Yelvi Levani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.21666

Tuberculosis (TB) is the most common opportunistic infection in people living with HIV/AIDS in Indonesia, and HIV infection promotes Mycobacterium tuberculosis infection. In ODHIV, the probability of contracting TB is 10% per year. According to the Indonesian Ministry of Health, East Java is in second place with 71,909 cases and has the second highest number of AIDS patients and 824,000 TB cases in Indonesia. This study aims to determine the characteristics of pulmonary tuberculosis patients with HIV at DR Harjono Ponorogo Hospital for the period January 2018 - December 2022. This study applied descriptive research methodology with quantitative techniques with secondary data from medical records of pulmonary TB patients with HIV at Dr. Harjono Ponorogo Hospital for the period January 2018 - December 2022. The results showed a total sample of 130 medical records, there were several characteristics of TB patients with HIV, namely the highest age group of 30-39 years by 29.2%, more in male gender 73%. More patients had last high school education 38.5%, more treatment duration in patients who did for 9 months 61.5% and the results showed more patients with poor prognosis 56%. In conclusion, the characteristics of TB patients with HIV with the highest group at the age of 3-39 years, having male gender, more high school education, with more treatment duration of 9 months, and the results showed a poor prognosis.

Efek Pemberian Eucheuma spinosum sebagai Profilaksis dalam Penghambatan Peningkatan SGPT pada Tikus yang Diinduksi Dexamethasone HANDAJANI, FITRI; PERMANA, I GEDE PUTU BAYU TIRTA; TARUNA, DODY; UNTARI, NI KOMANG SRI DEWI
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.359

Serum Glutamic Pyruvate Transaminase (SGPT) is a specific biomarker for detecting liver disease. This study aimed to determine the effect of giving 200 mg/Kg BW of Euchema spinosum extract as a prophylaxis against increasing SGPT in Rattus norvegicus rats injected with dexamethasone 8mg/Kg BW for six days. This experimental study with a randomized posttest-only control group design using 24 white male rats which were divided into three groups; group 1 was the untreated group, group 2 was given dexamethasone 8 mg/Kg BW for six days, the group 3 was given prophylactic 200 mg/Kg BW Eucheuma sp. extract for 13 days. After the treatment period, the group was terminated, and SGPT levels were measured using Cobas Integra. SGPT levels were then analyzed using SPSS. The normality test results for SGPT levels obtained a value of p> 0.05, and this value was only obtained from group 1 (p = 0.085) and group 2 (p = 0.224), while the group 3 showed that the distribution of data was not normally distributed (p = 0.022). The Kruskal-Wallis test showed a mean difference in SGPT levels between groups. The Mann-Whitney U test obtained a lower SGPT score in group 3 than in group 2 (p=0.007). Group 1, compared to group 3, decreased (p=0.001). Giving extract of Eucheuma sp. at a dose of 200 mg/Kg BW can inhibit the increase in SGPT levels in dexamethasone-induced white male rats (Rattus norvegicus).

Patin sebagai sumber omega 3 untuk menurunkan faktor resiko terjadinya MAFLD karena DM tipe 2 Rahayu, Indri N.; Kumala, Asami Rietta; Taruna, Dody; Husodo, Stefanus Djoni; Dagradi, Eric Mayo; Sukmana, Judya
Surabaya Biomedical Journal Vol 3 No 1 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v3i1.114

Diet asam lemak tak jenuh ganda (PUFA) telah diteliti dan terbukti dapat memodulasi peradangan, namun, hanya sedikit beberapa penelitian yang fokusnya pada patobiologi PUFA dengan menggunakan diet isokalori dan isolipid namun belum dapat dijelaskan apakah patologi terkait tersebut disebabkan oleh komposisi diet PUFA, metabolisme lipid, atau obesitas, karena sebagian besar penelitian membandingkan diet dengan yang diberi makan ad libitum. Stres oksidatif dan mitokondria hati berperan dalam patogenesis penyakit hati berlemak nonalcohol. Omega-3 PUFA memiliki peran protektif yang potensial terhadap kerusakan sel oksidatif yang diinduksi ROS pada tikus organ, terutama di hati. Atenuasi hepatic fibrosis oleh EPA (asam eicosapentaenoic) secara signifikan berhubungan dengan kadar ROS hati. EPA juga menekan peningkatan kadar ROS hati dan penurunan penanda oksidatif serum, seperti 8-isoprostan dan feritin. Ikan patin memiliki kandungan asam lemak tak jenuh ganda omega 3 serta selenium yang merupakan antioksidan sehingga dapat menghambat terjadinya progresifisitas kejadian NAFLD maupun MAFLD. Mekanismenya antara lain melalui jalur penghambatan stress oksidatif yang merupakan patofisiologi terjadinya NAFLD maupun MAFLD.

Karakteristik Pasien Tuberkulosis Paru Dengan HIV di Rumah Sakit Umum Daerah Dr Harjono Ponorogo Periode Januari 2018 - Desember 2022 Kusuma Dewi, Anindya Zalfaa; Pratama A., Ronald; Taruna, Dody; M. Dikman, Irmawati; Soedarsono, Soedarsono; Levani, Yelvi
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.21666

Tuberculosis (TB) is the most common opportunistic infection in people living with HIV/AIDS in Indonesia, and HIV infection promotes Mycobacterium tuberculosis infection. In ODHIV, the probability of contracting TB is 10% per year. According to the Indonesian Ministry of Health, East Java is in second place with 71,909 cases and has the second highest number of AIDS patients and 824,000 TB cases in Indonesia. This study aims to determine the characteristics of pulmonary tuberculosis patients with HIV at DR Harjono Ponorogo Hospital for the period January 2018 - December 2022. This study applied descriptive research methodology with quantitative techniques with secondary data from medical records of pulmonary TB patients with HIV at Dr. Harjono Ponorogo Hospital for the period January 2018 - December 2022. The results showed a total sample of 130 medical records, there were several characteristics of TB patients with HIV, namely the highest age group of 30-39 years by 29.2%, more in male gender 73%. More patients had last high school education 38.5%, more treatment duration in patients who did for 9 months 61.5% and the results showed more patients with poor prognosis 56%. In conclusion, the characteristics of TB patients with HIV with the highest group at the age of 3-39 years, having male gender, more high school education, with more treatment duration of 9 months, and the results showed a poor prognosis.

In-Silico Study of Black Sea Cucumber (Holothuria atra) Active Compounds against Plasmepsin 2 Protein of Plasmodium falciparum De. Bima Kurnia Ramadhan; Prawesty Diah Utami; Nita Pranitasari; I Dewa Made Widi Hersana; Dody Taruna
WMJ (Warmadewa Medical Journal) Vol 10 No 1 (2025): May 2025
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.10.1.11823.12-27

The existence of evidence of resistance to artemisinin derivatives as first-line malaria therapy is a problem that must be resolved. One of them is a marine biota, which has the potential to act as an anti-malarial, namely the black sea cucumber (Holothuria atra/ H.atra). The aim of this research is to analyze H. atra antimalarial activity against P. falciparum - plasmepsin 2 protein used in-silico approach. This type of research is experimental, using in-silico tests (computerized tests) on bioactive compounds and target proteins. This research analyzes several aspects: the preparation of materials and tools, the preparation of P. falciparum protein, the preparation of active compounds for H. atra, the prediction of compound and pathway potential, the prediction of interactions between plasmepsin protein and bioactive compounds, and the prediction of antimalarial inhibitors on active compounds. The results of Quantitative Structure–Activity Relationship/ analysis show that the biologically active compounds of sea cucumbers have anti-parasitic properties. Furthermore, the docking results show that 3 biologically active compounds from sea cucumbers have quite good inhibitory activity against Plasmepsin2 proteins, especially the compounds chlorogenic acid, catechin, and rutin. Chlorogenic acid compounds also have high PA values as antiparasitic agents, especially greater than 0.4. ADME/T demonstrated that chlorogenic acid and catechin conform to Lipinski's rule, but rutin fails to satisfy Lipinski's rule. Toxicity analysis showed that catechin (level 6) has lower toxicity than chlorogenic acid (level 4), and rutin (level 5). Therefore, it can be predicted that chlorogenic acid is the most potent compound in sea cucumbers with anti-malarial effects

The Effect of Aerobic Exercise on Lowering the Pulse Rate of Isitirahat in Women Over 40 Years of Age Who Work Indoors Regina Safira Patricia; Prima Arundani; Dody Taruna; Asami Rietta Kumala
Journal of Social Research Vol. 5 No. 3 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i3.3068

This study aims to determine the effect of aerobic exercise on reducing resting heart rate in women over 40 years old who work indoors. This research employed an experimental quantitative design with a one-group pre-test–post-test approach. The sample consisted of 30 women aged over 40 years who worked indoors and met the inclusion criteria. The intervention involved low-impact aerobic exercise performed for four weeks, three times per week, for 30 minutes per session. Resting heart rate was measured before and after the intervention. Data were analyzed using the paired sample t-test after fulfilling the Shapiro–Wilk normality test. The results showed that the average resting heart rate before aerobic exercise was 80.50 bpm and decreased to 73.07 bpm after the intervention. The reduction of 7.43 bpm was statistically significant (p = 0.000), indicating cardiovascular adaptations such as increased parasympathetic activity and improved cardiac efficiency. Aerobic exercise has a significant effect on reducing resting heart rate in women over 40 years old who work indoors. Regular aerobic exercise for four weeks is effective in improving cardiac efficiency and cardiovascular fitness.

Patin sebagai sumber omega 3 untuk menurunkan faktor resiko terjadinya MAFLD karena DM tipe 2 Indri N. Rahayu; Asami Rietta Kumala; Dody Taruna; Stefanus Djoni Husodo; Eric Mayo Dagradi; Judya Sukmana
Surabaya Biomedical Journal Vol. 3 No. 1 (2023): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v3i1.114

Diet asam lemak tak jenuh ganda (PUFA) telah diteliti dan terbukti dapat memodulasi peradangan, namun, hanya sedikit beberapa penelitian yang fokusnya pada patobiologi PUFA dengan menggunakan diet isokalori dan isolipid namun belum dapat dijelaskan apakah patologi terkait tersebut disebabkan oleh komposisi diet PUFA, metabolisme lipid, atau obesitas, karena sebagian besar penelitian membandingkan diet dengan yang diberi makan ad libitum. Stres oksidatif dan mitokondria hati berperan dalam patogenesis penyakit hati berlemak nonalcohol. Omega-3 PUFA memiliki peran protektif yang potensial terhadap kerusakan sel oksidatif yang diinduksi ROS pada tikus organ, terutama di hati. Atenuasi hepatic fibrosis oleh EPA (asam eicosapentaenoic) secara signifikan berhubungan dengan kadar ROS hati. EPA juga menekan peningkatan kadar ROS hati dan penurunan penanda oksidatif serum, seperti 8-isoprostan dan feritin. Ikan patin memiliki kandungan asam lemak tak jenuh ganda omega 3 serta selenium yang merupakan antioksidan sehingga dapat menghambat terjadinya progresifisitas kejadian NAFLD maupun MAFLD. Mekanismenya antara lain melalui jalur penghambatan stress oksidatif yang merupakan patofisiologi terjadinya NAFLD maupun MAFLD.

Efek Pemberian Eucheuma spinosum sebagai Profilaksis dalam Penghambatan Peningkatan SGPT pada Tikus yang Diinduksi Dexamethasone HANDAJANI, FITRI; PERMANA, I GEDE PUTU BAYU TIRTA; TARUNA, DODY; UNTARI, NI KOMANG SRI DEWI
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.359

Serum Glutamic Pyruvate Transaminase (SGPT) is a specific biomarker for detecting liver disease. This study aimed to determine the effect of giving 200 mg/Kg BW of Euchema spinosum extract as a prophylaxis against increasing SGPT in Rattus norvegicus rats injected with dexamethasone 8mg/Kg BW for six days. This experimental study with a randomized posttest-only control group design using 24 white male rats which were divided into three groups; group 1 was the untreated group, group 2 was given dexamethasone 8 mg/Kg BW for six days, the group 3 was given prophylactic 200 mg/Kg BW Eucheuma sp. extract for 13 days. After the treatment period, the group was terminated, and SGPT levels were measured using Cobas Integra. SGPT levels were then analyzed using SPSS. The normality test results for SGPT levels obtained a value of p> 0.05, and this value was only obtained from group 1 (p = 0.085) and group 2 (p = 0.224), while the group 3 showed that the distribution of data was not normally distributed (p = 0.022). The Kruskal-Wallis test showed a mean difference in SGPT levels between groups. The Mann-Whitney U test obtained a lower SGPT score in group 3 than in group 2 (p=0.007). Group 1, compared to group 3, decreased (p=0.001). Giving extract of Eucheuma sp. at a dose of 200 mg/Kg BW can inhibit the increase in SGPT levels in dexamethasone-induced white male rats (Rattus norvegicus).

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